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Stiff-person Syndrome: more detail

The Official Patient's Sourcebook on Stiff-Person Syndrome: A Revised and Updated Directory for the Internet Age by Icon Health Publications, 2002-10-10

Stiff Person Syndrome

Stiff person syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Bruno Azevedo, Iuri, MD, PhD Louro, 2005

Rare disease may offer clues to MS. (Moersch-Woltman syndrome): An article from: Inside MS by Phyllis Shaw, 1989-06-22

lists with details

Patient 40 Selftest
Patient 40 stiffperson syndrome 1. Which of the following is a diagnosticfeature of the classical stiff-person syndrome? A. rigidity
http://www.bcm.tmc.edu/neurol/challeng/pat40/selftest.html

Extractions: 3. Which of the following electromyographic findings stongly suggests a diagnosis of stiff-person syndrome? A. increased motor unit activity on exercise B. decreased muscle activity or electromyographic silence C. signficant decrement or repetitive nerve stimulation D. increased spontaneous motor unit activity which cannot be abolished on relaxation
Patient 40 Test Answer 4e
Patient 40 Question 4 stiffperson syndrome You are correct. All of the above autoantibodieshave been reported in patients with the stiff-person syndrome.
http://www.bcm.tmc.edu/neurol/challeng/pat40/answer4e.html

Extractions: All of the above autoantibodies have been reported in patients with the stiff-person syndrome. The best evidence for a potential pathogenic role for autoantibodies in the stiff-person syndrome is found in the association with anti-GAD antibodies. Research is ongoing as to whether anti-amphiphysin antibodies may also play a pathogenic role. Antibodies against endocrine glands may coexist with the stiff-person syndrome, and may potentially play a pathogenic role in autoimmune disorders associated with this syndrome. Department of Neurology, Baylor College of Medicine
Stiff-Person Syndrome
The Official Patient's Sourcebook on stiffperson syndrome (Moersch-WoltmannSyndrome; Muscular Rigidity - Progressive Spasm; Stiff Man Syndrome).
http://www.icongrouponline.com/health/Stiff_Person_Syndrome.html

Extractions: (Moersch-Woltmann Syndrome; Muscular Rigidity - Progressive Spasm; Stiff Man Syndrome) Revised and Updated for the Internet Age Paperback Book Order by phone: 800-843-2665 (within USA) 1-201-272-3651 (from outside USA) Electronic File * E-Book version sent via e-mail in 2 business days Electronic File * E-Book version sent via e-mail in 2 business days Pages Price $28.95(USD) ISBN Published Synopsis A comprehensive manual for anyone interested in self-directed research on Stiff Person Syndrome. Fully referenced with ample Internet listings and glossary. Related Conditions/Synonyms Moersch-Woltmann Syndrome; Muscular Rigidity - Progressive Spasm; Stiff Man Syndrome Description Table of Contents Introduction Overview Organization Scope Moving Forward PART I: THE ESSENTIALS Chapter 1. The Essentials on Stiff-Person Syndrome: Guidelines Overview What Is Stiff-Person Syndrome? Is There Any Treatment? What Is the Prognosis? What Research Is Being Done?
The Health Library Nervous System And Brain
Stiff Person Syndrome. stiffperson syndromeNINDS. Stiff-Man SyndromeAmericanAutoimmune Related Diseases Association. Stiff Person SyndromeNINDS.
http://healthlibrary.stanford.edu/resources/internet/bodysystems/nervoussystem2.

Extractions: Diseases and Disorders Use these links to jump directly to your topic of interest: Anatomy Autoimmune Nervous System Diseases Brain Diseases Brain Injury ... Transplantation Nervous System and Brain: Page 1 Page 3 Page 4 Page 5 ... Page 9 Dementias General Information Dementia:MEDLINEplus Forgetfulness:It's Not Always What You Think: National Institute on Aging (NIA) Dementia:Family Caregiver Alliance Mild Cognitive Impairment (NIA Memory Impairment Study):NIA ... Tauopathies: New Discoveries, New Knowledge:NIA Alzheimer's Disease:MEDLINEplus Alzheimer's Disease:National Institute of Mental Health (NIMH) About Alzheimer's Disease:NIA Alzheimer's Disease,Unraveling the Mystery: NIA ... Let's Talk About When Someone You Love Has Alzheimer's Disease:netLibrary [for Kids] Speaking Our Minds : Personal Reflections From Individuals With Alzheimer's:netLibrary Early-Stage Alzheimer's Disease:Family Caregiver Alliance Alzheimer's Disease and Plaques:Society for Neuroscience Interpreting Alzheimer's Abnormalities:Society for Neuroscience ... Early-Onset Familial Alzheimer Disease:GeneReviews, University of Washington See also Senior Health, Alzheimer's Care
The Health Library Immune System
Scleroderma. Fibromyalgia. Sjogren's Syndrome. Grave's Disease. stiffperson syndrome.Guillain-Barre Syndrome. Transverse Myelitis. Goodpasture Syndrome. Uveitis.
http://healthlibrary.stanford.edu/resources/internet/bodysystems/immune3.html

Extractions: Diseases and Disorders Use these links to jump directly to your topic of interest: Acquired Immune Deficiency Syndrome Allergies Autoimmune Diseases General Immune System ... Transplantation Immunology Immune System: Page 1 Page 2 Autoimmune Diseases Autoimmune Diseases (General):MEDLINEplus Understanding Autoimmune Diseases:National Institute of Allergies and Infectious Diseases Frequently Asked Questions About Autoimmunity:American Autoimmune Related Diseases Association Coping With Autoimmunity:American Autoimmune Related Diseases Association ... Autoimmune Disease in Women:American Autoimmune Related Diseases Association Index to Specific Autoimmune Diseases Addison's Disease Immune Thrombocytopenic Purpura Alopecia Areata IgA Nephropathy ... Wegener's Granulomatosis Antiphospholipid Syndrome Antiphospholipid Antibody Syndrome:Aetna InteliHealth Antiphospholipid Syndrome:Women's Health, UK Antiphospholipid Syndrome:American Autoimmune Related Diseases Association Chronic Fatigue Syndrome Chronic Fatigue Syndrome:MEDLINEplus Chronic Fatigue Syndrome:NIAID About Chronic Fatigue and Immune Dysfunction Syndrome:CFIDS Association of America Chronic Fatigue Syndrome:Centers for Disease Control and Prevention ... Chronic Fatigue Syndrome State of the Science Conference (2000):U.S. Dept of Health and Human Services [PDF] Chronic Fatigue Immune Dysfunction Syndrome:American Autoimmune Related Diseases Association Essential Mixed Cryoglobulinemia Essential Mixed Cryoglobulinemia:MedicineNet Cryoglobulinemia:Johns Hopkins Vasculitis Center Essential Mixed Cryoglobulinemia:American Autoimmune related Diseases Association Fibromyalgia
Untitled Document
Unwanted motor unit activation is known to occur in the stiffperson syndrome and,consequently, this syndrome will be the core dysfunction of the course.
http://www.akm.ch/ens2003/programme/teachingCourse_sa.htm
References
Levy LM, Dalakas MC, Floeter M. The stiffperson syndrome an autoimmune disorderaffecting neurotransmission of gamma-aminobutyric acid. Ann Intern Med.
http://www.medscape.com/content/2001/00/41/50/415033/415033_sug.html

Extractions: Suggested Reading for: Case 9: A Woman with Spasms and Stiff Legs Antoine JC, Absi L, Honnorat J, et al. Antiamphiphysin antibodies are associated with various paraneoplastic neurological syndromes and tumors, Arch Neurol. 1999;56:172-177. Barker RA, Revesz T, Thom M, Marsden CD, Brown P. Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity. Neurol Neurosurg Psychiatry. 1998;65:633-640. Brown P, Marsden CD. The stiff man and stiff man plus syndrome. J Neurol. 1999;246: 648-652. Fathallah-Shaykh HM. Paraneoplastic neurological syndromes: paraneoplastic or neurological? Arch Neurol. 1999;56:151-152. Floyd S, Butler MH, Cremona O, et al. Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. Mol Med. 1998;4:29-39. Levy LM, Dalakas MC, Floeter M. The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid. Ann Intern Med. 1999;131:522-530. Murinson BB, Vincent A. Stiff-person syndrome: autoimmunity and the central nervous system. CNS Spectrums. 2001;6:427-433.
References
2001 Medscape Portals, Inc. Table 1. Differential Diagnosis of StiffPersonSyndrome. Peripheral Central stiff-person syndrome. Focal lesions of spinal cord
http://www.medscape.com/content/2001/00/41/50/415033/415033_tab.html

Extractions: Tables for: Case 9: A Woman with Spasms and Stiff Legs Peripheral Central Infectious/toxic causes Classic SPS Paraneoplastic SPS Patient population Sporadic Occult or diagnosed cancer Autoantibody GAD, Other* Amphiphysin, Hu , Gephyrin Disease association Type 1 diabetes mellitus, intractable epilepsy Breast cancer and SCLC Colon cancer, Hodgkin's disease Clinical presentation Increased lumbar lordosis, proximal limb stiffness Upper or lower limb stiffness EMG Continuous motor unit activity (CMUA) Continuous motor unit activity NCS Normal Normal Antimicrosomal, antithyroglobulin, anti-islet cell, and anti-parietal cell antibodies. Anti-Hu antibodies can be seen in a majority of patients with antiampiphysin antibodies and small cell lung cancer (SCLC).
Directory :: Look.com
stiffperson syndrome (4) See Also. Sites. MCW HealthLink An article aboutstiff-person syndrome, a rare progressive neurological disorder.
http://www.look.com/searchroute/directorysearch.asp?p=594583
WebGuest - Open Directory : Health : Conditions And Diseases : Neurological Diso
Sites MCW HealthLink An article about stiff-person syndrome, a rareprogressive neurological disorder. NORD - Stiff Person Syndrome
http://directory.webguest.com/index.cgi/Health/Conditions_and_Diseases/Neurologi
The Infography About Stiff-Man Syndrome
Floeter MK, VallsSole J, Toro C, Jacobowitz D, Hallett M. Physiologic studiesof spinal inhibitory circuits in patients with stiff-person syndrome.
http://www.infography.com/content/865274012491.html

Extractions: Search The Infography: Stiff-Man Syndrome Lorish TR, Thorsteinsson G, Howard FM Jr. Stiff-man syndrome updated. Mayo Clin Proc. 1989 Jun;64(6):629-36. Review. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med. 1990 May 31;322(22):1555-60. Solimena M, De Camilli P. Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus. Trends Neurosci. 1991 Oct;14(10):452-7. Review. Stayer C, Meinck HM. Stiff-man syndrome: an overview. Neurologia. 1998 Feb;13(2):83-8. Review. Folli F, Solimena M, Cofiell R, Austoni M, Tallini G, Fassetta G, Bates D, Cartlidge N, Bottazzo GF, Piccolo G, et al. Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer. N Engl J Med. 1993 Feb 25;328(8):546-51. Butler MH, Hayashi A, Ohkoshi N, Villmann C, Becker CM, Feng G, De Camilli P, Solimena M. Autoimmunity to gephyrin in Stiff-Man syndrome. Neuron. 2000 May;26(2):307-12. Gordon EE, Januszko DM, Kaufman L. A critical survey of stiff-man syndrome. Am J Med. 1967 Apr;42(4):582-99. Review.
Mary Kay Floeter, Electromyography Section, NINDS
Sandbrink F, NA Syed, M Fujii, MC Dalakas, and MK Floeter (2000) Motorcortex excitability in stiffperson syndrome, Brain 123, 2231-2239 .
http://intra.ninds.nih.gov/Lab.asp?Org_ID=97
Ivanhoe's Medical Breakthroughs - Discussion Groups
wkhazen03@cox.net 03/17/03; stiffperson syndrome - judy nicol 03/06/03» RE stiff-person syndrome dschaerer@hotmail.com 03/07/03;
http://www.ivanhoe.com/discussion/p_discussion.cfm?forumID=84&action=msglist
Stiff-man Syndrome
NLM Medline definition of stiffperson syndrome A condition characterized by persistentspasms (SPASM) involving multiple muscles, primarily in the lower
http://www.ion.ucl.ac.uk/library/patient/stiff.htm

Extractions: Stiff-Man Syndrome NLM Medline definition of stiff-person syndrome: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advance cases. Pubmed Medline search on stiff-man syndrome
Cleveland Clinic Health System - Health Information
Search Results The following information is available for the topic StiffPersonSyndrome. Please select one. , stiff-person syndrome. New Search.
http://www.cchs.net/health/getcontents.asp?DocID=do-query&TopicId=1361
Cleveland Clinic Health System - Health Information
, Stenosis, Spinal. , Steroids. -, Steroids, Anabolic. -, stiff-person syndrome.-, Stomach Cancer (Gastric Cancer). -, Strep Throat. -, Stress Management. -, StressTest.
http://www.cchs.net/health/getcontents.asp?DocID=do-query&txtChar=S
Neuromuscular Diseases
stiffperson syndrome About stiff-person syndrome - NINDS (US); StiffmanSyndrome Foundation Geilman family - (US); Stiff-man Syndrome
http://www.mic.ki.se/Diseases/c10.668.html

Extractions: Motor Neuron Disease Lower and Upper Motor Neuron Disorders - Merck Manual Motor Neuron Awareness S Killeen ] - (IE) Clinical Features of Motor Neuron Disease - Bethlehem Health Care, Inc. (AU) Motor Neuron Disease and Animal Models - WUSTL (US) About Primary Lateral Sclerosis - NINDS/NIH (US) Primary Lateral Sclerosis F Reyerse Primary Lateral Sclerosis (PLS) C Armon ] - eMedicine A question + answer re Primary Lateral Sclerosis by the experts at MDA A two pages Open letter to Dr. Prahl about his anti-PLS drug C-3036
Zeal.com - United States - New - Personal - Health - Conditions & Illnesses - Br
Add a Site Profile. 1. Cleveland Clinic stiff-person syndrome http//www.clevelandclinic.org/health/health-info/docs/1300/
http://www.zeal.com/category/preview.jhtml?cid=274722
IM Abstract 40-9 Case 20
stiffperson syndrome Associated with Cerebellar Ataxia and High GlutamicAcid Decarboxylase Antibody Titer Satoshi Kono, Hiroaki
http://www.naika.or.jp/im/im40/ab40-9/c400920.html

Extractions: Stiff-person Syndrome Associated with Cerebellar Ataxia and High Glutamic Acid Decarboxylase Antibody Titer Satoshi Kono, Hiroaki Miyajima, Masahiro Sugimoto, Yoji Suzuki, Yoshitomo Takahashi and Akira Hishida From the First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu Glutamic acid decarboxylase (GAD) is the main target of humoral autoimmunity in patients with insulin-dependent diabetes mellitus (IDDM) and stiff-person syndrome. We reviewed the case of a 46-year-old woman who had cerebellar ataxia before getting stiff-person syndrome and IDDM with high anti-GAD autoantibody titers. This was a rare case in which there were both the clinical symptoms of stiff-person syndrome and cerebellar ataxia. In western blot analysis her serum reacted with 65-kDa proteins from rat cerebellum, cerebral cortex, and spinal cord. Autoantibodies to GAD may cause functional impairment of Á-aminobutyric acid (GABA) neurons in the spinal cord as well as in the cerebellum.
Stiff-Person Syndrome Website Results :: Linkspider UK
stiffperson syndrome Websites from Linkspider UK. Keyword Stiff-PersonSyndrome. Linkspider UK Directory stiff-person syndrome Search for.
http://www.linkspider.co.uk/Health/ConditionsandDiseases/NeurologicalDisorders/M

Extractions: See Also: Health: Conditions and Diseases: Neurological Disorders: Spinal Cord Health: Conditions and Diseases: Rare Disorders MCW HealthLink - An article about Stiff-person syndrome, a rare progressive neurological disorder. NORD - Stiff Person Syndrome - Offers synonyms, a general discussion and further resources. WorldMedicus - A description of Stiff-Person syndrome, the alternate names and a link to articles. Stiff-Person Syndrome - Information sheet compiled by National Institute of Neurological Disorders and Stroke.

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