81. Systemic Lupus Erythematosus From Pediatrics / Rheumatology systemic lupus erythematosus systemic lupus erythematosus (SLE) is a rheumaticdisease characterized by autoantibodies directed against self-antigens, immune http://author.emedicine.com/PED/topic2199.htm

eMedicine Journal Pediatrics Rheumatology Systemic Lupus Erythematosus Synonyms, Key Words, and Related Terms: lupus, SLE Author Information Introduction Clinical Differentials ... Bibliography AUTHOR INFORMATION Section 1 of 11 Authored by Marisa S Klein-Gitelman, MD, MPH, MS , Assistant Professor, Department of Pediatrics, Section of Immunology-Rheumatology, Northwestern University and Children's Memorial Hospital Marisa S Klein-Gitelman, MD, MPH, MS, is a member of the following medical societies: American College of Rheumatology Edited by Barry L Myones, MD Robert Konop, PharmD , Clinical Assistant Professor, Department of Pharmacy, Section of Clinical Pharmacology, University of Minnesota; Thomas JA Lehman, MD , Chief, Division of Pediatric Rheumatology, Clinical Professor, Department of Pediatrics, Hospital for Special Surgery and Cornell University; Daniel Rauch, MD , Program Director, Associate Professor, Department of Pediatrics, Albert Einstein College of Medicine and Jacobi Medical Center; and Norman T Ilowite, MD , Chief, Rheumatology Division, Schneider Children's Hospital; Professor, Department of Pediatrics, Albert Einstein College of Medicine

82. Systemic Lupus Erythematosus: One Disease, A Thousand Faces Healing Journal 1992;8(12) Back to bibliography. systemic lupus erythematosusone disease, a thousand faces, a potent management. by Gar Hildenbrand. http://gerson-research.org/docs/HildenbrandGLG-1992-4/

Gerson Research Organization Hildenbrand GLG. Systemic lupus erythematosus: one disease, a thousand faces, a potent management. Healing Journal Back to bibliography Systemic lupus erythematosus: one disease, a thousand faces, a potent management by Gar Hildenbrand Lupus, Latin for wolf , is the word used historically to describe any chronic, usually ulcerating, skin disease. Dr. Max Gerson's rise to medical prominence in pre-WWII Germany was owed to the curative effect in lupus vulgaris of a salt-free diet bearing his name. Lupus vulgaris, a European plague of the early part of this century, was tuberculosis of the skin, a bacterial disease that has been largely eliminated through improved public health measures and, to a lesser extent, by antibacterial drugs. Today's lupus is systemic lupus erythematosus (SLE), an inflammatory disorder of connective tissue which frequently targets skin (hence the designation lupus ) as well as joints, kidneys, mucous membranes, the nervous system, and virtually any other organ or system in the body. Onset of the disease may be sudden and acute, with fever, painful and swollen joints, skin rash, and influenza-like symptoms; or it may smolder for years with low level malaise and intermittent fevers.

83. Nature Publishing Group Full Paper. Association tests with systemic lupus erythematosus (SLE) of IL10 markersindicate a direct involvement of a CA repeat in the 5' regulatory region. http://www.nature.com/cgi-taf/DynaPage.taf?file=/gene/journal/v3/n8/abs/6363928a

84. Systemic Lupus Erythematosus systemic lupus erythematosus. systemic lupus erythematosus. In Harrison's Principlesof Internal Medicine, 14th ed., edited by Anthony S. Fauci, et al. http://www.chclibrary.org/micromed/00067210.html

Main Search Index Definition Description Causes ... Resources Systemic lupus erythematosus Systemic lupus erythematosus (SLE) is an autoimmune disease in which the individual's immune system attacks, injures, and destroys the body's own organs and tissues. Nearly every system of the body can be affected by SLE, as depicted in the illustration above. (Illustration by Electronic Illustrators Group.) Definition Systemic lupus erythematosus (also called lupus or SLE) is a disease where a person's immune system attacks and injures the body's own organs and tissues. Almost every system of the body can be affected by SLE. Description The body's immune system is a network of cells and tissues responsible for clearing the body of invading foreign organisms, like bacteria, viruses, and fungi. Antibodies are special immune cells that recognize these foreign invaders, and begin a chain of events to destroy them. In an autoimmune disorder like SLE, a person's antibodies begin to recognize the body's own tissues as foreign. Cells and chemicals of the immune system damage the tissues of the body. The reaction that occurs in tissue is called inflammation. Inflammation includes swelling, redness, increased blood flow, and tissue destruction. In SLE, some of the common antibodies that normally fight diseases are thought to be out of control. These include antinuclear antibodies and anti-DNA antibodies. Antinuclear antibodies are directed against the cell's central structure that contains genetic material (the nucleus). Anti-DNA antibodies are directed against the cell's genetic material. DNA is the chemical substance that makes up the chromosomes and genes.

85. Arthritis Research Therapy Abstract Systemic Lupus Review systemic lupus erythematosus and the type I interferon system Lars Rönnblom1 and Gunnar V Alm 2 1 Department of Medical Sciences, Section of http://arthritis-research.com/content/5/2/68/abstract

86. Virtual Hospital: University Of Iowa Family Practice Handbook, Fourth Edition: R University of Iowa Family Practice Handbook, Fourth Edition, Chapter7. Rheumatology systemic lupus erythematosus. David C. Krupp http://www.vh.org/adult/provider/familymedicine/FPHandbook/Chapter07/12-7.html

For Providers University of Iowa Family Practice Handbook, Fourth Edition, Chapter 7 Rheumatology: Systemic Lupus Erythematosus David C. Krupp, MD and Mark A. Graber, MD Departments of Family Medicine and Emergency Medicine University of Iowa Hospitals and Clinics and College of Medicine Peer Review Status: Externally Peer Reviewed by Mosby Overview . Systemic lupus erythematosus (SLE) is a systemic illness characterized by chronic inflammation; clinical manifestations are protean. It most commonly has its onset between 15 and 40 years of age and has an 8:1 female-to-male ratio. Genetic, environmental, and hormonal factors play a role in its etiology. The prevalence is 2.9 to 4 per 100,000; SLE is more common in blacks and some Asian populations. Diagnosis of SLE requires the presence of 4 of 11 criteria (see A through K below). Keep in mind that a positive ANA is neither required for a diagnosis of lupus nor sufficient in itself to make a diagnosis of lupus. Initial workup for suspected lupus should include CBC, chemistry panel, ANA, ESR or CRP, CK, UA, ECG, and CXR. Malar rash (fixed, raised, or flat).

87. Virtual Hospital: The International Thoracic Teaching Resource: Diseases Of Alte systemic lupus erythematosus (SLE). Jeffrey radiograph. systemic lupus erythematosus(SLE) icon gif systemic lupus erythematosus (SLE) icon gif. http://www.vh.org/adult/provider/radiology/ITTR/SLE/SLE.html

For Providers The International Thoracic Teaching Resource: Diseases of Altered Immunity and Diseases of Uncertain Etiology Systemic lupus erythematosus (SLE) Jeffrey R. Galvin, M.D.; Michael P. D'Alessandro, M.D.; Yasayuki Kurihara, M.D. Peer Review Status: Internally Peer Reviewed Clinical Sx: Pleural involvement is the most common respiratory component in patients with SLE. It has been found at the autopsy in from 50-83%. SLE pleuritis is usually associated with small-to-moderate pleural effusions, pleural pain, cough, dyspnea, and fever. Acute lupus pneumonia is a syndrome presenting as an abrupt onset of dyspnea, cough, and fever and in some patients, hemoptysis. Acute lupus pneumonitis is a diagnosis of exclusion. The physician must carefully exclude the possibility of bacterial pneumonia in patients with SLE who present with fever and infiltrates. The risk for developing acute lupus pneumonitis is increased immediately postpartum. Etiology/Pathophysiology: The process of acute lupus pneumonitis and alveolar hemorrhage are histologically similar and are characterized by acute alveolar-capillary damage probably mediated by immune complex deposition. The causes of pulmonary arterial hypertension include (1) interstitial pneumonitis, (2) small pulmonary artery vasculitis, (3) thrombosis, and (4) "primary" pulmonary hypertension. Pathology: Acute lupus pneumonitis is characterized with alveolar wall inflammation, alveolar wall necrosis, alveolar hemorrhage, edema, hyaline membrane formation, infiltration of the interstitium by inflammatory cells, and capillary thrombi.

88. Lupus (Systemic Lupus Erythematosus) Immune System. systemic lupus erythematosus. Systemic lupus the body.systemic lupus erythematosus What is systemic lupus erythematosus? http://jhhs.client.web-health.com/web-health/topics/GeneralHealth/generalhealths

89. SYSTEMIC LUPUS ERYTHEMATOSUS systemic lupus erythematosus. General Considerations. systemic lupus erythematosusis an inflammatory autoimmune disorder that may affect multiple organ systems. http://www.geocities.com/alexandr_semikin/joints/systemic_lupus_erythematosus.ht

Home page Pain guide Pain navigator Anatomy SYSTEMIC LUPUS ERYTHEMATOSUS Essentials of Diagnosis • Occurs mainly in young women • Rash over areas exposed to sunlight. • Joint symptoms in 90% of patients. • Multiple system involvement. • Depression of hemoglobin, white blood cells, platelets. • Serologic findings: antinuclear antibody with high titer to native DNA. General Considerations Systemic lupus erythematosus is an inflammatory autoimmune disorder that may affect multiple organ systems. Its clinical manifestations are thought to be secondary to the trapping of antigen-antibody complexes in capillaries of visceral structures. The clinical course may vary from a mild episodic disorder to a rapidly fulminating fatal illness. Systemic lupus erythematosus is not uncommon. Figures from a large representative urban community population indicate a prevalence exceeding one in 2000 persons. About 85% of patients are women. Although the disease may occur at any age, most patients arc between ages 10 and 50, with greatest clustering between 20 and 40. Blacks are affected more often than members of other races. Before making a diagnosis of spontaneous systemic lupus erythematosus, it is imperative to ascertain that the condition has not been induced by a drug- Approximately 25 phannacologic agents have been implicated as causing a lupuslike syndrome, but only a few cause the disorder with appreciable frequency. Procainamide and hydralazine are the most important and best studied of these drugs. While antinuclear antibody tests and other serologic findings become positive in many persons receiving these agents, in only a few do clinical manifestations occur.

90. Systemic Lupus Erythematosus (SLE) systemic lupus erythematosus (SLE), is an autoimmune illness that causes a characteristicrash accompanied by inflammation of connective tissue, particularly http://www.hollandandbarrett.com/Concern/Lupus.htm

Systemic Lupus Erythematosus Also indexed as: Discoid Lupus Erythematosus (DLE), Lupus, SLE Systemic lupus erythematosus (SLE), is an autoimmune illness that causes a characteristic rash accompanied by inflammation of connective tissue, particularly joints, throughout the body. In autoimmune diseases, the immune system attacks the body instead of protecting it. Kidney, lung, and vascular damage are potential problems resulting from SLE. The cause of SLE is unknown, though 90% of cases occur in women of childbearing age. Several drugs, such as procainamide, hydralazine methyldopa , and chlorpromazine, can create SLE-like symptoms. Similarly, environmental pollution and industrial emissions may also trigger SLE-like symptoms in some people. In one reported case, zinc supplementation appears to have aggravated drug-induced SLE. Risk factors include a family history of SLE, other collagen diseases or asthma menstrual irregularity, beginning menstruation at age 15 or later, exposure to toxic chemicals, and low blood levels of antioxidant nutrients, such as

91. Defining Systemic Lupus Erythematosus - KC Dockal Defining systemic lupus erythematosus. systemic lupus erythematosus(SLE), also called Lupus, is an autoimmune disease related to http://www.ghg.net/schwerpt/deflup.htm

Defining Systemic Lupus Erythematosus Systemic Lupus Erythematosus (SLE), also called Lupus, is an autoimmune disease related to Rheumatoid Arthritis and other Connective Tissue Diseases. SLE is perhaps best known as "the Great Immitator". It can manifest in such varied ways as to put doctors through hoops looking for numerous other diseases. For a more detailed discussion of why this is so, see Defining Connective Tissue Disease There are 11 criteria which the medical community (U.S.) uses to diagnose this illness. These criteria are weighted - i.e., one can have several of these symptoms but with no tell-tale lab results and therefore no SLE diagnosis. Generally, different doctors weight the criteria differently making things rather confusing for patients and physicians alike. There are also a host of other symptoms which I found through a highly unscientific survey to be common among members of the Hamline University Lupus-L List. It is important to note that these other symptoms are not diagnostic.

92. The Clinical Management Of Systemic Lupus Erythematosus This concise yet comprehensive volume provides clinicians with practical guidanceon the diagnosis and management of systemic lupus erythematosus. http://www.lww.com/product/0,0,0-397-51473-5,00.html

Home Shopping Cart My Account Contact LWW ... Login . Not a member? Register Product Search Keyword Author ISBN/ISSN Title Advanced Help Please submit your email for LWW.com Updates and LWW.com Insider The Clinical Management of Systemic Lupus Erythematosus , Hardbound Associated Specialties: Dermatology Immunology Internal Medicine Nephrology ... Urology Author(s): Peter H. Schur MD Availability: In Stock This concise yet comprehensive volume provides clinicians with practical guidance on the diagnosis and management of systemic lupus erythematosus. Revised and updated to reflect recent diagnostic and therapeutic breakthroughs, the book offers expert advice on the day-to-day care of patients with the varied manifestations of this disease. The opening chapters describe the general symptoms of lupus, its immunological mechanisms, and the criteria for diagnosis. A major portion of the book focuses on the manifestations of lupus in specific organ systemsmusculoskeletal, cutaneous, cardiac, pulmonary, hematologic, renal, gastrointestinal, and neurologic. Full consideration is given to the psychiatric aspects of lupus and the special problems of pregnant women, children, and adolescents with the disease. Coverage also includes chapters on antiphospholipid syndrome and on lupus-like syndromes related to drugs and environmental factors. The concluding chapters present current guidelines for patient monitoring, therapy, and use of medications. May we also recommend: Dubois' Lupus Erythematosus , Book Arthritis and Allied Conditions , Book

93. Systemic Lupus Erythematosus systemic lupus erythematosus. March 2000. WHAT IS systemic lupus erythematosus?systemic lupus erythematosus is a chronic, often http://wellness.ucdavis.edu/medical_conditions_az/systemiclupus63.html

Systemic Lupus Erythematosus March 2000 WHAT IS SYSTEMIC LUPUS ERYTHEMATOSUS? Systemic lupus erythematosus is a chronic, often life-long, autoimmune disease that ranges from mild to severe and afflicts mostly women. The primary characteristics of the disease are fatigue, joint pain, and recurrent injuries in the vessels that course through the body. Systemic lupus erythematosus (SLE) may affect widespread sites, but it often manifests in the skin, joints, blood, and kidneys. SLE was first described in 1828. Its name includes "lupus," from the Latin term for wolf, because the disease often produces a rash that extends across the bridge of the nose and upper cheekbones and was thought to resemble a wolf bite. The term erythematosus (from the Greek word for red) refers to the color of the rash, and the term systemic is used because the disease can affect organs and tissue throughout the body. WHAT CAUSES SYSTEMIC LUPUS ERYTHEMATOSUS? Systemic lupus erythematosus is a complex disorder that occurs as a consequence of a number of independent biologic and other factors. An autoimmune response, in which immune factors attack the person's own cells, is central to the disease process. Such a response is probably activated in people with a combination of genetic factors that make them susceptible to it. In addition, factors, such as viruses or sunlight, that assault the body's cells or affect other changes are necessary to trigger the abnormal immune response to begin with.

94. Member Sign In Echolalia as a Novel Manifestation of Neuropsychiatric Systemic LupusErythematosus from Southern Medical Journal Michael Zapor, MD http://www.medscape.com/viewarticle/410706

If you are having trouble logging in: In order to use Medscape, your browser must be set to accept "cookies." To find out how to adjust your browser settings, please click here Log In Username Password Forgot your password? Not a Member? Register Now for free access to: MEDLINE (Optimized for Physicians) 200+ Free CME Courses 25 Medical Specialty Sites 100+ Medical Journals Conference Coverage Daily Medical News About Medscape Help WebMD Health

95. Pathology Of Systemic Lupus Erythematosus Pathology of systemic lupus erythematosus. General Features. Systemic lupuserythematosus (SLE) is a chronic disease with many manifestations. http://www.mold-survivor.com/lupus.htm

Pathology of Systemic Lupus Erythematosus General Features Systemic lupus erythematosus (SLE) is a chronic disease with many manifestations. SLE is an autoimmune disease in which the body's own immune system is directed against the body's own tissues. The etiology of SLE is not known. It can occur at all ages, but is more common in young women. The production of autoantibodies leads to immune complex formation. The immune complex deposition in many tissues leads to the manifestations of the disease. Immune complexes can be deposited in glomeruli, skin, lungs, synovium, mesothelium, and other places. Many SLE patients develop renal complications. Laboratory Testing The presence of autoantibodies can usually be determined by the antinuclear antibody (ANA) test performed on patient serum from blood. The titer, or strength, of the ANA gives a rough indication of the severity of the disease. Not all positive ANA tests indicate autoimmune disease, particularly when the titer is low. After a positive screening ANA test, more specific tests for SLE include detection of auto-antibodies to double stranded DNA and to Smith antigen. Dermatologic Manifestations Skin rashes are common with SLE. The most characteristic rash is seen across the malar region of the face, the so-called "butterfly rash" that is accentuated by sun exposure. SLE must be distinguished from discoid lupus erythematosus (DLE) which affects the skin (but only in sun exposed regions) and is unlikely to be associated with systemic illness, such as renal disease. A biopsy of sun exposed skin that is not involved with a rash will demonstrate immune complex deposition with SLE, but not with DLE.

96. PERIPHERAL ULCERATIVE KERATITIS IN SYSTEMIC LUPUS ERYTHEMATOSUS Peripheral Ulcerative Keratitis in systemic lupus erythematosus. Cataracts,OU (OS OD); systemic lupus erythematosus. Patient Course. http://www.djo.harvard.edu/meei/OA/SLE/SLE.html

P eripheral Ulcerative Keratitis in Systemic Lupus Erythematosus Benalexander A. Pedro, M.D. Department of Ophthalmology, Division of Immunology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA Amyna Merchant, M.D. Department of Ophthalmology, Division of Immunology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA C. Stephen Foster, M.D. Chief Division of Immunology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Address correspondence to: Benalexander A. Pedro, M.D. Massachusetts Eye and Ear Infirmary, Harvard Medical School 243 Charles Street Boston, MA 02114 ABSTRACT Purpose/Methods : Systemic Lupus Erythematosus (SLE) is a chronic multisystem disease with a wide range of inflammatory involvement in almost every organ of the body. The manifestations of SLE in the eye are as protean as those seen in the other organs of the body. We present the saga of a patient who presented with uncommon but significant manifestations of SLE and discuss its evaluation and management. Results/Conclusions This case underscores the uniqueness of SLE as a disease affecting the eye. Careful patient evaluation, as well as a logical stepwise approach to management of the ocular and systemic manifestations prove to be an effective way to prevent the blinding ocular consequences of this disease..

97. Systemic Lupus Erythematosus systemic lupus erythematosus. What is it? Systemic Lupus Erythrmatosus(SLE) is an autoimmune disorder in which the body’s immune http://www.hmc.psu.edu/healthinfo/jkl/lupus.htm

98. SLE - Systemic Lupus Erythematosus (Lupus) systemic lupus erythematosus. What is lupus? systemic lupus erythematosus is a diseaseof the immune system the system that prevents and fights infection. http://renux.dmed.ed.ac.uk/EdREN/EdRenINFObits/LupusNonRen.html

Systemic lupus erythematosus from EdREN , the website of the Renal Unit of the Royal Infirmary of Edinburgh Systemic lupus erythematosus, often shortened to Lupus or SLE , is one of the 'autoimmune' diseases that can affect a wide variety of organs. This information is about lupus in general, and comes from Arthritis Care . See also our information on SLE and the kidneys What is lupus? What will happen to me? Who gets lupus? ... What is the treatment? What is lupus? Systemic lupus erythematosus is a disease of the immune system - the system that prevents and fights infection. In lupus the immune system becomes unbalanced resulting in the body reacting against healthy tissue. This is why the symptoms of lupus can vary so much. Occasionally the disease is caused by using certain drugs. This is known as drug-induced lupus. Systemic lupus erythematosus (SLE) is classified as a rheumatic disease. It can cause inflammation in the joints and several of the body's organ systems. (For example: the skin, the kidneys and various other internal organs.) Hence the term systemic. The term 'lupus erythematosus' refers to the red rash on the face. Discoid lupus affects the skin and is a relatively mild disease. Sometimes it is treated by a rheumatologist (a specialist in arthritis and rheumatic disease) but more commonly by a dermatologist (a specialist in skin disorders).

99. Systemic Lupus Erythematosus (SLE, Or Lupus) - Lucile Packard Children's Hospita Pediatric Arthritis Other Rheumatic Diseases. systemic lupus erythematosus(SLE, or Lupus) What is lupus? systemic lupus erythematosus http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/arthritis/lupus.html

Day Hospital Rheumatology Clinic Rheumatologists Pediatric Arthritis and Other Rheumatic Diseases Systemic Lupus Erythematosus (SLE, or Lupus) What is lupus? Systemic lupus erythematosus, also known as SLE, or simply lupus, is a disease that is characterized by periodic episodes of inflammation of and damage to the joints, tendons, other connective tissues, and organs, including the heart, lungs, blood vessels, brain, kidneys, and skin. The heart, lungs, kidneys, and brain are the organs most affected. Lupus affects each individual differently and the effects of the illness range from mild to severe. Lupus can potentially be fatal. The majority of people who have lupus are young women (late teens to 30s). This may be due to the fact that estrogen (a female hormone) seems to be associated with SLE. Lupus affects more African-Americans than Caucasians, Asian Americans, Latinos, or Native Americans in the US. Lupus in children occurs most often at the age of ten and older; lupus is rare in children younger than 5 years of age. The disease is known to have periods of flare-ups and periods of remission (partial or complete lack of symptoms). Children with lupus can have a large degree of kidney involvement. The severity of the kidney involvement can alter the survival rate of patients with lupus. In some cases, kidney damage is so severe it leads to kidney failure.

100. Entrez-PubMed Comment in Circulation. 2001 Oct 16;104(16)18767. Click here to read Riskfactors for cardiovascular disease in systemic lupus erythematosus. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

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