Hemolytic Uremic Syndrome - Lucile Packard Children's Hospital Genitourinary Kidney Disorders. hemolytic uremic syndrome What is hemolyticuremic syndrome (HUS)? What causes hemolytic uremic syndrome? http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/urology/hus.html
Extractions: What is hemolytic uremic syndrome (HUS)? HUS is a rare condition that can lead to kidney failure in children. Kidney failure develops as a result of destruction of the small, functional structures and vessels inside the kidney. HUS is a serious illness and potentially fatal. What causes hemolytic uremic syndrome? HUS is more common during the summer months and may occur in outbreaks. Outbreaks have been reported in daycare centers, water parks, and fast food restaurants as a result of inadequately cooked hamburger meat. HUS is most common in younger children between 6 months and 4 years, but can occur at any age. HUS has several known causes and some unknown causes. Typically in children, HUS develops after an infection with the E. coli bacterium. E. coli may be found in contaminated food such as dairy products and meat. HUS can also develop as a result of taking certain medications, or may result from a cancer present in the body, although these causes are less common. In less than 5 percent of HUS cases, the disorder is inherited by a dominant gene (a gene passed from parent to child with a 50/50 risk) or recessive gene (each parent carries one copy of the gene and the child inherits both copies; the chance is 25 percent with each pregnancy). What are the symptoms of hemolytic uremic syndrome?
Extractions: Disease Index NJ InTouch What You Should Know About. . . Hemolytic Uremic Syndrome (HUS) What is Hemolytic Uremic Syndrome? Hemolytic Uremic Syndrome is an illness in which the red blood cells become damaged or destroyed causing anemia (low number of red blood cells), and the kidney becomes damaged causing it to fail to function properly. Blood clotting problems also may occur. Who gets Hemolytic Uremic Syndrome? Most cases of Hemolytic Uremic Syndrome follow a gastrointestinal illness characterized by bloody diarrhea. The most common microorganisms associated with post-diarrheal Hemolytic Uremic Syndrome are Escherichia coli (E. coli) and Shigella. The syndrome may also follow the use of some drugs, or follow pregnancy or cancer. How is Hemolytic Uremic Syndrome spread? Hemolytic Uremic Syndrome is not spread from person to person nor is it spread through contaminated food. However, the organisms which are associated with post-diarrheal Hemolytic Uremic Syndrome may be spread from person to person through an infected individual who has poor personal hygiene or through food which has become contaminated with one of the associated organisms. However, most individuals who become infected with one of those organisms will not develop post-diarrheal Hemolytic Uremic Syndrome. It is not known why a few individuals who become infected with one of these organisms develop post-diarrheal Hemolytic Uremic Syndrome. What are the symptoms of Hemolytic Uremic Syndrome?
DHSS, Hemolytic Uremic Syndrome (HUS Surveillance Case Definition. hemolytic uremic syndrome (HUS). CLINICALDESCRIPTION. HUS is an acute illness characterized by the sudden http://www.state.nj.us/health/cd/cd_hus.htm
Extractions: Disease Index NJ InTouch Surveillance Case Definition Hemolytic Uremic Syndrome (HUS) CLINICAL DESCRIPTION HUS is an acute illness characterized by the sudden onset of thrombocytopenia and hemolysis with fragmented red blood cells, and acute anuric renal failure. Only HUS or thrombocytopenic purpura (TTP) that follows an acute diarrheal illness should be reported. For HUS caused by infection with a Shiga toxin-producing organism, the syndrome will usually manifest itself 3 to 10 days after the onset of a diarrheal illness, often including bloody diarrhea. Diarrhea may have resolved and the patient may appear to be improving when the onset of HUS occurs. (For the incubation periods of the specific bacteria, refer to the chapters on E. coli O157:H7 and Shigella Approximately 2 - 7% of cases of EHEC, such as Escherichia coli O157:H7, develop HUS. TTP is another potential consequence of infection with a Shiga toxin-producing organism. TTP is similar to HUS with more prominent neurologic signs. HUS is most commonly seen in children, whereas TTP is more commonly seen in adults. HUS is children can be fatal. Most cases of HUS, but few cases of TTP, follow an acute gastrointestinal illness (usually diarrhea). Some investigators consider HUS and TTP to be part of a continuum of disease. Therefore, criteria for diagnosing TTP on the basis of CNS involvement and fever are not provided; however, patients diagnosed clinically with post-diarrheal TTP should meet be reported as HUS.
Extractions: hemolytic uremic syndrome By John Wegmann, MD Images (click to view larger image) Hemolytic uremic syndrome is a poorly understood condition that affects the blood and kidneys. It usually follows an infection that has caused diarrhea What is going on in the body? There are many causes for HUS. By far, the most common cause is an episode of diarrhea caused by infection with a special strain of the bacterium, E. coli. There have been a number of epidemics of HUS in recent years linked to eating undercooked beef containing this strain of bacterium. This bacterium produces a toxin that is very harmful to cells, particularly those of the kidneys, blood vessels, and intestinal lining. There are other less common causes of HUS in which the exact cause is not as clear. HUS is thought to develop when the lining of small blood vessels become damaged. This most commonly occurs in the blood vessels that supply blood to the kidney. The damage causes the blood vessels to swell. Tiny blood clots can form in affected blood vessels, narrowing the vessels or blocking them completely. Because blood cannot pass through these blocked or narrowed vessels, the kidneys are less able to filter waste products from the body and may become damaged. Certain cells in the blood, such as red blood cells that carry oxygen and platelets that help clot the blood, are damaged as they try to pass the narrowed vessels. This leads to anemia , or low blood counts, and poor clotting ability.
OHSU Doernbecher - Genitourinary & Kidney Disorders hemolytic uremic syndrome, RELATED SERVICES. What is hemolytic uremic syndrome(HUS)? HUS is a rare condition that can lead to kidney failure in children. http://www.ohsuhealth.com/dch/health/urology/hemolytic.asp
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Conference On Hemolytic Uremic Syndrome (HUS) KS Logo, STOP Announces Medical Conference on hemolytic uremic syndrome (HUS). Focusis Longterm Health Implications for Survivors June 01, 2000. advertisement. http://www.kidsource.com/health/HUS.html
Extractions: (Chicago, IL.) S.T.O.P. - Safe Tables Our Priority today announced that it is hosting a one day medical conference of specific interest to survivors of E. coli O157:H7, their parents and physicians. Entitled "Long-term Health Implications of Hemolytic Uremic Syndrome: A Multi-Disciplinary Conference," the event will be held on Saturday, October 7, 2000 in Seattle, Washington. Internationally renown medical experts on HUS will be presenting the latest information about health challenges faced by individuals who survive the catastrophic phase of illness and hospitalization. In the United States, Hemolytic Uremic Syndrome, also known as HUS, is the leading cause of acute kidney failure in children. Approximately 90% of children who develop Hemolytic Uremic Syndrome after an infection with E. coli O157:H7 survive but may face a lifetime of complications from the disease. "By the time victims of E. coli O157:H7 poisoning and their loved ones are ready to leave the hospital, they have been through an incredible traumatic and brutally painful experience," said President Nancy Donley. "Oftentimes, there are many lingering medical problems and scores of unanswered questions. This is the first conference of its kind, assembling international authorities on HUS who can provide answers and bring the latest available information to persons most needing it." Though many medical conferences are centered around a single medical specialty, HUS involves so many of the body's systems that physicians and researchers for this event come from many disciplines, including nutrition, hematology, endocrinology, cardiovascular surgery, gastroenterology, and neuropsychology.
Hemolytic Uremic Syndrome Answer hemolytic uremic syndrome, likely caused by E. Coli H0157.hemolytic uremic syndrome remains the most common form of acquired http://hsc.virginia.edu/medicine/clinical/pediatrics/CMC/cases/newans4.html
Extractions: Hemolytic uremic syndrome remains the most common form of acquired renal insufficiency in young children. The syndrome was first described in 1955 and is characterized by the triad of nephropathy, thrombocytopenia, and microangiopathic hemolytic anemia. There are a number of potential causative factors, however the most commonly implicated is the toxin producing H:0157 strain of E. Coli. The syndrome has also been associated with a variety of other viral and bacterial pathogens. The syndrome typically has a prodrome of bloody diarrhea occuring five to seven days before onset of renal insufficiency. Colonoscopy is generally non-specific and shows hemorrhagic colitis At the time of diagnosis, most children are extremely pale and very irritable. Hypertension and hyponatremia may be associated with convulsions and are generally a result of fluid and salt overload. Laboratory findings generally include anemia and thrombocytopenia, hyponatremia, hyperkalemia, hypocalcemia, and metabolic acidosis. The anemia is characterized by negative direct and indirect Coombs tests and a smear consistent with mechanical destruction of erythrocytes in small vessels. Renal pathologic findings consist of glomerular endothelial injury. The endothelium separates and the subendothelial space is filled with fibrin strands and erythrocyte fragments. Capillary thrombosis is quite prominent. There is no evidence of immune-complex deposition. Similar pathologic findings can be demonstrated in virtually all other organs including the brain, liver, and intestine.
Thrombotic Thrombocytopenic Purpura And The Hemolytic-Uremic Syndrome hemolytic uremic syndrome (HUS) and other thrombotic microangiopathies ADAMTS 13activity varies over a broad range, but is not less than about 10% of normal. http://www.cap.org/thrombophiliaconference/thrombotic_thrombocytopenic_purpura_m
Extractions: Conclusions Von Willebrand factor (vWF)-cleaving metalloprotease: ADAMTS 13 (A Disintigrin And Metalloprotease with Thrombospondin domains). Thrombotic thrombocytopenic purpura (TTP): ADAMTS 13 activity is less than about 5-10% of the activity in normal pooled plasma. Hemolytic uremic syndrome (HUS) and other thrombotic microangiopathies: ADAMTS 13 activity varies over a broad range, but is not less than about 10% of normal. Chronic relapsing TTP:ADAMTS 13 gene mutations (chromosome 9q34) causes activity levels that are chronically less than about 5-10% of normal.
Hemolytic Uremic Syndrome MEDSTUDENTS PEDIATRICS hemolytic uremic syndrome. The enlargement of kidneys and angiography help distinguishbilateral renal vein thrombosis from the hemolytic uremic syndrome. http://www.medstudents.com.br/pedia/pedia5.htm
Extractions: Medstudents'Homepage The hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in infants and young children, and an important cause of cronic renal failure and shock during youth. It is estimated that 90% of cases are preceded by a prodrome of bloody diarrhea. The syndrome may also follow the use of some drugs, malignancy, pregnancy, glomerulopathies, or it may be idiopathic. The classic diagnostic criteria are microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure, following an acute episode of bloody diarrhea. There may be incomplete syndromes, when the diagnosis becomes unclear. The differential diagnosis include disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP), bilateral renal vein thrombosis and lupus. In DIC, partial thromboplastin time and prothrombin time are prolonged, and the patient may be septic. TTP is common in adults, specially young women, with central nervous system involvement, fever and cutaneous manifestations, and tends to occur as a relapsing illness. The enlargement of kidneys and angiography help distinguish bilateral renal vein thrombosis from the hemolytic uremic syndrome. The most common microorganisms associated to the post-diarrhea hemolytic uremic syndrome are Escherichia coli (0157:H7 strain) and type 1 Shigella dysenteriae . The enterohemorrhagic E. coli
Extractions: Consultant and Head, Department of Pediatric Nephrology, Riyadh Medical Complex, P.O. Box 7855, Riyadh 11117, Saudi Arabia. Accepted for publication 10 July 1994. Ann Saudi Med 1995;15(2):113-116. Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure.1-3 There are at least two main subgroups that can be identified;4 a typical form of HUS which follows a diarrheal prodrome (D+HUS) and usually occurs in preschool children, and an atypical form which occurs at any age without diarrheal prodrome (D-HUS). Familial and recurrent HUS are occasionally observed.5 The D+HUS occurs in sporadic or epidemic outbreaks. Hemorrhagic colitis is the most common and widely recognized gastrointestinal manifestation of D+HUS. The most common infectious trigger in North America is
Hemolytic Uremic Syndrome - Keep Kids Healthy A discussion of hemolytic uremic syndrome, which usually follows diarrheacaused by E coli 0157, causing acute renal failure and anemia. http://www.keepkidshealthy.com/welcome/conditions/hus.html
Extractions: Main Diseases and Conditions Hemolytic uremic syndrome (HUS) is a disorder that usually causes microangiopathic hemolytic anemia (destruction of red blood cells in small and medium sized blood vessels), thrombocytopenia (a low platelet count), and acute renal failure . It is the most common cause of acute renal failure in infants and children and there are about 2-4 cases per 100,000 children in the United States, usually during the summer and early fall. HUS most commonly affects kids between the ages of six months and four years of age, who usually have the classic or epidemic form of HUS, which is preceded by diarrhea for 3-4 days. The diarrhea is usually watery and may be bloody and associated with vomiting and/or abdominal pain. The diarrhea can last up to 12 days and is most commonly caused by eating meat that is contaminated with the
SupportPath.com: Hemolytic Uremic Syndrome SupportPath.com, hemolytic uremic syndrome. Also called HUS. NoneListed. Clinical Trials Research on hemolytic uremic syndrome http://www.supportpath.com/sl_h/hemolytic_uremic_syndrome.htm
Extractions: Description: NORD is "a unique federation of voluntary health organizations dedicated to helping people with rare "orphan" diseases and assisting the organizations that serve them. NORD is committed to the identification, treatment, and cure of rare disorders through programs of education, advocacy, research, and service." View their Hemolytic Uremic Syndrome page.
Child Health Library - Urology - Hemolytic Uremic Syndrome Information Concerning hemolytic uremic syndrome from the Child Health Libraryof Children's Hopital of Pittsburgh. hemolytic uremic syndrome. http://www.chp.edu/greystone/urology/hus_sa.php
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Hemolytic Uremic Syndrome hemolytic uremic syndrome. Clinical Presentation Hemolytic anemia,thrombocytopenia, and renal failure. 90% occur between 6 months http://gucfm.georgetown.edu/welchjj/netscut/heme_onc/hemolytic_uremic_syndrome.h
JAMA -- Page Not Found 288;31103112, December 25, 2002, Risk of hemolytic uremic syndrome From AntibioticTreatment of Escherichia coli O157H7 Colitis, Christopher J. Gill, MD, MS http://jama.ama-assn.org/issues/v288n24/ffull/jlt1225-2.html
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JAMA -- Page Not Found Risk of hemolytic uremic syndrome After Antibiotic Treatment of Escherichia coliO157H7 Enteritis A Metaanalysis Author Information Nasia Safdar, MD; Adnan http://jama.ama-assn.org/issues/v288n8/abs/jma20001.html
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Vm.cfsan.fda.gov/cgi-bin/bbbglos?Hemolytic-Uremic=Syndrome Similar pages Hemolyticuremic syndrome Other hemolytic uremic syndromeVideotape. Lois Joy Galler Foundation for HemolyticUremic Syndrome, Inc., 1995. Fact Sheet hemolytic uremic syndrome. http://vm.cfsan.fda.gov/cgi-bin/bbbglos?Hemolytic-Uremic=Syndrome