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Adiposis Dolorosa:     more detail

Adiposis Dolorosa, 300 B.C. by LeRoy Crummer, 1924 Conditions of the Subcutaneous Fat: Adiposis Dolorosa, Erythema Nodosum, Tumor Lysis Syndrome, Barraquer-simons Syndrome, Lipodermatosclerosis Three cases of a hitherto unclassified affection resembling in its grosser aspects obesity, but associated with special nervous symptoms -adiposis dolorosa by Francis X Dercum, 1892

lists with details

1. Article: Corticosteroid-Induced Juxta-articular Adiposis Dolorosa (Dercum's Dise
   This article discusses a case of Dercum's Disease in the knee that was apparently caused by corticosteroi Category Health Conditions and Diseases Dercum DiseaseThis site discusses the symptoms, personal stories and research that has beendone in the study of Dercum's Disease (adiposis dolorosa).  
   http://dercums_data.tripod.com/greenbaum.html
   
   Extractions: Adiposis dolorosa is an uncommon disorder of subcutaneous tissue that was first described by Dercum in 1892 at Jefferson Medical College, Philadelphia, Pa. The understanding of this disease has not progressed very much in the past 98 years. It remains better understood as a clinical entity than as a physiologic or metabolic process.

2. Dercum's Disease - Aka Adiposis Dolorosa
   Symptoms, personal stories, and research that has been done in the study of Dercum's Disease. Includes Category Health Conditions and Diseases Dercum DiseaseThis site discusses the symptoms, personal stories and research that hasbeen done in the study of Dercum's Disease (adiposis dolorosa).  
   http://dercums_data.tripod.com/
   
   Extractions: (or 10 p.m. EDST) on AOL at Dercum Chat on Homestead "Evidently the disease is not simple obesity. If so, how are we to dispose of the nervous elements present? Equally plain is it there we have not myxoedema to deal with. ... It would seem, then, that we have here to deal with a connective-tissue dystrophy, a fatty metamorphosis of various stages of completeness, occurring in separate regions, or at best unevenly distributed and associated with symptoms suggestive of an irregular and fugitive irritation of the nerve-trunks – possibly a neuritis … Inasmuch as fatty swelling and pain are the most prominent features of the disease, I propose for it the name Adiposis Dolorosa." [ From: Dercum FX.

3. OMIM ENTRY 103200
   This OMIM (Online Mendelian Inheritance in Man) site uses some very limited research (2 papers dealing with 3 families) to conclude that this may be an inherited illness.  
   http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?103200

4. Brorson/Fagher Article On Dercum's Disease Or Adiposis Dolorosa
   This is an excellent overview article on the disease characterized by painful lipomas (benign fatty tumors). Note that the first part of the article is a biography of Dr. Dercum.  
   http://dercums_data.tripod.com/brorson.html
   
   Extractions: to get to the description of the disease, click here! This article is © 1996 by LÄKARTIDENINGEN - The Journal of the Swedish Medical Association Translation courtesy of Ruth Weaver (many thanks for an excellent job!) DERCUM'S DISEASE Fatty tissue rheumatism caused by immune defense reaction? Authors: Håkan Brorson, M.D., Ph.D.

5. EMedicine - Adiposis Dolorosa : Article By Nada Macaron, MD
   Overview article describing Dercum's Disease. It is a melding of the various existing Dercum articles Category Health Conditions and Diseases Dercum Diseaseadiposis dolorosa First described in 1892 by the American neurologist Francis XavierDercum at Jefferson Medical College in Philadelphia, Pa, Dercum disease  
   http://www.emedicine.com/derm/topic839.htm
   
   Extractions: (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Diseases Of The Subcutaneous Tissue Last Updated: February 4, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: Dercum’s disease, Dercum disease, painful lipoma, fatty tissue rheumatism, juxta-articular adiposis dolorosa (occurs around the knees) AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Nada Macaron, MD , Staff Physician, Department of Pathology, Emory University School of Medicine Coauthor(s): Jack Arbiser, MD, PhD , Assistant Professor, Department of Dermatology, Emory University School of Medicine Nada Macaron, MD, is a member of the following medical societies: College of American Pathologists , and United States and Canadian Academy of Pathology Editor(s): C Lisa Kauffman, MD , Chief of Dermatology, Associate Professor, Departments of Internal Medicine and Pathology, Georgetown University Medical Center; David F Butler, MD

6. EMedicine - Adiposis Dolorosa : Article Excerpt By: Nada Macaron, MD
   adiposis dolorosa First described in 1892 by the American neurologist Francis XavierDercum at Jefferson Medical College, Philadelphia, Pa, Dercum disease is  
   http://www.emedicine.com/derm/byname/adiposis-dolorosa.htm
   
   Extractions: (advertisement) Synonyms, Key Words, and Related Terms: Dercum’s disease, Dercum disease, painful lipoma, fatty tissue rheumatism, juxta-articular adiposis dolorosa (occurs around the knees) Background: First described in 1892 by the American neurologist Francis Xavier Dercum at Jefferson Medical College in Philadelphia, Pa, Dercum disease is an unusual progressive syndrome of unknown etiology characterized by multiple painful lipomas that arise in adult life, most often affecting postmenopausal women who are obese (Dercum, 1982). The onset is insidious, and the pain is out of proportion to the physical findings and is often described by patients as “all fat hurts.” The pain increases with the increase in fatty tissue and in connection to menstruation. Estrogen at menopause does not reduce the pain. Since the original description of this disease, the clinical spectrum has changed to include, in addition to the painful nodular fatty deposits, other components of adiposis dolorosa. General obesity; fatigability; weakness; and a wide variety of unexplained emotional disturbances, such as depression, confusion, and dementia, are reported. This observation is why Dercum disease has been proposed to be relabeled as Dercum syndrome (Palmer, 1981). Adiposis dolorosa is a disease that has been classified by the World Health Organization (WHO), and a paraphrase from the National Organization of Rare Diseases (NORD) says “Dercum Disease is a rare disorder in which there are fatty deposits which apply pressure to the nerves, resulting in weakness and pain. Various areas of the body may swell for no apparent reason. The swelling may disappear without treatment, leaving hardened tissue or pendulous skin folds.”

7. HONselect - Adiposis Dolorosa
   Language MeSH term Accepted terms English adiposis dolorosa, Dercum's Disease- Dercum Disease - Dercums Disease - Disease, Dercum - Disease, Dercum's.  
   http://www.hon.ch/HONselect/RareDiseases/C17.800.849.077.html

8. LIPOMAS, LIPOMATOSIS, AND CERTAIN CLINICAL TYPES OF ABNORMAL FAT DEPOSIT
   This is an older article (1974) that has a section describing the adiposis dolorosa (Dercum's Disease or Dercum Syndrome), as well as other diseases affecting the fatty deposits.  
   http://www.jeghers.com/annts/lipomas.htm
   
   Extractions: LIPOMAS, LIPOMATOSIS, AND CERTAIN CLINICAL TYPES OF ABNORMAL FAT DEPOSIT (Annotations and Bibliographies of Selected References) Prepared for: Medical Grand Rounds St. Vincent Hospital Worcester, Mass. Date: June 14, 1974 Prepared by: Harold J. Jeghers, M.D. and Solomon O. Oyesola, M.S.L.S., A.L.A. (On study leave from Medical Library, College of Medicine, University of Lagos, Nigeria. Presently at Case Western Reserve University, School of Library Science) Does not include data on ordinary obesity, obesity related to endocrine disorders, atrophy or necrosis of subcutaneous fat tissue, etc. **Read First *Read Next ADIPOSE TISSUE (General Information) There is an enormous literature on the type of obesity related to imbalance of caloric intake and energy output and abnormalities of body fat distribution related to certain endocrine disorders. It is well known that the amount and distribution of body fat varies with age, sex and race. By contrast, less attention has been paid to certain disorders characterized by abnormal localized forms of excess adipose tissue. Reading a few selected articles related to basic science concepts and general orientation to the subject of adipose tissue will be helpful. **Wells: Adipose tissue, a neglected subject. JAMA 114: 2177-2183; 2284-2289, 1940 (a scholarly and classic paper; literature; several helpful illustrations)

9. NORD - National Organization For Rare Disorders, Inc.
   A discussion about this rare disorder (aka Dercum's Disease, adiposis dolorosa), characterized by pressure of fatty deposits on nerves, resulting in weakness and pain. Some resources are listed for further study. This entry is provided by NORD (National Organization for Rare Disorders).  
   http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Dercum Diseas

10. Dercum's Disease - Aka Adiposis Dolorosa
    This site discusses the symptoms, personal stories and research that has been done in the study of Dercum's Disease (adiposis dolorosa). Contains much reference material. and pain are the most prominent features of the disease, I propose for it the name adiposis dolorosa." From Dercum FX.  
    http://members.tripod.com/Dercums_Data
    
    Extractions: (or 10 p.m. EDST) on AOL at Dercum Chat on Homestead "Evidently the disease is not simple obesity. If so, how are we to dispose of the nervous elements present? Equally plain is it there we have not myxoedema to deal with. ... It would seem, then, that we have here to deal with a connective-tissue dystrophy, a fatty metamorphosis of various stages of completeness, occurring in separate regions, or at best unevenly distributed and associated with symptoms suggestive of an irregular and fugitive irritation of the nerve-trunks – possibly a neuritis … Inasmuch as fatty swelling and pain are the most prominent features of the disease, I propose for it the name Adiposis Dolorosa." [ From: Dercum FX.

11. HON - List Of Rare Diseases
    Acrocephalosyndactylia, Acrodermatitis. Addison's Disease, Adie Syndrome.adiposis dolorosa, Alagille Syndrome. Amylose, Amyotrophic Lateral Sclerosis.  
    http://www.hon.ch/HONselect/RareDiseases/

12. CANCER: CAUSES AND EFFECTS
    Chapter from Dr. Ed Friedlander's online textbook. adiposis dolorosa (Dercum's Disease) is mentioned (search for adiposis ). Even though the lipomas (tumors) are benign, they can cause problems just by being, and he lists a number of examples.  
    http://www.pathguy.com/lectures/neo-2-3.htm
    
    Extractions: erf@uhs.edu Cyberfriends: The help you're looking for is probably here. Welcome to Ed's Pathology Notes, placed here originally for the convenience of medical students at my school. You need to check the accuracy of any information, from any source, against other credible sources. I cannot diagnose or treat over the web, I cannot comment on the health care you have already received, and these notes cannot substitute for your own doctor's care. I am good at helping people find resources and answers. If you need me, send me an E-mail at erf@uhs.edu Your confidentiality is completely respected. Allan N. Spreen MD also handles internet questions at no charge, with a primary focus on nutrition. Dr. Spreen is also my former student and my close friend. DoctorGeorge.com is a larger, full-time service. There is also a fee site at myphysicians.com , and another at www.afraidtoask.com Translate this page automatically With one of four large boxes of "Pathguy" replies. I'm still doing my best to answer everybody. Sometimes I get backlogged, sometimes my E-mail crashes, and sometimes my literature search software crashes. If you've not heard from me in a week, post me again. I send my most challenging questions to the medical student pathology interest group, minus the name, but with your E-mail where you can receive a reply.

13. Adiposis Dolorosa / Dercum Disease
    The new address for Heartland/Hills1674 is Heartland/Pines2905 Please update your bookmarks now to reflect these changes. This notice will be removed in 4 weeks. Thank you.  
    http://www.geocities.com/Heartland/Hills/1674

14. Emerging Worlds Chronic Illness And Viral Infections
    Dercums Disease/adiposis dolorosa First identified by Francis X. Dercum,in 1892, Dercums Disease (also Dercum Disease or Adiposis  
    http://emergingworlds.com/ch_conditions_detail.cfm?vPageid=157

15. Adiposis Dolorosa
    adiposis dolorosa. IN EUROPE. Dercum's Disease / adiposis dolorosa. IN THE REST OFTHE WORLD. Dercum's Disease / adiposis dolorosa. Dercum's Disease (SE).  
    http://www.eadv.org/skinweb/adipdol.html

16. Dercum's Disease (Adiposis Dolorosa) - PubMed MedLine References
    This is a listing of the references to Dercum's Disease culled from Medline, the National Library of Medicine data base.  (aka Dercum Syndrome, adiposis dolorosa)  
    http://Dercums_Data.tripod.com/ref-list.html
    
    Extractions: Get Five DVDs for $.49 each. Join now. Tell me when this page is updated Dercum's Disease PubMed MedLine References This is a listing of the all the references I've found (so far) that discuss Dercum's disease or Adiposis Dolorosa or some aspect that might be of interest. Sometimes there is only the title (typically of foreign language articles) because no abstract is available. The Pub Med document number is included for reference. Web author comments are in blue (like this statement). A few of the articles have links that allow you access the actual article. Dr. Dercum's article (#64) and some other older ones have been recently added and can be found at the bottom of the list. Humangenetik 1973 Mar 23;18(1):89-91 PMID: 4721343, UI: 73226373 Am Fam Physician 1981 Nov;24(5):155-7 PMID: 7293909, UI: 82043245 Vestn Khir 1969 Jun;102(6):123-4

17. Diseases In The Rest Of The World
    Rosacea Rhinophyma SkinSite Rosacea - Family Health Radio (US) The US Nat'l RosaceaSociety - Barrington, Illinois (US) adiposis dolorosa Dercum's Disease  
    http://www.eadv.org/skionweb/diseasrow.html

18. ORPHANET® : Adiposis Dolorosa
    Translate this page ORPHANET. ORPHANET database access. adiposis dolorosa. Direct accessto details Alias Dercum's disease,Neurolipomatosis. Home Page.  
    http://www.orpha.net/static/GB/adiposis_dolorosa.html

19. Dercum's Disease (Dercum Disease, Adiposis Dolorosa) Articles Available HERE!
    This site discusses Dercum's Disease (Dercum Disease, adiposis dolorosa) the symptoms,personal stories and research that has been done in the study of the  
    http://dercum.tripod.com/articles.html
    
    Extractions: Dercum's Disease (Dercum Disease, Adiposis Dolorosa) Articles available HERE! We have collected a number of Dercum articles, and have made them available on this site. They are: Overview Article This article, by Håkan Brorson and Birger Fagher, is a good description and overview of the disease. (please be patient - it's a long article with lots of pictures and takes time to load). Original article in Swedish. A Pain in the Groin - This article is of great interest because it is the story of an older woman with a history of Dercum's Disease who goes to her doctor with a pain in her groin. They end up doing a hysterectomy and other stuff, and the pain did not go away. Finally, after some months, as the pain got worse, the doctors were able to convince the women to go back into surgery (she was not keen on it, since the previous surgeries did not solve the problem) and they finally operated on her again and took out a sizable lipoma. Maureen has talked to a lady who had a similar pain, and the doctor took out her appendix to relieve the pain. He took out the wrong thing. Again, it was a Dercum's lipoma. [ Reference #54] This article is also courtesy of The Lancet. Lethal infection by a previously unrecognised metazoan parasite - 1996 - This article was written by a number of doctors in the San Francisco/San Jose area. The summary states:

20. Dorlands Medical Dictionary
    adiposis tubero¢sa sim¢plex, a disorder resembling adiposis dolorosa, marked bydevelopment in the subcutaneous tissue of fatty masses which are sometimes  
    http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

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