1. Von Willebrand's Disease University of Carolina's information on diagnosis and treatment. http://www.med.unc.edu/wrkunits/3ctrpgm/thromb/comprehe/vwd.htm

von Willebrand's disease Genetics of von Willebrand's disease Diagnosis of von Willebrand's disease Classification of von Willebrand's disease Clinical Manifestations of von Willebrand's disease ... Sources Cited

2. Hemophilia Offers information about von willebrand disease. Includes the types, the symptoms, treatment, and heredity.Category Health Conditions and Diseases von willebrand......von willebrand Disease von willebrand Disease. Introduction. Types of von willebrandDisease. Heredity. Symptoms. Diagnosis. Treatment. Blood Products. http://www.hemophilia.ca/en/2.2.html

Von Willebrand Disease Von Willebrand Disease Introduction Types of Von Willebrand Disease Heredity Symptoms ... Make a Donation

3. Von Willebrand Disease How to test and diagnose this bleeding disorder. http://www.awsaclub.com/healthgenetics/von.htm

von Willebrand Diease Author: Judy Huston When I started asking breeder friends of mine about vWF, most stated versions of the following: Their vet advised them the test was inaccurate so there was not much point in doing it. If properly performed, the test is NOT unreliable – but a commercial company marketing a DNA marker test for certain breeds (not GSD), has claimed so. Their worth has never been published and current literature no longer claims that blood test is "unreliable" – good thing as it is unprofessional and ……. They stated the disease is not in their lines so again there is no reason to do the test. The Type I disease is much more common than the other types of vWD and has been recognized in more than 50 breeds to date. Breeds with a high prevalence of the vWD gene include the Doberman Pinscher (80%), Scottish Terrier, Minature Poodle, Pembroke Welsh Corgi, German Shepherd (vWD Gene 15 to 80%), Rottweiler, Standard and Toy Manchester Terrier, Keeshond, and the Standard and Miniature Dachschund. Although relatively few have severe problems and even fewer die from it, many animals are affected by vWD. Bleeding typically involves mucosal surfaces. The bleeding episodes are worsened by physical, emotional, and physiological stresses as well as by other concomitant diseases. Typical clinical signs include: recurrent gastrointestinal hemorrhage with or without diarrhea; recurrent hematuria; existaxis; bleeding from the gums, vagina, or penis; lameness that mimics eisinophilic panosteitis; stillbirths or neonatal deaths ("fading pups") with evidence of bleeding at necropsy; prolonged bleeding at estrus or after whelping; bruises or hematomas on the surface of the body, limbs, or head; excessive umbilical cord bleeding at birth; and excessive bleeding from toenails cut too short or after tail docking, ear cropping, and dew claw removal. Affected dogs may bleed to death from surgical procedures.

4. DNA Studies In Doberman Von Willebrand’s Disease. is very excited about our discovery of the mutation that causes von willebrand's disease (vWD) in the Doberman Pinscher. http://www.vetgen.com/vwdrpt.html

DNA Studies in Doberman von Willebrand's Disease. The Mutation Discovered and a DNA Test Developed by George J. Brewer, Professor, Department of Human Genetics and Internal Medicine, University of Michigan Medical School, Co-Founder of VetGen LLC Our research team is very excited about our discovery of the mutation that causes von Willebrand's disease (vWD) in the Doberman Pinscher. Credit for the discovery must include my colleagues, Dr.'s Patrick Venta, Vilma Yuzbasiyan-Gurkan, and William Schall, of the College of Veterinary Medicine at Michigan State University, and to Dr. Jianping Li, who works in my laboratory at the University of Michigan as well as at VetGen LLC, and who did all the DNA sequencing. This discovery is a nice example of the productive cooperation between the two universities and the company mentioned, as well as four funding organizations that provided support, The Doberman Pinscher Foundation of America, Inc., The Orthopedic Foundation for Animals, the Morris Animal Foundation, and the American Kennel Club. The mutation itself has some interesting aspects. For one thing, precisely the same mutation has occurred in some human patients with vWD. It is a little unusual to see mutations be identical across species. This shows how closely we are related to our canine brethren! Second, the mutation is of a type such that completely normal von Willebrand's factor (vWf) is made about 5-10% of the time. Technically, the mutation is called a splice site mutation, with alternative splicing occurring about 90-95% of the time. That jargon won't mean much to the average Doberman breeder or owner, but let me explain what is happening in layperson language. It may be useful for the Doberman fancy to understand the mutation to a certain extent, because its nature explains why it was so confusing to understand for a long time, and it also explains why affected Dobermans have a milder disease than, say, affected Scotties.

5. OBGYN.net - Von Willebrand Q And A von willebrand Disease Information Sheet A Brief History von willebrand disease (vWD) is thought to be the most common hereditary bleeding disorder, affecting up to 3% of the U.S. population. http://www.obgyn.net/ENGLISH/PUBS/ANNOUNCEMENTS/VWD_Q_A.HTM

von Willebrand Disease Information Sheet A Brief History von Willebrand disease (vWD) is thought to be the most common hereditary bleeding disorder, affecting up to 3% of the U.S. population. vWD was first recognized in 1925 by Erik von Willebrand, a Finnish physician, who described a new type of bleeding disorder in inhabitants of the C land Islands. Using simple laboratory equipment, von Willebrand observed that his patients had an abnormality in blood platelet function. We now know that their platelets behaved abnormally because their plasma lacked von Willebrand factor. von Willebrand factor helps platelets adhere to damaged blood vessels to form a platelet plug, an integral aspect of hemostasis. von Willebrand factor also serves as a carrier protein for plasma factor VIII. vWD affects men and women in equal numbers, but it does not affect them equally. Because the most common symptoms of vWD in women (heavy and prolonged menstrual periods) are often misunderstood to be a gynecologic rather than a hematologic problem, the risk of misdiagnosis and undertreatment poses a greater health concern for women than it does for men. vWD in its mildest form can cause an inconvenience for women. They may require pre-treatment for certain dental procedures, surgery, or child birth. But for women with moderate to severe vWD, the bleeding disorder can be debilitating and potentially life threatening if undiagnosed and untreated.

6. JRTCA - Jack Russell - Medical: Canine Von Willebrand's Disease Information on this disease from the Jack Russell Terrier Club of America. http://www.terrier.com/breed/vonwill.php3

Preserve, Protect and Work the Jack Russell Jack Russell Terrier Club of America Home JRTCA Breed Rescue ... Medical Menu Von Willebrand's Disease History Lesson Breed Standard Bad Dog Talk Online Profiler ... Certificates JRT Book Store "The Dog Who Loved Too Much: Tales, Treatments, and the Psychology of Dogs" View Book Details All Books Join Today! Web Site Survey Canine Von Willebrand's Disease Diagnosis can be performed by measurement of plasma concentrations of vWF. TESTING SHOULD BE DONE AT AN EARLY AGE SINCE THE DISORDER OFTEN DIMINISHES WITH AGE, CAUSING FALSE-NEGATIVE TEST RESULTS IN OLDER ANIMALS. Additional screening tests such as bleeding times or platelet agglutination assays can also be performed. Precautions should be taken before surgery, so it is important to let your veterinarian know of bleeding problems in the past. Different breeds exhibit different variations of the disease, and some individual animals appear to "acquire" vWD. While the bulk of the information available is based upon purebred dogs, the disease is not unknown in mixed breeds. The total number of breeds affected by vWF exceeds 50. The disease also appears in cats, pigs, horses, and humans. Human variants of vWD are broken into three main types which can be used to describe canine vWD. Type I vWD is characterized by a low concentration of normally structured protein. In screening studies done at Cornell over a period of years (1982-1992), percentages of dogs of some breeds tested as carrying the disease, and with concentrations of vWF less than 50% of standard (considered to be at risk) were the following breeds: Corgi, Poodle (std. and min), Scottie, Golden Retriever, Doberman, Sheltie, Akita, Cairn.

7. Matt Klimshuk's Home Page Information on von willebrand's Disease and links to von willebrand's and Hemophilia sites.Category Health Conditions and Diseases von willebrand...... Information is Power . Providing Information on von willebrand's Disease. andLinks to von willebrand's Hemophilia Web Pages Go To Personal Information. http://www.mindspring.com/~mattrk/

"Information is Power" Providing Information on von Willebrand's Disease Go To Personal Information What Is Von Willebrand's Disease? Von Willebrand's Disease (vWD) is not a disease at all, but the most common genetic disorder in the world (classic hemophilia is more well known due to its connection with the royal families of Europe). In fact, vWD is times more common than classic hemophilia! It was discovered by a Finnish doctor in the 1920s, who named it after himself and called it a disease. Later, Dr. von Willebrand discovered in truth that the illness was linked to a missing blood factor, which assists with the clotting of blood. He named the factor after himself as well - von Willebrand's Factor (vWF). The disorder is not sex linked (autosomal), meaning that both men and women can have it, but some can be carriers only and not manifest any of the symptoms. VWD occurs when the body makes either inferior vWF or none at all. Other blood factors can be short-changed as well. Generally, vWD is divided into three types: Type I (mild), Type II (Medium) and Type III (severe). The lower the type, the less the symptoms will occur and the less strenuous they will be. What Are the Symptoms?

8. Treatment Of Von Willebrand Disease Information on symptoms, testing and treatment.Category Health Conditions and Diseases von willebrand...... Most people with von willebrand Disease display very mild symptoms, unless theyare suffering form type 3. Many people do not realise that they are suffering http://www.lifesciences.napier.ac.uk/courses/projects99/vwillibrand/treatmen.htm

Sy mptoms, testing and treatment Symptoms Testing Treatment Symptoms Most people with von Willebrand Disease display very mild symptoms, unless they are suffering form type 3. Many people do not realise that they are suffering from the disease until another family member is diagnosed. These symptoms are highly variable even within a family and not every sufferer displays every sign. von Willebrand disease is associated with easy bruising, recurrent nosebleeds, mucocutaneous haemorrhage and prolonged or posttraumatic bleeding. plasma von Willebrand Factor and Factor VIII levels increase during pregnancy. In patients suffering from type 3 spontaneous hemorrhage from mucous membranes and gastrointestinal tract is quite common and can be life threating. For women suffering from this type and for those people whom have just undertaken surgery bleeding is controlled by hormone replacement therapy. Sufferers are advised against competing in any sport that carries a high risk of injury. This is to prevent injury that would be followed by the above symptoms. For classification of von Willebrand disease click here back to top Testing In a clinical laboratory there are five basic phenotypic tests to diagnosis von Willebrand disease and one genetic test.

9. Hemophilia Resources Of America (HRA): About Hemophilia Von Willebrand Disease F Information from Hemophilia Resources of America.Category Health Conditions and Diseases von willebrand...... Diagnosis Treatment Resources for additional information What causes vonWillebrand disease? What are the symptoms of von willebrand disease? http://www.hrahemo.com/abouthemo/vonwillebrand.html

This information sheet was compiled by Doris Michalovic, RN, MS, FNP Clinical Director, Hemophilia Resources of America Phone (800) 549-2654 Causes Symptoms Who should be tested? Diagnosis ... Resources for additional information What causes von Willebrand disease? Von Willebrand (VWD) is a genetic disorder which can be inherited from either parent. It affects both males and females. VWD is the most common bleeding disorder. It is estimated to occur in approximately one in 100 people and affects all ethnic groups. Over 3,000,000 people in the U.S. are affected. Most people who have this disorder do not know that they have it. What are the symptoms of von Willebrand disease? Symptoms in people with VWD vary from time to time. They may range from none to severe. Typical symptoms include: Frequent or prolonged nosebleeds Easy bruising Heavy or prolonged menstrual periods Prolonged bleeding after injury, surgery, childbirth, or dental work.

10. Von Willebrand's Disease Vetinfo.com's information on this disease, treatments and signs. http://www.vetinfo.com/dvonwillebrands.html

Sitemap vetinfo vetindex catindex ... Secure e-mail subscription form Please note: The information on our site is for everyone to read. Please use it as often as you like. Please use the search engine or one of the indexes to access the information you need on our website. Subscriber Info The income from subscriptions helps defray the cost of maintaining the site and allows us to keep the large amount of information on www.vetinfo.com free to our readers. vonWillebrand's disease vonWillebrand's Disease care von Willebrand's disease von Willerand's and anemia also see blood disorders vonWillebrand's Disease care Question: Dear Dr. Richards, I recently had our 5 1/2 month old Doberman tested for vonWillebrand's Disease before I had her spayed. She has the disease. My vet said that she had only 3% of the vonWillebrand's factor, which sounds pretty bad to me. The plan is to take her in the afternoon before her surgery and give her a plasma transfusion, then do the surgery the next morning. I know nothing about this disease or what to expect or how to take care of her in the future. I have looked for information on the internet and what I have

11. Von Willebrand's Disease von willebrand's Disease VON WILLERBRANDS DISEASE von willebrands disease (wVD) is the most common inherited bleeding disorder in dogs. Although dogs of any breed (even mixed breeds) can have vWD, certain breeds are more prone to it than http://www.cah.com/library/vwd.html

Von Willebrand's Disease Veterinarians have a new blood test that measures very small and very large amounts of vWF with greater accuracy (and in less time) than the old test. Accurately measuring vWF helps predict if a dog will be affected by vWD or will merely be a carrier - unaffected by the disease but with the potential to pass along the defect to its offspring. There is also a genetic test for the disease in Dobermans, Scottish Terriers, Poodles, Shetland Sheepdogs, Manchester Terriers and Pembroke Welsh Corgis. There are two companies offering this testing. The first to develop it was Vet Gen. For more information, they have a website for which I have included the link. http://www.vetgen.com/ They also have a rival company offering the same testing considerably cheaper. However, there is a lawsuit pending because Vet Gen has a patent on these tests. The other company is Gene Search. They can be found at : http://www.genesearch.net/ The information of the above two paragraphs came from Nancy Troyer a Doberman Pincher breeder http://home.mindspring.com/~suntana/index.html

12. October 1994 - Von Willebrand Disease von willebrand DISEASE Margaret V. Ragni, M.D., M.P.H., Medical Director, Hemophilia Center of Western Pennsylvania von willebrand disease (VWD) is the most common congenital bleeding disorder. http://www.itxm.org/Archive/tmu10-94.htm

October, 1994 VON WILLEBRAND DISEASE Margaret V. Ragni, M.D., M.P.H., Medical Director, Hemophilia Center of Western Pennsylvania INTRODUCTION Von Willebrand disease (VWD) is the most common congenital bleeding disorder. It is estimated to occur at a frequency of one in 100 individuals, but is symptomatic in only about one in 10,000. Von Willebrand disease is caused by mutations in von Willebrand factor (VWF). The gene for von Willebrand Factor is located on chromosome 12, and the disease is inherited in an autosomal manner, affecting both males and females. Von Willebrand factor is a glycoprotein consisting of disulfide-linked high molecular weight multimeric FVIII proteins (multimers), and is synthesized in megakaryocytes and endothelial cells, and stored in platelets and endothelial cells. Von Willebrand factor serves as a carrier protein for FVIII and promotes platelet aggregation after vessel injury. Von Willebrand disease is a clinically heterogeneous disease with a number of disease variants, each characterized by different quantitative and/or qualitative defects in von Willebrand factor. It is import to determine the specific von Willebrand disease variant in order to establish the best and safest treatment for each patient. Recently a revised simplified classification system for von Willebrand disease was proposed by the international Society of Thrombosis and Hemostasis (ISTH) (Sadler JE.

13. All About Bleeding - An Informational Resource About Von Willebrand Disease. A resource for education, guidance and support for people who have or suspect they have von willebrand Category Health Conditions and Diseases von willebrand......Your personal resource for education, guidance and support for peoplewho have or suspect they have von willebrand disease. http://www.allaboutbleeding.com/

Get to Know the Types of von Willebrand Disease Order Your Copy of A Guide to Living with von Willebrand Disease Aventis Behring welcomes you to allaboutbleeding.com , your personal resource for education, guidance and support for people who have or suspect they have von Willebrand disease . Many people with von Willebrand disease do not have any symptoms, but those who do may experience frequent nosebleeds, easy bruising, heavy menstrual flow or excessive bleeding from the mouth. Whether you, a friend, or family member is diagnosed with von Willebrand disease or experience its symptoms, allaboutbleeding.com offers you personalized tools, information resources, community support, and other important information about this bleeding disorder. Registered members may take advantage of allaboutbleeding.com 's personalized tools, information resources and community support including... Journal Track your bleeding symptoms, doctor appointments, medication, diet and exercise with a personal interactive journal. Your personalized page will then post reminders for medication, doctor visits, and more. You can even print out reports to discuss with your doctor. Resource Center Gives you a wide range of information to educate and empower you to better understand von Willebrand disease, its symptoms and treatment. Learn how von Willebrand disease is passed on, how to detect it and what to do if you think you might have it. Even after diagnosis, the Resource Center will provide guidance and tips regarding your condition.

14. AnimalForum.com: Von Willebrand's Disease Article on von willebrand's disease identifying breeds most commanly affected as well as symptoms and treatment. http://www.animalforum.com/dbreed/medvonwill.htm

[Your user agent does not support inline frames or is currently configured not to display frames. However, you may visit the related document. Check out our suggested books for dog owners Von Willebrand's disease By Brandon Brooks, DVM V on Willebrand's Disease (vWD) is both an inherited and acquired condition. Breeds most commonly inheriting the trait for this disease are Doberman Pinschers, standard poodles, Pembroke Welsh Corgis, Scotties, Shelties and golden retrievers, among others. This disease, which is a deficiency in a certain clotting factor (a blood protein), can also be caused by other conditions such as hypothyroidism, estrus, pregnancy, infections and certain drugs including NSAIDs like aspirin. vWD is the most common inherited bleeding disorder in dogs, and it is a recessive trait that can affect males and females equally. These dogs lack the ability to manufacture von Willebrand's factor, or Factor VIII (8), a blood protein essential in the clotting cascade. With its absence, blood cannot clot properly and many affected animals will spontaneously bleed. Without the ability to clot reliably, these animals are at serious risk of bleeding to death. Sometimes problems are noted first when the animal bleeds spontaneously, such as a nosebleed. vWD can also be picked up during things like a nail trim, and if one of the nails is "quicked" it doesn't stop bleeding, even with much application of styptic powder. It can also be noticed at the time of spaying or neutering, or during examination when blood is drawn for a heartworm test. Bleeding can also be noted in vomitus or in the stool, and the presence of a dark tarry stool indicates bleeding in the upper GI tract.

15. Von Willebrand's Seattle Veterinary Associates facts on diagnosis and treatment. http://www.seattleveterinaryassociates.com/von_willebrand's.htm

CANINE von WILLEBRAND's DISEASE What is von Willebrand's disease? Von Willebrand's disease (VWD) is the most common inherited bleeding disorder of both man and animals. It is caused by a deficiency in the amount of a protein needed to help platelets (a blood cell used in clotting) seal broken blood vessels. The deficient protein is called von Willebrand factor antigen. Which breeds are most commonly affected by VWD? About 30 different breeds are known to be affected but the Doberman Pinscher is the breed most commonly associated with this disease. Of 15,000 Dobermans screened, more than 70% were found to be carriers of the disease. Fortunately, most of these are not clinically affected (i.e., we see no evidence of bleeding). However, the number of Dobermans with a history of bleeding appears to be on the rise. Although Dobermans are commonly affected, they usually have the mildest form of the disease. The average at diagnosis for this breed is about four years of age. One study showed that 30% of Scotties and 28% of Shelties had abnormally low concentrations of von Willebrand factor. Chesapeake Bay Retrievers and Scotties are affected with the most severe form of the disease. What are some of the signs of VWD?

16. Von Willebrand Factor (VWF) Database vWF Database von willebrand Factor (VWF) Database. This VWF Database websitehas moved and is no longer maintained at the University of Michigan. http://mmg2.im.med.umich.edu/VWF/

vWF Database von Willebrand Factor (VWF) Database This VWF Database website has moved and is no longer maintained at the University of Michigan. The ISTH SSC VWF Database is now maintained at the University of Sheffield. Please direct all inquiries to Stuart Croft of the Division of Genomic Medicine at the University of Sheffield. Please change your bookmark to reflect this new location http://www.shef.ac.uk/vwf You will be redirected to the new location in 10 seconds.

17. Invalid URL! Sheltie von willebrand's Disease Can Now Be Diagnosed by a DNA Test http://mmg2.im.med.umich.edu/vWF

Document not found! I couldn't find the document you requested - it may have moved or been renamed. Try starting at the to see if you can find what you were looking for. For some of you, your browser will automatically go there after three seconds. Last modified: Mon Apr 28 11:26:20 1997

18. Sheltie Von Willebrand’s Disease Can Now Be Diagnosed By A DNA Test Sheltie von willebrand's Disease Can Now Be Diagnosed by a DNA Test. The vWD testavailable in the past has been an assay of von willebrand factor protein. http://www.vetgen.com/sheltvwd.html

Sheltie von Willebrand's Disease Can Now Be Diagnosed by a DNA Test by George J. Brewer, Professor, Department of Human Genetics and Internal Medicine, University of Michigan Medical School and Patrick J. Venta, Assistant Professor, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, Co-Founders of VetGen LLC Von Willebrand's disease vWD, an inherited bleeding disorder, usually comes in two major types, type I and type III. (There is also a rarer Type II, not relevant to Shelties). Type III is a severe bleeding disorder with a high risk of spontaneous bleeding as well as a risk of serious bleeding from trauma and surgery. It is probably best known in Scottish Terriers. Type I is milder, with most of the risk coming from trauma or surgery. It is probably best known in Doberman Pinschers. The Sheltie breed has type III vWD, the severe type. There may also be a second less prevalent defect, causing some Shelties to have the less severe Type I vWD, but this is uncertain at present. Enter the era of DNA testing! DNA tests have now been developed for the type III vWD of Scotties, the type I vWD of Dobermans, and the type III vWD for Shelties. These DNA tests can be done at any age, can be done from mouth swabs collected by the breeder/owner (the swabs pick up cells from inside the mouth which provide the DNA), and unambiguously classify dogs for the rest of their lives into affected, carrier, and clear animals. With this test the breeder can rapidly eliminate the vWD disease gene from the breed. If a particularly valuable dog turns out to be a carrier, it can be bred to a clear animal, and non-carrier puppies saved for the next round of breeding.

19. Gentiva Health Services - Page Not Found Designed to help you understand hemophilia, von willebrand's disease and other bleeding disorders and provide valuable information. http://www.gentiva.com/consumer/hemophilia/

About Gentiva Services Investor Relations Career Opportunities ... gentiva.com Page Not Found We are sorry, but the URL you requested could not be found. The page you are looking for may have been renamed, moved, or deleted. If you feel you have reached this page in error, please use the Back button of your browser or check the address you entered and try again. If you reached this page from another part of gentiva.com, please let us know so we can fix the problem. Please check the URL for spelling, capitalization, and punctuation errors, and click the "reload" button on your browser. To view a current site map of gentiva.com click here , or to return to the gentiva.com home page click here Company Information Services Investor Relations ... Legal Statement

20. David Ginsburg David Ginsburg, M.D An article covering von willebrand Factor, coagulation factor V, plasminogen activator inhibitor1, primary pulmonary hypertension and bone marrow transplantation. http://www.hhmi.org/science/genetics/ginsburg.htm

HHMI INVESTIGATORS / David Ginsburg HHMI INVESTIGATORS INTERNATIONAL RESEARCH SCHOLARS HHMI-NIH RESEARCH SCHOLARS LAB SAFETY ... HHMI HOME ALSO OF INTEREST Search PubMed Researchers Pinpoint Cause of Deadly Blood-Clotting Disorder The Ginsburg Lab Molecular Genetics of Blood Clotting David Ginsburg, M.D. Investigator, University of Michigan Medical School Biography... Summary: David Ginsburg is interested in understanding the components of the blood-clotting system and how disturbances in their function lead to human bleeding and blood-clotting disorders. Precise control of the blood-clotting system is essential for maintenance of the circulation in all higher animals. Deficient function of this system can lead to fatal bleeding following even a minor injury, whereas overactivity of this system can produce unwanted blood clots, resulting in blockages to critical blood vessels, as occurs in such diseases as heart attack and stroke. von Willebrand Factor von Willebrand factor (VWF) is an important part of the body's blood-clotting system. It functions as a bridge connecting blood platelets to the wall of injured blood vessels, thereby helping to control bleeding. VWF also serves as the carrier for factor VIII, the substance missing in patients with hemophilia. Abnormalities in VWF result in von Willebrand disease (VWD), the most common human inherited bleeding disorder.

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