Geometry.Net - Health_Conditions: Charcot-marie-tooth Disease

Genetics Research: Charcot Marie Tooth
charcotmarie-tooth disease Type 1A. Principal Investigator PragnaI. Patel, Ph.D. Autosomal dominant inheritance pattern; Frequency
http://www.bcm.tmc.edu/neurol/research/genes/genes3.html

Extractions: Patel, P.I., and Lupski, J.R. Charcot-Marie-Tooth disease: A new paradigm for the mechanism of inherited disease. Trends. Genet., 10:128-133, 1994. Patel, P.I., Roa, B., Welcher, A., Schoener-Scott, R., Trask, B.J., Pentao, L., Snipes, G.J., Garcia, C.A., Francke, U., Shooter, E., Lupski, J.R., and Suter, U. The gene for the peripheral myelin protein PMP-22 gene is a candidate for Charcot-Marie-Tooth disease type 1A. Nature Genetics, 1:159-165, 1992. Lupski, J.R., Montes de Oca-Luna, R., Slaugenhaupt, S., Pentao, L., Guzzetta, V., Trask, B.J., Saucedo-Cardenas, O., Barker, D.F., Killian, J.M., Garcia, C.A., Chakravarti, A., and Patel, P.I. DNA duplication associated with Charcot- Marie-Tooth disease type 1A. Cell, 66:219-232, 1991.
Charcot-Marie-Tooth Disease (CMT)
charcotmarie-tooth disease (CMT). What is it? Charcot-Marie-ToothDisease (CMT) is an inherited disorder that affects the nerves
http://www.hmc.psu.edu/healthinfo/c/cmt.htm
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Preliminary Study of Large and Small Peripheral Nerve Fibers in CharcotMarie-ToothDisease, Type I. Hanson P, Deltombe T Am J Phys Med Rehabil 1998; 77(1)45-8
http://www.medscape.com/viewarticle/431507
Charcot-Marie-Tooth Disease
Edit this Page Attachments to this Page History of this Page Home Recent ChangesSearch the Swiki Help Guide charcotmarie-tooth disease. NICE JOB!
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History Of Charcot-Marie-Tooth Disease
History of charcotmarie-tooth disease. Version, Name, User, Date, Time. current,charcot-marie-tooth disease, 63.116.28.123, 20 January 2003, 40938 pm.
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Extractions: This document contains a history of this page, from the current version to the earliest one available. Version Name User Date Time current Charcot-Marie-Tooth Disease 20 January 2003 4:09:38 pm Charcot-Marie-Tooth Disease hps0084484.hps.gatech.edu 10 December 2002 10:09:13 am Charcot-Marie-Tooth Disease hps0084484.hps.gatech.edu 10 December 2002 9:54:06 am Charcot-Marie-Tooth Disease hps0084484.hps.gatech.edu 10 December 2002 9:51:48 am Charcot-Marie-Tooth Disease w205d66.lawn.gatech.edu 6 December 2002 6:39:16 pm Charcot-Marie-Tooth Disease w205d66.lawn.gatech.edu 6 December 2002 6:38 pm Charcot-Marie-Tooth Disease w205d66.lawn.gatech.edu 6 December 2002 6:37:47 pm Charcot-Marie-Tooth Disease w205d66.lawn.gatech.edu 6 December 2002 6:37:37 pm Charcot-Marie-Tooth Disease w205d66.lawn.gatech.edu 6 December 2002 6:37:27 pm Charcot-Marie-Tooth Disease w205d66.lawn.gatech.edu 6 December 2002 6:37:18 pm Charcot-Marie-Tooth Disease w205d66.lawn.gatech.edu 6 December 2002 6:37:06 pm Charcot-Marie-Tooth Disease w205d66.lawn.gatech.edu
Charcot-Marie-Tooth Disease - Tutorial
The first cases of charcotmarie-tooth disease (CMT) were reported in 1855 by Aranand Virchow. Sabir M, Lyttle D. Pathogenesis of charcot-marie-tooth disease.
http://ortho.hyperguides.com/Tutorials/pediatric_ort/charcot-marie/tutorial.asp

Extractions: Type Classification I The hypertrophic form of CMT, also known as Roussy-Levy disease. It has autosomal dominant inheritance. Clinically, it is a demyelinating disease with distal extremity weakness, no DTR, and slow motor NCV. II The neuronal form of CMT. This type has a variable inheritance. Clinically, this form is less severe than type I and displays a mild decrease in NCVs and present DTRs. The onset of disease is later than type I. III IV Known as Refsum's disease, this type is characterized by excessive phytanic acid (a fatty acid).
Pediatrics: Charcot-Marie - Tooth Disease
charcotmarie-tooth disease Henry Boucher, MD. Paul D. Sponseller,MD Professor and Head of the Division of Pediatric Orthopedics
http://ortho.hyperguides.com/Tutorials/pediatric_ort/charcot-marie/default.asp
Charcot-Marie-Tooth Disorders - For Patients And Families - The Center For Human
What is charcotmarie-tooth disease? charcot-marie-tooth disease (CMT) is themost common inherited disease that affects the peripheral nerves in humans.
http://www.chg.duke.edu/patients/cmtd.html

Extractions: Charcot-Marie-Tooth disease (CMT) is the most common inherited disease that affects the peripheral nerves in humans. These nerves carry signals from the spinal cord to the muscles for strength and movement and from the sensory organs to the spinal cord for appreciation of touch, pain, temperature, and position. Signs of CMT include weakness and loss of muscle bulk in feet, lower legs, and hands with some decrease in the sensation of touch and pain. Symptoms can be quite variable even within families. The disabilities experienced range from mild to severe because of muscle weakness and less often because of sensory loss. The many different forms of CMT taken together affect one in 2,500 persons in the general population.
Major Classes Of Charcot-Marie-Tooth Disorders - For Patients And Families - The
For Patients and Families CharcotMarie-Tooth Disorders Major Classesof charcot-marie-tooth disease. CMT1. CMT inherited as an autosomal
http://www.chg.duke.edu/patients/cmtsum.html

Extractions: Charcot-Marie-Tooth Disorders Major Classes of Charcot-Marie-Tooth Disease CMT inherited as an autosomal dominant disease has a classic CMT presentation where the motor symptoms (muscle weakness) is much more of a problem to the patient than the sensory changes. This is probably the most common form of the disorder. HNPP: Hereditary Neuropathy with liability to Pressure Palsies (HNPP) is a distinct peripheral nerve disease both clinically and pathologically. Pressure on a specific nerve(s) result in weakness in muscles activated by the nerve(s). Although occasionally diagnosed as CMT, it can usually be differentiated by its more "patchy" findings. Sausage-like swellings are seen in myelin of these nerves when viewed under the microscope. In the families reported, HNPP follows autosomal dominant inheritance and is caused by a deletion of the same genetic material that is duplicated in CMT1A (the PMP-22 gene on chromosome 17). Dejerine-Sottas Disease: Dejerine-Sottas disease is named after the physicians who described the first cases. Patients have an earlier onset of more severe symptoms than those usually diagnosed by other forms of CMT. However, it turns out that the disease can be caused by point mutations in either the PMP-22 gene or the Po gene. In a pure molecular genetic sense, Dejerine-Sottas disease can be considered a form of CMT1.
CHARCOT MARIE TOOTH
FACT SHEET. CHARCOT MARIE - TOOTH DISEASE What is Chacot-Marie-Toothdisease? How does a person get charcot-marie-tooth disease?
http://www.mda.org.au/specific/mdacmt.html

Extractions: What is Chacot-Marie-Tooth disease? Charcot-Marie-Tooth disease is a hereditary disorder marked by slowly progressive muscle weakness in the feet, lower legs, hands and forearms, and a mild loss of sensation in limbs, fingers, and toes. The weakness results from the degeneration of nerves that stimulate muscle rather than from a degenerative process in the muscle tissue itself. The disorder, named for three physicians who first identified it in 1886, is also known as peroneal muscular atrophy because if primarily affects the peroneal muscles. which are located in the lower leg. There are now thought to be at least two types of the disease - hypertrophic and neuronal - that differ to some degree in severity.
Wheeless' Textbook Of Orthopaedics
1993. p 16991714. Spinal deformities in patients with charcot-marie-tooth disease.A review of 12 patients. Pathophysiology of charcot-marie-tooth disease.
http://www.ortho-u.net/o16/94.htm

Extractions: Main Menu Home Page - Discussion: type I type II , and type III are most common; - type IV: - is also referred to as Refsum disease; - associated w/ excess phytanic acid; - type V: - inherited spastic paraplegia with distal weakness in the limbs; - usually presents in the second decade of life or later; - patients develop awkward gait and equinus foot deformities; - type VI involves optic atrophy in association with peroneal muscular atrophy; - type VII is characterized by retinitis pigmentosa associated with distal muscle weakness in the limbs and atrophy; - Clinical Features: - patients may present w/ muscle cramps, difficulty with gait or w/ deformities of the feet; - upper extremity in CMT: - hip joint: look for proximal muscle weakness, and hip dysplasia; - pes cavus in CMT : - loss of proprioception and vibratory sensation is common in the lower extremities; - young patients should be checked for ataxia, as this might indicate Friedreich's Ataxia (rather than CMT);
Charcot-Marie-Tooth Disease (hereditary)
charcotmarie-tooth disease (hereditary). Definition Charcot-Marie-Toothdisease defines a group of slowly progressive, inherited
http://www.pennhealth.com/ency/article/000727.htm

Extractions: Disease Injury Nutrition Poison ... Prevention Definition: Charcot-Marie-Tooth disease defines a group of slowly progressive, inherited disorders that result from progressive damage to nerves. In addition to loss of sensation, there is wasting of muscle tissue in the feet and legs, then hands and arms. Causes, incidence, and risk factors: Charcot-Marie-Tooth diseases involve damage to nerves (neuropathy), usually from demyelination or loss of the electrical insulation around nerve fibers. All nerves are affected, but motor nerves are disproportionately so. The nerves in the legs are affected first and most severely. Symptoms usually begin between mid-childhood and early adulthood. The disorder is inherited, with autosomal dominant and recessive as well as X-linked recessive inheritance patterns. At least four genes have been discovered to be the cause of this group of diseases.
Charcot-Marie-Tooth Disease
BACK TO FACT SHEETS INDEX. CHARCOTMARIE TOOTH DISEASE. What is Charcot-Marie-Toothdisease? Back to Top . How does a person get charcot-marie-tooth disease?
http://www.mdansw.org/CMT.htm

Extractions: INDEX What is Charcot-Marie-Tooth disease? Charcot-Marie-Tooth (CMT) disease is hereditary and is marked by slowly progressive muscle weakness in the feet, lower legs, hands, and forearms, and a mild loss of sensation in the toes, feet and fingers. The weakness results from the degeneration of nerves that stimulate muscle rather than from a degenerative process in the muscle tissues themselves. The disease, named for three physicians who first identified it in 1886, is also known as Peroneal Muscular Atrophy because it affects the nerves to the peroneal muscles, which are located in the lower leg. There are now known to be at least five genetic causes of the disease that lead to two distinct types of nerve disease - demyelinating (damage to nerve fibre insulation) or neuronal (damage to nerve fibres themselves). How disabling is the disease?
Health Library: All Topics: C: Charcot-Marie-Tooth Disease - Healthfinder®
home health library all topics C charcotmarie-tooth disease.displaying 11 of 1 document see categories and related topics,
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Experts, Consultants, Authorities - Charcot-Marie-Tooth Disease (CMT)
Specialty charcotmarie-tooth disease (CMT). Physicians For Quality.1017 W. Hopkins San Marcos, Texas 78666 Tel 800-284-3627, Fax
http://www.hgexperts.com/listing/Medical-Experts-Charcot-Marie-Tooth-Disease-CMT

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Charcot-Marie-Tooth Disease
You are here Health topics Health conditions Neuromuscular system Otherconditions charcotmarie-tooth disease. charcot-marie-tooth disease.
http://www.disability.vic.gov.au/dsonline/dsarticles.nsf/pages/Charcot_Marie_Too
Health Ency.: Disease: Charcot-Marie-Tooth Disease (hereditary)
com Important notice. Ency. home Disease C CharcotMarie-Toothdisease (hereditary). charcot-marie-tooth disease (hereditary).
http://www.austin360.com/shared/health/adam/ency/article/000727.html

Extractions: Important notice Ency. home Disease C Charcot-Marie-Tooth disease (hereditary) Overview Symptoms Treatment Prevention Alternative names: Progressive neuropathic (peroneal) muscular atrophy; Hereditary peroneal nerve dysfunction; Neuropathy - peroneal (hereditary); Hereditary motor and sensory neuropathy Definition: Charcot-Marie-Tooth disease defines a group of slowly progressive, inherited disorders that result from progressive damage to nerves. In addition to loss of sensation, there is wasting of muscle tissue in the feet and legs, then hands and arms. Causes and Risks Charcot-Marie-Tooth diseases involve damage to nerves (neuropathy), usually from demyelination or loss of the electrical insulation around nerve fibers. All nerves are affected, but motor nerves are disproportionately so. The nerves in the legs are affected first and most severely. Symptoms usually begin between mid-childhood and early adulthood. The disorder is inherited, with autosomal dominant and recessive as well as X-linked recessive inheritance patterns. At least four genes have been discovered to be the cause of this group of diseases.
Charcot-Marie-Tooth Disease
charcotmarie-tooth disease. Definition charcot-marie-tooth disease(CMT) is the name for a group of inherited disorders of nerve
http://www.chclibrary.org/micromed/00042210.html

Extractions: CMT affects the peripheral nerves, those groups of nerve cells carrying information to and from the spinal cord. CMT decreases the ability of these nerves to carry motor commands to muscles, especially those furthest from the spinal cord in the feet and hands. As a result, these muscles are weakened. CMT also causes mild sensory loss. CMT is named for the three neurologists who first described it, and does not involve the teeth in any way. It is also known as hereditary motor and sensory neuropathy, and is also sometimes called peroneal muscular atrophy, referring to the muscles in the leg affected early on in the disease. The symptoms grouped together under the name CMT can be caused by any of at least six different genetic defects. Most of the defects, identified as of early 1998, affect myelin, the coating that insulates nerve cells to promote efficient conduction. Myelin defects cause either a reduction in nerve conduction velocities, or a diminished nerve signal. CMT is currently subdivided into type 1A, type 1B, type 2, and type X, based on the particular genetic defect involved. All but type X exhibit the inheritance pattern known as autosomal dominant. In this pattern, only one defective gene copy is needed to develop the disease, which may be inherited from either parent (who will also have the disease). A person with CMT of this type has a 50% chance of passing the gene along to each offspring. CMT type X is inherited as an X-linked trait, meaning the gene is carried on the X chromosome. Women carry two X chromosomes, while men carry only one. Without a "backup" copy of the normal gene, a man with the CMT type X gene is more likely to be seriously affected than is a woman. Expression of the gene does occur in women to a lesser extent, leading to disease of variable severity. Affected men may pass the gene on to their daughters, but not to their sons.
ORPHANET® : Charcot-Marie-Tooth Disease
Translate this page ORPHANET. ORPHANET database access. Charcot-Marie-Toothdisease. Direct access to details Alias Home Page.
http://www.orpha.net/static/GB/charcot_marie_tooth.html
Avera Health - Charcot-Marie-Tooth Disease (hereditary)
charcotmarie-tooth disease (hereditary). Definition There is no known cure forcharcot-marie-tooth disease. Treatment is aimed at maximizing independence.
http://www.avera.org/adam/ency/article/000727.htm

Extractions: Disease Injury Nutrition Poison ... Central nervous system Definition: Charcot-Marie-Tooth disease defines a group of slowly progressive, inherited disorders that result from progressive damage to nerves. In addition to loss of sensation, there is wasting of muscle tissue in the feet and legs, then hands and arms. Causes, incidence, and risk factors: Charcot-Marie-Tooth diseases involve damage to nerves (neuropathy), usually from demyelination or loss of the electrical insulation around nerve fibers. All nerves are affected, but motor nerves are disproportionately so. The nerves in the legs are affected first and most severely. Symptoms usually begin between mid-childhood and early adulthood. The disorder is inherited, with autosomal dominant and recessive as well as X-linked recessive inheritance patterns. At least four genes have been discovered to be the cause of this group of diseases.

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