41. Systemic Lupus Erythematosus systemic lupus erythematosus (SLE) is an autoimmune illness that causes a characteristicrash accompanied by inflammation of connective tissue, particularly http://www.gnc.com/health_notes/Concern/Lupus.htm

Systemic Lupus Erythematosus Also indexed as: Discoid Lupus Erythematosus (DLE), DLE, Lupus, SLE Introduction Checklist Symptoms Treatments ... References Systemic lupus erythematosus (SLE) is an autoimmune illness that causes a characteristic rash accompanied by inflammation of connective tissue, particularly joints, throughout the body. In autoimmune diseases, the immune system attacks the body instead of protecting it. Kidney, lung, and vascular damage are potential problems resulting from SLE. The cause of SLE is unknown, though 90% of cases occur in women of childbearing age. Several drugs, such as procainamide, hydralazine methyldopa , and chlorpromazine, may create SLE-like symptoms. Similarly, environmental pollution and industrial emissions may also trigger SLE-like symptoms in some people. In one reported case, zinc supplementation appears to have aggravated drug-induced SLE. Ultraviolet radiation from sun exposure is a commonly recognized trigger of lupus. Some chemicals found in dyes, such as hydrazine and tartrazine

42. Ask NOAH About: Lupus (Systemic Lupus Erythematosus) Lupus Foundation DrugInduced Lupus Erythematosus - MEDLINEplus Rheumatology Drug-InducedLupus - Virtual Hospital systemic lupus erythematosus Handout on http://www.noah-health.org/english/illness/arthritis/lupus.html

Ask NOAH About: Lupus What is Lupus? Care and Treatment Complications and Concerns The Basics Lupus and Children ... Information Resources What is Lupus? The Basics The Immune System and Lupus - LupusCanada (also in French Late Onset Lupus Fact Sheet - Lupus Foundation of America Lupus - National Library of Medicine (Interactive Flash Presentation) Lupus - Arthritis Canada (also in French) Lupus, An Introduction - LupusCanada (also in French Frequently Asked Questions About Lupus - Lupus Foundation of America Lupus: The Disease with 1,000 Faces - LupusCanada (also in French What is Lupus? - Lupus Foundation of America (also in Spanish Genetics Genetics and Lupus - Raphael J. DeHoratius, MD Researchers Locate Lupus Gene on Chromosome 1 - NIH Lupus and Children Childhood Lupus - Lupus Foundation of America Living with Lupus - KidsHealth Lupus and Teens The Adolescent With Lupus As A Young Adult - Lupus Foundation of Minnesota Life with Lupus - KidsHealth Lupus and Gender Lupus in Men - Lupus Foundation of America Men With Lupus and Antiphospholipid Syndrome - Lupus Foundation of Minnesota Lupus and Race/Ethnicity The Many Shades of Lupus - National Institute of Arthritis and Musculoskeletal and Skin Diseases What Black Women Should Know About Lupus - National Institute of Arthritis and Musculoskeletal and Skin Diseases What Hispanic Women Need to Know About Lupus - The S.L.E. Foundation

43. Medic-Planet Systemic Lupus Erythematosus systemic lupus erythematosus Advertisement See also Anemias, Arrhythmias, Autoimmunediseases, Bleeding and bruises, Congenital heart defects, Embryo, Heart http://www.medic-planet.com/MP_article/internal_reference/Systemic_lupus_erythem

44. Medic-Planet Systemic Lupus Erythematosus systemic lupus erythematosus Advertisement See also Anemias, Arrhythmias, Autoimmunediseases, Bleeding and bruises, Congenital heart defects, Embryo, Heart http://www.medic-planet.com/MP_article/internal_reference/systemic_lupus_erythem

45. ThirdAge - Adam - Systemic Lupus Erythematosus systemic lupus erythematosus. Definition A chronic, inflammatoryautoimmune disorder that may affect many organ systems including http://www.thirdage.com/health/adam/ency/article/000435.htm

document.write(''); document.write(''); document.write('<'); document.write('/SCRIPT>'); document.write(''); document.write(''); document.write('<'); document.write('/A>'); document.write('<'); document.write('/NOSCRIPT>'); document.write('<'); document.write('/IFRAME>'); Activities Computers Family Tree Health ... Prevention Systemic lupus erythematosus Definition: A chronic, inflammatory autoimmune disorder that may affect many organ systems including the skin, joints, and internal organs. Alternative Names: Disseminated lupus erythematosus; SLE; Lupus; Lupus erythematosus Causes, incidence, and risk factors: Normally the immune system controls the body's defenses against infection. In systemic lupus erythematosus (SLE) and other autoimmune diseases , these defenses are turned against the body when antibodies are produced against its own cells. These antibodies fight against the body's blood cells, organs, and tissues, causing chronic diseases. The mechanism or cause of autoimmune diseases is not fully known. The disease affects 9 times as many women as men. It may occur at any age, but appears mostly in people between the ages of 10 and 50 years. SLE may also be caused by certain drugs. When this occurs, it is known as

46. Systemic Lupus Erythematosus -- ECureMe.com systemic lupus erythematosus, more about systemic lupus erythematosus, Normal,Abnormal, Abnormal. more about systemic lupus erythematosus, .. http://www.ecureme.com/emyhealth/data/Systemic_lupus_erythematosus.asp

March 31, 2003 Select a Health Topic ADD/ADHD Allergy Alternative Medicine Arthritis Asthma Beyond Dieting Body Aches and Pains Breast Cancer Cancer Awareness Cardio Health Children's Health Colon Cancer Contraception COPD/Emphysema Dental Health Diabetes Elder Care Emergency Room Epilepsy Erectile Dysfunction Eye Care Fertility Fitness Gastrointestinal Health Glands and Hormones Gynecologic Health Hair Loss Headache Healthcare Today Healthy Aging HIV and AIDS Infectious Diseases Kidney Health Leukemia Liver Health Lung Cancer Lymphoma Multiple Sclerosis Men's Health Mental Health Nutrition Osteoporosis Parkinson's Disease Sexual Health Skin Health Sleep Disorders Special Events Stroke Surgeries and Procedures Teen Health Thyroid Health Urologic Health Vascular Disease Women's Health Workplace Health Ask The Doctor Lifestyle Counseling Ask by mail My Health Chart ... Hospitals Systemic Lupus Erythematosus more about Systemic Lupus Erythematosus Normal Abnormal Abnormal This is an autoimmune disease (the body's immune system mistakenly attacks itself). The disease is also called, "SLE", or "lupus." Almost every organ in the body is susceptible to this disease. It affects the joints (causes arthritis) in 90% of those affected with the disease.

47. Systemic Lupus Erythematosus MAIN SEARCH INDEX systemic lupus erythematosus. systemic lupus erythematosus. In Harrison's Principles of Internal Medicine, ed. Anthony S. Fauci, et al. http://www.hendrickhealth.org/healthy/001323.htm

MAIN SEARCH INDEX Systemic lupus erythematosus Definition Description Causes and symptoms Diagnosis ... Resources Systemic lupus erythematosus (SLE) is an autoimmune disease in which the individual's immune system attacks, injures, and destroys the body's own organs and tissues. Nearly every system of the body can be affected by SLE, as depicted in the illustration above. (Illustration by Electronic Illustrators Group.) Definition Systemic lupus erythematosus (also called lupus or SLE) is a disease where a person's immune system attacks and injures the body's own organs and tissues. Almost every system of the body can be affected by SLE. Description The body's immune system is a network of cells and tissues responsible for clearing the body of invading foreign organisms, like bacteria, viruses, and fungi. Antibodies are special immune cells that recognize these foreign invaders, and begin a chain of events to destroy them. In an autoimmune disorder like SLE, a person's antibodies begin to recognize the body's own tissues as foreign. Cells and chemicals of the immune system damage the tissues of the body. The reaction that occurs in tissue is called inflammation. Inflammation includes swelling, redness, increased blood flow, and tissue destruction. In SLE, some of the common antibodies that normally fight diseases are thought to be out of control. These include antinuclear antibodies and anti-DNA antibodies. Antinuclear antibodies are directed against the cell's central structure that contains genetic material (the nucleus). Anti-DNA antibodies are directed against the cell's genetic material. DNA is the chemical substance that makes up the chromosomes and genes.

48. NIH Guide: NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS NEUROPSYCHIATRIC systemic lupus erythematosus Release Date July 17, 2001 RFARFAAR-01-007 National Institute of Arthritis and Musculoskeletal and Skin http://grants.nih.gov/grants/guide/rfa-files/RFA-AR-01-007.html

NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS Release Date: July 17, 2001 RFA: RFA-AR-01-007 National Institute of Arthritis and Musculoskeletal and Skin Diseases Letter of Intent Receipt Date: November 2, 2001 Application Receipt Date: December 14, 2001 THIS RFA USES "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. USE THE MODULAR BUDGET INSTRUCTIONS THAT BEGIN ON PAGE 13 IN THE PHS 398 (REVISION 5/2001) AVAILABLE AT http://grants.nih.gov/grants/funding/phs398/phs398.pdf http://www.nih.gov/niams/reports/reportnmsle.htm . HEALTHY PEOPLE 2010 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS- led national activity for setting priority areas. This RFA is related to one or more of the priority areas. Potential applicants may obtain "Healthy People 2010" at http://www.health.gov/healthypeople http://www.nih.gov/niams/clinical/dsmb3.html ). R01 Applications. The individual research grant (R01) is a specific, circumscribed project to be performed by the named investigator(s) who has a specific interest and competency in an area of interest to this RFA. The total project period for an R01 application submitted in response to this RFA may not exceed 5 years. Future unsolicited competing continuation applications will compete with all investigator-initiated applications and be reviewed according to the customary peer review procedures. Because the nature and scope of the research proposed in response to this RFA may vary, it is anticipated that the size of an R01 award will vary also. Modular budgeting procedures apply for grants up to $250,000. Specific R01 application instructions have been modified to reflect "modular grant" and "just-in-time" streamlining efforts. Complete instructions and information on modular grants can be found at

49. NIH Guide: SYSTEMIC LUPUS ERYTHEMATOSUS IN WOMEN AND MINORITIES Full Text AR93-006 systemic lupus erythematosus IN WOMEN AND MINORITIES NIH GUIDE,Volume 22, Number 1, January 8, 1993 RFA AR-93-006 PT 34, FF, II Keywords http://grants.nih.gov/grants/guide/rfa-files/RFA-AR-93-006.html

Return to RFAs Index Return to NIH Guide Main Index Department of Health and Human Services National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892

50. Handbook Of Ocular Disease Management - Systemic Lupus Erythematosus systemic lupus erythematosus. Malar rash on a patient with systemiclupus erythematosus. 1. Haskes LP. systemic lupus erythematosus. http://www.revoptom.com/handbook/oct02_sec7_1.htm

Systemic Lupus Erythematosus Malar rash on a patient with systemic lupus erythematosus. Signs and Symptoms: Systemic lupus erythematosus (SLE) commonly presents in young and middle-aged women, who comprise up to 90% of all SLE sufferers. SLE is three times more common in blacks than in other races, and Asians display an increased incidence of SLE vs. Caucasians. Patients suffer chronic relapses and an unpredictable course secondary to a hyperactive immune system and excessive autoantibody production. Because lupus affects many organ systems, it creates a diverse clinical picture including erythematosus rash, polyarthralgia and arthritis, anemia, and cardiac, renal and neurologic abnormalities. Renal failure is a major cause of death in those suffering from severe, chronic SLE. The skin changes associated with SLE are described as a butterfly rash, often the primary manifestation of SLE. Ocular manifestations, which occur in up to 20% of SLE patients, also may be the initial presenting sign, and may precede systemic signs or symptoms by several months.

51. Adult Health Advisor 2002.1: Systemic Lupus Erythematosus systemic lupus erythematosus. What is systemic lupus erythematosus (SLE)?systemic lupus erythematosus (SLE) is an autoimmune disease. http://www.med.umich.edu/1libr/aha/aha_lupus_crs.htm

Adult Health Topics All Health Topics Find a UMHS Doctor Search Adult Topics Search All Topics T his information is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. McKesson Clinical Reference Systems: Adult Health Advisor 2002.1 Systemic Lupus Erythematosus What is systemic lupus erythematosus (SLE)? Systemic lupus erythematosus (SLE) is an autoimmune disease. This means that your body's defenses against infection are attacking your own tissue. This causes inflammation. Areas of the skin or joints become painful, red, and swollen. Other parts of the body can also become inflamed, including the muscles, kidneys, nervous system, blood, lungs, and heart. SLE, also called lupus, is a serious, chronic disease, which means it never goes away completely. Some people have severe, even fatal, cases of lupus, but for most people symptoms can be controlled. Lupus affects mainly young women, particularly black women in the US, West Indian women, and Chinese women. Cutaneous lupus (also called discoid lupus) is a form of lupus that affects the skin only. It is milder and more common than SLE.

52. Diagnostic Clinic Of Houston - Systemic Lupus Erythematosus systemic lupus erythematosus. WHAT IS systemic lupus erythematosus? Systemiclupus erythematosus (SLE) is an autoimmune disease of unknown cause. http://www.diagnosticclinic.com/health/lupus.html

Systemic Lupus Erythematosus WHAT IS SYSTEMIC LUPUS ERYTHEMATOSUS? Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown cause. The disease is characterized by inflammation and disordered function of potentially many different body parts. Antibodies formed against various cell parts are seen in this disease. These antibodies may take a direct part in the abnormalities seen by directly injuring cells and organs, or by participating in protein complexes, which can be deposited in organs to cause dysfunction. Sometimes these antibodies "sensitize" cells so that the host (patient) sees a "foreign" cell and begins an attack, essentially on herself/himself. Sometimes blood vessels can become involved in the autoimmune process, so that the organs these blood vessels supply can be damaged. WHO DEVELOPS SLE? SLE is primarily a disease of young women. Most cases occur during child-bearing years, and , in fact, SLE may be made worse by pregnancy. Men may also develop SLE, but in an incidence 5 times lower than women. SLE may occur in children, as well. There is even neonatal lupus occurring at birth (in children born to mothers with SLE or mothers with certain antibodies.) There is also most likely a hereditary predisposition to SLE, which we have seen by studying families and siblings with the disease. However, the exact gene involved (if there is one) is not known. WHAT ARE THE MANITFESTATIONS OF SLE?

53. Systemic Lupus Erythematosus Table of Contents Conditions systemic lupus erythematosus, Systemiclupus erythematosus (SLE) is the most common form of lupus. http://www.healthandage.com/html/res/com/ConsConditions/SystemicLupusErythematos

Table of Contents Conditions Systemic Lupus Erythematosus Also Listed As: Signs and Symptoms What Causes It? Who's Most At Risk? What to Expect at Your Provider's Office ... Supporting Research Lupus usually first affects people between the ages of 15 and 45 years, but it can also occur in childhood or later in life. Patients experience periods of chronic disease and remission. The prevalence of the disease is not precisely known, ranging from an estimated 15 to 50 cases per 100,000 people. Signs and Symptoms Lupus is often accompanied by the following signs and symptoms. Extreme fatigue Painful or swollen joints (arthritis) Muscle pain and stiffness Unexplained fever Skin rashes Kidney problems Hair loss Nausea, vomiting, abdominal pain Headaches, migraine, seizures, stroke Depression, anxiety, confusion Photosensitivity (sensitivity to sunlight) What Causes It? The cause of lupus is unknown. Researchers believe that there is probably no single cause but rather a combination of genetic, environmental, and possibly hormonal factors that work together. Who's Most At Risk?

54. Systemic Lupus Erythematosus systemic lupus erythematosus. WHAT IS systemic lupus erythematosus? Systemiclupus erythematosus is a chronic, often lifelong, autoimmune http://www.ucdmc.ucdavis.edu/ucdhs/health/a-z/63SystemicLupus/doc63.html

Systemic Lupus Erythematosus WHAT IS SYSTEMIC LUPUS ERYTHEMATOSUS? Systemic lupus erythematosus is a chronic, often life-long, autoimmune disease that ranges from mild to severe and afflicts mostly women. Systemic lupus erythematosus (SLE) may affect widespread sites, but it most often manifests in the skin, joints, blood, and kidneys. SLE was first described in 1828. Its very name helps define the disease: Systemic is used because the disease can affect organs and tissue throughout the body. Lupus is Latin for wolf. It refers to the rash that extends across the bridge of the nose and upper cheekbones and was thought to resemble a wolf bite. Erythematosus is from the Greek word for red and refers to the color of the rash. The primary characteristics of the disease are the following: Fatigue. Joint pain. Recurrent injuries in the vessels that course through the body. Definition of Systemic Lupus Erythematosus Causes Risk Factors Symptoms Severity and Outlook ... Support Organizations

55. WHAT ARE SPECIFIC AGENTS USED FOR SEVERE SYSTEMIC LUPUS ERYTHEMATOSUS? WHAT ARE SPECIFIC AGENTS USED FOR SEVERE systemic lupus erythematosus? Corticosteroids. TREATMENTSFOR SOME COMPLICATIONS OF systemic lupus erythematosus. http://www.ucdmc.ucdavis.edu/ucdhs/health/a-z/63SystemicLupus/doc63agents2.html

WHAT ARE SPECIFIC AGENTS USED FOR SEVERE SYSTEMIC LUPUS ERYTHEMATOSUS? Corticosteroids Severe SLE is treated with corticosteroids, also called steroids, which suppress the inflammatory process, and help relieve many of the complications and symptoms, including anemia and kidney involvement. Oral prednisone (Deltasone, Orasone) is usually prescribed. Other agents include methylprednisolone (Medrol, Solumedrol), hydrocortisone, and dexamethasone (Decadron). Some people need to take oral prednisone for only a short time; others may require it for long durations. An intravenous administration of methylprednisolone using "pulse" therapy for three days is proving useful for flare-ups in the joints. Combinations with other drugs, particularly immunosuppressants, may be beneficial. Regimens vary widely depending on the severity and location of the disease. Most SLE patients can eventually function without prednisone, although some may have to choose between the long-term toxicity of corticosteroids and the complications of active disease. Side Effects of Long-Term Oral Corticosteroids.

56. NINDS Neurological Sequelae Of Lupus Information Page Information sheet compiled by National Institute of Neurological Disorders and Stroke.Category Health Conditions and Diseases Connective Tissue Lupus...... NINDS Neurological Sequelae Of Lupus Information Page Synonym(s) Lupus Neurological Sequelae, systemic lupus erythematosus Reviewed 07-01-2001 http://www.ninds.nih.gov/health_and_medical/disorders/lupus_doc.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Neurological Sequelae Of Lupus Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Neurological Sequelae Of Lupus Information Page Synonym(s): Lupus - Neurological Sequelae, Systemic Lupus Erythematosus Reviewed 07-01-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What are Neurological Sequelae Of Lupus? Is there any treatment? What is the prognosis? What research is being done? ... Additional resources from MEDLINEplus What are Neurological Sequelae Of Lupus? Lupus (also called systemic lupus erythematosus or SLE) is a disorder of the immune system which normally functions to protect the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the patient's own tissues. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person, and the disease can range from mild to life-threatening. Typical features of lupus include a butterfly shaped rash over the cheeks, a skin rash appearing in areas exposed to the sun, sores in the mouth and nose, arthritis involving one or more joints, kidney inflammation, neurological disorders such as headaches, personality changes, organic brain syndrome, peripheral neuropathies, sensory neuropathy, psychological problems including paranoia, mania, and schizophrenia, seizures, transverse myelitis, and paralysis and stroke. Fever, weight loss, hair loss, poor circulation in the fingers and toes, chest pain when taking deep breaths, and abdominal pain may also occur.

57. Systemic Lupus Erythematosus systemic lupus erythematosus. This may be the first time you have seenor read anything about lupus. We hope that this pamphlet helps http://www.rheumatology.org.nz/nz08010.htm

Systemic Lupus Erythematosus This may be the first time you have seen or read anything about lupus. We hope that this pamphlet helps you to understand this bewildering disease a little better. WHAT IS LUPUS? Lupus is a disease which can affect joints, muscles and other parts of the body. Because of this it belongs to the family of rheumatic diseases and in New Zealand. people with lupus are often treated by a Rheumatologist. However, lupus can also affect the skin. kidneys, lungs, heart, nervous system and blood and in particular the immune system. Lupus is often described as an auto-immune disease. This means that for some reason people with lupus seem to develop antibodies (which usually fight bacteria and viruses) that attack healthy tissue instead. This produces inflammation in different parts of the body resulting in pain and swelling. Lupus is a chronic disease which means that it lasts a long time. However, different symptoms of the disease may come and go. When the disease seems to go away we say that it is in remission; when it comes back we call it a flare. Some people have remissions which last for several vears. HOW SERIOUS IS LUPUS?

58. Systemic Lupus Erythematosus systemic lupus erythematosus, systemic lupus erythematosus (SLE) isthe most common form of lupus. Lupus is an autoimmune disease http://www.ivillagehealth.com/library/onemed/content/0,,241012_245889,00.html

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59. EMJA: Godfrey & Ryan, Systemic Lupus Erythematosus: Current Management Editorial systemic lupus erythematosus current management. A long term study of hydroxychloroquinewithdrawal on exacerbations in systemic lupus erythematosus. http://www.mja.com.au/public/issues/175_03_060801/godfrey/godfrey.html

Home Issues Classifieds More... ... Search Editorial Systemic lupus erythematosus: current management Use the available agents innovatively, and aggressively treat the risk factors for premature vascular disease MJA Systemic lupus erythematosus is an autoimmune disease that may affect many organs, especially the skin, musculoskeletal, vascular and renal systems. It occurs predominantly in women of childbearing age, but also affects people in their sixth decade or older. In these patients, female predominance is less marked and renal disease less common. The natural history of the disease has changed over the past 20-30 years; survival rates have increased from 50% at five years in the 1950s to 80%-90% at 10 years in the 1990s. The explanations for this improvement include earlier diagnosis, recognition of milder disease, advances in medical therapy, and better supportive care, including renal replacement therapy. Despite these advances, the standardised mortality ratio for lupus remains at 3. Morbidity and mortality rates are bimodal, with early events related to disease activity or infection and later events often due to premature vascular disease such as stroke and myocardial ischaemia. Currently, minor manifestations of systemic lupus erythematosus (cutaneous, musculoskeletal, fatigue) are managed with non-steroidal anti-inflammatory drugs (NSAIDs), antimalarial drugs (particularly hydroxychloroquine) and low-dose corticosteroids. The selective COX-2 inhibitors, celecoxib (a sulfonamide) and rofecoxib, are now available in Australia. With their lower gastrointestinal toxicity, they represent a significant advance. Patients with lupus, however, have a high prevalence of sulfonamide allergy (20% in some studies) and 30%-50% have antiphospholipid antibodies, which are associated with arteriovenous thrombosis and miscarriages (the antiphospholipid syndrome). Case reports of thrombotic events in patients with antiphospholipid antibodies taking COX-2 inhibitors necessitate judicious use of these drugs until further data are available.

60. LookSmart - Systemic Lupus Erythematosus Or SLE systemic lupus erythematosus or SLE Resources on the cause, symptoms, diagnosisand treatment of lupus. Includes lupus forums and clubs. Featured Sponsors. http://www.looksmart.com/eus1/eus317837/eus317920/eus53948/eus217275/eus931705/e

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