Renal Agenesis Surveillance -- United States November 10, 1988 / 37(44);679680 685-686 renal agenesis Surveillance United States During 1970-1978, this code was classified only as renal agenesisthe congenital absence of one (unilateral) or both http://www.cdc.gov/epo/mmwr/preview/mmwrhtml/00001301.htm
Extractions: November 10, 1988 / 37(44);679-680,685-686 Newborns with bilateral renal agenesis have low-set, floppy ears, a broad, flat nose, and underdeveloped lungs. These newborns often die of respiratory failure within a few hours of birth. Lungs of infants with at least one functional kidney usually develop normally; thus, unilateral renal agenesis is often not detected during the perinatal period. The cases in this evaluation included 1404 newborns with an ICD code of 753.0. Participating hospitals provided copies of the discharge summary, pathology reports, and x-ray reports. For 966 (69%) of the infants, hospital reports supported the diagnosis of renal agenesis or renal dysgenesis. Of these, 468 (48%) had bilateral renal agenesis, 105 (11%) had one agenic and one dysgenic kidney, 229 (24%) had bilateral renal dysgenesis, 136 (14%) had unilateral renal agenesis, and 28 (3%) had unilateral renal dysgenesis. For the 14-year period 1970-1983, clinical reports of anomalies coded to 753.0 showed the following trends: 1) the annual frequency of bilateral renal agenesis varied considerably but appeared to increase slowly; 2) the prevalence at birth of one agenic and one dysgenic kidney remained constant; 3) the annual frequency of unilateral renal agenesis varied, although the number of infants with this diagnosis was small, and most cases were found incidentally during autopsy; and 4) the incidence of bilateral renal dysgenesis increased 10-fold from 0.03 per 10,000 births in 1970 to 0.33 per 10,000 births in 1983.
Extractions: Abdominal Cardiac Chromosome ... Other INTRODUCTION Renal agenesis anomaly may affect one or both kidneys and has an unknown aetiology. Bilateral renal agenesis (BRA) occurs sporadically but there is some evidence that genetic factors are involved and it is important to screen both parents and siblings. BRA can also occur as part of syndromes such as VATER and branchio-oto-renal syndrome but it is more commonly an isolated finding. BRA occurs more frequently in males (2:1) and is incompatible with life. Unilateral renal agenesis (URA) is much more common than BRA and is associated with some ear and ureteral anomalies.
Extractions: Renal Agenesis Unilateral Renal Agenesis (Arrow) Bilateral Renal Agenesis Bilateral Renal Agenesis (lying down adrenal) (arrowhead) Absence of the fetal kidney on one side with normal appearance of the: kidney on the other side, urinary bladder and amniotic fluid volume. No evidence of a fetal kidney was seen in an ectopic location. In the other two cases, fetal kidneys were not identified, nor was the urinary bladder or amniotic fluid seen. This is a case of unilateral renal agenesis. While this is more common than bilateral renal agenesis, it has little significance to the developing fetus if the contralateral kidney is normal. The majority of this discussion will center on bilateral renal agenesis, which is a lethal fetal and neonatal disease. Bilateral renal agenesis is a rare abnormality of renal development occuring in one to three per 10,000 births. Despite its association with chromosomal, x-linked recessive, autosomal dominant and recessive or non-Mendelian syndromes, it most often occurs without an associated syndrome. Bilateral renal agenesis is 2 to 3 times more common in males than females and is said to carry a recurrence risk of 3% for sporadic cases. A study by Roodhooft et al showed that the frequency of renal malformations in parents and siblings of patients with bilateral or unilateral renal agenesis or renal dysplasia was significantly higher than in a matched control group (9% vs 0.3%) In their review the anomalies often seen were unilateral renal agenesis, double ureters, hydronephrosis, multicystic kidneys and multiple renal cysts. They also noted that approximately 30% of patients with previously affected babies themselves had a "silent" genitourinary malformation.
Renal Agenesis a CHORUS notecard document about renal agenesis Disclaimer. Feedback. Search. renal agenesis. associated with http://chorus.rad.mcw.edu/doc/00464.html
"The Teaching File Case 1" seminal vesicle cysts are associated with ipsilateral renal agenesis. When findings such as this case occur (renal http://www.uab.edu/pedradpath/case1.html
Extractions: Clinical Information: Ten-month-old white male with constipation. A nontender mass is palpated on rectal exam. A. B. IVU: Intravenous urogram (B) demonstrates non-visualization of the left kidney and conpensatory hypertrophy of the right kidney. A mass in the left pelvis indents the bladder. Pelvic ultrasound: A transverse US image (A) reveals a mid to left sided retrovesicular simple cyst with displacement of the urinary bladder anteriorly and to the right. No solid component is seen. C. D. Pathologic specimen: The gross specimen (D) reveals a cystic mass of the left seminal vesicle which was resected with the cyst. Microscopic evaluation (C) revealed a simple cyst with the cyst wall consisting of smooth muscle and fibrous connective tissue with a small amount of stratified squamous epithelium. These findings are typical for a seminal vesicle cyst. Discussion: Seminal Vesicle Cyst with Ipsilateral Renal Agenesis Ipsilateral renal agenesis and cyst of the seminal vesicle are associated due to the common origin of the ureteral bud and seminal vesicle from the mesonephric (Wolffian duct). If an insult occurs approximately at the 12th gestational week, the embryogenesis of the kidney, ureter, seminal vesicle, and vas deferens can be altered.
Extractions: Disease : Renal agenesis, urogenital adysplasia, hereditary, bilateral OMIM number : Body System : Renal disorder Type : Inheritance pattern : Incidence/prevalence : I Population surveyed : Date of survey : Number of cases : Size of population surveyed : Frequency figure (1 in ...) : Frequency figure for females : Method (direct/indirect) : D Reference : Carter CO, Evans K, Pescia G. A family study of renal agenesis. J Med Genet 1979;16:176-188. Comments : Based on necropsy report, the figure may be an underestimate.
Extractions: Disease : Renal agenesis, urogenital adysplasia, hereditary, unilateral OMIM number : Body System : Renal disorder Type : Inheritance pattern : Incidence/prevalence : I Population surveyed : Date of survey : Number of cases : Size of population surveyed : Frequency figure (1 in ...) : Frequency figure for females : Method (direct/indirect) : D Reference : Carter CO, Evans K, Pescia G. A family study of renal agenesis. J Med Genet 1979;16:176-188. Comments : Based on necropsy report, the figure may be an underestimate.
Renal Agenesis Description, clinical features, and management.Category Health Conditions and Diseases renal agenesisrenal agenesis and Hypoplastic Lung Syndrome Vol 2. No. 10 Ande L.Karimu MD PhD. Resident ObGyn Yale New Haven Hospital Renal http://www.hygeia.org/poems22.htm
Extractions: Renal agenesis and hypoplastic lung syndrome are congenital malformations of the neonates involving the kidneys and the lungs respectively i.e. the newborns are born with these disorders. The etiology of these malformations is probably multifactorial i.e. there are both inherited and environmental factors in the causation of the malformations. Oftentime both conditions co-exist as part of multiple congenital malformations. There are two kidneys in the human under normal circumstances. Absence of the kidney could be unilateral or bilateral. If it is unilateral, it means only one kidney is absent. However, if it is bilateral, it means both kidneys are absent. Unilateral absence of the kidneys is compatible with life whereas bilateral absence of the kidneys is incompatible with life.
Renal Agenesis , clinical features, and management. http://hygeia.org/poems22.htm
Extractions: Renal agenesis and hypoplastic lung syndrome are congenital malformations of the neonates involving the kidneys and the lungs respectively i.e. the newborns are born with these disorders. The etiology of these malformations is probably multifactorial i.e. there are both inherited and environmental factors in the causation of the malformations. Oftentime both conditions co-exist as part of multiple congenital malformations. There are two kidneys in the human under normal circumstances. Absence of the kidney could be unilateral or bilateral. If it is unilateral, it means only one kidney is absent. However, if it is bilateral, it means both kidneys are absent. Unilateral absence of the kidneys is compatible with life whereas bilateral absence of the kidneys is incompatible with life.
Pediatric Pathology are absent from the retroperitoneum, and this renal agenesis will result in oligohydramnios, because amniotic fluid is http://www-medlib.med.utah.edu/WebPath/PEDHTML/PED202.html
Extractions: Larry D. Edmonds, M.S.P.H. Levy M. James, M.S. Birth Defects and Genetic Diseases Branch Division of Birth Defects and Developmental Disabilities Center for Environmental Health and Injury Control Summary The Birth Defects Monitoring Program (BDMP) is a national program that monitors congenital malformations by using hospital discharge data concerning newborns. BDMP data for 38 selected malformations were examined for temporal trends. The prevalence at birth of these malformations for the two periods 1979-1980 and 1986-1987 was compared and then grouped into three time-trend categories: increasing greater than or equal to 2% annually, decreasing greater than or equal to 2% annually, and remaining stable. Results showed that 29 malformations had increasing trends, two had decreasing trends and seven remained stable. Follow-up studies are needed to evaluate whether these trends are real or due to improved ascertainment of the respective malformations. INTRODUCTION The BDMP functions primarily as an early warning system; however, it can be useful also for correlating incidence patterns with such trends as the temporal and geographic distribution of drugs, chemicals, and other possible human teratogens. It is one of the few data bases currently available that enables researchers to review long-term trends in the prevalence at birth of congenital malformations in the United States. The current BDMP data base contains data from 1970 to the present on 15 million births that have occurred in 1,200 predominantly mid-sized community hospitals. In 1987, 575,000 births (15% of U.S. births) were monitored. METHODS
Development -- Summaries: Schuchardt Et Al. 122 (6): 1919 Summary of a study titled renal agenesis and hypodysplasia in retk- mutant mice result from defects in ureteric bud development . http://dev.biologists.org/cgi/content/abstract/122/6/1919
Extractions: Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, NY 10032, USA. The c-ret gene encodes a receptor tyrosine kinase that is expressed in the Wolffian duct and ureteric bud of the developing excretory system. Newborn mice homozygous for a mutation in c-ret displayed renal agenesis or severe hypodysplasia, suggesting a critical role for this gene in metanephric kidney development. To investigate the embryological basis of these defects, we characterized the early development of the excretory system in mutant homozygotes, and observed a range of defects in the formation
Fetal Sonogram - Ultrasound Educational Press *For this Demo go to the Genitourinary Tract Heading and click on the case of RenalAgenesis. Amniotic Fluid (Images Only/Unknowns). renal agenesis. Hypospadias. http://www.fetalsono.com/Demo/TeachFilesDemo.html
Extractions: Teaching File Cases *Click on the Organ Systems Below to take you to an Index listing of unknowns and individual cases Ectopic Pregnancy Neural Axis Ovary Multiple Gestations Genitourinary Tract Abdomen Skeletal System Placenta Amniotic Fluid Uterus Thorax Artifacts and Pitfalls For subscribers one can either click on the main heading title and see a group of unknown images or go to an individual case. Oligohydramnios Assessment of Amniotic Fluid Volume Polyhydramnios Herniated Bowel (1st Trimester) Omphalocele Duodenal Atresia Tracheoesophageal Fistula (Esophageal Atresia Echogenic Fetal Bowel Cervical Ectopic Pregnancy Color Doppler Flow Imaging in Ectopic Pregnancy Multicystic Dysplastic Kidney Renal Agenesis Hypospadias Meckel-Gruber Syndrome Acardiac-Acephalic Twin Dichorionic Twins Monochorionic Twins Entangled Cords (Monoamniotic Twins) "Lemon Sign" (Myelomenigocele) Cephalocele Agenesis of the Corpus Callosum Ventriculomegaly / Hydrocephalus Diastematomyelia Ovarian Torsion Endometriosis Dermoid Tumor Abruptio Placenta Entangled Cords (Monoamniotic Twins)
Renal Agenesis renal agenesis. associated with duplicated vagina and/or uterus (mullerianduct anomaly); seminal vesicle cysts. Home Kidney Disclaimer http://chorus.rad.mcw.edu/to-go/00464.html
Renal Agenesis renal agenesis. DESCRIPTION. renal agenesis is the absence of one or bothof the kidneys. Bilateral renal agenesis is invariably fatal. http://www.tdh.state.tx.us/tbdmd/risk/risk22-renal.htm
Extractions: Get an Adobe Acrobat version of this document. Important information about this document. Return to Risk Factor Menu Renal agenesis is the absence of one or both of the kidneys. Bilateral renal agenesis is invariably fatal. Unilateral renal agenesis may be asymptomatic and is often incidentally diagnosed by abdominal ultrasound or computed tomography (CT) scan secondary to another condition. In infants with unilateral renal agenesis, the remaining kidney may be enlarged, and there is increased risk of problems with the remaining kidney. Renal agenesis has been associated with such chromosomal abnormalities as trisomy 21, trisomy 22, trisomy 7, trisomy 10, 45,X mosaicism, and 22q11 microdeletion (Bianchi et al., 2000). Fetal deaths have been reported to account for 10-33% of cases of renal agenesis (Bianchi et al., 2000; Riley et al., 1998; Cunniff et al., 1994). Renal agenesis can be prenatally detected by ultrasound (Bianchi et al., 2000). Thus, in regions where elective termination is allowed, prenatal diagnosis and elective termination may reduce the birth prevalence of renal agenesis (Riley et al., 1998; Sipek et al., 1997; Chi et al., 1995; Papp et al., 1995; Stoll et al., 1995a; Stoll et al., 1995b; Cunniff et al., 1994; Julian-Reynier et al., 1994; Stoll et al., 1992). The metanephric buds begin to develop into kidneys in the fifth week of gestation. If the metanephric buds fail to develop, renal agenesis results.
Health Library - Renal Agenesis, Bilateral renal agenesis, Bilateral. Synonyms Disorder Subdivisions General DiscussionResources Bilateral renal agenesis is the absence of both kidneys at birth. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=
Renal Agenesis Articles, Support Groups, And Resources renal agenesis articles, support groups, and resources for patientsfrom Med Help International (www.medhelp.org). renal agenesis. http://www.medhelp.org/HealthTopics/Renal_Agenesis.html
