Geometry.Net - Health_Conditions: Neuroleptic Malignant Syndrome

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18.10 neuroleptic malignant syndrome. Overview 18. 18.10.01 DiagnosticCriteria of Caroff et al for the neuroleptic malignant syndrome. Overview
http://www.medal.org/docs_ch18/doc_ch18.10.html

Extractions: Neuroleptic Malignant Syndrome Overview: The Neuroleptic Malignant Syndrome is difficult (1) to define precisely (2) to separate from other related syndromes and (3) to even specify precipitating agents. It appears to be related to changes in central dopaminergic activity. One suggestion has been to rename it the drug-induced central hyperthermic syndrome (Heyland Can Med Assoc J. 1991; 145: 817-819). This is an area likely to be modified over the coming years. Table of Contents, Chap. 18 Diagnostic Criteria of Caroff et al for the Neuroleptic Malignant Syndrome Overview: The Neuroleptic Malignant Syndrome (NMS) is a syndrome which may occur in patients receiving neuroleptic agents. Its presentation and symptoms may vary but the classic tetrad is fever rigidity altered sensorium and autonomic dysfunction. It can be fatal if unrecognized. Caroff et al specified diagnostic criteria to aid in its recognition. Diagnostic Criteria for NMS (1) treatment with neuroleptic agent prior to onset within 7 days for oral agents within 2-4 weeks for depot forms (3) muscle rigidity (4) 5 or more of the following change in mental status tachycardia hypertension or hypotension tachypnea or hypoxia diaphoresis (excessive sweating) or sialorrhea (excessive flow of saliva) tremor incontinence creatine phosphokinase (CK) elevation or myoglobinuria leukocytosis metabolic acidosis (5) exclusion of other drug-induced systemic or neuropsychiatric illnesses Differential diagnosis:
Myoglobinuria; Rhabdomyolysis
myoglobinuria. neuroleptic malignant syndrome (NMS). Drugs Butyrophenones;Lithium; Phenothiazines; Pimozide; Promethazine; Thioxanthines;
http://www.neuro.wustl.edu/neuromuscular/msys/myoglob.html
Health Library - Neuroleptic Malignant Syndrome
Your Health. Search. neuroleptic malignant syndrome. Synonyms Disorder SubdivisionsGeneral Discussion Resources National Organization for Rare Disorders.
http://yourhealth.stlukesonline.org/Library/HealthGuide/IllnessConditions/topic.
Neuroleptic Malignant Syndrome-like Conditions With An Aldosteronism-like Distur
neuroleptic malignant syndromelike conditions with an aldosteronism-like disturbanceof serum electrolytes induced by a combination of amoxapine and
http://www.pulsus.com/clin-pha/03_02/taji_ed.htm

Extractions: Order Full Text -For a nominal fee order online and receive a copy of this article either by email, fax or mail État évoquant le syndrome malin des neuroleptiques avec un déséquilibre des électrolytes du sérum ressemblant à un hyperaldostéronisme, induit par une combinaison damoxapine et de pravastatine RÉSUMÉ :
Neuroleptic Malignant Syndrome
neuroleptic malignant syndrome PubMed Medline search on neuroleptic malignantsyndrome. Support Groups. No specific support groups found disclaimer.
http://www.ion.ucl.ac.uk/library/patient/neurolep.htm

Extractions: Neuroleptic Malignant Syndrome Medline NLM definition : A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72) PubMed Medline search on neuroleptic malignant syndrome Support Groups No specific support groups found
Searchalot Directory For Neuroleptic Malignant Syndrome
Related Web Sites. Emergency Medicine An in depth look at neuroleptic malignantsyndrome beginning with an introduction. Authored by Theodore Benzer MD.
http://www.searchalot.com/Top/Health/ConditionsandDiseases/NeurologicalDisorders

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1Up Health > Health Links Directory > Conditions And Diseases: Neurological Diso
Sites. Emergency Medicine An in depth look at neuroleptic malignant syndromebeginning with an introduction. Authored by Theodore Benzer MD.
http://www.1uphealth.com/links/basal-ganglia-neuroleptic-malignant-syndrome.html
Glossary Definition
neuroleptic malignant syndrome is a serious disorder that can be caused bythe use of antipsychotic drugs. It affects the movements of the body.
http://cebmh.warne.ox.ac.uk/cebmh/elmh/schizophrenia/glossary/nms.html

Extractions: //tmtC_Resize_Window tmt_Resize_WindowX = 200; tmt_Resize_WindowY = 300; self.resizeTo(tmt_Resize_WindowX,tmt_Resize_WindowY);//tmtC_Resize_WindowEnd Neuroleptic malignant syndrome : is a serious disorder that can be caused by the use of antipsychotic drugs. It affects the movements of the body. People who have this syndrome may have muscle stiffness, a fast heartbeat, a high temperature and sometimes be tired. These symptoms can happen very quickly. CLOSE THIS WINDOW
Health Library - Neuroleptic Malignant Syndrome
Advanced Search. neuroleptic malignant syndrome. Synonyms Disorder SubdivisionsGeneral Discussion Resources National Organization for Rare Disorders.
http://www.stjudemedicalcenter.org/library/healthguide/IllnessConditions/topic.a
National Parkinson Foundation, Inc.
neuroleptic malignant syndrome (NMS). by Abe Lieberman MD Neurolepticmalignant syndrome (NMS) is an unusual reaction to neuroleptic
http://www.parkinson.org/nmsyndrome.htm

Extractions: by Abe Lieberman MD Neuroleptic malignant syndrome (NMS) is an unusual reaction to neuroleptic drugs (drugs used as major tranquillizers) and to abrupt withdrawal of levodopa. The NMS is characterized by high fever, ., unresponsiveness, rigidity, and autonomic nervous system dysfunction. Laboratory abnormalities include elevated serum creatine phosphokinase (a muscle enzyme) and myoglobinuria (breakdown products of muscle in the urine). The symptoms of NMS may develop from a few days to a few weeks following neuroleptic drug use or a few days after stopping levodopa. The symptoms are progressive. NMS occurs in 1% of patients who receive neuroleptic drugs and is attributed by some to a dopamine receptor blockade in the basal ganglia and hypothalamus, and by others to a disturbance of calcium uptake in skeletal muscle. The morality rate associated with NMS, when not recognized and treated is at least 20%. Treatment consists of the withdrawal of the neuroleptic drug (if this is the cause of the NMS syndrome), or the reinstitution of levodopa (if this is the cause of the NMS syndrome), supportive care, and the use of a dopamine agonist or sodium dantrolene. The NMS will not be recognized if it is not considered when a high fever, rigidity, and autonomic nervous system dysfunction (rapid heart rate, high blood pressure, rapid respirations) occur while using neuroleptic drugs or after stopping levodopa. When these symptoms occur the first thought is to look for infections or metabolic disturbances and not consider the symptoms as arising from the use of neuroleptic drugs or after stopping levodopa. NMS may result from dopamine receptor blockade in the basal ganglia and hypothalamus. This blockade can then result in inhibition of calcium uptake in skeletal muscle, which can then result in rigidity. The rigidity may be so severe as to result in immobility, which may lead to high fever, shortness of breathing, decreased oxygen saturation and death.
National Parkinson Foundation, Inc.
Olanzapine induced neuroleptic malignant syndrome a case review. Three databaseswere searched using the terms olanzapine and neuroleptic malignant syndrome.
http://www.parkinson.org/olanzapine.htm
Australian Adverse Drug Reactions Bulletin, May 1997
1995. MMWR 1995; 44 892900 (JAMA 1996; 275 96-98). Top of page.2. CLOZAPINE INDUCED neuroleptic malignant syndrome. Clozapine
http://www.health.gov.au/tga/docs/html/aadrbltn/aadr9705.htm

Extractions: TGA Adverse Drug Reactions Australian Adverse Drug Reactions Bulletin Prepared by the ADVERSE DRUG REACTIONS ADVISORY COMMITTEE (ADRAC), a subcommittee of the Australian Drug Evaluation Committee. ADRAC is Dr Tim Mathew (Chair), Dr Ross Bradbury, Dr Paul Desmond, Dr Cecilie Lander, Professor Gillian Shenfield, Dr Dana Wainwright, Professor Lindon Wing. Kombucha tea has become increasingly popular in recent years because it has been claimed to have a large number of beneficial effects including the prevention of cancer, relief of arthritis, treatment of insomnia, stimulation of the immune system and even the regrowth of hair. The tea is brewed from the Kombucha mushroom which is actually a symbiotic yeast and bacteria aggregate surrounded by a permeable membrane. The "mushroom", which grows like a round flat gray fungus about the size of a dinner plate, is fermented in sugared tea to obtain the Kombucha tea. The mushrooms are sold or distributed by naturopaths and other alternative practitioners and are often passed on from person to person. The tea has been described to contain a mixture of many substances including alcohol, glucuronic acid, acetic acid, heparin and lactic acid. In the last year, ADRAC has received two reports of hepatotoxicity in association with Kombucha tea. There have also been reports of both hepatotoxicity and lactic acidosis in the United States.
PD INDEX: A Directory Of Parkinson's Disease Information On The Internet
on the Internet Information sources under area DRUG THERAPY for topics beginningwith N neuroleptic malignant syndrome and drug withdrawal An algorithm for
http://www.pdindex.org/isc1n.htm
NEUROLOGIC MALIGNANT SYNDROME - A CHRONOLOGICAL ANNOTATED BIBLIOGRAPHY
may show widespread fasciculations (ref Anderson SA, Weinschenk K Peripheranl neuropathyas a component of the neuroleptic malignant syndrome Am J Med 1987
http://www.oism.info/ospiti/articoli/2002-01.htm

Extractions: February 5, 1997 This catastrophic reaction to dopamine blocking agents,especially HALDOL, more recently RESPIRADOL, (but all the so-called major tranquilizers have been implicated) can lead to death in up to 50% of cases, especially if not immediately recognized. The causative agents must be stopped immediately and never started again. Three Principal Indicators: Extreme muscle rigidity - one patient had to have a tenosynovotomy of her Achilles tendons (heel cords cut). Extreme autonomic instability especially rapid heart rate (over 100), temperatures up to 108 (at which point the brain's proteins denature like the white of an egg and there's no return), sweating, high blood pressure (sometimes over 200 systolic), incontinence. Pulmonary emboli may occur. Extreme mental status changes including restlessness, delirium, stupor and coma although patient may be conscious and "locked in." Often mistaken for catatonic schizophrenia (another imaginary "disease of the mind") and treated with even more of the hair of the dog, the anti-psychotic medications and even with electroconvulsive therapy (ECT)!
NEUROLOGIC MALIGNANT SYNDROME - A CHRONOLOGICAL ANNOTATED BIBLIOGRAPHY
Translate this page fascicolazioni ampiamente diffuse (riferim. Anderson SA, Weinschenk K Peripheranlneuropathy as a component of the neuroleptic malignant syndrome Am J Med
http://www.oism.info/ospiti/articoli/2002-01-it.htm

Extractions: SINDROME NEUROLOGICA MALIGNA (SNM) 1959-1980 Una bibliografia cronologica commentata preparata da John M. Friedberg, MD 5 febbraio 1997 Traduzione a cura di Tristano Ajmone Questa catastrofica reazione agli agenti bloccanti la dopamina, specialmente l'Aldolo, più recentemente il Respiradol , (ma tutti i cosiddetti tranquillanti maggiori sono stati implicati) può condurre alla morte fino al 50% dei casi, specialmente se non riconosciuta immediatamente. [La somministrazione degli] agenti causativi deve essere immediatamente interrotta e mai più ripresa. Tre indicatori principali: estrema rigidità muscolare una paziente dovette ricevere un intervento chirurgico ai tendini di Achille ( recisone delle corde del tallone). estrema instabilità autonomica, specialmente ritmo cardiaco rapido (oltre 100), temperature fino a 42°C (punto in cui le proteine cerebrali denaturano come l'albume dell'uovo e non vi è ritorno), sudorazione, pressione sanguigna alta (a volte oltre 200 sistolica), incontinenza. Può aver luogo embolia polmonare. cambiamenti dello stato mentale estremi inclusi irrequietezza, delirio, stupore e coma nonostante il paziente possa essere conscio e "chiuso in sé stesso." Spesso scambiata per schizofrenia catatonica (un'altra "malattia della mente" immaginaria) e trattata come con il cicchettino che allevia la sbronza, con ulteriori aggiunte di farmaci antipsicotici ed anche con
NMS
Strategies for Patients who have had neuroleptic malignant syndrome. Atypicalantipsychotics and neuroleptic malignant syndrome.
http://www.mhc.com/Algorithms/Schizophrenia/nms.htm

Extractions: Strategies for Patients who have had Neuroleptic Malignant Syndrome The most common clinical symptoms of NMS are hyperthermia, EPS (muscle rigidity, akinesia, tremor), mental status alterations, autonomic signs (diaphoresis, tachycardia, labile blood pressure), and elevated creatine kinase (CK) and leukocytosis. NMS can occur in any patient, and is not specific to any neuropsychiatric diagnosis, but the highest risk may be with individuals with mental retardation and brain infection/inflammation.(1) Since your patient has a history of NMS, the question of the risks of rechallenge is critical, but the data are unsatisfactory. 19 of 45 reports of rechallence with an atypical after NMS on a typical described recurrence of NMS (42%). Another group of 45 rechallenges with a typical after NMS on a typical had 17 recurrences (38%).(4) There was no difference. However, these data could be biased by lack of reporting in the literature of successful rechallenges on the new drugs. Experts still recommend use of atypicals for rechallenges, but expectations of recurrence should be significant and one should be on guard for early signs of the disorder.(4) It is preferable to wait at least two weeks since the last signs and symptoms of the NMS (e.g., fever, rigidity, elevated CK) have disappeared.(5) Longer might be preferable since there is a suggestion of heightened susceptibility in the period immediately after the first occurrence of NMS, which may be in part due to the necessary abrupt withdrawal of the antipsychotic.(4)
Drug Toxicity
neuroleptic malignant syndrome Search PUBMED for Neuroleptic MalignantSyndrome All Review Therapy Diagnosis; Neuroleptic Malignant
http://www.ohsu.edu/cliniweb/C21/C21.613.276.html
CJNS - Paradoxical Autonomic Response To Procyclidine In The Neuroleptic Maligna
Abstract, Close Window Paradoxical Autonomic Response to Procyclidinein the neuroleptic malignant syndrome. Martin V Balzan. Abstract
http://www.canjneurolsci.org/22augtoc/paradoxi.htm

Extractions: Close Window Abstract: Background: Neuroleptic Malignant Syndrome (NMS) is an adverse reaction to dopamine receptor antagonists, characterised by hyperpyrexia, extrapyramidal rigidity and impaired autonomic function. It might result from central dopamine receptor blockade that causes severe muscle contraction. Method: Case Study. Results: High dose intravenous therapy with the anticholinergic drug, procyclidine hydrochloride, temporarily diminished the muscle rigidity and reversed most of the autonomic features in a patient with NMS occurring after a single intramuscular dose of the dopamine antagonist metoclopramide. Paradoxically, however, the heart rate decreased and bowel movements increased with this atropine-like drug. Conclusion: Since the degree of tachypnoea, tachycardia, and bowel hypotonia closely paralleled the severity of the muscle rigidity, it is suggested that these autonomic features of NMS result from sustained muscle contraction rather than a direct effect of neuro-leptic drugs on the central nervous system.
Mioti: Medical Condition
Condition neuroleptic malignant syndrome. NINDS Neuroleptic MalignantSyndrome Information Page. NORD neuroleptic malignant syndrome.
http://www.mioti.com/cat/condition/condition.asp?Cat=Neuroleptic
Health Library - Neuroleptic Malignant Syndrome
Hometown commitment. neuroleptic malignant syndrome. Synonyms Disorder SubdivisionsGeneral Discussion Resources National Organization for Rare Disorders.
http://www.phoebeputney.com/library/healthguide/IllnessConditions/topic.asp?hwid

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