Extractions: Mouse with Iron Disorder Offers Clues to Parkinson's, Similar Diseases Mice engineered to lack a gene involved in iron metabolism may provide important clues for deciphering the nature of a group of brain disorders-similar to Parkinson's Disease-affecting movement, according to a study by researchers at the National Institute of Child Health and Human Development (NICHD). The researchers reported in the February issue of Nature Genetics that mice lacking the gene for iron regulatory protein 2 (IRP2) develop iron deposits in key areas of the brain. The progressive deterioration of the mice's nervous system is like that seen in people with Parkinson's Disease and Multiple System Atrophy (also known as Parkinson's Plus). "Researchers have long debated whether the characteristic iron deposits of these diseases are the cause or the result of the disease process," said Duane Alexander, M.D., Director of the NICHD. "This is a strong clue that iron may play a causative role in Parkinson's and similar disorders." Diseases in which excess brain iron has been observed include Parkinson's Disease, Friedreich's Ataxia and Hallervorden-Spatz disease. However, the brain areas affected differ from those in the IRP 2 deficient mice, and it is unlikely that IRP 2 is involved in these human diseases, said the study's senior investigator, Tracey A. Rouault, M.D., of NICHD's Cell Biology and Metabolism Branch. Still, the NICHD finding suggests that other genes involved in iron metabolism may be good candidates for investigations into the causes of these disorders.
Abstract 7 ganglia, thalamus, cerebellum, and brainstem of 72 subjects, including 14 withmultiple system atrophy of the ataxic (olivopontocerebellar atrophy) type, 5 http://odin.math.nau.edu/~rts/appabs4.html
The Spinocerebeller Ataxias Gene Name, Locus, Alternative Name, OMIM Link. SCA 1, 6p23, Spinocerebellaratrophy I; olivopontocerebellar atrophy I (OPCA 1); Menzel type OPCA, 164400. http://www.compgene.com/sca.htm
Extractions: The spinocerebellar ataxias are a group of autosomal dominantly inherited ataxias with heterogeneous presentation. Characteristic CAG repeat expansions in the coding sequences at several loci have been detected for certain of these disorders. Hence, a direct DNA test can provide an unequivocal diagnostic result for what are often complex clinical presentations. The loci reponsible for this group of disorders continues to grow and are the subject of research strategies evaluating trinucleotide (especially CAG trinucleotide) repeat expansions. A recent comprehensive clinical and molecular genetic reference is provided by Koshy and Zoghbi (1997), Brain Pathology 7:927-942. Although this is a recent review, it is out of date as the locus for SCA7 has been recently described (David et al. (1997) Nature Genetics 17:65-70; Koob et al. (1998) Nature Genetics 18:72-75.) The Table below provides a cross-reference of SCA genetic loci and a variety of alternative clinical names. In addition, by clicking on the highlighted OMIM reference number, you will be linked to the appropriate OMIM page. These pages provide current reviews of the genetics and clinical features of these disorders.
Olivopontocerebellar Atrophy olivopontocerebellar atrophy. A Hospital. A resource with informationon over 4000 medical topics including olivopontocerebellar atrophy. http://www.bloodandmarrowtransplant.com/medical-terms/02005.htm
[Dysphagia] Olivopontocerebellar Atrophy Dysphagia olivopontocerebellar atrophy. Subject Dysphagia Olivopontocerebellaratrophy; From virginia@accentoncommunication.com (Accent on Communication); http://www.b9.com/dysphagia/2002-June/msg00139.html
NAF Pamphlet - Sporadic OPCA NAF Pamphlet Sporadic OPCA. This response submitted by on 1/1/98.Email Address What is Sporadic olivopontocerebellar atrophy? http://neuro-www.mgh.harvard.edu/forum/CerebellarAtaxiaF/NAFPamphlet-SporadicOPC
Arch Neurol -- Page Not Found Patients and Methods Using MRI, we examined 31 patients genetically diagnosed ashaving MJD, 20 patients with sporadic olivopontocerebellar atrophy, and 26 http://archneur.ama-assn.org/issues/v55n1/abs/noc7063.html
Extractions: The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"
Error Page progressive external ophtalmoplegia Cerebellar ataxia, dominant pure Cerebelloolivaryatrophy olivopontocerebellar atrophy type 1 olivopontocerebellar atrophy http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=99
Ataxia olivopontocerebellar atrophy (OPCA) Background In 1900, Dejerine and Thomasfirst introduced the term olivopontocerebellar atrophy (OPCA). http://www.alaska.net/~mnewell/html/ataxia.html
Extractions: National Ataxia Foundation (NAF) (For people who have ataxia as a symptom of other medical conditions such as head injury, stroke, MS, or alcoholism, we recommend that you contact the organization related to your specific condition for the most up-to-date information. We will be happy to provide you with appropriate addresses and telephone numbers if needed.) What does NAF do?
Multisystem Atrophy - Symptoms - Neurologychannel OPCA (olivopontocerebellar atrophy) OPCAs are a group of disorders characterizedby cerebellar dysfunction manifested by ataxia (imbalance and incoordination http://www.neurologychannel.com/msa/symptoms.shtml
Extractions: Symptoms The symptoms vary and depend on which particular form of MSA the patient has. Striatonigral degeneration is practically indistinguishable from Parkinsons; OPCA is characterized by progressive ataxia (an inability to coordinate voluntary muscular movements) of the gait and arms and dysarthria (difficulty in articulating words); and Shy-Drager syndrome is characterized by Parkinsonism plus a much more pronounced failure of the autonomic nervous system. Striatonigral Degeneration Striatonigral degeneration is similar to Parkinsons except tremor is much less common, and cerebellar ataxia (failure of muscle coordination) often develops over time. Pathologically, striatonigral degeneration is defined by abnormalities in the putamen and substantia nigra that are more extensive and localized than what is typical of Parkinsons disease. Other portions of the basal ganglia (the part of the brain that is responsible for organization of motor movement) are also involved. Striatonigral degeneration is often indistinguishable from Parkinsons except for the fact that it does not respond to medications that are used to treat the latter. MRI brain images sometimes reveal the severe degeneration of the affected structures and may provide additional diagnostic information.
Multiple System Atrophy Multiple System Atrophy. Back to previous level olivopontocerebellar atrophySearch PUBMED for olivopontocerebellar atrophy All Review Therapy Diagnosis. http://www.ohsu.edu/cliniweb/C10/C10.228.140.79.612.html
Olivopontocerebellar Atrophy Website Results :: Linkspider UK olivopontocerebellar atrophy Websites from the Linkspider UK. OlivopontocerebellarAtrophy Directory. olivopontocerebellar atrophy Websites from Linkspider UK. http://www.linkspider.co.uk/Health/ConditionsandDiseases/NeurologicalDisorders/B
Extractions: See Also: Health: Conditions and Diseases: Neurological Disorders: Spinal Cord: Spinocerebellar Degenerations Health: Conditions and Diseases: Rare Disorders Opca Awareness - A site devoted to Olivopontocerebellar Atrophy. It has links, personal stories and a discussion board. NINDS: Olivopontocerebellar Atrophy - Information sheet compiled by National Institute of Neurological Disorders and Stroke. MCW Health Link - An article about olivopontocerebellar atrophy, which involves progressive loss of certain brain structures: the cerebellum, the pons, and the inferior olives. NORD - Olivopontocerebellar Atrophy - Offers synonyms, a general discussion and further resources.
Katalog - Wirtualna Polska Serwis Katalog w Wirtualna Polska S.A. pierwszy portal w Polsce. http://katalog.wp.pl/DMOZ/Health/Conditions_and_Diseases/Neurological_Disorders/
