Geometry.Net - Health_Conditions: Creutzfeldt Jakob Disease

CJD/BSE Creutzfeldt-Jakob Disease/Bovine Spongiform Encephalopathy
Information from the Department of Health (England) on CJD and BSE. Includes monthly statistics, press releases, and details of publications and guidance.
http://www.doh.gov.uk/cjd/cjd1.htm
Introduction To CJD
creutzfeldtjakob disease. Introduction. creutzfeldt-jakob disease (CJD) isa rare and fatal neurodegenerative disease of unknown cause.
http://www.cjd.ed.ac.uk/intro.htm

Extractions: Introduction Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disease of unknown cause. Patients are usually aged between 50 and 75 and typical clinical features include a rapidly progressive dementia associated, myoclonus and a characteristic electroencephalographic pattern. Neuropathological examination reveals cortical spongiform change, hence the term `spongiform encephalopathy'. H.G. Creutzfeldt is credited with the first description of the disorder in 1920, although by current diagnostic criteria his case would be highly atypical. A year later another German neurologist, A. Jakob, described four cases, at least two of whom had clinical features suggestive of the entity we recognise as CJD. Aetiology The nature of the transmissible agent is the matter of some controversy. Previously considered a `slow virus' no viral agent has ever been convincingly demonstrated and no evidence of an immunological response seen. Additionally the infectious pathogen shows a remarkable resistance to treatments that would normally be expected to inactivate viruses. The viral hypothesis has been elegantly challenged by the prion (` pro teinaceous in Epidemiology The majority of cases are sporadic (85%), between 10-15% are familial and the remainder are iatrogenic.
Creutzfeldt-Jakob Disease Foundation, Inc.
The creutzfeldtjakob disease Foundation, Inc. website permission. Copyright2002 creutzfeldt-jakob disease Foundation, Inc. All rights reserved.
http://cjdfoundation.org/
Information
CJD Info. An overview of creutzfeldtjakob disease. CJD Foundation, Inc. Info. Copyright1999 creutzfeldt-jakob disease Foundation, Inc. All rights reserved.
http://cjdfoundation.org/info.html

Extractions: CJD Info An overview of Creutzfeldt-Jakob Disease CJD Foundation, Inc. Info Background discussion about the Foundation Research Assistance Opportunities Current needs from the research community Conferences A listing of CJD related conferences/symposiums CJD Internet Resources A collection of CJD related websites Headlines The latest CJD/BSE headlines from major media outlets CJD Agent Theories Information about the nature of the CJD agent Website Statistics Up to the minute tracking data of the website
CDC - Bovine Spongiform Encephalopathy And Variant Creutzfeldt-Jakob Disease: Ba
Bovine Spongiform Encephalopathy and Variant creutzfeldtjakob disease Background,Evolution, and Current Concerns. Variant creutzfeldt-jakob disease (vCJD).
http://www.cdc.gov/ncidod/EID/vol7no1/brown.htm

Extractions: *National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA; National Creutzfeldt-Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh, Scotland; Central Veterinary Laboratory, New Haw, Addlestone, UK; §Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; ¶Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Robbinsville, New Jersey, USA The epidemic of bovine spongiform encephalopathy in the United Kingdom, which began in 1986 and has affected nearly 200,000 cattle, is waning to a conclusion, but leaves in its wake an outbreak of human Creutzfeldt-Jakob disease, most probably resulting from the consumption of beef products contaminated by central nervous system tissue. Although averaging only 10-15 cases a year since its first appearance in 1994, its future magnitude and geographic distribution (in countries that have imported infected British cattle or cattle products, or have endogenous BSE) cannot yet be predicted. The possibility that large numbers of apparently healthy persons might be incubating the disease raises concerns about iatrogenic transmissions through instrumentation (surgery and medical diagnostic procedures) and blood and organ donations. Government agencies in many countries continue to implement new measures to minimize this risk.
Guardian Unlimited | Special Reports | Special Report: The BSE Crisis
Ongoing collection of news, commentary, audio, graphics and interactive guides about Bovine Spongiform Encephalopathy (BSE) and variant creutzfeldtjakob disease (CJD). From the Guardian Media Group. UK.
http://www.guardian.co.uk/bse/0,8250,388290,00.html

Extractions: Go to: Guardian Unlimited home UK news World news Archive search Arts Books Business EducationGuardian.co.uk Film Football Jobs MediaGuardian.co.uk Money The Observer Online Politics Shopping SocietyGuardian.co.uk Sport Talk Travel Audio Email services Special reports The Guardian The weblog The informer The northerner The wrap Advertising guide Crossword Dating Headline service Syndication services Events / offers Help / contacts Information Newsroom Style guide Travel offers TV listings Weather Web guides Guardian Weekly Money Observer Home UK Business Online ... Quiz
Blood Recall/Withdrawal - Creutzfeldt-Jakob Disease (CJD)
Main Create Edit Help
http://www.hometown.aol.com/debbieoney/blood.htm

Extractions: Margaret Mead Welcome to the Blood Recall/Withdrawal - Creutzfeldt-Jakob Disease (CJD) website. This website was created to fill the needs of people who have received notices that the blood products that they, or their children, received, or that were used in the In Vitro Fertilization (IVF) cultures that produced their children, were recalled/withdrawn from the market because a member of the donor pool was diagnosed with Creutzfeldt-Jakob Disease (CJD) or was at risk for the disease. CJD is an infectious rapidly progressive fatal brain-deteriorating disease for which there is no treatment or cure. It is a member of the class of diseases called Transmissible Spongiform Encephalopathies (TSEs). Another TSE is Bovine Spongiform Encephalopathy (i.e. Mad Cow Disease) which is found in England . The jury is still not in on whether CJD is transmitted through blood. The risk is said to be theoretical. There have been no documented cases of such transmission in humans. However, the CJD infectious agent has been found in blood. People who have received blood recall/withdrawal notifications can still donate blood.
Creutzfeldt-Jakob Disease Fact Sheet
creutzfeldtjakob disease (CJD) fact sheet compiled by the National Institute ofNeurological Disorders and Stroke (NINDS). What is creutzfeldt-jakob disease?
http://www.ninds.nih.gov/health_and_medical/pubs/creutzfeldt-jakob_disease_fact_

Extractions: Request free mailed brochure What is Creutzfeldt-Jakob Disease? What are the Symptoms of the Disease? How is CJD Diagnosed? How is the Disease Treated? ... Where Can I Get Help? Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, invariably fatal brain disorder. It affects about one person in every one million people per year worldwide; in the United States there are about 200 cases per year. CJD usually appears in later life and runs a rapid course. Typically, onset of symptoms occurs about age 60, and about 90 percent of patients die within 1 year. In the early stages of disease, patients may have failing memory, behavioral changes, lack of coordination and visual disturbances. As the illness progresses, mental deterioration becomes pronounced and involuntary movements, blindness, weakness of extremities, and coma may occur. There are three major categories of CJD:
Variant Creutzfeldt-Jakob Disease
Variant creutzfeldtjakob disease. Fact sheet No. Variant creutzfeldt-jakobdisease (vCJD) is a rare and fatal human neurodegenerative condition.
http://www.who.int/entity/mediacentre/factsheets/fs180/en

Extractions: Revised November 2002 Variant Creutzfeldt-Jakob disease (vCJD) is a rare and fatal human neurodegenerative condition. As with Creutzfeldt-Jakob disease, vCJD is classified as a Transmissible Spongiform Encephalopathy (TSE) because of characteristic spongy degeneration of the brain and its ability to be transmitted. vCJD is a new disease that was first described in March 1996. Before the identification of vCJD, CJD was recognized to exist in only three forms. Sporadic cases, which have an unknown cause and occur throughout the world at the rate of about one per million people, account for 85â90% of CJD cases. Familial cases are associated with a gene mutation and make up 5â10% of all CJD cases. Iatrogenic cases result from the accidental transmission of the causative agent via contaminated surgical equipment or as a result of cornea or dura mater transplants or the administration of human-derived pituitary growth hormones. Less than 5% of CJD cases are iatrogenic. In contrast to the traditional forms of CJD, vCJD has affected younger patients (average age 29 years, as opposed to 65 years), has a relatively longer duration of illness (median of 14 months as opposed to 4.5 months) and is strongly linked to exposure, probably through food, to a TSE of cattle called Bovine Spongiform Encephalopathy (BSE).
MEDLINEplus: Creutzfeldt-Jakob Disease
Search MEDLINE for recent research articles on creutzfeldtjakobdisease. You may More News on creutzfeldt-jakob disease. From the
http://www.nlm.nih.gov/medlineplus/creutzfeldtjakobdisease.html

Extractions: Latest News Therapy Fights "Mad Cow"-Like Illness in Mice (03/05/2003, Reuters Health) From the National Institutes of Health Creutzfeldt-Jakob Disease (National Institute of Neurological Disorders and Stroke) Creutzfeldt-Jakob Disease (National Institute of Neurological Disorders and Stroke) Administration Continues to Strengthen BSE Protection Systems (Dept. of Agriculture) Reducing the Possible Risk of Transmission of Variant Creutzfeldt-Jakob Disease ("Mad Cow") by Blood and Blood Products (Food and Drug Administration) Trying to Keep "Mad Cow Disease" Out of U.S. Herds
Official Mad Cow Disease Home Page
Contains thousands of articles on mad cow and other diseases.Category Society Lifestyle Choices BSE - Mad Cow disease largest and most authoritative site for prions, mad cow disease (bovine spongiformencephalopathy or BSE), scrapie, creutzfeldtjakob disease (CJD and nvCJD
http://www.mad-cow.org/
Alzheimer's Society - CJD Support Network
UK support network for all forms of creutzfeldtjakob disease. Offers information about the group as well as the disorder and contact details.
http://www.alzheimers.org.uk/CJD

Extractions: home page Creutzfeldt-Jakob disease (CJD) is one of a small group of fatal diseases caused by infectious agents called prions. These attack the brain, killing cells and creating gaps in tissue. The brain takes on a characteristic sponge-like appearance. Early symptoms include memory problems, mood changes and lack of co-ordination. The disease progresses to shakiness and dementia. Those affected are eventually unable to move or speak. The CJD Support Network is the only registered charity providing help and support for people with Creutzfeldt-Jakob disease, their carers and concerned professionals. Founded in 1994 by relatives of people with CJD, with the help of the Alzheimer's Society and other professionals, the aims of the Network include:
Medicine-Worldwide: Creutzfeldt-Jakob-Disease (CJD)
Translate this page creutzfeldt-jakob-disease (CJD). Allgemeines. Die creutzfeldt-jakob-Krankeit=diseasewurde 1920 erstmals beschrieben. Sie tritt sehr selten auf.
http://www.m-ww.de/krankheiten/prionenkrankheiten/cjd.html

Extractions: Sie befinden sich hier: startseite krankheiten prionenkrankheiten Prionenkrankheiten ... Über uns Zusammenfassung Allgemeines Erreger Symptome ... Therapie Die Creutzfeldt-Jakob-Erkrankung (CJD), die 1920 zum ersten Mal beschrieben wurde und sehr selten auftritt, hat durch Bekanntwerden einer neuen Variante (nvCJD) (sporadisch) auftretende Form von einer dominant vererbbaren Die sogenannte neue Variante der Krankheit nvCreutzfeldt-Jakob-Krankheit hier Es gilt mittlerweile als nahezu sicher, dass Prionen die Erreger dieser Krankheit sind. Sc C ) gebildet werden. Der Zusatz "Sc" steht für Scrapie- spezifisch, der von "C" für cellulär, also für körpereigen. Die Prionen (PrP Sc Sc C Die Diagnose wird anhand des neurologischen Befundes gestellt. Die erste Veränderung, die man an Hirnbiopsien unter dem Mikroskop sehen kann, ist die Astrogliose. Darunter versteht man die Tatsache, dass zunächst die Astrozyten im Bereich ihrer Endplatten, die den Hirngefäßen anliegen, beginnen anzuschwellen und dann später die gesamte Zelle. Als Neuroglia ("Leim") bezeichnet man das Hüll- und Stützgewebe des Gehirns. Es besteht aus Astrozyten (Makroglia), Oligodendrozyten (Oligodendroglia) und Hortegazellen (Mikroglia). Außerdem wird vermehrt ein bestimmtes Eiweiß mit der Bezeichnung glial fibrillary acidic protein (GFAP) gebildet. Dieses Eiweiß ist nach einer besonderen Anfärbung im Mikroskop sichtbar.
Medicine-Worldwide: New Variant Creutzfeldt- Jakob-Disease (nvCJD)
Translate this page New variant creutzfeldt - jakob-disease (nvCJD). Zusammenfassung -Allgemeines - Erreger - Häufigkeit - Symptome - Inkubationszeit
http://www.m-ww.de/krankheiten/prionenkrankheiten/nvcjd.html

Extractions: Sie befinden sich hier: startseite krankheiten prionenkrankheiten Prionenkrankheiten ... Über uns Zusammenfassung Allgemeines Erreger Symptome ... Therapie (CJD). Insgesamt sind an dieser Krankheit nachgewiesenermassen bisher 107 Personen in England, 3 in Frankreich und eine in Irland verstorben (Stand: Oktober 2001). Es gilt mittlerweile als nahezu sicher, dass Prionen die Erreger dieser Krankheit sind. Sc C ) gebildet werden. Das Gen, welches die Information für dieses Prion-Protein trägt, liegt auf dem Chromosom 20. Der Zusatz "Sc" steht für Scrapie- spezifisch, der von "C" für cellulär, also für körpereigen. Die Prionen (PrP Sc Diese Erkrankung war bis vor wenigen Jahren nahezu unbekannt und auch die "normale" Creutzfeldt- Jakob- Erkrankung kam nur extrem selten vor. Dies hat sich in allerletzter Zeit teilweise dramatisch geändert. Im Mutterland von BSE, also in England, sind bis Mai 2001 99 Menschen an der nvCJD verstorben. In Frankreich hat es bisher 3 Todesfälle an nv CJD gegeben, sowie einen in Irland. Der englische Epidemiologe Roy Anderson aus Oxford hält bis zu 500.000 Tote in den nächsten 30 Jahren für nicht unmöglich. Tremor, also Zittern von Armen, Beinen oder dem Kopf
Alzheimer's Society - CJD Support Network
back to the home page. creutzfeldtjakob disease (CJD) is one of a smallgroup of fatal diseases caused by infectious agents called prions.
http://www.alzheimers.org.uk/cjd/

Extractions: home page Creutzfeldt-Jakob disease (CJD) is one of a small group of fatal diseases caused by infectious agents called prions. These attack the brain, killing cells and creating gaps in tissue. The brain takes on a characteristic sponge-like appearance. Early symptoms include memory problems, mood changes and lack of co-ordination. The disease progresses to shakiness and dementia. Those affected are eventually unable to move or speak. The CJD Support Network is the only registered charity providing help and support for people with Creutzfeldt-Jakob disease, their carers and concerned professionals. Founded in 1994 by relatives of people with CJD, with the help of the Alzheimer's Society and other professionals, the aims of the Network include:
Alzheimer's Society Information Sheet - What Is Creutzfeldt-Jakob Disease (CJD)?
What is creutzfeldtjakob disease (CJD)? Prions are dementia. The best-knownprion disease is creutzfeldt-jakob disease, or CJD. This
http://www.alzheimers.org.uk/about/info_cjd.html

Extractions: with dementia I have dementia information for ... Download this sheet Prions are infectious agents that attack the central nervous system and then invade the brain, causing dementia. The best-known prion disease is Creutzfeldt-Jakob disease, or CJD. This information sheet provides an overview of the symptoms and different types of CJD. Prions are abnormal forms of protein which are extremely hardy and cannot be eradicated by normal sterilisation procedures. Their presence in the brain results in spongiform encephalopathy, so-called because areas of the brain where cells have died take on a sponge-like appearance when viewed under the microscope.
CREUTZFELDT-JAKOB DISEASE AND RELATED DISORDERS
creutzfeldtjakob disease AND RELATED DISORDERS. Part 1. There are at feast 250+diagnosed cases of creutzfeldt-jakob disease every year in the United States.
http://www.biomed.lib.umn.edu/hw/creutzfeld.html

Extractions: ABSTRACT : An in-depth discussion and explanation of Creutzfeldt-Jakob disease along with several related prion driven disorders are covered for the elucidation and education of the embalmer. Early history of the various diseases is outlined with the interrelationships to kuru, scrapie, BSE and other similar neuro-degenerative diseases. The bizarre nature of the causative agent is discussed in detail along with its remarkable survivability. The dangers and concerns that embalmers have are delineated and placed in perspective. A suggested protocol to minimize risk during embalming is presented. A summation and suggestions for embalmers completes the article. INTRODUCTION : Creutzfeldt-Jakob disease is a disease of bizarre nature that almost every embalmer or funeral director has heard of but has virtually no idea concerning the facts and realities of the disease itself. There is a very small amount of information that has been available to the embalming profession concerning Creutzfeldt-Jakob disease and unfortunately it is either incomplete, misleading or outright incorrect. There is more conjecture and rumor involved with this disease than almost any other disease and there is virtually no valid information available to help the embalmer. This has resulted in a definite uncertainty and even panic in most situations involving embalmers when they encounter this disease during the course of their professional career. Nothing is more fearful than complete rack of information concerning a potentially deadly disease.
Creutzfeldt-Jakob Disease
B. creutzfeldtjakob disease (CJD) 1. Clinical Features a. Onset between 40 and80 years of age b. Clinical presentation The major features are dementia and
http://kobiljak.msu.edu/cai/pathology/CNS_Infections_F/CNS_2b.html

Extractions: b. Microscopic pathology: The major diagnostic change is spongiform encephalopathy in gray matter throughout brain and spinal cord. The tissue appears "spongy", i.e. containing holes. Severe neuronal loss and gliosis also are present and mild demyelination may occur. Ultrastructural changes include intracytoplasmic vacuoles as the basis for the spongy change. This microscopic image shows spongiform encephalopathy in a case of Creutzfeldt-Jakob disease.
Human Growth Hormone And Creutzfeldt-Jakob Disease
The creutzfeldtjakob disease (CJD) Foundation Inc. creutzfeldt-jakob disease (FactSheet of the National Institute of Neurological Disorders and Stroke, NIH).
http://www.niddk.nih.gov/health/endo/pubs/creutz/creutz.htm

Extractions: MAGIC (Major Aspects of Growth in Children) Foundation is a national, nonprofit organization that provides support and education about growth disorders in children and growth hormone deficiency in adults. Staff will help connect you with others who have similar interests or concerns. The Human Growth Foundation (HGF) is a nonprofit organization concerned with children's growth disorders and adult growth hormone deficiency. HGF can send you a brochure on adult growth hormone deficiency. The foundation also sponsors an Internet mailing list to support the exchange of information about adult growth hormone deficiency and adult growth hormone replacement therapy. To subscribe, follow the instructions on the HGF web page The Creutzfeldt-Jakob Disease (CJD) Foundation Inc. was created in 1993 by two families who lost relatives to CJD and the neurologist who treated the patients. This nonprofit corporation seeks to promote research, education, and awareness of CJD and to reach out to people who have lost loved ones to this illness. Update: Follow-Up Study of NHPP Growth Hormone Recipients (Public Health Service, June 1999)
OR 2.5 Preventing Transmission Of Creutzfeldt-Jakob Disease
Preventing Transmission of creutzfeldtjakob disease, Each online course ONLY $15.00!!! creutzfeldt-jakobdisease Possible medical risk factors. Neurology.
http://www.iceinstitute.com/online/OR25.html

Extractions: Victoria M. Steelman, PhD, RN, CNOR, and Carolyn Elliott, RN, CNOR Objectives: 1. To identify the causative organism 2. To list the ways the disease has been transmitted 3. To list three infectious body tissues and fluids 4. To identify effective means of eliminating infectivity of prions Creutzfeldt-Jakob disease (CJD) is an infectious, progressive, degenerative, neurological disorder. The severity of symptoms progresses steadily until death. There is no known treatment for the disease, and the course is always fatal. Although the disease is rare, CJD has been transmitted in healthcare settings. Special isolation precautions in the OR and decontamination areas are needed to prevent this tragedy from occurring. Although it has received a great deal of media coverage during the past two years, CJD is not actually a new disease. It was first identified in the 1920s by two German physicians after whom the disease was named. They described a cluster of symptoms including confusion, memory loss, impaired gait, vertigo, and visual disturbances. These symptoms rapidly progressed to death. Today, diagnosis of the disease remains a challenge. Routine blood chemistry, urinalysis, and cultures do not provide the necessary information. The electoencephalogram may show spikes and a computerized tomography (CT) scan will likely show cerebral atrophy.

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