Hemiplegic Migraine List of symptoms associated with hemiplegic migraine.Category Health Conditions and Diseases Migraine Hemiplegic hemiplegic migraine. http://www.achenet.org/kids/hemi.php
Arch Neurol -- Page Not Found Summary of a case report published in the September 2000 issue of Archives of Neurology. http://archneur.ama-assn.org/issues/v57n9/abs/nob90016.html
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JAMA Migraine Information Center - Commentary - Familial 543552, Nov. 1, 1996 Familial hemiplegic migraine and Episodic Ataxia Type-2 AreCaused by Mutations in the Ca 2+ Channel Gene CACNL1A4 Roel A. Ophoff et al http://www.ama-assn.org/special/migraine/library/scan/migcom5.htm
Extractions: A n abnormally structured gene is the culprit in familial hemiplegic migraine, a rare inherited form of migraine. People with a similar neurological disorder, episodic ataxia type-2, have other alterations in the same gene, researchers found. The gene resides on chromosome 19, the organization and structure of which has long been studied by Lawrence Livermore National Laboratory's Human Genome Center. Three years ago, medical scientists at Leiden University in The Netherlands initiated a collaboration with the LLNL researchers to complete the physical mapping of the chromosome and clone the DNA of the gene for this form of migraine. Armed with the cloned DNA fragments and data from human patients studies, the Dutch researchers discovered the gene that regulates the transport of calcium into specific classes of brain cells. The researchers noted alterations in the DNA sequence in patients from the migraine families. These alterations result in the production of nonfunctional protein, which prevents calcium from being properly transported. The movement of calcium into brain cells regulates the release of neurotransmitters, which are critical elements in the network of communication among cells of the nervous system. While the type of Familial Hemiplegic Migraine associated with this gene is rare, many of its symptoms are similar to those of more common migraines. Scientists believe knowledge gained in studying this form of migraine will help understand the cause of other forms of the disorder.
ACHE Articles As it turns out, a definite inheritance pattern has been found in a few familieswho suffer with a severe form of migraine called hemiplegic migraine. http://www.achenet.org/articles/gardner.php
Extractions: Genes and Migraine By Kathy Gardner, MD Many migraineurs have other family members who also suffer with migraine headache. Mom used to have migraine headaches with her menstrual cycle, grandmother once had "sick" headaches, and brother has "sinus" headaches which are less severe but sound strangely similar to migraine if you ask questions about symptoms and triggers. For years scientists have argued whether disorders such as migraine that tend to run in families do so because of shared genes or the shared environment. People often assume that any disorder that occurs in several family members must be genetic. However, families tend to share similar diets, exposures and lifestyles, all of which might be involved in making someone susceptible to a specific disorder. A combination of genetic and environmental factors seems to be the best overall explanation for most common disorders, including migraine. Nevertheless, the fact that you occasionally find large families with many members suffering from migraine suggest a stronger genetic basis for those particular families. As it turns out, a definite inheritance pattern has been found in a few families who suffer with a severe form of migraine called hemiplegic migraine. Hemiplegic Migraine The inherited or "familial" form of hemiplegic migraine is a rare disorder found in families where two or more people suffer migraine-type headache associated with a "stroke-like" aura of weakness on one side of the body. Other neurologic symptoms can also occur and might include visual loss, difficulty with speech, confusion and numbness. In these families, hemiplegic migraine has an
JAMA Migraine Information Center - Neurotology Of Migraine in a brain calciumchannel gene in families with hemiplegic migraine and in families with episodic vertigo and ataxia http://www.ama-assn.org/special/migraine/library/readroom/neuroful.htm
National Headache Foundation: Hemiplegic Migraine Brief description of the condition.Category Health Conditions and Diseases Migraine Hemiplegichemiplegic migraine. With hemiplegic migraine, there is often a familial occurrence.A physician should be consulted for this type of headache. top of page. http://www.headaches.org/consumer/topicsheets/hemiplegic.html
Extractions: HEMIPLEGIC MIGRAINE A very rare form of migraine which is considered to be one of the more severe types of migraine. The sufferer may develop some temporary motor paralysis and/or sensory disturbances on one side of the body, immediately followed by the headache. This may be accompanied by numbness or a pins-and-needles sensation. The neurological symptoms usually leave when the headache appears. With hemiplegic migraine, there is often a familial occurrence. A physician should be consulted for this type of headache. top of page
Extractions: Search through: Entire site Hemiplegic DIRECTORY Health/Fitness Diseases Neurological Disorders ... American Council for Headache Education Hemiplegic Migraine Page - List of symptoms associated with hemiplegic migraine. Hemiplegic Migraine Induced by Exertion - Summary of a case report published in the September 2000 issue of Archives of Neurology. JAMA Migraine Information Center - Involvement of a Ca2+ Channel Gene in Familial Hemiplegic Migraine and Migraine With and Without Aura - Abstract of research published in the September 1997 issue of Headache. Migraine Gene Discovered - Article discusses rare form of hemiplegic migraine linked to gene on chromosome 19. National Headache Foundation - Brief description of the condition. The Genetic Basis of Migraine: How Much Do We Know? - Abstract of an article published in the November 1999 issue of the Canadian Journal of Neurological Sciences.
Glossary Back To Top. hemiplegic migraine A very rare form of migraine in whichthere is paralysis of the arm or leg on one side of the body. http://www.headaches.org/consumer/educationalmodules/completeguide/gatoz.html
Extractions: Abdominal migraine: A type of migraine, in which the pain is over the upper part of the abdomen and lasts a few hours. It is most common in female children. Diagnosis is easily made because of the family history of migraine, the infrequency of the attacks, and the frequent simultaneous occurrence of headache. If it remains undiagnosed, however, the patient may be subjected to unnecessary surgery for abdominal complaints. Back To Top Aneurysm: A weakness in the blood vessel wall that balloons out and may rupture at some point. Aneurysms rarely cause symptoms before the rupture, unless they are large. They do not mimic the symptoms of migraine or cluster headache. It is vital to discover them before they rupture and have catastrophic consequences such as paralysis or death.
JAMA Migraine Information Center - The Clinical Spectrum Of of Medicine Vol 345, pp 1724, July 5, 2001 The Clinical Spectrum of Familialhemiplegic migraine Associated with Mutations in a Neuronal Calcium Channel http://www.ama-assn.org/special/migraine/library/scan/ducros.htm
Extractions: References Recent studies have shed more light onto the genetical basis of familial hemiplegic migraine (FHM) as a channelopathy due to 3 abnormal loci of the brain specific P/Q type calcium channel alpha 1A subunit gene (CACNA1A) on chromosome 1 and 19p13 [1]. CACNA1A regulates the release of various neurotransmitters, probably including serotonin. Circulatory changes detected by different imaging techniques during migraine also support the pathophysiological role of spreading depression at least in migraine with aura [2]. Nevertheless there is much left to learn about the specific pathophysiology leading to clinically recognized phenomena such as headache and transient palsy. In this report we present some neurophysiological and imaging data from a 32-year old man with FHM, which were recorded during a hemiplegic attack lasting for 7 days. Recent studies have shed more light onto the genetical basis of familial hemiplegic migraine (FHM) as a channelopathy due to 3 abnormal loci of the brain specific P/Q type calcium channel alpha 1A subunit gene (CACNA1A) on chromosome 1 and 19p13 [
Familial Hemiplegic Migraine Families - HUM-MOLGEN Author, Topic Familial hemiplegic migraine Families. Dear Colleagues We arecurrently looking for genes involved in familial hemiplegic migraine (FHM). http://www.hum-molgen.de/bb/Forum2/HTML/000116.html
Extractions: Member posted 11-05-2002 08:31 PM Dear Colleagues: We are currently looking for genes involved in familial hemiplegic migraine (FHM). We are interested in forming collaborations with clinicians/researchers with access to large Mendelian families with FHM. We would prefer to study families with greater than ten affecteds but families with six or more affecteds will be considered. We look forward to hearing from you. Please respond directly to:
Extractions: Anne Ducros, M.D., Ph.D., Christian Denier, M.D., Anne Joutel, M.D., Ph.D., Michaelle Cecillon, Christelle Lescoat, Katayoun Vahedi, M.D., Francoise Darcel, M.D., Eric Vicaut, M.D., Ph.D., Marie-Germaine Bousser, M.D., and Elisabeth Tournier-Lasserve, M.D. Table of Contents Full Text of this article PDF of this article Editors' Summaries Related editorials in the Journal: Hoffman, E. P. Find Similar Articles in the Journal Notify a friend about this article Journal Watch Neurology Summary ... Alert me when this article is cited ISI Web of Science Related Articles Citing Articles (26) Related Articles in Medline Articles in Medline by Author: Ducros, A. Tournier-Lasserve, E. Medline Citation Neurologic Disease ...
NEJM -- Sign In Editorial from The New England Journal of Medicine HemiplegicMigraine Downstream of a SingleBase Change. http://content.nejm.org/cgi/content/full/345/1/57
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Extractions: I am sorry about your symptoms. I do not think that you have hemiplegia migraine. The word Hemi-means one side and your symptoms are both sides. Hemiplegia migraine is something that you would not develop from taking immetrix. I am not sure what is causing your symptoms. What might be happening is that the injection of serotinon was inducing vasospasm and causing your numbness. However, this does not explain why your getting symptoms without the medication. It might be that one of your other diseases is beginning to have more dominant symptoms. It is difficult to tell over the internet. I would favor the latter.
Extractions: Anne Ducros, M.D., Ph.D., Christian Denier, M.D., Anne Joutel, M.D., Ph.D., Michaelle Cecillon, Christelle Lescoat, Katayoun Vahedi, M.D., Francoise Darcel, M.D., Eric Vicaut, M.D., Ph.D., Marie-Germaine Bousser, M.D., and Elisabeth Tournier-Lasserve, M.D. Table of Contents Full Text of this article PDF of this article Editors' Summaries Related editorials in the Journal: Hoffman, E. P. Find Similar Articles in the Journal Notify a friend about this article Journal Watch Neurology Summary ... Alert me when this article is cited ISI Web of Science Related Articles Citing Articles (26) Related Articles in Medline Articles in Medline by Author: Ducros, A. Tournier-Lasserve, E. Medline Citation Neurologic Disease ...
Extractions: I am sorry about your symptoms. I do not think that you have hemiplegia migraine. The word Hemi-means one side and your symptoms are both sides. Hemiplegia migraine is something that you would not develop from taking immetrix. I am not sure what is causing your symptoms. What might be happening is that the injection of serotinon was inducing vasospasm and causing your numbness. However, this does not explain why your getting symptoms without the medication. It might be that one of your other diseases is beginning to have more dominant symptoms. It is difficult to tell over the internet. I would favor the latter.
