41. Ciprofloxacin-induced Toxic Epidermal Necrolysis Ciprofloxacininduced toxic epidermal necrolysis Moshfeghi M, Mandler HD. Departmentof Pharmacy, Cooper Hospital/University Medical Center, Camden, NJ. http://www.drugvictims.org/papers/93apen.html

Home Newspaper Reports Medical Papers Quinolones ... Personal Stories Search Online databases and journal websites can be searched to find papers about quinolone drugs. PubMed A service of the National Library of Medicine, provides access to over 11 million MEDLINE citations back to the mid-1960's and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. British Medical Journal www.bmj.com The Lancet www.thelancet.com New England Journal of Medicine www.nejm.org Southern Medical Journal www.sma.org Medical Papers about Quinolones Ciprofloxacin-induced toxic epidermal necrolysis Moshfeghi M, Mandler HD. Department of Pharmacy, Cooper Hospital/University Medical Center, Camden, NJ. Ann Pharmacother 1993 Dec; 27(12):1467-9

42. Arch Otolaryngol Head Neck Surg -- Page Not Found Hypopharyngeal Stenosis and Dysphagia Complicating toxic epidermal necrolysis AuthorInformation Jose E. Barrera, MD; Arlen D. Meyers, MD; Edward C. Hartford http://archotol.ama-assn.org/issues/v124n12/abs/ocn7311.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

43. Dermatology - Toxic Epidermal Necrolysis Find a Physician. toxic epidermal necrolysis What is toxic epidermalnecrolysis? toxic epidermal necrolysis is a lifethreatening http://www.mccg.org/adulthealth/derm/toxic.asp

About MCCG News MCCG Careers Health Careers ... Home You are here Home Adult Health Dermatology Inside Adult Health SEARCH Adult Health Adult Health Home Allergy and Asthma Arthritis and Other Rheumatic Diseases Bio-Terrorism Bone Disorders Breast Health Cardiovascular Diseases Dermatology Diabetes Digestive Disorders Ear, Nose, and Throat (Otolaryngology) Endocrinology Environmental Medicine Eye Care Glossary Gynecological Health Hematology and Blood Disorders Home Health, Hospice, and Elder Care Liver, Biliary, and Pancreatic Disorders Infectious Diseases Men's Health Mental Health Disorders Nervous System Disorders Non-Tramatic Emergencies Oral Health Orthopaedic surgery Pathology Pediatrics Plastic Surgery Physicial Medicine and Rehabilitation Pregnancy and Childbirth Prostate Health Radiology Respiratory Disorders Skin Cancer Spine, Pelvic and Shoulder Disorders Surgical Care Travel Medicine Urology Women's Health Find a Physician Toxic Epidermal Necrolysis What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction - frequently antibiotics or anticonvulsives. About one-third of all diagnosed cases of toxic epidermal necrolysis do not have an identifiable cause.

44. The Medical Center Of Central Georgia Find a Physician. toxic epidermal necrolysis. What is toxic epidermalnecrolysis? toxic epidermal necrolysis is a lifethreatening http://www.mccg.org/childrenshealth/derm/necrolys_jm.asp

About MCCG News MCCG Careers Health Careers ... Home You are here Home Children's Health Dermatology Inside Children's Health SEARCH Children's Health Children's Health Home Adolescent Medicine Allergy, Asthma and Immunology Pediatric Arthritis and Other Rheumatic Diseases Burns Cardiovascular Disorders Craniofacial Anomalies Dental and Oral Health Dermatology Diabetes and Other Endocrine Metabolic Disorders Digestive and Liver Disorders Ear, Nose and Throat Eye Care Medical Genetics Growth and Development Hematology and Blood Disorders High-Risk Newborn High-Risk Pregnancy Infectious Diseases Child and Adolescent Mental Health Neurological Disorders Normal Newborn Oncology Orthopaedics Common Childhood Injuries and Poisonings Pregnancy and Childbirth Respiratory Disorders Safety and Injury Prevention The Child Having Surgery Care of the Terminally Ill Child Transplantation Genitourinary and Kidney Disorders Find a Physician Toxic Epidermal Necrolysis What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction - frequently antibiotics or anticonvulsives. About one-third of all diagnosed cases of toxic epidermal necrolysis do not have an identifiable cause.

45. HONselect - Epidermal Necrolysis, Toxic Translate this page Lyell's Syndrome - Scalded Skin Syndrome, Nonstaphylococcal - NonstaphylococcalScalded Skin Syndrome - toxic epidermal necrolysis - Epidermal Necrolyses http://www.hon.ch/HONselect/RareDiseases/C17.800.174.600.350.html

List of rare diseases: English Deutsch Language: MeSH term: Accepted terms: English: Epidermal Necrolysis, Toxic - Lyell's Syndrome - Scalded Skin Syndrome, Nonstaphylococcal - Nonstaphylococcal Scalded Skin Syndrome - Toxic Epidermal Necrolysis - Epidermal Necrolyses, Toxic - Lyell Syndrome Français: LYELL, SYNDROME - EPIDERMOLYSE BULLEUSE TOXIQUE - EPIDERMOLYSE NECROSANTE SURAIGUE - ERYTHRODERMIE BULLEUSE AVEC EPIDERMOLYSE - NECROLYSE EPIDERMIQUE TOXIQUE Deutsch: Epidermale Nekrolyse, toxische - Lyell-Syndrom - Symptom der verbrühten Haut Español: NECROLISIS EPIDERMICA TOXICA - SINDROME DE LYELL - SINDROME DE PIEL QUEMADA NO ESTAFILOCOCICA Português: NECROLISE EPIDERMICA TOXICA - SINDROME DE LYELL - SINDROME DA PELE ESCALDADA NAO ESTAFILOCOCICA HONselect ressources Definition: Yes Articles: Yes Images: No News: No Conferences: No Clinical trials: No Web sites: English Yes Français Yes Deutsch No Español No Português No Home About us Site map Feedback ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/C17.800.174.600.350.html Last modified: Thu Jul 25 2002

46. Dermatology - Toxic Epidermal Necrolysis Dermatology toxic epidermal necrolysis. What is toxic epidermal necrolysis? Whatare the symptoms of toxic epidermal necrolysis? http://www.mmhs.com/clinical/peds/english/derm/necrolys.htm

English - Adult English - Pediatric Spanish - Adult Spanish - Pediatric Dermatology Toxic Epidermal Necrolysis What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction - frequently antibiotics or anticonvulsives. About one-third of all diagnosed cases of toxic epidermal necrolysis do not have an identifiable cause. What are the symptoms of toxic epidermal necrolysis? Toxic epidermal necrolysis causes the skin to peel in sheets, leaving large, raw areas. The loss of skin allows fluids and salts to ooze from the raw, damaged areas and can easily become infected. The following are the most common symptoms of toxic epidermal necrolysis. However, each child may experience symptoms differently. Symptoms may include: a painful, red area that spreads quickly the skin may peel without blistering raw areas of skin discomfort fever condition spread to eyes, mouth, and genitals

47. Cook Children's Health Care // 404 Page Not Found     toxic epidermal necrolysis What is toxic epidermal necrolysis? Toxic epidermalnecrolysis is a lifethreatening skin disorder characterized http://www.cookchildrens.com/CC/Ped/derm/necrolys.htm

Site Doctors Donate Now Contact Us Home About Cook Children's ... Wish List Testimonials -Angelica, mother of heart patient 404 Page Not Found "Four Oh Four." Oops! The page you have requested has moved or is no longer available. Please go to the Cook Children's home page or search our site. [back to top] Related Information Related Physicians Find A Physician Related Pages Find a Physician Find a Service Kids' Health Quiz The buddy system is an OK means to keep children safe in the water? A True B False privacy notice

48. Toxic Epidermal Necrolysis | Principal Health News toxic epidermal necrolysis. Camer, Richard H. Advances in toxic epidermal necrolysis. Seminars in Cutaneous Medicine and Surgery 15 (December 1996) 258266. http://www.principalhealthnews.com/topic/topic100587580

About This Site Registration FAQ Contact Us ... Site Awards You are here: Home Health A to Z Toxic Epidermal Necrolysis Toxic Epidermal Necrolysis Camer, Richard H. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Toxic epidermal necrolysis is a rare condition that causes large portions of the epidermis, the skin's outermost layer, to detach from the layers of skin below. A reaction to a medication is the primary cause. Description Toxic epidermal necrolysis (TEN) begins with fever, cough, and other nonspecific symptoms, and is soon followed by purplish, bloody-looking lesions on the skin and mucous membranes. These early lesions, typically found on the head, neck, and upper chest, soon merge and blister. Sheets of epidermis then begin to detach from the skin layers below. In time, the entire surface of the skin may be involved, with detachment of 100% of the epidermis. Causes and symptoms The main cause of TEN is a severe drug reaction. Some investigators believe there may be additional infectious causes. A severe reaction in transplant patients, called graft-vs.-host disease, can also produce TEN. One study reported more than 100 different drugs as causes of TEN. The drugs most commonly implicated, however, include antibacterial sulfonamides such as sulfadiazine, antibiotics such as aminopenicillins and cephalosporins, and anticonvulsants like phenytoin. TEN is extremely rare. Researchers estimate that there are 0.2 cases per million users of aminopenicillins and 4.5 cases per million users of sulfonamides.

49. 1st Diagnosis Case 4 A 29year-old woman in shock. Submitted by Manish Kumar, MD.Your Diagnosis toxic epidermal necrolysis Incorrect. This disorder http://erl.pathology.iupui.edu/cases/dermcases/diag1.cfm?case=4

50. 4th Diagnosis Case 10 Bullae and erosions in a newborn boy. Submitted by Laura Stitle, WendyWilson, Sonya Johnson MD. Your Diagnosis toxic epidermal necrolysis Incorrect. http://erl.pathology.iupui.edu/cases/dermcases/diag4.cfm?case=10

51. Toxic Epidermal Necrolysis And Stevens-Johnson Syndrome Does OBJECTIVE To determine whether the timing of causative drug withdrawal is relatedto the prognosis of patients with toxic epidermal necrolysis (TEN) or. http://www.aegis.com/pubs/aidsline/2000/jun/A0061829.html

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date. Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? [see comments] Arch Dermatol. 2000 Mar;136(3):323-7. Unique Identifier : AIDSLINE MED/20186788 Garcia-Doval I; LeCleach L; Bocquet H; Otero XL; Roujeau JC; Department of Dermatology, Hospital Provincial de Pontevedra,; Spain. Abstract: Keywords: Comment in: Arch Dermatol 2000 Mar;136(3):410-1 National Library of Medicine . Reproduced under license with the National Library of Medicine, Bethesda, MD. AEGiS is made possible through unrestricted grants from Boehringer Ingelheim iMetrikus, Inc. , the National Library of Medicine , and donations from users like you. Always watch for outdated information. This article first appeared in 2000. This material is designed to support, not replace, the relationship that exists between you and your doctor. AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

52. Nevirapine-induced Overlap Stevens-johnson Syndrome/toxic Click here to return to AIDSLINE main menu Nevirapineinduced overlap stevens-johnsonsyndrome/toxic epidermal necrolysis letter Br J Dermatol. http://www.aegis.com/pubs/aidsline/2000/jul/A0071486.html

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date. Nevirapine-induced overlap stevens-johnson syndrome/toxic epidermal necrolysis [letter] Br J Dermatol. 1999 May;140(5):980-2. Unique Identifier : AIDSLINE MED/99282248 Wetterwald E; Le Cleach L; Michel C; David F; Revuz J Keywords: LETTER JOURNAL ARTICLE Adult Anti-HIV Agents/*ADVERSE EFFECTS/THERAPEUTIC USE Case Report Epidermal Necrolysis, Toxic/*ETIOLOGY Human HIV Seropositivity/*DRUG THERAPY Male Nevirapine/*ADVERSE EFFECTS/THERAPEUTIC USE Stevens-Johnson Syndrome/*CHEMICALLY INDUCED National Library of Medicine . Reproduced under license with the National Library of Medicine, Bethesda, MD. AEGiS is made possible through unrestricted grants from Boehringer Ingelheim iMetrikus, Inc. , the National Library of Medicine , and donations from users like you. Always watch for outdated information. This article first appeared in 2000. This material is designed to support, not replace, the relationship that exists between you and your doctor. AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

53. Toxic Epidermal Necrolysis - General Practice Notebook toxic epidermal necrolysis. toxic epidermal necrolysis is a rare condition wherethere is widespread lysis of the epidermidis with subsequent sloughing of skin. http://www.gpnotebook.co.uk/cache/1510342685.htm

toxic epidermal necrolysis Toxic epidermal necrolysis is a rare condition where there is widespread lysis of the epidermidis with subsequent sloughing of skin. It occurs predominantly in children; 50% of adults have antibodies to the toxin. The offending bacterium is usually found colonising the throat. Click here for more information...

54. Drug-induced Toxic Epidermal Necrolysis - General Practice Notebook medical information from General Practice Notebook. druginduced toxicepidermal necrolysis. Causes include sulphonamides; barbiturates; http://www.gpnotebook.co.uk/cache/-617283563.htm

drug-induced toxic epidermal necrolysis Causes include: sulphonamides barbiturates carbamazepine phenytoin penicillins NSAIDS Click here for more information...

55. Toxic Epidermal Necrolysis And Stevens-Johnson Syndrome toxic epidermal necrolysis and StevensJohnson Syndrome. Keywords Etiology, intravenousimmunoglobulin, Stevens-Johnson syndrome, toxic epidermal necrolysis. http://www.fmshk.com.hk/journal/hksdv/v10n02-001.htm

Volume 10 Number 2, June 2002 Abstract Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome Dr. C. K. Yeung Department of Medicine, Queen Mary Hospital, The University of Hong Kong Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are uncommon but serious cutaneous reactions with significant mortality and long-term morbidity. Multiple aspects of TEN and SJS are reviewed including classification and therapeutic options with emphasis on the importance of early diagnosis, burns unit care and the controversies in the use of systemic corticosteroids. Keywords : Etiology, intravenous immunoglobulin, Stevens-Johnson syndrome, toxic epidermal necrolysis Back to Previous Page

56. Publications Translate this page Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnsonsyndrome and erythema multiforme. Arch Dermatol 129 92-96 (1993). http://www.ukl.uni-freiburg.de/haut/dzh/puble.htm

Publications Bastuji-Garin S, Rzany B, Stern R S, Shear N H, Naldi L, Roujeau JC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome and erythema multiforme. Arch Dermatol 129: 92-96 (1993). Baur S, Rzany B, Mockenhaupt M, Gritze G, Gehring W, Schöpf E. Toxisch epidermale Nekrolyse nach Herpes simplex labialis recidivans in loco und Aciclovir-Therapie bei einem HIV-positiven Patienten. Dermatologische Monatsschrift 179: 327-329 (1993). Dietrich A, Kawakubo Y, Rzany B, Mockenhaupt M, Simon JC, Schöpf E. Low N-acetylating capacity in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. Exp Dermatol 4: 313-316 (1995). Holländer N, Rzany B, Mockenhaupt M, Schöpf E. Statistische Ansätze zur Beurteilung seltener Arzneimittelrisiken in einer Fallstudie. Informatik, Biometrie und Epidemiologie in Medizin und Biologie 26: 154-165 (1995) Kelly JP, Auquier A, Rzany B, Naldi L, Bastuji-Garin S, Correia O, Shapiro S, Kaufman DW. An international collaborative case-control study of severe cutaneous adverse reactions (SCAR). Design and methods. J Clin Epidemiol 48: 1099-1108 (1995).

57. See The Journal Of Burns In Volume 2 - 2003 Acute Pulmonary Manifestations of toxic epidermal necrolysis Martha Burk, AkshaySood Division of Pulmonary and Critical Care Medicine, Southern Illinois http://www.journalofburns.com/read.php?articlerow=50

58. Toxic Epidermal Necrolysis | Ahealthyme.com You are here Home Health A to Z toxic epidermal necrolysis. ToxicEpidermal Necrolysis. toxic epidermal necrolysis Camer, Richard H. http://www.ahealthyme.com/topic/topic100587580

Search AHealthyMe! Personalize AHealthyMe! Sign up for our Newsletter! You are here: Home Health A to Z Toxic Epidermal Necrolysis Camer, Richard H. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Toxic epidermal necrolysis is a rare condition that causes large portions of the epidermis, the skin's outermost layer, to detach from the layers of skin below. A reaction to a medication is the primary cause. Description Toxic epidermal necrolysis (TEN) begins with fever, cough, and other nonspecific symptoms, and is soon followed by purplish, bloody-looking lesions on the skin and mucous membranes. These early lesions, typically found on the head, neck, and upper chest, soon merge and blister. Sheets of epidermis then begin to detach from the skin layers below. In time, the entire surface of the skin may be involved, with detachment of 100% of the epidermis. Causes and symptoms The main cause of TEN is a severe drug reaction. Some investigators believe there may be additional infectious causes. A severe reaction in transplant patients, called graft-vs.-host disease, can also produce TEN. One study reported more than 100 different drugs as causes of TEN. The drugs most commonly implicated, however, include antibacterial sulfonamides such as sulfadiazine, antibiotics such as aminopenicillins and cephalosporins, and anticonvulsants like phenytoin. TEN is extremely rare. Researchers estimate that there are 0.2 cases per million users of aminopenicillins and 4.5 cases per million users of sulfonamides.

59. MEDLINEplus Medical Encyclopedia: Erythema Multiforme Alternative names Return to top Lyell's syndrome; StevensJohnsonsyndrome; toxic epidermal necrolysis. Definition Return to top http://www.nlm.nih.gov/medlineplus/ency/article/000851.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Erythema multiforme Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Calling your health care provider Illustrations Erythema multiforme on the hands Erythema multiforme, circular lesions - hands Erythema multiforme, target lesions on the palm Erythema multiforme on the leg ... Exfoliation following erythroderma Alternative names Return to top Lyell's syndrome; Stevens-Johnson syndrome; Toxic epidermal necrolysis Definition Return to top Erythema multiforme is a skin disorder resulting from an allergic reaction Causes, incidence, and risk factors Return to top Erythema multiforme is a type of hypersensitivity (allergic) reaction that occurs in response to medications, infections, or illness. Medications associated with erythema multiforme include sulfonamides, penicillins, barbiturates, and phenytoin. Associated infections include herpes simplex and mycoplasma infections. The exact cause is unknown. The disorder is believed to involve damage to the blood vessels of the skin with subsequent damage to skin tissues. Approximately 90% of erythema multiforme cases are associated with herpes simplex or Mycoplasma infections. The disorder occurs primarily in children and young adults.

60. Publication SJS Publication A decade of TEN An update on toxic epidermal necrolysis;Stevens Johnson Syndrome Article; What is Stevens Johnson Syndrome? http://members.aol.com/sjsupport/public.htm

SJS Publication A decade of TEN: An update on Toxic Epidermal Necrolysis Stevens Johnson Syndrome Article What is Stevens Johnson Syndrome? The Horror of Stevens Johnson Syndrome ... Erythema.com: Information about Erythema What is toxic epidermal necrolysis? Dermatology - Toxic Epidermal Necrolysis Treatment of severe drug reactions :: Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis and Hypersensitivity syndrome

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