CIS Summer School 2002 Summer School in primary immune Deficiency disorders Old San Juan,Puerto Rico August 28September 1, 2002. The Clinical Immunology http://www.clinimmsoc.org/summer_overview.htm
Extractions: August 28-September 1, 2002 The four-day course consisted of faculty presentations intermingled with student case presentations on Primary Immune Deficiency Disorders. Topics covered include: SCID, transplantation, defects of B cells, Hyper IgM syndrome, neutrophil disorders, cytokine receptor defects, Di George syndrome, new defects, IPEX and some unknown cases. The close interaction between the faculty and students throughout the weekend was invaluable. The weekend wasn't all lectures and note taking. The group had an opportunity to see the sights of Old San Juan and take in some of the nightlife. There are rumors that some people stayed out till the wee hours of the night dancing the Salsa, but this has not been verified! At the end of the weekend, the group parted with valuable handouts and materials to be used and shared with others in their labs, contact information to keep the lines of communication open, and a better understanding of Primary Immune Deficiency Disorders. It was a great learning experience for all that attended. Charlotte Cunningham-Rundles, MD, PhD
Extractions: Recurrent infections 10 episodes acute otitis media per year (infant and children) 2 episodes consolidated pneumonia per year 2 life-threatening infections per life-time Unusual organisms Unusual response to organisms Recurrent autoimmune phenomena Dysmorphic features associated with recurrent infection Infections worsening chronic disorders (asthma or seizure Development of vaccine pathogen after vaccination Family history of immunodeficiencies or recurrent infections
Extractions: Earlier Detection and Treatment Means Healthier Lives Primary immunodeficiency diseases-little-known immune system disorders caused by genetic flaws-appear less often among members of minority groups in the United States than among non-minorities. Scientists suspect that difference may be due to under-diagnosis of those disorders in minority populations. Why so few cases are discovered among minorities remains unclear, but now a three-year, $1.3 million study funded by the National Institutes of Health (NIH) could help doctors and nurses spot and treat primary immunodeficiency diseases earlier among African Americans, Hispanics and other ethnic populations. Immunologist Charlotte Cunningham-Rundles, M.D., Ph.D., will direct the new study at Mount Sinai School of Medicine in New York City. She and a team of computer scientists, statisticians, nurses and heath educators will develop a computer-assisted method to screen patients for primary immunodeficiency diseases as well as educational materials for health care workers serving minority populations. The study is co-funded by the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Child Health and Human Development, and the National Cancer Institute. It is an example of increased collaboration among NIH components to fund research that addresses health disparities, notes Denise Wiesch, Ph.D., the NIAID program officer overseeing the award.
NIH Guide: GENE TRANSFER FOR PRIMARY IMMUNE DEFICIENCY FOR primary immune DEFICIENCY NIH GUIDE, Volume 24, Number 10, March 17, 1995PA NUMBER PA95-039 PT 34 Keywords Gene Therapy+ immune System disorders http://grants.nih.gov/grants/guide/pa-files/PA-95-039.html
Immunologic Diseases Univ of Leicester (UK) Severe Autoimmunity disorders and Cyclophosphamide primaryImmunodeficiency Association in the UK primary immune Deficiency Diseases http://www.mic.ki.se/Diseases/c20.html
BioSpace Clinical Development: Gammar-P IV Detail To treat primary immune deficiency (PID Diseases Children's Health (misc) (Children's Health) immune Disorder (nonspecific)(immune disorders) http://www.biospace.com/ccis/detail.cfm?ClinicalID=48
SCID & PID Links from the The New England Journal of Medicine February 18, 1999 Volume 340,Number 7 primary immune Deficiency disorders That Mimic AIDS (Located at http://www.scid.net/scidpid.html
Links primary immune Deficiency A Website for Parents and School Personnel. Disease RelatedWebsites Website. NORD National Association for Rare disorders, Inc. http://www.scid.net/cd5cd19pid/links.html
Health Library - Immune/Autoimmune Disorders immune/Autoimmune disorders. immune Deficiency Foundation. Founded 1980.Provides supportand education for families affected by primary immune deficiency diseases http://hvelink.saint-lukes.org/library/healthguide/SelfHelp/topic.asp?hwid=shc29
CIPO - What Are Primary Immune Deficiencies ? primary immune deficiency diseases (PiDs) are inherited disorders in which partof the body's immune system is missing or does not function properly. http://cipo.net/english/pids.htm
Extractions: Canadian Immunodeficiencies Patient Organization Contact Us Events Guest Book Links ... Home What are Primary Immune Deficiencies? Primary immune deficiency diseases (PiDs) are inherited disorders in which part of the body's immune system is missing or does not function properly. AID's is NOT a PiD. The World Health Organization recognizes approximately 70 primary immune deficiencies including X-Linked Agammaglobulinemia (Bruton's Disease), Common Variable Immune Deficiency (also called CVID or Hypogammaglobulinemia), Selective IgA Deficiency, Severe Combined Immune Deficiency (SCID) and many others.
Allergic And Immune Disorders Of The Larynx overzealous response of the immune system to and pemphigoid are idiopathic, autoimmuneepithelial disorders. The primary distinctions between the two entities http://www.bgsm.edu/voice/immune_disorders.html
Extractions: Hypersensitivity and autoimmune diseases of the larynx are uncommon, and they occur when the body overreacts to a foreign substance, or misinterprets part of the self as foreign and mounts an immune attack. Hypersensitivity and autoimmune diseases of the larynx occur with sufficient frequency that the otolaryngologist should be familiar with these conditions. HYPERSENSITIVITY REACTIONS The term hypersensitivity implies an overzealous response of the immune system to an antigenic stimulus. Hypersensitivity reactions include conditions such as allergic rhinitis, contact dermatitis, and urticaria, but these conditions do not produce life-threatening, obstructive edema within the airway. Anaphylaxis, an acute and profoundly life-threatening immunologic allergic response, is made up of a triad of clinical manifestations: (1) flushing, pruritus, and/or urticaria; (2) airway obstruction (angioedema, laryngospasm, and/or bronchospasm); and (3) circulatory collapse (shock).
Extractions: Auto Immune Disorders Find out how you can modulate your immune system to defend against: Allergies, Asthma, Chronic Fatigue, Sinusitis, Rheumatoid Arthritis, Type 1 Diabetes, Fibromyalgia, Crohn's Disease, Lupus, Psoriasis , Eczema. In many cases, these are Auto Immune Disorders. Therapy for these types of disorders should include an immune system "modulator", such as the Transfer Factor. Infectious diseases, such as measles, strep, and staph killed 180,000 loved ones last year. A strong and modulated immune system is your best defense. A new breakthrough product, Transfer Factor Plus , is an immune system modulator. Tested by independent lab, it is 500% more effective than any of the 196 products tested. Some M.D.s are calling it a miracle product. They believe this amazing molecule called "transfer factor" is the answer to the declining state of health in our nation. Transfer Factor Some have recommended that Transfer Factor™ be used in autoimmune conditions. List of autoimmune disorders Neuromuscular system Myasthenia gravis Emos-Lumbert myasthenic syndrome Stiff man syndrome Acute disseminated encephalomyelitis Multiple Sclerosis Gullain-Barre syndrome Chronic inflammatory demyelinating Polyradiculoneuropathy Multifocal motor neuropathy with Conduction block Chronic neuropathy with monoclonal Gammopathy Paraneoplastic neurologic disorders Opsoclonus-myoclonujs syndrome Cerebellar degneration Encephalomyelitis Rectimopathy Hepatobiliary system: Autoimmune chronic active hepatitis
Extractions: Our immune system is the body's defense against infections and other foreign invaders. Infections can result from being exposed to bacteria, viruses, fungi and parasites which are in our environment. Fortunately, most of these invaders never get past the body's natural barriers such as the skin, hair, secretions of the stomach and the mucus linings of the nose and lungs. Occasionally, a few do break through the natural barriers and are confronted by our immune system. The immune system has two major functions: 1. To recognize substances that are foreign to the body, and 2. To react to them. An immune system that is functioning adequately may defend the body from infectious microorganisms (bacteria, viruses, fungi and parasites) and protect the body from the development of tumors and cancer. The two mechanisms within the body that provide these defenses are the specific immune response involving the T cells, B cells and immunoglobulins and the nonspecific responses. Unfortunately, some individuals have a weakened or absent immune system that is unable to recognize and react to foreign substances. The immune system's ability to kill invading microorganisms and limit the spread of infections may not be functioning well.
Extractions: Getting to know your immune system Click here for a larger view A long misunderstood process within the human body, the immune system is much more than meets the eye. A complex network of cells and organs that protect the body against disease, this vital system has many critical functions, not the least of which is fighting harmful infections. Even in the absence of identifiable disease or infection, the immune system is hard at work keeping us healthy. It only takes one simple "mistake" on the cellular level and our defenses against the outside world can break down, exposing us to a multitude of diseases, including allergies, immune deficiency, asthma and even AIDS. The role of the immune system The immune system has two major functions: to recognize substances foreign to the body (antigens) and to react against them. Antigens can vary from microorganisms to cancerous cells. As the immune system strives to keep the body healthy, it is constantly challenged by bacteria, viruses, fungi and more. Without it, the body has no defense against invading microorganisms, resulting in unchecked infectious disease. Sometimes, the immune system can overreact to otherwise harmless substances. For people with allergic disease, this overreaction might be triggered by allergens such as pollen or animal dander, causing runny nose, sneezing, itchy and watery eyes, and a number of other symptoms.
Control Your Allergies & Asthma is great primary and secondary immunodeficiency, rheumatologic diseases, vasculitis,immunologic lung diseases, immunemediated endocrine disorders, immune- http://www.aaaai.org/springallergy/2003/whatis.stm
Extractions: Immunology is the study of the complex and sophisticated immune system. The immune system is a network of cells and organs that work together to defend the body against attacks by "foreign" invaders or germs. The body provides an excellent environment for germs. When they do break into a system, it is the immune system's job to keep them out or to seek and destroy them. Clinical immunologists research new tests and treatments involving allergic and immunologic disorders of the immune system. They work with physicians in general practice and in hospital-based specialties to treat diseases using complex and sophisticated clinical techniques. The science of clinical immunology is a fast developing area of the medical profession. The role of the immunologist is increasingly important, both in laboratory work and in patient care. Prevalence of allergic and immunologic disorders Allergic and immunologic diseases are common chronic conditions that affect 50 million Americans. According to 1994 data from the Centers for Disease Control, over 14 million people suffer from asthma. This number is almost double the rate reported in 1980. Other studies indicate the prevalence of asthma is rising, especially in urban areas, and the mortality rate due to severe asthma is increasing. Approximately 9% of Americans suffer from allergic rhinitis, or hayfever, resulting in almost $4 billion in lost workplace productivity. Additionally, 35 million suffer from chronic sinusitis. There are over 70 forms of primary immunodeficiency, affecting more people than leukemia and lymphoma combined, and an even larger number of autoimmune and other immunologic diseases.
Extractions: IPOPI is an international organization whose members are national patient organizations for the primary immunodeficiencies (PID's). It was formed to benefit and serve its members and patients with primary immunodeficiencies. Its pupose is to unite the experience, expertise, resources and influence of its members in order to achieve worldwide improvement in the care and treatment of patients with PID's.
Canine Dermatology Series: Atopy It is well established that in addition to causing allergic disorders,IgE antibodies are the primary immune defense against parasites. http://www.labbies.com/atopy.htm
Extractions: A Multipart Series Atopy (Environmental Allergies Affecting the Skin) Atopy is a disorder by which dogs have a predisposition for developing antibodies to environmental allergens. Atopy is the most common disorder causing hypersensitive skin reaction in non-flea allergic patients presenting with dermatitis and accounts for up to 70% to 90% of all hypersensitive conditions. As such, atopy is significantly more prevalent than food allergy in the canine, which accounts for up to only 10% to 30% of hypersensitive conditions. Furthermore, although it has been found that up to 10% of dogs with atopy may also have food allergy, up to 80% of the dogs diagnosed with food allergy will also have atopy, thus accounting for the high rate of failure to treat food-allergy patients through manipulation of diet alone. Cause: anaphylactic reactions . Current studies are aimed at exploring the role of IgGd antibodies in the atopic disease process. Symptoms: The most common symptom of atopy is "pruritis" (itching) usually beginning around the face and paws and which may eventually become more diffuse over other areas of the body particularly the ears, the armpits (axillae), the elbows, and the groin. Recurrent ear infections (
Thrombocytopenic Purpura - Blood Disorders Medical Consumer Guide Medical information - primary care health, elective care othersare associated with infection, pregnancy, or immune disorders such as http://www.medicalconsumerguide.com/primary_care/blood_disorders/thrombocytopeni
Extractions: Vision ... Thrombocytopenia Purpura THROMBOCYTOPENIC PURPURA Immune Thrombocytopenic Purpura (ITP) is a disorder of the blood. Immune refers to the immune system's involvement in this disorder. Antibodies, part of the body's immunological defense against infection, attach to blood platelets, cells that help stop bleeding, and cause their destruction. Thrombocytopenia refers to decrease in blood platelet. Purpura refers to the purplish-looking areas of the skin and mucous membranes (such as the lining of the mouth) where bleeding has occurred as a result of decreased platelet. Some cases of ITP are caused by drugs, and others are associated with infection, pregnancy, or immune disorders such as systemic lupus erythematosus. About half of all cases are classified as "idiopathic," meaning the cause is unknown. What are the Symptoms of Immune Thrombocytopenic Purpura?