Extractions: (advertisement) Synonyms, Key Words, and Related Terms: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes Background: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or growth factor. POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase (by which it is known in Japan) syndrome by Nakanishi in a study of 102 cases in Japan. In 1980, the acronym POEMS was coined by Bardwick et al based on the 5 main features of the disease, namely, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. No specific case definition for POEMS exists; however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 systems involved. The pathophysiology of the disease is not known; however, elevated levels of cytokines and growth factors have been implicated. Polyneuropathy: The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. It involves both motor and sensory nerves, begins distally, and has a progressive proximal spread. Associated cranial or autonomic nerves are not involved. Both demyelination and axonal degeneration are noted.
Extractions: (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Internal Medicine Last Updated: June 14, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Wingfield Rehmus, MD, MPH , Staff Physician, Department of Dermatology, Stanford University Medical Center Coauthor(s): Alexa Boer Kimball, MD, MPH , Director of Clinical Trials, Assistant Professor, Department of Dermatology, Stanford University School of Medicine Wingfield Rehmus, MD, MPH, is a member of the following medical societies: American Academy of Dermatology Editor(s): Neil Shear, MD , Professor and Chief of Dermatology, Professor of Medicine, Pediatrics and Pharmacology, University of Toronto Medical School; Head of Dermatology, Sunnybrook Women's College Health Sciences Center, Canada;
POEMS_SupportGroup Other names for the disease is crowfukase syndrome or Takatsuki syndrome http://www.poems-sg.netfirms.com/
Birth Disorder Information Directory - CO-CZ List of Sites. Crow Fukase Syndrome (PEP Syndrome, POEMS Syndrome, Shimpo's Syndrome,Takatsuki's Syndrome) crowfukase syndrome. Cryptophthalmos-Syndactyly http://www.bdid.com/defectco.htm
Alzhheimer crowfukase syndrome a case associated with vasospastic angina. Theskin changes in the Crow-Fukase (POEMS) syndrome. A case report. http://tuftsneurology.org/webres/poems.htm
Extractions: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammapathy, Skin changes Syndrome MEDLINE Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome - Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 . - Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? - Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines . - Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina. - Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report.
ORPHANET® : POEMS Syndrome Base de données sur les maladies rares et les médicaments orphelins POEMS syndrome. Direct access to details. Alias crowfukase syndrome http://orphanet.infobiogen.fr/static/GB/poems.html
Tufts University Neurology crowfukase syndrome a case associated with vasospastic angina (Medline) Acta Neurol(Napoli) 1994 Aug;16(4)170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu http://tuftsneurology.org/training/references/links/poems.html
Alzhheimer Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK. crowfukase syndrome a case associated with vasospastic angina. http://www.tuftsneurology.org/webres/poems.htm
Extractions: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammapathy, Skin changes Syndrome MEDLINE Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome - Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 . - Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? - Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines . - Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina. - Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report.
Service Page - Pathologie Information DISEASE POEMS syndrome, Synonym(s) crowfukase syndrome, Sign(s)of the disease (23), Other website(s) (2), Outpatient clinic(s). http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2905
Tufts University Neurology crowfukase syndrome a case associated with vasospastic angina http://www.tuftsneurology.org/training/references/links/poems.html
IM Abstract 39-12 Case 13 the serum, and the levels of IL1ß, IL-6, TNF-a, and thiamine, which were thoughtin past reports to be mediators of PH in crow-fukase syndrome, were normal. http://www.naika.or.jp/im/im39/ab39_12/c391213.html
Extractions: From the Third Department of Internal Medicine, Kagoshima University, Kagoshima and *the Department of Clinical Laboratory Medicine, Kagoshima University, Kagoshima We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH). In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL-1À, IL-6, TNF-¿, and thiamine, which were thought in past reports to be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolone therapy, PH disappeared with a dramatic decrease in serum VEGF. Our results suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome.
IM Abstract 41-8 Case 3 crowfukase syndrome Associated with High-Output Heart Failure Tsutomu Araki, TetsuoKonno, Ryuichiro Soma, Akikatsu Nakashima, Hiroaki Takimoto, Yohei Tofuku http://www.naika.or.jp/im/im41/ab41_8/c410803.html
Extractions: From the Department of Internal Medicine, Saiseikai Kanazawa Hospital, Kanazawa and *Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa A 64-year-old woman was admitted with systemic edema and exertional dyspnea. High-output heart failure was diagnosed by right heart catheterization and she was treated with diuretics. After 3 weeks, her symptoms disappeared but a high cardiac output state persisted. A diagnosis of Crow-Fukase syndrome was made based on the presence of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Her serum vascular endothelial growth factor (VEGF) level was markedly elevated after recovery from heart failure. We suspect that an elevated VEGF level and a high cardiac output state may play a role in the pathogenesis of heart failure in Crow-Fukase syndrome.
Health Library - POEMS Syndrome covered by this report. Synonyms. crowfukase syndrome; PEP Syndrome;Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions; http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=
COLLEGE DE FRANCE Translate this page 27) 1919-1923. Hitoshi S. (1995), crow-fukase syndrome (Japanese),Nippon Rinsho, 53 (3) 747-751. Eidner T., Oelzner P http://www.ifrance.com/ihpst/AFLcollege2001/AFL2903.htm
Lymph_node Hyaline vascular type ? plasma cell type plasma cell () ? (+) crow-fukase syndrome (?). http://www2d.biglobe.ne.jp/~aquila/medical/p9/m29.html
NORD - National Organization For Rare Disorders, Inc. POEMS Syndrome. To purchase fulltext report ($7.50) View Cart/Checkout. Copyright1991, 2000, 2002 Synonyms of POEMS Syndrome crow-fukase syndrome; PEP Syndrome; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=POEMS Syndrom
Member Sign In Hospital, Chicago, Ill. Introduction. POEMS syndrome, also knownas the crowfukase syndrome, was first reported in 1956. 1 It http://www.medscape.com/viewarticle/409056
Member Sign In Introduction. POEMS syndrome, also known as the crowfukase syndrome, was firstreported in 1956. The crow-fukase syndrome a study of 102 cases in Japan. http://www.medscape.com/viewarticle/409056_print
Untitled VEGF was greatly increased in serum (1,850 pg/ml), which has been foundto be increased exclusively in patients with crowfukase syndrome. http://www.med.tohoku.ac.jp/study_room/50/ITOYAMA/abst/004.html
