1. National Tay-Sachs & Allied Diseases Association An organization offering support and programs geared to families affected by tay-sachs disease and Category Health Conditions and Diseases Tay-Sachs......The National TaySachs Allied Diseases Association (NTSAD) is dedicated to thetreatment and prevention of Tay-Sachs, Canavan, and related diseases, and to http://www.ntsad.org/

Publications Links Contact Us 25th ANNUAL FAMILY CONFERENCE Conference Information Tay-Sachs Canavan , and related diseases, and to provide information and support services to individuals and families affected by these diseases, as well as the public at large. Strategies for achieving these goals include public and professional education, research, genetic screening, family services and advocacy. NTSAD's foundations and its future. The Allied Diseases profiled. The basis of genetics for the Allied Diseases. NTSAD programs for affected children and families. Further sources of information. Our thanks to those responsible for assembling the information found on this website President: Mark P. Madsen Director: Jayne C. Gershkowitz NTSAD Scientific Advisory Committee NTSAD Chapters Information found on this and any website should not be construed as a substitution for professional medical care. NTSAD and NYU Medical Center wish to emphasize that you should always consult your physician regarding your child's health.

2. NINDS Tay-Sachs Disease Information Page Information sheet on this disease addressing what it is, treatment and prognosis.Category Health Conditions and Diseases Tay-Sachs...... More about taysachs disease, Studies with patients, Research literature, Pressreleases, Disclaimer, NINDS tay-sachs disease Information Page Reviewed 12-05-2001 http://www.ninds.nih.gov/health_and_medical/disorders/taysachs_doc.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Tay-Sachs Disease Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Tay-Sachs Disease Information Page Reviewed 12-05-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Tay-Sachs Disease? Is there any treatment? What is the prognosis? What research is being done? ... Additional resources from MEDLINEplus What is Tay-Sachs Disease? Is there any treatment? Presently there is no treatment for Tay-Sachs. What is the prognosis? Even with the best of care, children with Tay-Sachs disease usually die by age 5. What research is being done? NINDS supports research to discover new ways to treat, prevent, or cure disorders that strike the brain and nervous system, including Tay-Sachs. Organizations Genetic Alliance 4301 Connecticut Avenue, N.W.

3. Tay-Sachs Disease taysachs diseasetay-sachs disease, a heritable metabolic disorder commonly associatedwith Ashkenazi Jews, has also been found in the French Canadians of http://www.ncbi.nlm.nih.gov/disease/Tay_Sachs.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View HEXA on chromosome 15 Databases PubMed The Literature Key papers Recent literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information Fact Sheet from National Institute of Neurological Disorders and Stroke NTSAD GeneClinics a medical genetics resource Tay-Sachs Disease Tay-Sachs disease, a heritable metabolic disorder commonly associated with Ashkenazi Jews, has also been found in the French Canadians of Southeastern Quebec, the Cajuns of Southwest Louisiana, and other populations throughout the world. The severity of expression and the age at onset of Tay-Sachs varies from infantile and juvenile forms that exhibit paralysis, dementia, blindness and early death to a chronic adult form that exhibits neuron dysfunction and psychosis. Tay-Sachs is an autosomal recessive disease caused by mutations in both alleles of a gene (HEXA) on chromosome 15. HEXA codes for the alpha subunit of the enzyme beta-hexosaminidase A. This enzyme is found in lysosomes, organelles that break down large molecules for recycling by the cell. Normally, beta- hexosaminidase A helps to degrade a lipid called GM2 ganglioside, but in Tay-Sachs individuals, the enzyme is absent or present only in very reduced amounts, allowing excessive accumulation of the GM2 ganglioside in neurons. The progressive neurodegeneration seen in the varied forms of Tay-Sachs depends upon the speed and degree of GM2 ganglioside accumulation, which in turn is dependent upon the level of functional beta-hexosaminidase A present in the body.

4. Merrill Text . Clinical Symptoms Late onset taysachs diseaseis a newly recognized and relatively rare form of Tay-Sachs. Description Prepared by Elizabeth Merrill, MS an article about the clinical symptoms, molecular basis of the disease, Category Health Conditions and Diseases Tay-Sachs...... General http://neuro-oas.mgh.harvard.edu/lots/merrilltxt.html

Late Onset Tay-Sachs Data Sheet prepared by Elizabeth Merrill, MS Table of Contents: Clinical Symptoms Molecular Basis of the Disease Pattern of Inheritance Treatment Common Synonyms: Adult GM2 Gangliosidosis Chronic GM2 Gangliosidosis Adult-Onset Tay-Sachs Enzyme Deficiency: beta-hexosaminidase A (Hex A) General Description Clinical Symptoms: The onset of symptoms in late onset Tay-Sachs is usually apparent between adolescence and the mid-30's, although this may vary. Precise determination of age of onset is difficult because the disorder is slowly progressive. Subsequent to diagnosis some affected individuals realize, in retrospect, that there were subtle signs even before adolescence, such as clumsiness, tremor, falls, abnormal behaviors, or mood alterations. In some persons with late onset Tay-Sachs intellectual function may be affected to some degree. Memory impairment, difficulty with comprehension, and deterioration in school performance may occur in some affected individuals. Parents of individuals with late onset Tay-Sachs sometimes report short attention spans, acting out episodes, tangential answering of questions, and change in affect or personality. Psychiatric findings are a feature of the disorder in about 40$ of cases. They usually present as recurrent psychotic episodes (loss of contact with reality) or as depression which may be associated with psychotic features as well. In some cases the psychiatric manifestations may precede the neurological manifestations, and delay the diagnosis of late onset Tay-Sachs, but more often they occur in conjunction with a neurodegenerative clinical presentation. Post-partum psychosis following a first pregnancy has bee reported in one female patient, who did not have a prior psychiatric history. In some patients with psychiatric involvement, personality disturbance with marked shyness and social withdrawal precedes actual psychosis.

5. March Of Dimes: Tay-Sachs Disease taysachs disease and other conditions. Sandhoff Disease, Fabry Disease, Gaucher Disease, Niemann-Pick Disease, Canavan http://www.noah-health.org/english/pregnancy/march_of_dimes/birth_defects/taysac

Ask NOAH About: Pregnancy Tay-Sachs Disease Public Health Education Information Sheet What is Tay-Sachs disease? Who Is at Risk of Tay-Sachs Disease? How Is the Disease Transmitted? Are There Other Forms of Tay-Sachs Disease Besides the Classical Type That Affects Babies? ... References What is Tay-Sachs disease? Tay-Sachs disease is a fatal inherited disease of the central nervous system. The most common form of the disease affects babies. Affected babies appear healthy at birth and seem to develop normally for the first few months of life. After this time, development slows and symptoms begin. Sadly, there is no effective treatment for these babies. Babies with Tay-Sachs lack an enzyme (protein) called hexosaminidase A (hex A) necessary for breaking down certain fatty substances in brain and nerve cells. These substances build up and gradually destroy brain and nerve cells, until the entire central nervous system stops working. Symptoms of classical Tay-Sachs disease first appear at 4 to 6 months of age when an apparently healthy baby gradually stops smiling, crawling or turning over, loses its ability to grasp or reach out and, eventually, becomes blind, paralyzed and unaware of its surroundings. Death occurs by age 5. Who Is at Risk of Tay-Sachs Disease?

6. Show HD Leaflets A description along with prognosis and treatment of this disease. http://www.healthtouch.com/bin/EContent_HT/showAllLfts.asp?lftname=NINDS201&

7. The NTSAD Diseases Family: Tay-Sachs Disease taysachs disease (Classical Infantile Form). Contents. 1, What is Tay-SachsDisease? See also Late-Onset tay-sachs disease. What is tay-sachs disease? http://www.ntsad.org/pages/t-sachs.htm

Tay-Sachs Disease (Classical Infantile Form) Contents What is Tay-Sachs Disease? How is Tay-Sachs Disease Transmitted? Are Certain Populations at Higher Risk? Is There a Test to Identify Carriers? ... Additional information links [See also: Late-Onset Tay-Sachs Disease What is Tay-Sachs Disease? THE CLASSICAL FORM OF TAY-SACHS disease (TSD) is a fatal genetic disorder in children that causes progressive destruction of the central nervous system. T he disease is named for Warren Tay (1843-1927), a British ophthalmologist who in 1881 described a patient with a cherry-red spot on the retina of the eye. It is also named for Bernard Sachs (1858-1944), a New York neurologist whose work several years later provided the first description of the cellular changes in Tay-Sachs disease. Sachs also recognized the familial nature of the disorder, and, by observing numerous cases, he noted that most babies with Tay-Sachs disease were of eastern European Jewish origin. T ay-Sachs disease is caused by the absence of a vital enzyme called hexosaminidase A (Hex-A). Without Hex-A, a fatty substance or lipid called GM2 ganglioside accumulates abnormally in cells, especially in the nerve cells of the brain. This ongoing accumulation causes progressive damage to the cells. The destructive process begins in the fetus early in pregnancy, although the disease is not clinically apparent until the child is several months old. By the time a child with TSD is three or four years old, the nervous system is so badly affected that life itself cannot be supported. Even with the best of care, all children with classical TSD die early in childhood, usually by the age of five.

8. Molecular Genetics Testing Laboratory The Ashkenazi Jewish Genetic Disease Screen tests for seven common inherited diseases in the Ashkenazi Jewish population taysachs disease, Canavan disease, cystic fibrosis, Gaucher disease, Bloom syndrome , Familial dysautonomia and Fanconi anemia. Among Ashkenazi Jews, the carrier frequencies and disease incidences for Cystic Fibrosis is 13600. The Molecular Genetics Laboratory performs multiplex assays to screen for all seven diseases in individuals at risk. http://www.med.nyu.edu/genetics/ashkenazi.html

Molecular Genetics Testing Laboratory Ashkenazi Jewish Genetic Disease Screen The Importance of Genetic Screening for Ashkenazi Jewish People. See the video: Genetic Screening Video real player needed The Ashkenazi Jewish Genetic Disease Screen tests for seven common inherited diseases in the Ashkenazi Jewish population: Tay-Sachs disease, Canavan disease, cystic fibrosis, Gaucher disease, Bloom syndrome , Familial dysautonomia and Fanconi anemia. Among Ashkenazi Jews, the carrier frequencies and disease incidences for each of these has been estimated to be 1:25 and 1:3000 for Tay-Sachs disease; 1:30 and 1:3600 for cystic fibrosis; 1:40 and 1:6400 for Canavan disease; 1:15 and 1:900 for Gaucher disease 1:100 and 1:10,000 for Bloom syndrome , 1:30 and 1:3600 for Familial dysautonomia and 1:80 and 1:6,400 for Fanconi anemia. The Molecular Genetics Laboratory performs multiplex assays to screen for all seven diseases in individuals at risk. NOTE: This screen is most appropriate for people who are Ashkenazi Jews. This screen is not appropriate for individuals from other ethnic backgrounds. Those individuals should use other testing approaches to assess their carrier risk for these diseases. Contact the laboratory to determine appropriate testing for individuals of mixed heritage.

9. Tay-Sachs Disease Hub Links to information and resources. http://www.genomelink.org/taysachs

10. OMIM ENTRY 272800 taysachs disease. Who to Contact. Where to Go to Chat with Others http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?272800

11. Late Onset Tay-Sachs - MGH LATE ONSET TAYSACHS. Massachusetts General Hospital. Department of Neurology.tay-sachs disease- Information for patients, families and professionals. http://neuro-oas.mgh.harvard.edu/lots/main.html

LATE ONSET TAY-SACHS Massachusetts General Hospital Department of Neurology Tay-Sachs Disease - Information for patients, families and professionals Announcements Internet Resources Clinical Resources Research ... HORIZON - The Late Onset Tay-Sachs Foundation Newsletter Writings - Recent publications or essays References Questions and Comments - We want to hear from you COMING SOON Invited Essay Online Discussion Forum Endorsed by The Late Onset Tay-Sachs Foundation Designed and maintained by Katherine B. Sims , M.D. sims@helix.mgh.harvard.edu Our goal is to improve communication for all those interested in Late Onset Tay-Sachs. If you have a resource you would like listed, please contact me. MGH Neurology Home

12. National Tay-Sachs & Allied Diseases Association Of Delaware Valley baby with taysachs disease appears healthy at birth, and seems to be developingnormally for a few months. Why is a baby born with tay-sachs disease? http://www.tay-sachs.org/whatista.htm

What is Tay-Sachs Disease? What is Canavan Disease? Who we are Our History ... Contact us baby with Tay-Sachs disease appears healthy at birth, and seems to be developing normally for a few months. Symptoms generally appear by six months of age. While symptoms vary from one child to the next, there is always a slowing down of development. Gradually, Tay-Sachs children lose motor skills and mental functions. Over time, the child becomes blind, deaf, mentally retarded, paralyzed and non responsive to the environment. Tay-Sachs children usually die by age five. Children with Tay-Sachs disease lack a vital enzyme, hexosaminidase A (Hex-A). Hex-A is needed for the body to break down a fatty waste substance found in brain cells. Without Hex-A, this substance accumulates abnormally and causes progressive damage until the nervous system can no longer sustain life. Why is a baby born with Tay-Sachs disease? Tay-Sachs is an inherited disease that only occurs when both parents carry a Tay-Sachs gene and each parent transmits the defective gene to their child. A child who inherits two Tay-Sachs genes (one from each parent) produces no functional Hex-A enzyme and is certain to develop Tay-Sachs disease. A person with only one Tay-Sachs gene is perfectly healthy, but is a Tay-Sachs carrier. When both parents are carriers, there is a 1 in 4 (25%) chance, with every pregnancy, of having a child with Tay-Sachs disease.

13. MEDLINEplus: Tay-Sachs Disease Topics. taysachs disease. Contents of Organizations. Search MEDLINEfor recent research articles on • tay-sachs disease. You may http://www.nlm.nih.gov/medlineplus/taysachsdisease.html

Skip navigation Other health topics: A B C D ... List of All Topics Tay-Sachs Disease Contents of this page: From the NIH General/Overviews Prevention/Screening Organizations Search MEDLINE for recent research articles on Tay-Sachs Disease You may also be interested in these MEDLINEplus related pages: Brain and Nervous System Genetics/Birth Defects From the National Institutes of Health Learning About Tay-Sachs Disease (National Human Genome Research Institute) Tay-Sachs Disease (National Institute of Neurological Disorders and Stroke) General/Overviews Tay-Sachs Disease (March of Dimes Birth Defects Foundation) Also available in: Spanish Prevention/Screening Tay-Sachs, Gaucher, and Canavan Disease (American Association for Clinical Chemistry) Specific Conditions/Aspects Sandhoff Disease (National Institute of Neurological Disorders and Stroke) Organizations National Institute of Neurological Disorders and Stroke Information from the Medical Encyclopedia: Tay-Sachs Disease Health services in North Carolina Other states coming - learn more The primary NIH organization for research on Tay-Sachs Disease is the National Institute of Neurological Disorders and Stroke Health Topics Drug Information Encyclopedia ... U.S. National Library of Medicine

14. MEDLINEplus Medical Encyclopedia: Tay-Sachs Disease taysachs disease. tay-sachs disease is inherited as a recessive gene, and 1 outof every 25 members of the Ashkenazi Jewish population carries the gene. http://www.nlm.nih.gov/medlineplus/ency/article/001417.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Tay-Sachs disease Contents of this page: Definition Causes, incidence, and risk factors Symptoms Signs and tests ... Prevention Definition A familial disorder found predominantly in Ashkenazi Jewish families, which results in early death. Causes, incidence, and risk factors Tay-Sachs disease is caused by a deficiency of hexosaminidase, an enzyme that is important in the metabolism of gangliosides (a type of chemical substance found in nerve tissue). These gangliosides, particularly ganglioside GM2, then accumulate in the brain, causing neurological deterioration. Tay-Sachs disease is inherited as a recessive gene, and 1 out of every 25 members of the Ashkenazi Jewish population carries the gene. The incidence is 1 out of 2,500 people in this population. Depending on the age of onset and clinical features, Tay-Sachs has been classified into infantile-, juvenile-, and adult-onset forms. The majority of people with Tay-Sachs, however, have infantile forms. Symptoms begin to appear at 3 to 6 months old. The disease unfortunately tends to progress rapidly, and the child usually dies by the age of 4 or 5 years.

15. Medical References: Tay-Sachs Disease Quick Reference and Fact Sheets. taysachs disease What Is tay-sachs disease? Tay-Sachsdisease is a fatal inherited disease of the central nervous system. http://www.marchofdimes.com/professionals/681_1227.asp

View All Chapters Find Your Local Chapter March 31, 2003 Select one Folic Acid Pregnancy Prenatal Screening Infections/Diseases Loss Concerns Newborn Information Birth Defects Polio Genetics Research Funding Perinatal Statistics Medical References Continuing Education ... Prematurity Quick Reference and Fact Sheets Tay-Sachs Disease What Is Tay-Sachs Disease? Tay-Sachs disease is a fatal inherited disease of the central nervous system. The most common form of the disease affects babies. Affected babies appear healthy at birth and seem to develop normally for the first few months of life. After this time, development slows and symptoms begin. Sadly, there is no effective treatment for these babies. Babies with Tay-Sachs lack an enzyme (protein) called hexosaminidase A (hex A) necessary for breaking down certain fatty substances in brain and nerve cells. These substances build up and gradually destroy brain and nerve cells, until the entire central nervous system stops working. Symptoms of classical Tay-Sachs disease first appear at 4 to 6 months of age when an apparently healthy baby gradually stops smiling, crawling or turning over, loses its ability to grasp or reach out and, eventually, becomes blind, paralyzed and unaware of its surroundings. Death occurs by age 5. Who Is at Risk of Tay-Sachs Disease?

16. Medical References: Tay-Sachs Disease taysachs disease What Is tay-sachs disease? tay-sachs disease is afatal inherited disease of the central nervous system. The most http://www.marchofdimes.com/printableArticles/681_1227.asp

View All Chapters Find Your Local Chapter March 31, 2003 Select one Folic Acid Pregnancy Prenatal Screening Infections/Diseases Loss Concerns Newborn Information Birth Defects Polio Genetics Research Funding Perinatal Statistics Medical References Continuing Education ... Prematurity Tay-Sachs Disease What Is Tay-Sachs Disease? Tay-Sachs disease is a fatal inherited disease of the central nervous system. The most common form of the disease affects babies. Affected babies appear healthy at birth and seem to develop normally for the first few months of life. After this time, development slows and symptoms begin. Sadly, there is no effective treatment for these babies. Babies with Tay-Sachs lack an enzyme (protein) called hexosaminidase A (hex A) necessary for breaking down certain fatty substances in brain and nerve cells. These substances build up and gradually destroy brain and nerve cells, until the entire central nervous system stops working. Symptoms of classical Tay-Sachs disease first appear at 4 to 6 months of age when an apparently healthy baby gradually stops smiling, crawling or turning over, loses its ability to grasp or reach out and, eventually, becomes blind, paralyzed and unaware of its surroundings. Death occurs by age 5. Who Is at Risk of Tay-Sachs Disease?

17. Family Village / Library / Tay-Sachs Disease Library S T. tay-sachs disease. http://www.familyvillage.wisc.edu/lib_tays.htm

Tay-Sachs Disease Who to Contact Where to Go to Chat with Others Learn More About It Books ... Search AltaVista for "Tay-Sachs Disease" Who to Contact 2001 Beacon Street Brookline, MA 02146 National Foundation for Jewish Genetic Disease, Inc. 250 Park Ave New York, NY 10017 Phone: (212)371-1030 Late-Onset Tay-Sachs Foundation 1303 Paper Mill Road Erdenheim, PA 19038 In PA: 1-215-836-9426 Where to Go to Chat with Others Tay-Sachs This is a supportive list for parents, families and friends of people dealing with children who have Tay-Sachs disease, a fatal genetic disease commonly found among people of eastern european Jewish descent, French Canadian and Cajun descent, but also among the general population. This list is not moderated at this time, however, it is important to stay on topic and be respectful of the feelings and grave nature of posts which might appear here. To subscribe send an e-mail message to this address: TaySachs-subscribe@onelist.com The Genetic Disease Mailing List This list is a means of networking and communication for individuals concerned with the various genetically-transmitted diseases existing within Jewish populations. Everyone is invited to participate, however, because diseases common among Jewish people may, and almost always do, affect individuals from all of the world's cultural and ethnic groups. To subscribe send an e-mail message to: listserv@maelstrom.stjohns.edu

18. Tay Sachs Disease - Information And Support Resources , NeimanPick. ?, tay-sachs disease. ?, Ulcerative Colitis. Interactive ?. ?, Jewish Genetic Diseases Boards. tay-sachs disease. http://www.mazornet.com/genetics/tay-sachs.asp

Jewish Genetic Diseases A Mazornet Guide VISIT MazorNet's other Jewish Guides The MazorNet-Jewish Celebrations Kosher Restaurant Guide The MazorNet- Jewish Celebrations Vendor Directory ( ... Photographers, Kosher Caterers, Bridal Gowns, and Much More) Important Information Home Page Genetic Counseling and Screening Genetic Screening Laboratories - A Directory A Brief Key to Basic Genetic ... s Select Disorder Bloom's Syndrome Breast and Ovarian Cancers Breast Cancers - Prevention and Resources Canavan Disease ... Ulcerative Colitis Recommended Reeading Genetic Diversity Among Jews - Diseases and Markers at the DNA Level Provides an authoritative, up-to-date account of the impact of molecular genetics on our understanding of genetic diseases prevalent among Jews. Jewish Genetic Disorders : A Layman's Guide Guide to genetic disorders that tend to affect the Jewish population more than the non-Jewish, including a short history of the Jews and basic facts concerning genetics and genetic disorders. Interactive Jewish Genetic Diseases Boards Tay-Sachs Disease Tay-Sachs disease, the most well known Jewish genetic disease, is an inherited metabolic disorder. The basic defect in affected children is the deficiency of an enzyme, hexosaminidase A. Without Hex A, a fatty substance called GM2 ganglioside accumulates abnormally in cells especially in nerve cells of the brain. This continual accumulation causes progressive damage to the cells. There are two forms of this disease, the well known infantile-onset form and a lesser known, late-onset or adult form designated "chronic GM2-gangliosidosis".

19. Tay-Sachs Disease taysachs disease. Classical tay-sachs disease is an especially tragic inheritedbirth defect. For more Information about tay-sachs disease Contact http://gunsmoke.ecn.purdue.edu/~kpasquet/project/tays.html

Tay-Sachs Disease Children with juvenile hex A deficiency develop symptoms between the ages of 2 and 5 years that closely resemble the symptoms of the classical, infantile form. Though the course of the disease is slower, death generally occurs by age 15. Symptoms of chronic hex A deficiency also may begin by age 5, but are far milder than those that characterize the infantile and juvenile forms. Mental abilities, vision and hearing remain intact; but affected individuals develop slurred speech, muscle weakness, muscle cramps, tremors, unsteady gait and sometimes mental illness. Doctors have only recently discovered that symptoms of hex A deficiency may not begin until adulthood. Individuals with adult-onset hex A deficiency experience many of the same variable symptoms as individuals with chronic hex A deficiency, but symptoms begin later in life. You can take a blood test to see if you are a carrier. This test measures the amount of the hex A enzyme in your blood. Tay-Sachs carriers have about half as much of the enzyme as non-carriers, but this is plenty for the carrier's own needs. A blood sample also can be used to perform genetic testing. Doctors have recently developed tests that look for known mutations (changes) in the hex A gene that cause the four forms of Tay-Sachs disease. Genetic testing may be recommended if the results of the usual carrier screening test discussed above are uncertain. Genetic tests also can be used to diagnose late-onset forms of hex A deficiency. Tragically, there is no cure and no treatment that will prevent the disease from running its course. Affected children can only be made as comfortable as possible.

20. Tay-Sachs Disease - DrGreene.com - Caring For The Next Generation taysachs disease. Also known as Gangliosidosis, TSD Introduction Thestory of tay-sachs disease is one of heartbreaking poignancy. http://www.drgreene.com/21_1202.html

QUICK SEARCH A - Z Guide Allergies Allergy Care Guide Asthma Care Guide Bedwetting Breastfeeding Childhood Obesity Diabetes Care Guide Ear Infections Genetics Immunizations Infectious Diseases Parenting Potty Training Rashes Safety Sleep DrGreene.com Topic Centers Mission Reviews Awards Readers Comments Press Room Partners and Supporters Contact Us Pediatric Information A-Z Guide Allergy Care Guide Asthma Care Guide Diabetes Care Guide DrGreene´s Chats FAQ Fast Facts Feature Articles Guidelines Pediatric Updates Special Feature Top Tips Community Activty Guide Advanced Search Community Central Chat Chat Schedule Cute Faces Family Friendly Recipes Parent-to-Parent Resources The DrGreene Team Newsletter Prenatal Newborn Infants Toddlers Pre-Schoolers School Age Teens / Adolescents Multimedia Library Children's Health Fertility Tay-Sachs Disease Also known as: Gangliosidosis, TSD Introduction: The story of Tay-Sachs disease is one of heartbreaking poignancy. The magical experience of a wonderful, normal baby gives way to a desperate, heroic challenge of love and loss as developmental milestones begin to slip away. The normal human lifespan, from

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