Urinary Reading 8 This action reduces the urine output and may aggravate the edema. The nephroticsyndrome sometimes appears in young children who have lipoid nephrosis. http://www.mhhe.com/biosci/ap/seeleyap/urinary/reading8.mhtml
Extractions: The Nephrotic Syndrome The nephrotic syndrome is a set of symptoms that often appears in patients with renal diseases. It causes considerable loss of plasma proteins into the urine (proteinuria), widespread edema, and increased susceptibility to infections. Plasma proteins are lost into the urine because of increased permeability of the glomerular membranes, which accompanies renal disorders such as glomerulonephritis. As a consequence of a decreasing plasma protein concentration (hypoproteinemia), the plasma osmotic pressure falls, increasing filtration pressure in capillaries throughout the body. This may lead to widespread, severe edema as a large volume of fluid accumulates in the interstitial spaces within the tissues and in body spaces such as the abdominal cavity, pleural cavity, pericardial cavity, and joint cavities. Also, as edema develops, blood volume decreases and blood pressure drops. These changes may activate the renin-angiotensin system, leading to the release of aidosterone from the adrenal cortex, which in turn, stimulates the kidneys to conserve sodium ions and water. This action reduces the urine output and may aggravate the edema. The nephrotic syndrome sometimes appears in young children who have lipoid nephrosis. The cause of this condition is unknown, but it alters the epithelial cells of the glomeruli so that the glomerular membranes enlarge and distort, allowing proteins to leak through.
Discussion.html lipoid nephrosis (minimal change lesion) is responsible for 80% of all cases in children,SLE and other collagen diseases would be prominent considerations in http://cats.med.uvm.edu/cats_teachingmod/pathology/colloquium/case__20/discussio
Extractions: Discussion Back to Home This woman has generalized edema as noted by gain in weight and swelling of the face, legs, and hands. When fluid retention and edema occur (expansion of the interstitial component of the extracellular fluid volume), three possibilities immediately come to mind: congestive heart failure (CHF), cirrhosis of the liver, and the nephrotic syndrome. Less likely considerations are idiopathic cyclic edema, often characterized by abrupt weight changes correlating with the menstrual cycle, and hypothyroidism where brawny swelling can be mistaken for pitting edema. Venous or lymphatic obstruction in the legs can be ruled out by the presence of facial and hand edema too. Good exercise tolerance and lack of dyspnea or fatigue on exertion tend to exclude CHF. Further, there is no history of congenital heart disease, acute rheumatic fever, hypertension, or murmurs, which might be expected in a young woman with CHF. Absence of drug or alcohol abuse, and no history of jaundice make severe liver disease unlikely. Tolerance to cold, normal bowel habits, and absence of other related symptoms refute thyroid hypofunction; cyclic premenstrual edema is denied by the history. nocturia is a common manifestation of edema from any cause, and relates to more effective renal perfusion in the reclining position. Foamy urine occurs in patients with massive proteinuria. So far, then, the evidence points to the kidney as the source of her illness. Cirrhosis can now be ruled out by the absence of historical or physical evidence. CHF is also excluded by the normal cardiac and pulmonary findings. Myxedema, only a remote consideration, is eliminated by the absence of its facial features, the type of edema, and normal reflexes. The only abnormal findings are edema of the legs and a clue to its cause. The whitish bands in the nailbeds are call Muehreck's lines; they develop during periods of severe hypoalbuminemia (less than 2.0 gm/dl). The nephrotic syndrome is strongly suspected. There is clinical evidence of edema, hypoalbuminemia, and severe proteinuria (foamy urine)a highly suggestive cluster.
Extractions: Clinical Uses: Immunosuppressive Drugs return to menu I return to menu II Organ Transplantation: return to menu I return to menu II Primary Renal Disease: Two primary types of glomerular injury immune-mediated: systemic lupus erythematosus (renal aspect) acute glomerulonephritis immunosuppressive treatment may be beneficial not definitively resolved underlying disease may easily damage the new, transplanted kidney
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MedPix - Medical Image Database, Radiology Cases And Teaching File image, meningioma. image, Metastatic Carcinoma. image, Minimal ChangeDisease (lipoid nephrosis). image, Mixed Germ Cell Tumor of the Testis. http://rad.usuhs.mil/medpix/medpix.html?mode=cat_browse&expand=79
Extractions: Lab 3 Slides 70 Slides 51 Supplement ... Slides 28 Welcome to the Systemic Pathology Laboratory #3: Renal, Urinary Disease, and Male GU Please select a slide group to view by clicking on the appropriate slide button or text found on the left or top navigation bars. The contents of the each slide group are listed in the index below. Alternatively, you can click on the continue text below to proceed to the first slide group. To return to the Pathology Course Menu select from the text navigator bar below. Slides 70: Glomerulonephritis, Rapidly Progressive Slides 51: Membranous Glomerulopathy Supplement : No Glass Slides Slide 41: Acute Proliferative Glomerulonephritis, with Early Crescents Slides 40: Polycystic Disease (Adult, Autosomal Dominant) Slides 28: Prostate: Adenocarcinoma Continue to Slide 70 Lab 3 Slides 70 Slides 51 ... UMDNJ
Open Directory - Health: Conditions And Diseases: L 21); Leprosy@ (16); LeschNyhan Syndrome@ (5); Leukemia@ (105); Leukodystrophy@(30); Lice@ (21); lipoid nephrosis@ (5). Lissencephaly@ (5 http://www.mptdo.com/Health/Conditions_and_Diseases/L/
MemorialCare - Online Health Screenings By MyElectronicMD.com In children, boys are more commonly affected. In children, nephrotic syndromeusually is caused from minimal change disease, or lipoid nephrosis. http://mymd.i2net.com/mc_mymd/refr.php?Id=438
The Pathology Guy -- Online Help Amyloidosis. Minimal change ( nil ) disease ( lipoid nephrosis ). Focalsegmentalglomerulosclerosis. Wegener's granulomatosis. Small-vessel polyarteritis. http://www.pathguy.com/lectures.htm
Extractions: Verify here. Interested in an obscure disease? Obviously, I cannot be your doctor, cannot substitute for a physician of your own, and cannot diagnose or treat over the 'web. Whether you are a medical student seeking a study guide, or a sick person seeking answers, you must understand that these notes, and any correspondence we may have, are provided for informational purposes only, and with the understanding that I am not engaged in rendering medical or professional services. If you, or someone special to you, is sick, you need to review all information carefully with your health care provider. No physician can know everything. However, I'm honest and interested in being useful. And if there's something you need to know, I can probably help you find it. E-mail me at erf@uhs.edu and let me know how I can help. This is completely confidential. If you are still looking for information, and you are in the U.S., I suggest you use a Medline search from
Profuse e.g. lipoid. e.g. lipoid. nephrosis. nephrosis http://www.aspn.it/img/cameron.pdf
Health Ency.: Disease: Minimal Change Disease Alternative names Minimal change nephrotic syndrome; Nil disease; Lipoidnephrosis; Idiopathic nephrotic syndrome of childhood. Definition http://www.austin360.com/shared/health/adam/ency/article/000496.html
Extractions: Important notice Ency. home Disease M Minimal change disease Overview Symptoms Treatment Prevention Alternative names: Minimal change nephrotic syndrome; Nil disease; Lipoid nephrosis; Idiopathic nephrotic syndrome of childhood Definition: A disorder of the kidneys that affects the structures (glomeruli) which include small capillaries surrounded by membranes through which the blood is filtered to form urine. Causes and Risks Minimal change disease is one cause of nephrotic syndrome . It is named because under a light microscope the glomeruli appear totally normal. Under an electron microscope characteristic changes in the glomeruli can be seen, including the fusion of a portion of the epithelial layer.
NSW Health - ICD-9-CM 580-629 581.3 With lesion of minimal change glomerulonephritis Foot process disease Lipoidnephrosis Minimal change glomerular disease glomerulitis nephrotic syndrome; http://www.health.nsw.gov.au/public-health/icd/580-629.htm
Extractions: Excludes : hypertensive renal disease (403.00-403.91) With lesion of proliferative glomerulonephritis With lesion of membranous glomerulonephritis Epimembranous nephritis Idiopathic membranous glomerular disease Nephrotic syndrome with lesion of: focal glomerulosclerosis sclerosing membranous glomerulonephritis segmental hyalinosis
S60-07 The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set. http://webabst.niph.go.jp/content/shinshin/ssh_1985_07.htm
