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Microscopic Polyangiitis: more detail

Microscopic polyangiitis presenting with liver dysfunction preceding rapidly progressive necrotizing glomerulonephritis.(Case Report): An article from: Southern Medical Journal by Kohzo Takebayashi, Yoshimasa Aso, et all 2004-09-01

Microscopic polyangiitis in a pregnant woman. (Case Reports).: An article from: Southern Medical Journal by Ramazan Cetinkaya, Ali Riza Odabas, et all 2002-12-01

lists with details

FastDates.com Pit Lane News - November 2002 Page 1
The Colin has been suffering from microscopic polyangiitis since the end of August. Microscopicpolyangiitis is a form of vasculitis which is extremely rare.
http://www.fastdates.com/PitLaneNews2002.11.1.HTM
Final Diagnosis -- Case 59
DIAGNOSIS Spinal subarachnoid hemorrhage secondary to microscopic polyangiitis(Idiopathic lateonset cerebellar ataxia). DISCUSSION
http://path.upmc.edu/divisions/neuropath/bpath/cases/case59/dx.html

Extractions: DIAGNOSIS: Spinal subarachnoid hemorrhage secondary to microscopic polyangiitis (Idiopathic late-onset cerebellar ataxia) DISCUSSION: Spinal SAH was an unexpected postmortem finding in this elderly man. In the past, he had been investigated for 20 years of (non-familial) progressive ataxia, receiving a diagnosis of sporadic cerebellar degeneration. His neurodegenerative disorder had prompted a neuropathological referral, a diagnosis of idiopathic late-onset cerebellar ataxia being made. His terminal illness had been characterised by renal failure and laboratory evidence of an immunogenic disorder. Spinal SAH usually presents with intense back pain and spinal rigidity, to be followed by the consequences of damage to the spinal cord and nerve roots. This presentation was not apparent, but may have been obscured by other clinical problems. Histological examination revealed non-granulomatous inflammation of arcuate and interlobular arteries in the kidney and small arteries and venules in the spinal leptomeninges. A diagnosis of microscopic polyangiitis (MPA) is consistent with these findings and the immunology results (1, 2). Wegener's granulomatosis (WG), another small vessel vasculitis, and polyarteritis nodosa (PAN) comprise the differential diagnosis. According to modern classifications (1), PAN is excluded on the basis that it affects predominantly medium-sized vessels and not venules, and is rarely associated with ANCA. WG may appear histologically similar to MPA, and both may affect the respiratory system. However, WG usually displays granulomatous inflammation, and is associated much more with cANCA than pANCA (1, 3).
Health Waikato ICU - General - Presentations
Asthma 95%, Pulmonary infiltrates 70%, Renal up to 49%. microscopic polyangiitisSystemic Necrotizing vasculitis that affects small vessels without granulomas.
http://anaes-icu-waikato.org.nz/ICU/general/presentations.php?cat=anca
PUBLICATIONS INTERNATIONALES DU GERM"O"P
Translate this page microscopic polyangiitis with alveolar hemorrhage. A clinical and follow-upstudy of 32 cases. microscopic polyangiitis with alveolar hemorrhage.
http://germop.univ-lyon1.fr/fr/germop/publications.htm
Abstract: Mortality And Morbidity In Peripheral Neuropathy Associated Churg-Stra
ChurgStrauss syndrome (CSS) and microscopic polyangiitis (MPA) are commonly characterizedby systemic necrotizing vasculitis and frequent occurrence of axonal
http://www.jrheum.com/abstracts/abstracts02/1408.html

Extractions: Objective. Churg-Strauss syndrome (CSS) and microscopic polyangiitis (MPA) are commonly characterized by systemic necrotizing vasculitis and frequent occurrence of axonal neuropathy. We investigated whether the neuropathy in these 2 diseases reveals differences in clinicopathologic features and predicts survival and functional outcome. We compared 30 patients with CSS associated neuropathy with 26 patients with MPA associated neuropathy in terms of clinical, laboratory, electrophysiologic, and outcome data. MPA cases showed a significantly higher age at onset, a higher male/female ratio, and more extensive systemic organ involvement than CSS. Inflammatory markers including antimyeloperoxidase antibody titers were also significantly higher in MPA. Both CSS and MPA showed similar neuropathic symptoms, electrophysiologic findings, and sural nerve biopsy findings representing acute axonal changes. Functional disability assessed by modified Rankin score, muscle strength, and nerve conduction variables were similar in CSS and MPA, both in the acute peak phase and during longterm followup. However, survival was significantly worse in MPA than CSS. Neuropathy associated CSS and MPA shared common neuropathic features throughout the course, but systemic organ involvement, inflammatory marker concentrations, and relapse rates were significantly higher in MPA, which showed a poorer survival rate. (J Rheumatol 2002;29:1408-14)
Florida State University College Of Medicine Digital Library
microscopic polyangiitis Access document. Noble Textbook of Primary Care Medicine,3rd Ed.2001 (MD Consult) Table of contents - Medical Library subscription
http://fsumed-dl.slis.ua.edu/clinical/rheumatology/autoimmune/vasculitides/syste

Extractions: Clinical Resources by Topic: Cardiovascular Disorders Polyangiitis Overlap Syndrome Clinical Resources Atlases Pathology Clinical Guidelines Miscellaneous Resources See also: Principles of Treatment: Access document Goldman: Cecil Textbook of Medicine 21st Ed.-2000 (MD Consult): Table of contents Medical Library subscription INFO Ruddy: Kelly's Textbook of Rheumatology 6th Ed.-2001 (MD Consult): Table of contents Medical Library subscription INFO Feldman: Sleisenger and Fordtran's Gastrointestinal and Liver Disease 7th Ed.-2002 (MD Consult):
Cordier226-243.html
Wegener's granulomatosis, microscopic polyangiitis, and ChurgStrauss syndromeare the three biggest vasculitides with pulmonary manifestations.
http://www.personal.u-net.com/~ersj/ERM/Monograph files/14 summaries/cordier226-

Extractions: Pulmonary vasculitis often remains difficult to recognize, especially because this type of pulmonary "orphan" disease is seldom encountered by pulmonary physicians. Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome are the three biggest vasculitides with pulmonary manifestations. All three are associated with antineutrophil cytoplasmic antibodies, which have become a major biological diagnostic tool. Early diagnosis of pulmonary vasculitis is necessary to start treatment with corticosteroids and immunosuppressors without delay. Keywords: Churg-Strauss syndrome, microscopic polyangiitis, pulmonary vasculitis; Wegener's granulomatosis. Back to Contents
P990820a - Polyarteritis Nodosa
Title Treatment of polyarteritis nodosa and microscopic polyangiitis. Title Polyarteritisnodosa, microscopic polyangiitis, and ChurgStrauss syndrome.
http://www.emory.edu/WHSCL/grady/amreport/litsrch99/p990820a.html

Extractions: Polyarteritis Nodosa (Lubin) Question: What is polyarteritis nodosa? Fulltext Available in MDConsult using Journal Search and the search term: Unique Identifier: 99086413 Authors: Guillevin L. Lhote F. Institution: Hopital Avicenne, Universite Paris-Nord, Bobigny, France. Title: Treatment of polyarteritis nodosa and microscopic polyangiitis. [Review] [49 refs] Unique Identifier: 96160004 Authors: Lhote F. Guillevin L. Institution: Hopital Delafontaine, Saint-Denis, France. Title: Polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome. Clinical aspects and treatment. [Review] [132 refs] Source: Rheumatic Diseases Clinics of North America. 21(4):911-47, 1995 Nov. Abstract: In this article, three systemic vasculitidespolyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndromeare reviewed, focusing on advances in the understanding of the pathogenesis, new classification nomenclature, and major clinical features of these vasculitides. Distinguishing criteria between polyarteritis nodosa and microscopic polyangiitis are also presented in detail, and recent advances in the clinical management of these diseases according to appropriate therapeutic strategies are recommended. [References: 132] Morning Report Emory University School of Medicine 1999 Edition Participating Faculty: Daniel Stephens MD / Donald Brady MD dbrady@emory.edu
Baylor College Medicine Monthly Summary
Hotline Aids - Social Issues - Health Medicine - AIDS/HIV microscopic polyangiitis- microscopic polyangiitis (MPA) is vasculitis of small vessels.
http://www.fizgigs.com/page.php?page=baylor college medicine monthly summary
INFLAMMATORY MYOPATHIES IN THE 21ST CENTURY
The largest case series reported to date included 14 patients with Wegener's granulomatosis,11 patients with microscopic polyangiitis, and a patient with
http://www.rheuma21st.com/archives/cutting_edge_immunoglobulin.html

Extractions: The first use of intravenous immunoglobulin (IVIg) was for patients with various immunodeficiency states. Currently, it is also an accepted treatment in some autoimmune diseases, such as polymyositis/dermatomyositis, Guillain-Barre syndrome, and immune thrombocytopenic purpura. The use of IVIg and its beneficial role in other autoimmune conditions is not yet established, and, in some cases, is even controversial. In this cutting edge article, the main reports of IVIg use in three groups of human autoimmune diseases will be discussed: systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and autoimmune vasculitis.
Investigations
Specificity and sensitivity of ANCA serology testing for Wegener's granulomatosisand microscopic polyangiitis (adapted from Hagen et al, Kidney Int 1998;53
http://www.wellclosesquare.co.uk/rheum/invest.htm

Extractions: Erosion of vertebral end-plates ("squared off"). Psoriatic arthropathy Asymmetrical small joint erosions (DIP) and periosteal reaction. Chondrocalcinosis AP knees Chronic tophaceous gout "Punched-out" sclerotic erosions Inflammation results in release of soluble mediators (cytokines, including interleukins 1-6 and TNF) which results in: Anti nuclear antibody ( ANA +ve in Systemic lupus erythematosus (active) 99% Systemic lupus erythematosus (inactive) 95% Drug induced lupus 99% Mixed connective tissue disease 99% Rheumatoid arthritis 32% Juvenile rheumatoid arthritis 76% Chronic active hepatitis 75% % Sjorgen's syndrome 68% Progressive systemic sclerosis 64% "Normal" controls 0-2% (Increase with age - 20% at 70yrs)
Medicalseek - Search Engine For The Healthcare Industry
Conditions and DiseasesImmune DisordersAutoImmunemicroscopic polyangiitis MicroscopicPolyangiitis in a Pediatric Patient From Archives of Family Medicine
http://www.medicalseek.net/Conditions_and_Diseases_Immune_Disorders_Auto_Immune_

Extractions: Immunity Products and alternative treatments. Immune Advantage is a natural, concentrated source of immunoglobulin and other immuno-proteins that promote a natural resistance to illness and infection. Just as colostrum passes immunity from mother to child, Immune Advantage utilizes concentrated blood serum, the precursor to colostrum, to help boost immunity and support the body against invading pathogens.
CCHS Clinical Digital Library
microscopic polyangiitis Access document. Feldman Sleisenger and Fordtran's Gastrointestinaland Liver Disease 7th Ed.2002 (MD Consult) Table of contents
http://cchs-dl.slis.ua.edu/clinical/rheumatology/autoimmune/vasculitides/systemi

Extractions: Clinical Resources by Topic: Cardiovascular Disorders Polyangiitis Overlap Syndrome Clinical Resources Atlases Pathology Clinical Guidelines Miscellaneous Resources See also: Principles of Treatment: Access document Goldman: Cecil Textbook of Medicine 21st Ed.-2000 (MD Consult): Table of contents Health Sciences Library subscription INFO Ruddy: Kelly's Textbook of Rheumatology 6th Ed.-2001 (MD Consult): Table of contents Health Sciences Library subscription INFO Feldman: Sleisenger and Fordtran's Gastrointestinal and Liver Disease 7th Ed.-2002 (MD Consult):
Microscopic Polyangiitis
microscopic polyangiitis Rachael's MPA Support Site http//www.users.fast.netSupport and information for people fighting microscopic polyangiitis.
http://www.medlina.com/microscopic_polyangiitis.htm
Blood Vessels (9/25)
PANCA (perinuclear) act against myeloperoxidase in the neutrophils and areassociated with microscopic polyangiitis and Churg-Strauss syndrome.
http://www.med.uiuc.edu/m2/Pathology/bloodtwo.htm

Extractions: BLOOD VESSELS II Lecture Handout Jill Conway, 9/19/00 Important Terms: Fibrinoid necrosis = necrotic tissue has fibrin-like eosinophilic material. This is associated with blood vessel and connective tissue disorders, malignant hypertension, and wound healing. Granuloma = nodular inflammatory lesions associated with immune reaction. Consists of focal area of epithelioid-like macrophages surrounded by a mononuclear infiltrate, mainly of lymphocytes and some plasma cells. Older granulomas develop fibrosis and are firm and nodular. Epithelioid cells may form giant cells with many nuclei arranged peripherally (Langhans-type) or haphazardly (foreign-body type). ESR = erythrocyte sedimentation rate in which blood cells are allowed to settle for one hour in a calibrated tube. Elevated values indicate inflammatory states that may increase fibrinogen in serum that helps RBCs form "rouleaux" which sediment more quickly. Palpable purpura = purpura is hemorrhage into the skin and palpable designates raised lesions Aneurysm shapes: berry = small, spherical about 1.5 cm in diameter.
Dr. Rose's Peripheral Brain-VASCULITIS
active Wegener's. Perinuclear ANCA (pANCA) is more closely associatedwith microscopic polyangiitis, a smaller-vessel vasculitis;
http://faculty.washington.edu/momus/PB/vasculit.htm

Extractions: VASCULITIDES I. Definitions and pathophysiology Inflammation in blood vessel walls, leading to Tissue ischemia and necrosis Aneurysms and rupture Can occur in any blood vessel Tends to be irregular and segmental May be focal or diffuse, acute or chronic In some forms, associated with immunoglobulin deposition, which presumably leads to complement activation and PMN recruitment Mechanisms of inflammation may vary in different forms of vasculitis Infection, including hep B and C may play a role in some vasculitis syndromes Neoplasms, e.g. lymphomas and hairy cell leukemia may also be associated II. Large artery vasculitides Takayasu's arteritis Pathophysiology Involves the aorta (us. the most severely affected vessel) and its primary branches, including renal and mesenteric aa. Continuous or patchy granulomatous inflammation with lymphocytes, histiocytes, and multinucleated giant cells Can produce either luminal compromise (more common) or dilatation and aneurysms Us. young women, most often Asian or European background, us. onset age 10-30y
Health Conditions And Diseases Immune Disorders Auto-Immune Microscopic Polyangi
Health Conditions and Diseases Immune Disorders AutoImmunemicroscopic polyangiitis 524278 Polish Yellow Pages YP.pl.
http://www.yellowpages.pl/ca/524278/Health/Conditions_and_Diseases/Immune_Disord
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main target antigen of cANCA, which is seen in Wegener's Granulomatosis, also canbe seen in other immune diseases, eg microscopic polyangiitis, Churg-Strauss
http://www.vghtpe.gov.tw/~im/gr97mar/gr5.htm
BioMed Central | Full Text | Polyarteritis Nodosa And Microscopic Polyangiitis:
Welcome guest user,
http://www.biomedcentral.com/1523-3774/4/75

Extractions: Welcome guest user home journals A-Z journals by subject advanced search ... my BioMed Central Although all research articles in Current Rheumatology Reports are available free, most other articles require a subscription Click here to view an abstract of this article Click here to login if you are already a subscriber to Current Rheumatology Reports Subscribe to Current Rheumatology Reports Register for a free online trial Ask your librarian to investigate institutional access Athens users please click here to gain access If you believe you are seeing this page in error,
References
Kandeel A, Ramesh S, Chen Y, Celik C, Jenis E, Ambrus JL Jr. Microscopicpolyangiitis in a pediatric patient. Arch Fam Med. 2000;911891192.
http://www.medscape.com/content/2002/00/43/25/432549/432549_ref.html

Extractions: References for: Crescentic Glomerulonephritis Requiring Hemodialysis and Elevated MPO-ANCA Level and Vasculitis Allergica Cutis in a 21-Year-Old Girl Smith G. Management of childhood nephrotic syndrome. BMJ. 1995;310:530-531. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides: proposal of an international consensus conference. Arthritis Rheum. 1994;37:187-192. Churg J, Strauss L. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol. 1951;27:277-301. Gross WL. Antineutrophil cytoplasmic autoantibody testing in vasculitis. Rheum Dis Clin North Am. 1995;21:987-1011. Niles JL. Antineutrophil cytoplasmic autoantibodies in the classification of vasculitis. Annu Rev Med. 1996;47:303-313. Lesavre P. Antineutrophil cytoplasmic autoantibodies antigen specificity. Am J Kidney Dis. 1991;18:159-163. Watts RA, Scott DGI. Small vessel vasculitis associated with antineutrophil cytoplasmic antibody. BMJ. 1995;310:1128-1132. Kandeel A, Ramesh S, Chen Y, Celik C, Jenis E, Ambrus JL Jr. Microscopic polyangiitis in a pediatric patient. Arch Fam Med. 2000;9:1189-1192. Guillevin L, Lhote F. Distinguishing polyarteritis nodosa from microscopic polyangiitis and implications for treatment. Curr Opin Rheumatol. 1995;7:20-24.

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