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Stiff-person Syndrome: more detail

The Official Patient's Sourcebook on Stiff-Person Syndrome: A Revised and Updated Directory for the Internet Age by Icon Health Publications, 2002-10-10

Stiff Person Syndrome

Stiff person syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Bruno Azevedo, Iuri, MD, PhD Louro, 2005

Rare disease may offer clues to MS. (Moersch-Woltman syndrome): An article from: Inside MS by Phyllis Shaw, 1989-06-22

lists with details

NINDS Stiff-Person Syndrome Information Page
Information sheet compiled by National Institute of Neurological Disorders and Stroke.Category Health Conditions and Diseases stiff-person syndrome More about stiffperson syndrome, Studies with patients, Research literature, Pressreleases, NINDS stiff-person syndrome Information Page Reviewed 05-09-2002
http://www.ninds.nih.gov/health_and_medical/disorders/stiffperson_doc.htm

Extractions: The drug diazepam, which relaxes the muscles, provides improvement in most cases. Baclofen, phenytoin, clonidine, or tizanidine may provide additional benefit. In some patients, immunomodulatory treatments such as intravenous immunoglobulin may be beneficial. Physical and rehabilitation therapy may also be needed. What is the prognosis?
Stiff-Person Syndrome
An article about stiffperson syndrome, a rare progressive neurological disorder.
http://healthlink.mcw.edu/article/921988627.html

Extractions: Subscribe now >> Stiff-person syndrome is a rare progressive neurological disorder characterized by constant painful contractions and spasms of voluntary muscles, particularly the muscles of the back and upper legs. Symptoms may occur gradually, spreading from the back and legs to involve the arms and neck. Symptoms may worsen when the affected individual is anxious or exposed to sudden motion or noise. Affected muscles may become twisted and contracted, resulting in bone fractures in the most severe cases. Individuals with stiff-person syndrome may have difficulty making sudden movements and may have a stiff-legged, unsteady gait. Sleep usually suppresses frequency of contractions. Stiffness may increase and patients may develop a hunched posture (kyphosis) or a swayback (lordosis). Researchers theorize that stiff-person syndrome may be an autoimmune disorder. Other autoimmune disorders such as diabetes, pernicious anemia (a chronic, progressive blood disorder), and thyroiditis (inflammation of the thyroid gland) may occur more frequently in patients with stiff-person syndrome.
STIFF MAN SYNDROME
Web sites devoted to health, nutrition, and fitness. Most of the links below are direct links to pages on stiff person syndrome (SPS, a.k.a.
http://www.stiff-man.org/

Extractions: Stiff Man Syndrome is a neuromuscular condition in which a hyperactive startle reflex results in the contraction of the muscles causing violent spasms. These spasms are capable of slamming the victim into walls and furniture. The disorder's cause is unknown, although evidence is pointing increasingly to the fact that it is an autoimmune disorder. Although they appear completely normal, those afflicted with Stiff-Man Syndrome must avoid any situation where they might be exposed to sudden sounds or stimulation. Often, they remain isolated in their home and excluded from normal living. They are orphaned from society by this rare and ruthless disorder. Use this page to subscribe to the SMS discussion list to receive information and to participate in raising the health professional and public awareness of this rare disease. To Join the Stiff-Man E-mail group: Then to post a message: Send E-mail to: stiffman@gurr.org
Healthlink Template
Drager Syndrome; Sleep Apnea; Soto's Syndrome; Spasticity; SpinaBifida; stiffperson syndrome; Sturge-Weber Syndrome; Sydenham Chorea;
http://healthlink.mcw.edu/search/search-page.php?neurology
NINDS Stiff-Person Syndrome Information Page
More about NINDS stiffperson syndrome Information Page. Content for thispage. NINDS stiff-person syndrome Information Page. Reviewed 05-09-2002.
http://accessible.ninds.nih.gov/health_and_medical/disorders/stiffperson_doc.htm

Extractions: Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Home About NINDS Disorders-you are in this section ... Find People The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury Studies with patients Research literature Press release NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us NINDS Stiff-Person Syndrome Information Page
Stiff-Person Syndrome
stiffperson syndrome. What is stiff-person syndrome? Researchers theorizethat stiff-person syndrome may be an autoimmune disorder.
http://www.clevelandclinic.org/health/health-info/docs/1300/1347.asp?index=6076
Show-documents.asp
New. The Cleveland Clinic, stiffperson syndrome Written Information.Care Treatment. - stiff-person syndrome. New Search1. The
http://www.clevelandclinic.org/health/search/do-query.asp?TopicId=1361
NEJM -- High-Dose Intravenous Immune Globulin For Stiff-Person Syndrome
HighDose Intravenous Immune Globulin for stiff-person syndrome Marinos C. Dalakas,MD, Mavis Fujii, MD, Mian Li, MD, Bashar Lutfi, MD, Joan Kyhos, BSN, and
http://content.nejm.org/cgi/content/short/345/26/1870

Extractions: Marinos C. Dalakas, M.D., Mavis Fujii, M.D., Mian Li, M.D., Bashar Lutfi, M.D., Joan Kyhos, B.S.N., and Beverly McElroy, C.N.R.N. Table of Contents Full Text of this article PDF of this article Editor's Summary ... Alert me when this article is cited ISI Web of Science Related Articles Citing Articles (9) Related Articles in Medline Articles in Medline by Author: Dalakas, M. C. McElroy, B. Medline Citation Neurologic Disease ... ABSTRACT Background Stiff-person syndrome is a disabling central nervous system disorder with no satisfactory treatment that is characterized by muscle rigidity, episodic muscle spasms, high titers of antibodies against glutamic acid decarboxylase (GAD65), and a frequent association with autoimmune disorders. Because stiff-person syndrome is most likely immune-mediated, we evaluated the efficacy of intravenous immune globulin.
NEJM -- High-Dose Intravenous Immune Globulin For Stiff-Person Syndrome
December 27, 2001 HighDose Intravenous Immune Globulin for Stiff-PersonSyndrome. Patients with stiff-person syndrome, a disabling
http://content.nejm.org/cgi/content-tweek/full/345/26/1861-a

Extractions: Patients with stiff-person syndrome, a disabling central nervous system disease with no effective therapy, are plagued by muscle rigidity and episodes of muscle spasm. Patients have high titers of antibodies against glutamic acid decarboxylase (anti-GAD65), suggesting an autoimmune pathogenesis. In this study, 16 patients were randomly assigned to receive either placebo or intravenous immune globulin for three months, followed by a washout period and then three months of therapy with the other agent. Eleven of the 14 patients who completed the study had a marked improvement in their condition with active therapy. Intravenous immune globulin is a safe and effective, though costly, therapy for patients with stiff-person syndrome and anti-GAD65 antibodies.
ClinicalTrials.gov - Linking Patients To Medical Research: Study Details
Cause, Development, and Progression of stiffperson syndrome. This studyis currently recruiting patients. Condition. stiff-person syndrome.
http://www.clinicaltrials.gov/ct/gui/show/NCT00030940?order=1
Annals Of Internal Medicine: Abstract
NIH CONFERENCES The stiffperson syndrome An Autoimmune Disorder AffectingNeurotransmission of -Aminobutyric Acid. Moderator Lucien
http://www.annals.org/issues/v131n7/abs/199910050-00008.html

Extractions: The stiff-person syndrome, a rare and disabling disorder, is characterized by muscle rigidity and episodic spasms that involve axial and limb musculature. Continuous contraction of agonist and antagonist muscles caused by involuntary motor-unit firing at rest are the hallmark clinical and electrophysiologic signs of the disease. Except for global muscle stiffness, results of neurologic examination are usually normal. Results of conventional computed tomography and magnetic resonance imaging of the brain are also normal. The cause of the stiff-person syndrome is unknown; however, an autoimmune pathogenesis is suspected because of 1) the presence of antibodies against glutamic acid decarboxylase (GAD), the rate-limiting enzyme for the synthesis of the inhibitory neurotransmitter -aminobutyric acid (GABA); 2) the association of the disease with other autoimmune conditions; 3) the presence of various autoantibodies; and 4) a strong immunogenetic association. Anti-GAD antibodies, which are found in high titers in most patients, seem to be directed against conformational forms of GAD. New evidence suggests that these antibodies may be pathogenic because they interfere with the synthesis of GABA. In addition, a reduction in brain levels of GABA, which is prominent in the motor cortex, has been demonstrated with magnetic resonance spectroscopy in patients with the stiff-person syndrome.
Health Library - Stiff Person Syndrome
Stiff Person Syndrome. Synonyms Disorder Subdivisions General Discussion Resources Theexact cause of stiffperson syndrome is not known.. Resources.
http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=
Health Library - Stiff Person Syndrome
Stiff Person Syndrome. Synonyms Disorder Subdivisions General Discussion Resources Theexact cause of stiffperson syndrome is not known.. Resources.
http://www.laurushealth.com/library/healthguide/illnessconditions/topic.asp?hwid
WorldMedicus
A description of stiffperson syndrome, the alternate names and a link to articles.
http://www.worldmedicus.com/servlet/Controller/$7006040b416e0000.sj/
ClinicalTrials.gov - Linking Patients To Medical Research: Results
Search results for stiffperson syndrome ALL-FIELDS are shown below. Show alltrials, including those no longer recruiting patients. 2 studies were found.
http://clinicaltrials.gov/search/term=Stiff-Person Syndrome
ACP-ASIM Online - Medicine In Quotations Online
Subject stiffperson syndrome (stiff-man syndrome). Contributor Huth,Edward J. Subject stiff-person syndrome (stiff-man syndrome).
http://www.acponline.org/cgi-bin/medquotes.pl?subject=Stiff-person syndrome (sti
Annals Of Internal Medicine: Table Of Contents
The stiffperson syndrome An Autoimmune Disorder Affecting Neurotransmissionof -Aminobutyric Acid LM Levy, MC Dalakas, and MK Floeter The stiff-person
http://www.acponline.org/journals/annals/05oct99/henney.htm
1Up Health > Health Links Directory > Conditions And Diseases: Neurological Diso
Sites. MCW HealthLink An article about stiffperson syndrome, a rareprogressive neurological disorder. NORD - Stiff Person Syndrome
http://www.1uphealth.com/links/muscle-diseases-stiff-person-syndrome.html

Extractions: The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only they do not constitute endorsements of those other sites.
Searchalot Directory For Stiff-Person Syndrome
Related Web Sites. MCW HealthLink An article about Stiff-personsyndrome, a rare progressive neurological disorder. NORD - Stiff
http://www.searchalot.com/Top/Health/ConditionsandDiseases/NeurologicalDisorders

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GoGuides.Org Directory | Stiff-Person Syndrome
Home Health Fitness Disabilities Disorders Conditions Diseases Nervous System Disorders Neuromuscular Diseases stiffperson syndrome
http://www.goguides.org/index.php/viewCat/13376

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