Product Description
What would it be like to navigate this life under the shadow of a deadly disease? How would you cope, both physically and psychologically? Approximately 30,000 people in our country live with the devastating illness, cystic fibrosis, and one in twenty Caucasians are carriers of its gene. Many among us are affected by CF, but few really know much about it.

David's Promise delivers an in-depth examination of a young man's life-long confrontation with cystic fibrosis. Through the fictional main character of David, the reader is given a deeply personal chance to experience love's ultimate triumph over illness.

The story explores all the complexities of David's life, and as each layer unfolds, the reader begins to look beyond David's medical diagnosis and into his heart. The young man is a teacher with a pregnant wife and a whole slew of struggles, including the implications of genetic testing, the question of abortion, and denial of medical insurance coverage in this country.

This novel does not pull any punches concerning the stark realities of cystic fibrosis, yet it was written to offer hope and understanding about an often hopeless and misunderstood disease.

AUTHOR BIO: Kathy Howell resides in southern New Mexico with Jack, her husband of thirty years. She is the mother of two adult sons, one who lives with cystic fibrosis. Kathy has also worked in the arena of Early Childhood Education for a large portion of her life.

When not writing, Kathy enjoys swimming, tennis and hiking. She received her B.A. and M.A.T. from Western New Mexico University. This is Kathy's first novel. ... Read more

Customer Reviews (1)

A Beautiful First Novel
I expected to like this book, but was surprised to find it so engaging, heart-warming and heart-wrenching.The main character is a disease.No other antagonist is needed.A lot of education is packed into the pages.I appreciated that and so will anyone who knows someone with CF.However I loved the story and the care with which the details were written.The struggles of the patient, his mother, his father, and others are alternately explored and given surprising depth in a few short pages.I couldn't put it down!

What a great launching pad for future work.I look forward to reading her next novel. ... Read more

Product Description
This digital document is an article from Pediatric News, published by International Medical News Group on December 1, 2003. The length of the article is 586 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Meropenem combo better for CF exacerbations: but advantages are short term.(Infectious Diseases)(cystic fibrosis)
Author: Bruce Jancin
Publication: Pediatric News (Magazine/Journal)
Date: December 1, 2003
Publisher: International Medical News Group
Volume: 37Issue: 12Page: 12(1)

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This digital document is an article from Pediatric Nursing, published by Thomson Gale on July 1, 2005. The length of the article is 3895 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: The effects of massage therapy in improving outcomes for youth with cystic fibrosis: an evidence review.(Evidence-Based Practice)
Author: Myra Martz Huth
Publication: Pediatric Nursing (Magazine/Journal)
Date: July 1, 2005
Publisher: Thomson Gale
Volume: 31Issue: 4Page: 328(5)

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Customer Reviews (2)

Excellent book giving a family perspective on coping with CF
Cloyce Jones is clearly a remarkable woman. She has a strength that most of us can only dream of. This book portrays her family's lives as they cope with death, illness and then the happiness that the birth of healthy child and eventually a successful lung tranplant for Tara bring. With CF it is often one challenge after another but this family found unending courage to battle on. I was saddened by the extra stress caused to a sick child by insurance rules that meant they had to travel hundreds of miles to retain their coverage. It was however warming to read of the joy that the 'Wish Upon a Star Foundation' was able to bring.

Bob Derr, author of "Burke's Tour"
I appreciate the willingness of the author to share this remarkable story -- it creates additional awareness of the disease and generates funds to help researchers find beneficial treatments and a cure for this disease.Our son, Burke (who died due to CF in 1997), would very much have appreciated the family emphasis here. ... Read more

Product Description
Cystic fibrosis (CF) is a complex multisystemic disease requiring specialized care. It is characterized by progressive pulmonary decline, with intermittent worsening of lung function, often called pulmonary exacerbations. Eighty-five percent of all deaths from CF are a result of pulmonary disease, and pulmonary exacerbations are associated with decline in lung function. Treating pulmonary exacerbations requires a multifaceted approach and includes a multidisciplinary team composed of a physician, nurse, respiratory therapist, physical therapist, and nutritionist. Recently, the Cystic Fibrosis Foundation published guidelines addressing the comprehensive treatment of pulmonary exacerbations. This article outlines the treatment goals established by these guidelines, including the evaluation and treatment of comorbid conditions (eg, CF-related diabetes) and serious complications associated with CF exacerbations (eg, pneumothorax). Proper treatment of pulmonary exacerbations in CF patients will continue to improve their health and quality of life. ... Read more

Product Description
This digital document is an article from Human Biology, published by Wayne State University Press on August 1, 1995. The length of the article is 3818 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: Examination of the European geographic patterns of the 10 relatively most frequent cystic fibrosis mutations, other than the DF508 one, shows that a founder effect is apparent for a number of them. The most evident examples are for the W1282X mutation in Jews, with a probable Asian origin, and the G551D and R117H mutations in Celts. Geographic distributions indicate that the main focus of the 621 + I G [right arrow] T and DI507 mutations is probably located in Wales. Also, the R1162X mutation probably originates from a circumscribed north Italian region. The N1303K mutation has a wide range in Europe with a clear preponderance in southern countries. Even the relatively common G542X and 1717.1 G [right arrow] A mutations have a local preponderance in Spain and Sicily and in northern Italy, respectively. Likelihood estimates for recurrent mutation and identity by descent strongly support the hypothesis of recurrence for the (mainly German) mutation R553X.

Citation Details
Title: Geographic and ethnic distributions of the more frequent cystic fibrosis mutations in Europe show that a founder effect is apparent for several mutant alleles.
Author: Gerard Lucotte
Publication: Human Biology (Refereed)
Date: August 1, 1995
Publisher: Wayne State University Press
Volume: v67Issue: n4Page: p561(16)

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Product Description
This up-to-date electronic book on CD-ROM provides the best collection available anywhere of official Federal government information and documents on the subject of cystic fibrosis. This CD-ROM uses next-generation search technology that allows complete indexing and makes all files on the disc fully searchable. For patients, practical information is provided in clearly written patient education documents. For medical professionals, doctor reference tools and texts have detailed technical information and clinical background material.

This thoroughly researched collection presents vital information from many authoritative sources: National Institutes of Health (NIH), Centers for Disease Control (CDC), Food and Drug Administration, National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of General Medical Sciences (NIGMS). Contents include clinical and medical information, with information on signs, symptoms, nutrition, testing, diagnosis, treatment, and more.

In addition, as a bonus we have included an encyclopedic collection of general medical and health documents – thousands of pages with extensive material from the CDC and NIH on hundreds of diseases and health topics from A to Z, along with FDA drug and medical publications, government consumer healthcare tips, disease prevention programs, dietary guidelines, and travelers’ health information. Since navigating the Internet to find additional non-governmental medical information can be confusing, we've also provided our exclusive "Guide to Leading Medical Websites" with updated links to 73 of the best sites for medical information! By using weblinks on the CD-ROM, you can quickly check for the latest clinical updates directly from the government.

This CD-ROM has over 30,000 pages reproduced using Adobe Acrobat PDF software and Reader software is included. Advanced search and indexing features are built into our reproduction, providing a complete full-text index. This enables the user to search all the files on the disk at one time for words or phrases using just one search command! The Acrobat cataloging technology adds enormous value and uncommon functionality to this impressive collection of government documents and material. There is no other reference that is as fast, convenient, comprehensive, and portable!

Our CD-ROMs are privately-compiled collections of official public domain U.S. government files and documents - they are not produced by the federal government. They are designed to provide a convenient user-friendly reference work, utilizing the benefits of the Acrobat format to uniformly present thousands of pages that can be rapidly reviewed or printed without untold hours of tedious searching and downloading. This book-on-a-disc makes a superb reference work and educational tool for patients and their families, physicians, and other medical professionals. (Information on this CD-ROM is NOT a substitute for professional medical advice; of course, readers are urged to consult with a professional health care provider for any suspected illness.) ... Read more

Product Description
This digital document is an article from Family Practice News, published by International Medical News Group on October 1, 2003. The length of the article is 492 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Four treatments have major impact on infants with CF: nutrition is the key.(Children's Health cystic fibrosis)
Author: Timothy F. Kirn
Publication: Family Practice News (Magazine/Journal)
Date: October 1, 2003
Publisher: International Medical News Group
Volume: 33Issue: 19Page: 68(1)

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Product Description
This up-to-date and comprehensive set of two CD-ROM discs provides a superb collection of official Federal government documents on the subject of cystic fibrosis. Cystic fibrosis (CF) is an inherited disease of the mucus and sweat glands. It affects mostly your lungs, pancreas, liver, intestines, sinuses and sex organs. CF causes your mucus to be thick and sticky. The mucus clogs the lungs, causing breathing problems and making it easy for bacteria to grow. This can lead to problems such as repeated lung infections and lung damage.For patients, practical information is provided in clearly written patient education documents. For medical professionals, doctor reference tools and texts have detailed technical information and clinical background material. There is no other reference that is as fast, convenient, and portable - everything you need to know, from the federal sources you trust. This thoroughly researched collection presents vital information from many authoritative sources: Food and Drug Administration (FDA), Centers for Disease Control (CDC), National Institutes of Health (NIH) and the relevant institute for this disease, and others.In addition to the comprehensive disease-specific coverage, this disc set also includes our Medical Encyclopedia, a $19.95 value! The Encyclopedia presents a collection of official documents about a wide range of medical topics, diseases, illnesses, health and wellness. There is vital information from the National Institutes of Health (NIH), the Centers for Disease Control (CDC), National Cancer Institute, and more. Topics covered include: major diseases, including cancer, heart and vascular disease, stroke, blood diseases and disorders, lung diseases, and neurological disorders such as dementia and epilepsy * CDC Health Topics A to Z, Foodborne Illnesses, Infants and Children, Injuries, Occupational Health, Older Adults, Women * CDC Travelers' Health - Destinations, Vaccinations, Diseases, Mosquito, Tick, Food, Water, Clinics, Yellow Book, Children, Airplanes, Cruise Ships, Special Needs, Relief Workers, * Dietary Guidelines * NIH A to Z from abnormalities to X-rays.Since navigating the Internet to find additional non-governmental medical information can be confusing, we've also provided our exclusive "Guide to Leading Medical Websites" with updated links to 67 of the best sites for medical information! Built-in weblinks let you quickly check for the latest clinical updates directly from the government and the best commercial portals, news sites, reference/textbook/non-commercial portals, and health organizations. ... Read more

Product Description
Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: Huntingtin, Cystic Fibrosis Transmembrane Conductance Regulator, Parkin, Dab1, Factor Xi, Aspm, Factor Viii, Research of Down Syndrome-Related Genes, Phenylalanine Hydroxylase, Factor Ix, Δf508, Ifi202, Common Gamma Chain, Usher 1c. Source: Wikipedia. Free updates online. Not illustrated. Excerpt: The Huntingtin gene, also called HTT or HD (Huntington disease) gene, or the IT15 ("interesting transcript 15") gene codes for a protein called the huntingtin protein. The gene and its product are under heavy investigation as part of Huntington's disease clinical research. It is variable in its structure as there are many polymorphisms of the gene which can lead to variable numbers of glutamine residues present in the protein. In its wild-type (normal) form, it contains 6-35 glutamine residues, however, in individuals affected by Huntington's Disease (an autosomal dominant genetic disorder), it contains greater than 36 glutamine residues (highest reported repeat length is about 250). Its commonly used name is derived from this disease, previously the IT15 label was commonly used. The mass of huntingtin protein is largely dependent on the number of glutamine residues it has, the predicted mass is around 350 kDa. Normal huntingtin is generally accepted to be 3144 amino acids in size. The exact function of this protein is not known, but it plays an important role in nerve cells. Within cells, huntingtin may be involved in signalling, transporting materials, binding proteins and other structures, and protecting against programmed cell death (apoptosis). The huntingtin protein is required for normal development before birth. It is expressed in many tissues in the body, with the highest levels of expression seen in the brain. The 5' end of the HD gene has a sequence of 3 DNA bases, cytosine-...More: http://booksllc.net/?id=3557975 ... Read more

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The article is excerpted fromGale Encyclopedia of Medicine.

Consultthe second edition of this authoritative, comprehensive, in-depthmedical guide for information on more than 1,700 medical topics inlanguage accessible to adult laypersons. Presented in a singlealphabetical sequence, articles range in length from one or twoparagraphs for minor topics, to several pages or more for major topics.Disease/disorder articles typically cover definition; description;causes and symptoms; diagnosis; treatments; prevention; and more.Test/treatment articles typically cover definition; purposes;precautions; preparation; risks; normal and abnormal results; and muchmore. This second edition includes more than 200 new entries, 300updated entries, approximately 650 color images and illustrations, anda comprehensive subject index. New features include biographical andhistorical sidebars throughout the text.

Disease/disorder articles contain some or all of the following sections:

• Definitions -- brief dictionary-style definition of the disorder
• Descriptions -- overview of the disorder; who gets it and why
• Causes & symptoms -- process, substance or organism thatproduces the condition; any risk factors that increase susceptibilityto the condition; signs and symptoms of the disease
• Diagnosis -- overview of procedures and tests used todiagnose the condition; how the test is done; who should be tested andwhen; time required; cost; whether it's typically covered by insurance
• Treatments -- overview of conventional methods of care ormanagement of the condition, such as drugs, surgeries, physicaltherapy, etc.
• Alternative treatments -- overview of alternative/complementary therapies that may be used to treat the condition
• Prognosis -- probable outcome of the disease
• Preventions -- what actions can be taken to prevent the condition from occurring

Test/treatment articles contain some or all of the following sections:

• Definitions -- brief dictionary-style definition of the test/treatment
• Purposes -- why and when this test/treatment is prescribed
• Precautions -- when this test/treatment should not be prescribed
• Descriptions -- overview of the test/treatment including cost,length of time required, procedures followed, whether typically coveredby insurance
• Preparation -- pre-test treatment procedures, if any
• Aftercare -- post-test treatment procedures, if any
• Risks -- any complications/side effects commonly associated with the test/treatment
• Normal results -- for tests, describes the normal values; for treatments, describes the anticipated outcomes
• Abnormal results -- defines abnormal test values

Published/Released: December 2001

Product Description
The Queen's University of Belfast, U.K. Research on the genetics, cell biology, and clinical aspects of cystic fibrosis, for clinicians and researchers. 36 contributors, 17 U.S. ... Read more

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Chapters: Cystic Fibrosis, Rickets, Coeliac Disease, Measles, Mumps, Coxsackie a Virus, Fragile X Syndrome, Sudden Infant Death Syndrome, Mmr Vaccine, Neonatal Heel Prick, Rotavirus, Meconium, Meconium Aspiration Syndrome, Pertussis, Febrile Seizure, Scarlet Fever, Rubella, Growth Hormone Treatment, Lesch-nyhan Syndrome, Childhood Obesity, Nocturnal Enuresis, Newborn Screening, Spina Bifida, Otitis Externa, Otitis Media, Chickenpox, Gastroenteritis, Neonatal Jaundice, Hip Dysplasia, Kawasaki Disease, Henoch-schönlein Purpura, Pulmonary Hypoplasia, List of Youngest Birth Mothers, Transient Synovitis, Menarche, Congenital Adrenal Hyperplasia, Juvenile Idiopathic Arthritis, Lipoid Congenital Adrenal Hyperplasia, Rh Disease, Developmental-Behavioral Screening and Surveillance, Inborn Error of Metabolism, Nephrotic Syndrome, Precocious Puberty, Neonatal Intensive-Care Unit, Homesickness, Primitive Reflexes, Reye's Syndrome, Shwachman-bodian-diamond Syndrome, Diamond-blackfan Anemia, Child Bone Fracture, Failure to Thrive, Eye Exercises, Wilms' Tumor, Delayed Puberty, Parvovirus B19, Craniosynostosis, Toddler, Infant Respiratory Distress Syndrome, Rotavirus Vaccine, Dopamine-Responsive Dystonia, Hypomagnesemia With Secondary Hypocalcemia, Croup, Fetus in Fetu, Baby Colic, Coarctation of the Aorta, 22q13 Deletion Syndrome, Hemolytic Disease of the Newborn, Bartter Syndrome, Infant Massage, Crigler-Najjar Syndrome, Necrotizing Enterocolitis, Ponseti Method, Dubowitz Syndrome, Congenital Hypothyroidism, Aarskog-Scott Syndrome, Child Life Specialist, Foreign Body, Congenital Adrenal Hyperplasia Due to 11β-Hydroxylase Deficiency, Video Game-Related Health Problems, Germinoma, Birth Mass, Congenital Adrenal Hyperplasia Due to 3 Beta-Hydroxysteroid Dehydrogenase Deficiency, Small for Gestational Age, Bronchiolitis, Viability, Persistent Truncus Arteriosus, Chédiak-higashi Syndrome, Constitutional Growth Delay, Alveolar Capillary Dysplasia...More: http://booksllc.net/?id=63526 ... Read more

Product Description
This digital document is an article from Human Biology, published by Wayne State University Press on June 1, 1997. The length of the article is 1432 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: When analyzed by origin, the frequency of the G542X cystic fibrosis (CF) mutation (the second most common CF mutation in Europe after DF508) varies between population groups in Europe. We show here that the frequency of G542X varies among different towns or regions of origin, being lower in northeastern Europeans than in southwestern Europeans. The G542X mutation mapping that we have defined by a multiple regression of G542X frequencies covers 28 countries (53 geographic points) and is based on data from 50 laboratories. The more elevated values of G542X frequency correspond to ancient sites of occupation by occidental Phoenicians.

Citation Details
Title: G542X as a probable Phoenician cystic fibrosis mutation.
Author: France Loirat
Publication: Human Biology (Refereed)
Date: June 1, 1997
Publisher: Wayne State University Press
Volume: v69Issue: n3Page: p419(7)

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