Geometry.Net - Health_Conditions: Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
systemic lupus erythematosus (SLE) is an autoimmune illness that causes a characteristicrash accompanied by inflammation of connective tissue, particularly
http://www.gnc.com/health_notes/Concern/Lupus.htm

Extractions: Systemic Lupus Erythematosus Also indexed as: Discoid Lupus Erythematosus (DLE), DLE, Lupus, SLE Systemic lupus erythematosus (SLE) is an autoimmune illness that causes a characteristic rash accompanied by inflammation of connective tissue, particularly joints, throughout the body. In autoimmune diseases, the immune system attacks the body instead of protecting it. Kidney, lung, and vascular damage are potential problems resulting from SLE. The cause of SLE is unknown, though 90% of cases occur in women of childbearing age. Several drugs, such as procainamide, hydralazine methyldopa , and chlorpromazine, may create SLE-like symptoms. Similarly, environmental pollution and industrial emissions may also trigger SLE-like symptoms in some people. In one reported case, zinc supplementation appears to have aggravated drug-induced SLE. Ultraviolet radiation from sun exposure is a commonly recognized trigger of lupus. Some chemicals found in dyes, such as hydrazine and tartrazine
Ask NOAH About: Lupus (Systemic Lupus Erythematosus)
Lupus Foundation DrugInduced Lupus Erythematosus - MEDLINEplus Rheumatology Drug-InducedLupus - Virtual Hospital systemic lupus erythematosus Handout on
http://www.noah-health.org/english/illness/arthritis/lupus.html

Extractions: Lupus and Children ... Information Resources Lupus and Children Lupus and Teens Lupus and Gender Lupus and Race/Ethnicity The Many Shades of Lupus - National Institute of Arthritis and Musculoskeletal and Skin Diseases What Black Women Should Know About Lupus - National Institute of Arthritis and Musculoskeletal and Skin Diseases What Hispanic Women Need to Know About Lupus - The S.L.E. Foundation
Medic-Planet Systemic Lupus Erythematosus
systemic lupus erythematosus Advertisement See also Anemias, Arrhythmias, Autoimmunediseases, Bleeding and bruises, Congenital heart defects, Embryo, Heart
http://www.medic-planet.com/MP_article/internal_reference/Systemic_lupus_erythem
Medic-Planet Systemic Lupus Erythematosus
systemic lupus erythematosus Advertisement See also Anemias, Arrhythmias, Autoimmunediseases, Bleeding and bruises, Congenital heart defects, Embryo, Heart
http://www.medic-planet.com/MP_article/internal_reference/systemic_lupus_erythem
ThirdAge - Adam - Systemic Lupus Erythematosus
systemic lupus erythematosus. Definition A chronic, inflammatoryautoimmune disorder that may affect many organ systems including
http://www.thirdage.com/health/adam/ency/article/000435.htm

Extractions: document.write(''); document.write(''); document.write(''); document.write(''); document.write(''); document.write(''); document.write(''); document.write(''); Activities Computers Family Tree Health ... Prevention Definition: A chronic, inflammatory autoimmune disorder that may affect many organ systems including the skin, joints, and internal organs. Causes, incidence, and risk factors: Normally the immune system controls the body's defenses against infection. In systemic lupus erythematosus (SLE) and other autoimmune diseases , these defenses are turned against the body when antibodies are produced against its own cells. These antibodies fight against the body's blood cells, organs, and tissues, causing chronic diseases. The mechanism or cause of autoimmune diseases is not fully known.
Systemic Lupus Erythematosus -- ECureMe.com
systemic lupus erythematosus, more about systemic lupus erythematosus, Normal,Abnormal, Abnormal. more about systemic lupus erythematosus, ..
http://www.ecureme.com/emyhealth/data/Systemic_lupus_erythematosus.asp

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Systemic Lupus Erythematosus
MAIN SEARCH INDEX systemic lupus erythematosus. systemic lupus erythematosus. In Harrison's Principles of Internal Medicine, ed. Anthony S. Fauci, et al.
http://www.hendrickhealth.org/healthy/001323.htm

Extractions: Systemic lupus erythematosus (SLE) is an autoimmune disease in which the individual's immune system attacks, injures, and destroys the body's own organs and tissues. Nearly every system of the body can be affected by SLE, as depicted in the illustration above. (Illustration by Electronic Illustrators Group.) Systemic lupus erythematosus (also called lupus or SLE) is a disease where a person's immune system attacks and injures the body's own organs and tissues. Almost every system of the body can be affected by SLE. The body's immune system is a network of cells and tissues responsible for clearing the body of invading foreign organisms, like bacteria, viruses, and fungi. Antibodies are special immune cells that recognize these foreign invaders, and begin a chain of events to destroy them. In an autoimmune disorder like SLE, a person's antibodies begin to recognize the body's own tissues as foreign. Cells and chemicals of the immune system damage the tissues of the body. The reaction that occurs in tissue is called inflammation. Inflammation includes swelling, redness, increased blood flow, and tissue destruction. In SLE, some of the common antibodies that normally fight diseases are thought to be out of control. These include antinuclear antibodies and anti-DNA antibodies. Antinuclear antibodies are directed against the cell's central structure that contains genetic material (the nucleus). Anti-DNA antibodies are directed against the cell's genetic material. DNA is the chemical substance that makes up the chromosomes and genes.
NIH Guide: NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS
NEUROPSYCHIATRIC systemic lupus erythematosus Release Date July 17, 2001 RFARFAAR-01-007 National Institute of Arthritis and Musculoskeletal and Skin
http://grants.nih.gov/grants/guide/rfa-files/RFA-AR-01-007.html

Extractions: NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS Release Date: July 17, 2001 RFA: RFA-AR-01-007 National Institute of Arthritis and Musculoskeletal and Skin Diseases Letter of Intent Receipt Date: November 2, 2001 Application Receipt Date: December 14, 2001 THIS RFA USES "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. USE THE MODULAR BUDGET INSTRUCTIONS THAT BEGIN ON PAGE 13 IN THE PHS 398 (REVISION 5/2001) AVAILABLE AT http://grants.nih.gov/grants/funding/phs398/phs398.pdf http://www.nih.gov/niams/reports/reportnmsle.htm . HEALTHY PEOPLE 2010 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS- led national activity for setting priority areas. This RFA is related to one or more of the priority areas. Potential applicants may obtain "Healthy People 2010" at http://www.health.gov/healthypeople http://www.nih.gov/niams/clinical/dsmb3.html ). R01 Applications. The individual research grant (R01) is a specific, circumscribed project to be performed by the named investigator(s) who has a specific interest and competency in an area of interest to this RFA. The total project period for an R01 application submitted in response to this RFA may not exceed 5 years. Future unsolicited competing continuation applications will compete with all investigator-initiated applications and be reviewed according to the customary peer review procedures. Because the nature and scope of the research proposed in response to this RFA may vary, it is anticipated that the size of an R01 award will vary also. Modular budgeting procedures apply for grants up to $250,000. Specific R01 application instructions have been modified to reflect "modular grant" and "just-in-time" streamlining efforts. Complete instructions and information on modular grants can be found at
NIH Guide: SYSTEMIC LUPUS ERYTHEMATOSUS IN WOMEN AND MINORITIES
Full Text AR93-006 systemic lupus erythematosus IN WOMEN AND MINORITIES NIH GUIDE,Volume 22, Number 1, January 8, 1993 RFA AR-93-006 PT 34, FF, II Keywords
http://grants.nih.gov/grants/guide/rfa-files/RFA-AR-93-006.html
Handbook Of Ocular Disease Management - Systemic Lupus Erythematosus
systemic lupus erythematosus. Malar rash on a patient with systemiclupus erythematosus. 1. Haskes LP. systemic lupus erythematosus.
http://www.revoptom.com/handbook/oct02_sec7_1.htm

Extractions: Systemic Lupus Erythematosus Malar rash on a patient with systemic lupus erythematosus. Signs and Symptoms: Systemic lupus erythematosus (SLE) commonly presents in young and middle-aged women, who comprise up to 90% of all SLE sufferers. SLE is three times more common in blacks than in other races, and Asians display an increased incidence of SLE vs. Caucasians. Patients suffer chronic relapses and an unpredictable course secondary to a hyperactive immune system and excessive autoantibody production. Because lupus affects many organ systems, it creates a diverse clinical picture including erythematosus rash, polyarthralgia and arthritis, anemia, and cardiac, renal and neurologic abnormalities. Renal failure is a major cause of death in those suffering from severe, chronic SLE. The skin changes associated with SLE are described as a butterfly rash, often the primary manifestation of SLE. Ocular manifestations, which occur in up to 20% of SLE patients, also may be the initial presenting sign, and may precede systemic signs or symptoms by several months.
Adult Health Advisor 2002.1: Systemic Lupus Erythematosus
systemic lupus erythematosus. What is systemic lupus erythematosus (SLE)?systemic lupus erythematosus (SLE) is an autoimmune disease.
http://www.med.umich.edu/1libr/aha/aha_lupus_crs.htm

Extractions: T his information is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. McKesson Clinical Reference Systems: Adult Health Advisor 2002.1 Systemic lupus erythematosus (SLE) is an autoimmune disease. This means that your body's defenses against infection are attacking your own tissue. This causes inflammation. Areas of the skin or joints become painful, red, and swollen. Other parts of the body can also become inflamed, including the muscles, kidneys, nervous system, blood, lungs, and heart. SLE, also called lupus, is a serious, chronic disease, which means it never goes away completely. Some people have severe, even fatal, cases of lupus, but for most people symptoms can be controlled. Lupus affects mainly young women, particularly black women in the US, West Indian women, and Chinese women. Cutaneous lupus (also called discoid lupus) is a form of lupus that affects the skin only. It is milder and more common than SLE.
Diagnostic Clinic Of Houston - Systemic Lupus Erythematosus
systemic lupus erythematosus. WHAT IS systemic lupus erythematosus? Systemiclupus erythematosus (SLE) is an autoimmune disease of unknown cause.
http://www.diagnosticclinic.com/health/lupus.html

Extractions: WHAT IS SYSTEMIC LUPUS ERYTHEMATOSUS? Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown cause. The disease is characterized by inflammation and disordered function of potentially many different body parts. Antibodies formed against various cell parts are seen in this disease. These antibodies may take a direct part in the abnormalities seen by directly injuring cells and organs, or by participating in protein complexes, which can be deposited in organs to cause dysfunction. Sometimes these antibodies "sensitize" cells so that the host (patient) sees a "foreign" cell and begins an attack, essentially on herself/himself. Sometimes blood vessels can become involved in the autoimmune process, so that the organs these blood vessels supply can be damaged. WHO DEVELOPS SLE? SLE is primarily a disease of young women. Most cases occur during child-bearing years, and , in fact, SLE may be made worse by pregnancy. Men may also develop SLE, but in an incidence 5 times lower than women. SLE may occur in children, as well. There is even neonatal lupus occurring at birth (in children born to mothers with SLE or mothers with certain antibodies.) There is also most likely a hereditary predisposition to SLE, which we have seen by studying families and siblings with the disease. However, the exact gene involved (if there is one) is not known. WHAT ARE THE MANITFESTATIONS OF SLE?
Systemic Lupus Erythematosus
Table of Contents Conditions systemic lupus erythematosus, Systemiclupus erythematosus (SLE) is the most common form of lupus.
http://www.healthandage.com/html/res/com/ConsConditions/SystemicLupusErythematos

Extractions: Table of Contents Conditions Systemic Lupus Erythematosus Also Listed As: Signs and Symptoms What Causes It? Who's Most At Risk? What to Expect at Your Provider's Office ... Supporting Research Lupus usually first affects people between the ages of 15 and 45 years, but it can also occur in childhood or later in life. Patients experience periods of chronic disease and remission. The prevalence of the disease is not precisely known, ranging from an estimated 15 to 50 cases per 100,000 people. Signs and Symptoms Lupus is often accompanied by the following signs and symptoms. What Causes It? The cause of lupus is unknown. Researchers believe that there is probably no single cause but rather a combination of genetic, environmental, and possibly hormonal factors that work together. Who's Most At Risk?
Systemic Lupus Erythematosus
systemic lupus erythematosus. WHAT IS systemic lupus erythematosus? Systemiclupus erythematosus is a chronic, often lifelong, autoimmune
http://www.ucdmc.ucdavis.edu/ucdhs/health/a-z/63SystemicLupus/doc63.html

Extractions: Systemic lupus erythematosus is a chronic, often life-long, autoimmune disease that ranges from mild to severe and afflicts mostly women. Systemic lupus erythematosus (SLE) may affect widespread sites, but it most often manifests in the skin, joints, blood, and kidneys. SLE was first described in 1828. Its very name helps define the disease:
WHAT ARE SPECIFIC AGENTS USED FOR SEVERE SYSTEMIC LUPUS ERYTHEMATOSUS?
WHAT ARE SPECIFIC AGENTS USED FOR SEVERE systemic lupus erythematosus? Corticosteroids. TREATMENTSFOR SOME COMPLICATIONS OF systemic lupus erythematosus.
http://www.ucdmc.ucdavis.edu/ucdhs/health/a-z/63SystemicLupus/doc63agents2.html

Extractions: Severe SLE is treated with corticosteroids, also called steroids, which suppress the inflammatory process, and help relieve many of the complications and symptoms, including anemia and kidney involvement. Oral prednisone (Deltasone, Orasone) is usually prescribed. Other agents include methylprednisolone (Medrol, Solumedrol), hydrocortisone, and dexamethasone (Decadron). Some people need to take oral prednisone for only a short time; others may require it for long durations. An intravenous administration of methylprednisolone using "pulse" therapy for three days is proving useful for flare-ups in the joints. Combinations with other drugs, particularly immunosuppressants, may be beneficial.
NINDS Neurological Sequelae Of Lupus Information Page
Information sheet compiled by National Institute of Neurological Disorders and Stroke.Category Health Conditions and Diseases Connective Tissue Lupus NINDS Neurological Sequelae Of Lupus Information Page Synonym(s) Lupus Neurological Sequelae, systemic lupus erythematosus Reviewed 07-01-2001
http://www.ninds.nih.gov/health_and_medical/disorders/lupus_doc.htm

Extractions: Lupus (also called systemic lupus erythematosus or SLE) is a disorder of the immune system which normally functions to protect the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the patient's own tissues. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person, and the disease can range from mild to life-threatening. Typical features of lupus include a butterfly shaped rash over the cheeks, a skin rash appearing in areas exposed to the sun, sores in the mouth and nose, arthritis involving one or more joints, kidney inflammation, neurological disorders such as headaches, personality changes, organic brain syndrome, peripheral neuropathies, sensory neuropathy, psychological problems including paranoia, mania, and schizophrenia, seizures, transverse myelitis, and paralysis and stroke. Fever, weight loss, hair loss, poor circulation in the fingers and toes, chest pain when taking deep breaths, and abdominal pain may also occur.
Systemic Lupus Erythematosus
systemic lupus erythematosus. This may be the first time you have seenor read anything about lupus. We hope that this pamphlet helps
http://www.rheumatology.org.nz/nz08010.htm

Extractions: This may be the first time you have seen or read anything about lupus. We hope that this pamphlet helps you to understand this bewildering disease a little better. Lupus is a disease which can affect joints, muscles and other parts of the body. Because of this it belongs to the family of rheumatic diseases and in New Zealand. people with lupus are often treated by a Rheumatologist. However, lupus can also affect the skin. kidneys, lungs, heart, nervous system and blood and in particular the immune system. Lupus is often described as an auto-immune disease. This means that for some reason people with lupus seem to develop antibodies (which usually fight bacteria and viruses) that attack healthy tissue instead. This produces inflammation in different parts of the body resulting in pain and swelling. Lupus is a chronic disease which means that it lasts a long time. However, different symptoms of the disease may come and go. When the disease seems to go away we say that it is in remission; when it comes back we call it a flare. Some people have remissions which last for several vears. HOW SERIOUS IS LUPUS?
Systemic Lupus Erythematosus
systemic lupus erythematosus, systemic lupus erythematosus (SLE) isthe most common form of lupus. Lupus is an autoimmune disease
http://www.ivillagehealth.com/library/onemed/content/0,,241012_245889,00.html

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EMJA: Godfrey & Ryan, Systemic Lupus Erythematosus: Current Management
Editorial systemic lupus erythematosus current management. A long term study of hydroxychloroquinewithdrawal on exacerbations in systemic lupus erythematosus.
http://www.mja.com.au/public/issues/175_03_060801/godfrey/godfrey.html

Extractions: Systemic lupus erythematosus is an autoimmune disease that may affect many organs, especially the skin, musculoskeletal, vascular and renal systems. It occurs predominantly in women of childbearing age, but also affects people in their sixth decade or older. In these patients, female predominance is less marked and renal disease less common. The natural history of the disease has changed over the past 20-30 years; survival rates have increased from 50% at five years in the 1950s to 80%-90% at 10 years in the 1990s. The explanations for this improvement include earlier diagnosis, recognition of milder disease, advances in medical therapy, and better supportive care, including renal replacement therapy. Despite these advances, the standardised mortality ratio for lupus remains at 3. Morbidity and mortality rates are bimodal, with early events related to disease activity or infection and later events often due to premature vascular disease such as stroke and myocardial ischaemia. Currently, minor manifestations of systemic lupus erythematosus (cutaneous, musculoskeletal, fatigue) are managed with non-steroidal anti-inflammatory drugs (NSAIDs), antimalarial drugs (particularly hydroxychloroquine) and low-dose corticosteroids. The selective COX-2 inhibitors, celecoxib (a sulfonamide) and rofecoxib, are now available in Australia. With their lower gastrointestinal toxicity, they represent a significant advance. Patients with lupus, however, have a high prevalence of sulfonamide allergy (20% in some studies) and 30%-50% have antiphospholipid antibodies, which are associated with arteriovenous thrombosis and miscarriages (the antiphospholipid syndrome). Case reports of thrombotic events in patients with antiphospholipid antibodies taking COX-2 inhibitors necessitate judicious use of these drugs until further data are available.
LookSmart - Systemic Lupus Erythematosus Or SLE
systemic lupus erythematosus or SLE Resources on the cause, symptoms, diagnosisand treatment of lupus. Includes lupus forums and clubs. Featured Sponsors.
http://www.looksmart.com/eus1/eus317837/eus317920/eus53948/eus217275/eus931705/e

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