41. Subacute Sclerosing Panencehalitis subacute sclerosing panencephalitis (SSPE). Please report any new casesof subacute sclerosing panencephalitis (SSPE) to Paul Dyken http://www.waisman.wisc.edu/child-neuro/seekpt-f/sspe.html

Subacute Sclerosing Panencephalitis (SSPE) Please report any new cases of subacute sclerosing panencephalitis (SSPE) to: Paul Dyken, M.D. World SSPE Registry P.O. Box 70191 283 Wingfield Drive Mobile, Alabama, USA 36670-0191 telephone USA 334-478-6424 fax USA 334-476-8277 mailto: pdyken@aol.com Go back to Child-Neuro Homepage Go back to Clinical Studies Seeking Patients page Last updated 06 October 1999

42. Dorlands Medical Dictionary subacute sclerosing panencephalitis, (SSPE) a rare and devastating formof leukoencephalitis usually affecting children and adolescents. http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

43. Health Library Find Information On Subacute Sclerosing Find information on subacute sclerosing panencephalitis at MerckSource.Learn subacute sclerosing panencephalitis. Definition SSPE http://www.mercksource.com/pp/us/cns/cns_hl_adam.jspzQzpgzEzzSzppdocszSzuszSzcns

44. UC Irvine Department Of Ophthalmology Wechsler, SL, Stallcup, KC, and Fields, BN (1978) A comparison of the intracellularpolypep­tides of measles and subacute sclerosing panencephalitis virus. http://www.ucihs.uci.edu/uceye/wechsler.html

UC Irvine Department of Ophthalmology Steven Lewis Wechsler, Ph.D. Dr. Wechsler is recognized as a leader in the field of HSV latency and is well published in high quality, peer-review journals. He earned his PhD. in Molecular Genetics from the University of North Carolina, Chapel Hill, NC. He went on to complete a postdoctoral fellowship with Dr. Bernard Fields at Harvard Medical School. Dr. Wechsler is currently principal investigator on three NIH/RO1 grants related to the study of HSV-1, and co-investigator on one additional RO1. He holds three US patents and has one patent pending relating to a herpes simplex virus type 1 mutant to selectively destroy brain tumors and A herpes simplex virus type 1 vector for delivery of genes to brain tumors and/or neurons. Review Articles and Book Chapters Wechsler, S.L., Stallcup, K.C., and Fields, B.N. (1978) A comparison of the intracellular polypep­tides of measles and subacute sclerosing panencephalitis virus. In: Negative Strand Viruses and the Host Cell (B.W.J. Mahy and R.D. Barry, eds.), pp. 169-180. Academic Press, Inc., New York. Wechsler, S.L., Meissner, H.C., Ray, U.R., Weiner, H.L., Rustigian, R., and Fields, B.N. (1981) Immune response in subacute sclerosing panencephalitis and multiple sclerosis: Antibody re­sponse to measles virus proteins. In: Replication of Negative Strand Viruses (D.H.L. Bishop and R. W. Compans, eds.), pp. 615-622. Elsevier North Holland, New York.

45. ClinicalTrials.gov - Linking Patients To Medical Research Search Query Details. No studies were found for subacute sclerosing panencephalitis ALLFIELDS. IndividualTerms, Count. subacute sclerosing panencephalitis , None. http://www.clinicaltrials.gov/search/term=Subacute Sclerosing Panencephalitis

46. ClinicalTrials.gov - Linking Patients To Medical Research Search Query Details. No studies were found for NINDS Subacute SclerosingPanencephalitis Information Page ALLFIELDS. Modify Your Search. http://www.clinicaltrials.gov/search/term=NINDS Subacute Sclerosing Panencephali

47. Subacute Sclerosing Panencephalitis | Building Better Health You are here Home Health A to Z subacute sclerosing panencephalitis HealthTopics AZ subacute sclerosing panencephalitis. Turkington, Carol A. http://www.buildingbetterhealth.com/topic/topic100587517

Medical Library Cool Tools Women's Health Men's Health ... Drug Dictionary You are here: Home Health A to Z Health Topics A-Z Subacute Sclerosing Panencephalitis Turkington, Carol A. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus. Description This fatal condition is a complication of measles, and affects children and young adults before the age of 20. It usually occurs in boys more often than in girls, but is extremely rare, appearing in only one out of a million cases of measles. Causes and symptoms Experts believe this condition is a form of measles encephalitis (swelling of the brain), caused by an improper response by the immune system to the measles virus. The condition begins with behavioral changes, memory loss, irritability, and problems with school work. As the neurological damage increases, the child experiences seizures, involuntary movements, and further neurological deterioration. Eventually, the child starts suffering from progressive dementia. The optic nerve begins to shrink and weaken (atrophy) and subsequently the child becomes blind. Diagnosis Blood tests and spinal fluid reveal high levels of antibodies to measles virus, and there is a characteristically abnormal electroencephalogram (EEG), or brain wave test. Typically, there is a history of measles infection two to ten years before symptoms begin.

48. Iritis And Uveitis - Review Questions Measles 4. The incidence of subacute sclerosing panencephalitis is EEG pattern. 6. Ocularsymptoms in the course of subacute sclerosing panencephalitis are present in http://www.uveitis.org/Enhanced/Review/rev_measles.htm

Measles Erik Letko, M.D. The most common ocular manifestation of acute measles infection is: conjunctivitis epithelial keratitis retinitis uveitis Koplik’s spots can be present in: buccal mucosa buccal mucosa and skin conjunctiva and buccal mucosa skin and conjunctiva The most common complication in acute measles infection leading to blindness is: subacute sclerosing panencephalitis bacterial keratitis retinitis optic neuritis The incidence of subacute sclerosing panencephalitis is: 1 to 10 cases per 10 million cases of measles 1 to 100 cases per 10 million cases of measles 1 to 10 cases per 1 million cases of measles 10 to 20 per 10 million cases of measles The diagnostic criteria for subacute sclerosing panencephalitis include all of the following EXCEPT: elevated globulin levels in cerebrospinal fluid elevated levels of IgG measles antibodies in serum and cerebrospinal fluid elevated levels of IgM measles antibodies in serum and cerebrospinal fluid Biopsy or necropsy result EEG pattern Ocular symptoms in the course of subacute sclerosing panencephalitis are present in: 30 to 50 % of patients 10 to 20 % of patients 70 to 90 % of patients 5 to 10 % of patients Ocular manifestations associated with subacute sclerosing panencephalitis include all of the following EXCEPT: vitritis retinitis serous retinal detachment

49. Cerebral Sclerosis, Diffuse Coll. of Wisconsin. subacute sclerosing panencephalitis Search PUBMEDfor subacute sclerosing panencephalitis All Review Therapy Diagnosis; http://www.ohsu.edu/cliniweb/C10/C10.228.140.276.html

Cerebral Sclerosis, Diffuse Back to previous level Encephalitis Periaxialis Search PUBMED for Encephalitis Periaxialis: All Review Therapy Diagnosis Leukodystrophy, Globoid Cell Search PUBMED for Leukodystrophy, Globoid Cell: All Review Therapy Diagnosis ... Globoid cell (Krabbe) leukodystrophy: Med. Coll. of Wisconsin Leukodystrophy, Metachromatic Search PUBMED for Leukodystrophy, Metachromatic: All Review Therapy Diagnosis ... Metachromatic Leukodystrophy: Med. Coll. of Wisconsin Subacute Sclerosing Panencephalitis Search PUBMED for Subacute Sclerosing Panencephalitis: All Review Therapy Diagnosis ... Subacute Sclerosing Panencephalitis: Virtual Hospital, U. of Iowa

50. Measles Measles. Back to previous level subacute sclerosing panencephalitis SearchPUBMED for subacute sclerosing panencephalitis All Review Therapy Diagnosis; http://www.ohsu.edu/cliniweb/C2/C2.782.580.600.500.500.html

Measles Back to previous level Subacute Sclerosing Panencephalitis Search PUBMED for Subacute Sclerosing Panencephalitis: All Review Therapy Diagnosis ... Subacute Sclerosing Panencephalitis: Virtual Hospital, U. of Iowa

51. NORD - National Organization For Rare Disorders, Inc. subacute sclerosing panencephalitis. Copyright 1986, 1987, 1994 Synonyms of SubacuteSclerosing Panencephalitis Panencephalitis, Subacute Sclerosing; SSPE. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Subacute Scle

52. Health Ency.: Disease: Subacute Sclerosing Panencephalitis Ency. home Disease S subacute sclerosing panencephalitis. Subacute sclerosingpanencephalitis. home Disease S subacute sclerosing panencephalitis. http://www.austin360.com/shared/health/adam/ency/article/001419.html

SEARCH: The Web Yellow Pages HOME Illustrated Health Encyclopedia Important notice Ency. home Disease S Subacute sclerosing panencephalitis Overview Symptoms Treatment Prevention Alternative names: SSPE; Dawson encephalitis Definition: SSPE is a neurologic disorder following infection with the measles rubeola ) virus. Causes and Risks SSPE occurs worldwide. However, the incidence of this disease has decreased dramatically in the United States following the nationwide measles immunization program. SSPE tends to occur several years after having measles ( rubeola ) even though the measle recovery appears to have been normal. More males are affected than females, and the disease generally occurs in children and adolescents. Affected individuals generally succumb one to two years after diagnosis, but some may survive for longer periods. SSPE begins slowly with subtle behavioral changes and mounting difficulty in school. As the disease progresses, behavior becomes bizarre and the person eventually develops dementia, stupor coma , and finally death. Physical signs are few until the disease is well advanced. Patients may have rhythmic jerking of the body every few seconds

53. Subacute Sclerosing Panencephalitis | Vhihealthe subacute sclerosing panencephalitis. http://www2.vhihealthe.com/topic/topic100587517

You are here: Home Health A to Z Subacute Sclerosing Panencephalitis Turkington, Carol A. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus. Description This fatal condition is a complication of measles, and affects children and young adults before the age of 20. It usually occurs in boys more often than in girls, but is extremely rare, appearing in only one out of a million cases of measles. Causes and symptoms Experts believe this condition is a form of measles encephalitis (swelling of the brain), caused by an improper response by the immune system to the measles virus. The condition begins with behavioral changes, memory loss, irritability, and problems with school work. As the neurological damage increases, the child experiences seizures, involuntary movements, and further neurological deterioration. Eventually, the child starts suffering from progressive dementia. The optic nerve begins to shrink and weaken (atrophy) and subsequently the child becomes blind. Diagnosis Blood tests and spinal fluid reveal high levels of antibodies to measles virus, and there is a characteristically abnormal electroencephalogram (EEG), or brain wave test. Typically, there is a history of measles infection two to ten years before symptoms begin.

54. THE MERCK MANUAL, Sec. 19, Ch. 265, Childhood Infections subacute sclerosing panencephalitis (SSPE) is also associated with measles virusand is discussed below. Diagnosis. subacute sclerosing panencephalitis. http://www.merck.com/pubs/mmanual/section19/chapter265/265b.htm

This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 19. Pediatrics Chapter 265. Childhood Infections Topics Bacterial Infections Viral Infections Miscellaneous Infections Viral Infections (For a summary of differential diagnosis of the more common exanthems, see Table 265-8. MEASLES (Rubeola; Morbilli; Nine-Day Measles) A highly contagious, acute viral infection characterized by fever, cough, coryza, conjunctivitis, enanthem (Koplik's spots) on the buccal or labial mucosa, and a spreading maculopapular cutaneous rash. Etiology and Pathogenesis Measles is caused by a paramyxovirus. Measles (like chickenpox) is extremely communicable and is spread mainly by small droplets from the nose, throat, and mouth of a person in the prodromal or an early eruptive stage of the disease or by airborne droplet nuclei. Indirect spread by uninfected persons or by objects is unusual. The communicable period of the disease begins 2 to 4 days before the rash appears until 2 to 5 days after onset. The virus disappears from nose and throat secretions by the time the rash clears. Persons who develop mild desquamation after the rash are no longer infectious. Atypical measles syndrome usually occurs in persons previously immunized with the original killed virus measles vaccines, which are no longer available. Presumably, inactivated measles virus vaccines do not prevent wild virus infection and can sensitize patients so that disease expression is altered significantly. However, atypical measles syndrome may also follow immunization with live, attenuated measles vaccine, perhaps resulting from inadvertent inactivation due to improper storage.

55. THE MERCK MANUALHome Edition, Sec. 23, Ch. 260, Viral subacute sclerosing panencephalitis. subacute sclerosing panencephalitisprobably results from brain infection by the measles virus. http://www.merck.com/mrkshared/mmanual_home/sec23/260.jsp

56. Subacute Sclerosing Panencephalitis The Official Parent's Sourcebook on subacute sclerosing panencephalitis(Dawson encephalitis; Panencephalitis, Subacute Sclerosing). http://www.icongrouponline.com/health/Subacute_Sclerosing_Panencephalitis.html

ICON Health Publications Official Health Sourcebooks The Official Parent's Sourcebook on SUBACUTE SCLEROSING PANENCEPHALITIS (Dawson encephalitis; Panencephalitis, Subacute Sclerosing) Revised and Updated for the Internet Age Paperback Book Order by phone: 800-843-2665 (within USA) 1-201-272-3651 (from outside USA) Electronic File * E-Book version sent via e-mail in 2 business days Electronic File * E-Book version sent via e-mail in 2 business days Pages Price $28.95(USD) ISBN Published Synopsis A comprehensive manual for anyone interested in self-directed research on Subacute Sclerosing Panencephalitis. Fully referenced with ample Internet listings and glossary. Related Conditions/Synonyms Dawson encephalitis; Panencephalitis, Subacute Sclerosing Description Table of Contents Introduction Overview Organization Scope Moving Forward PART I: THE ESSENTIALS Chapter 1. The Essentials on Subacute Sclerosing Panencephalitis: Guidelines Overview What Is Subacute Sclerosing Panencephalitis? Is There Any Treatment? What Is the Prognosis? What Research Is Being Done?

57. NEJM -- Detection Of Measles Virus RNA In Lymphocytes From Peripheral-blood And Detection of measles virus RNA in lymphocytes from peripheralblood and brain perivascularinfiltrates of patients with subacute sclerosing panencephalitis. http://content.nejm.org/cgi/content/short/313/15/910

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 313:910-915 October 10, 1985 Number 15 Next Detection of measles virus RNA in lymphocytes from peripheral-blood and brain perivascular infiltrates of patients with subacute sclerosing panencephalitis JG Fournier, M Tardieu, P Lebon, O Robain, G Ponsot, S Rozenblatt, and M Bouteille Table of Contents Find Similar Articles in the Journal Notify a friend about this article Add to Personal Archive ... Related Articles in Medline Articles in Medline by Author: Fournier, J. G. Bouteille, M. Medline Citation Abstract HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Comments and questions? Please contact us The New England Journal of Medicine is owned, published, and Massachusetts Medical Society

58. NEJM -- Detection Of Measles Virus RNA In Lymphocytes From Peripheral-blood And Detection of measles virus RNA in lymphocytes from peripheralblood and brain perivascularinfiltrates of patients with subacute sclerosing panencephalitis JG http://content.nejm.org/cgi/content/abstract/313/15/910

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 313:910-915 October 10, 1985 Number 15 Next Detection of measles virus RNA in lymphocytes from peripheral-blood and brain perivascular infiltrates of patients with subacute sclerosing panencephalitis JG Fournier, M Tardieu, P Lebon, O Robain, G Ponsot, S Rozenblatt, and M Bouteille Table of Contents Find Similar Articles in the Journal Notify a friend about this article Add to Personal Archive ... Related Articles in Medline Articles in Medline by Author: Fournier, J. G. Bouteille, M. Medline Citation Abstract HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Comments and questions? Please contact us The New England Journal of Medicine is owned, published, and Massachusetts Medical Society

59. Introduction Return to contents page THE EPIDEMIOLOGY OF subacute sclerosing panencephalitis(SSPE) IN NORTHERN IRAN. Sh. Modarres,* M. Ghofrani**. http://www.sums.ac.ir/IJMS/9812/modares9812.html

Return to contents page THE EPIDEMIOLOGY OF SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) IN NORTHERN IRAN Sh. Modarres,* M. Ghofrani** *Department of Virology, Pasteur Institute of Iran, **Department of Pediatrics Neurology, Shahid Beheshti University of Medical Sciences, Mofid Children's Hospital, Tehran, Iran Keywords: Measles virus, subacute sclerosing panencephalitis (SSPE), epidemiology Introduction Measles virus is endemic throughout the world. The introduction of an effective live-virus vaccine has dramatically reduced the incidence of this disease in industrialized countries. However, measles is still a leading cause of death in young children in some developing countries. Complications involving the central nervous system (CNS) caused by measles virus are dreadful. Subacute sclerosing panencephalitis (SSPE) is a late progressive disorder of the CNS caused by persistent measles virusinfection. The clinical features of SSPE were accurately described by several investigators in early decades of this century. A viral etiology was suggested in the early reports including that published by Dawson in 1934. However, it was not until the mid '60s that measles virus was clearly identified as the causative agent of SSPE. The clinical presentation of SSPE is variable with widespread disturbances of the CNS. SSPE generally is a fatal disease in children and adolescents, some patients die within a few months but others survive for years in adecerebrate state.

60. Subacute Sclerosing Panencephalitis. The American Heritage® Dictionary Of The E subacute sclerosing panencephalitis. The American Heritage® Dictionary of theEnglish Language Fourth Edition. 2000. subacute sclerosing panencephalitis. http://www.bartleby.com/61/30/S0833050.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference American Heritage Dictionary subacute ... BIBLIOGRAPHIC RECORD The American Heritage Dictionary of the English Language: Fourth Edition. subacute sclerosing panencephalitis SYLLABICATION: PRONUNCIATION skl -r s ng NOUN: An often fatal degenerative disease of the central nervous system occurring chiefly in young people, caused by slow infection with a measles virus and characterized by progressive loss of mental and motor functions ending in dementia and paralysis.

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