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John Sinclair and a panel of expert investigators present a comprehensive collection of cellular and molecular techniques for the analysis of cytomegalovirus (CMV) biology and its pathogenetic mechanisms. The methods-all described in step-by-step detail with ready reproducibility in mind-range from basic virus culture to complex molecular analysis of CMV structure and function. Included are methods for CMV detection using both immunological and biological techniques, methods for analyzing fundamental aspects of the CMV infection cycle, and methods for analyzing T cell response to cytomegalovirus infection in the human host. Comprehensive and state-of-the-art, Cytomegalovirus Protocols provides investigators with a collection of the key methods that are illuminating not only the basic biology of this complex and intriguing human herpesvirus, but also its significant role in human infectious diseases and their emergent therapies. ... Read more

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The cytomegalovirus is not only scientifically fascinating, but responsible for significant morbidity and mortality throughout the world. The Third International CMV Workshop provided the forum for a comprehensive analysis of the state of the art in the various fields of CMV research. This text contains the overviews and oral communications presented, evenly distributed between basic science and clinical sessions. Several up-to-date short reviews appear and each chapter is written by a leading expert in that field. Some subjects covered include new information on genome organization deduced from the complete nucleotide sequence, the clinical importance of CMV from classic diseases to novel associations, and virus-host-cell and CMV-HIV interactions. ... Read more

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In this book the current knowledge on human cytomegalovirus(HCMV) as a human pathogen is lucidly summarized, bringingthe reader fully up to datewith current knowledgeconcerning HCMV and all the known clincial and medicalaspects of diseases caused by, and associated with, HCMV.The book is divided into four parts: (I) Humancytomegalovirus and humandiseases; (II) humancytomegalovirus infections and the immunocompromised host;(III) diagnosis, treatment, and prevention of humancytomegalovirus and human diseases; and (IV) molecularaspects of human cytomegalovirus. Each part is put togetherfrom chapters written by experts in the respective fields,providing basic medical and molecular knowledge in additionto more specific understanding of HCMV infections. ... Read more

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In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading."Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. ... Read more

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University of Pittsburgh, Pennsylvania. Comprehensive review for researchers and clinicians. DNLM: Cytomegalic Inclusion Disease. ... Read more

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Hervé Guibert is considered one of the most important French novelists of this generation. His literary works began in earnest in 1981. The content of his work changed dramatically when he was diagnosed with AIDS, from which he died in 1991. Several of his works which speak directly with his struggle with the disease have already been translated into English. "Cytomegalovirus" presents Guibert's intimate observations during a three-week stay in the hospital. In this work, he confronts his fear about AIDS and the cytomegalovirus that is threatening him with blindness. Throughout the ordeal, he defiantly clings to his human dignity, refusing to be treated as an object of study or of compassion. The central importance of writing as a way of recording his experience, and therefore of preserving his humanity, remains a key to understanding this work. Of interest to students, scholars, and general readers of French literature, gay studies, and literature and medicine. ... Read more

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This book focuses on (1) the molecular biology of cytomegaloviruses and (2) the current understanding of the immune response to infection by this member of the herpesvirus group, including progress toward the development of vaccines. In two of the chapters, comparisons between human cytomegalovirus and animal models are made. Infection with human cytomegalovirus is found worldwide and can be associated with a wide spectrum of disease, particularly when infection occurs in a developing foetus or in an immunocompromised individual as, for example, in transplant patients and those with acquired immune deficiency syndrome (AIDS). Congenital infection can be inapparent, or can vary clinically from a mild self-limited syndrome to a frequently fatal disease. In some cases neurological sequelae are seen. A proportion of normal adults experiencing primary infection will develop mononucleosis or, rarely, a form of hepatitis or encephalitis. The new studies on transcription, proteins and immunity together with completion of the DNA sequence of the virus genome reported in this volume provide the basis for future advances in the understanding of gene expression, protein function, antiviral design and vaccine development. ... Read more

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Ganciclovir (formerly DHPG) is the first drug to show any effectiveness against diseases caused by cytomegalovirus, which include congenital infection, and conditions almost invariably fatal to organ recipients and patients with AIDS. Reviews the preclinical and clinical studies on the drug's pharma ... Read more

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This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.

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"I congratulate Lisa on producing a very good piece of work," says Gail J Demmler-Harrison, MD, Director of the Congenital CMV Disease Registry and Research Program, Baylor College of Medicine.Lisa Saunders says "no" to her daughter Jackie's pleas for a dog, fearing it will be too rambunctious around Jackie's disabled little sister Elizabeth. But she does make her a promise she thinks will never come to pass: "If God brings a dog to our door, then you can have it." But is this dog really Heaven-sent? PLUS: The latest news on how to prevent the far-reaching but under-reported effects of congenital CMV, the #1 viral cause of birth defects-more common a cause of disabilities than Down syndrome. It also contains highly useful sections with Resources, Contacts and Support for anyone whose life is touched by CMV. ... Read more

Customer Reviews (4)

Read it in one night - a wonderful book!
Lisa's book is both heartwarming and gutwrenching - she tells a marvelous story that will touch and inspire parents, as well as anyone who has ever owned a pet!Even better is the strong message to everyone even thinking about starting a family - congenital CMV is preventable, and everyone needs to know about it.
Stephanie Sosnowski, Deputy Director, Maternal-Infant Services Network of Orange, Sullivan and Ulster Counties, Inc.

Wonderful ,Entertaining and touching
Loved the book! I laughed and cried and so many moments were just plain touching. I laughed out loud about the blower incident because something similar happened to me and I could just imagine it! The book now sits among my best reads on my shelf--it will always be a part of my collection. Lisa Saunders really has a gift." Dan Elser, Dallas TX

A very important story
A must read for anyone who is thinking about becoming a parent, is a parent or knows a parent.

Touching book!
"Anything but a Dog!" rates among the most touching books I've read. If you love family stories about surviving tough times, related with humor and candor, you will love this book.
David Sisson, retired English professor ... Read more

Product Description
This digital document is an article from Emerging Infectious Diseases, published by Thomson Gale on October 1, 2006. The length of the article is 4015 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Active cytomegalovirus infection in patients with septic shock.
Author: Lutz von Muller
Publication: Emerging Infectious Diseases (Magazine/Journal)
Date: October 1, 2006
Publisher: Thomson Gale
Volume: 12Issue: 10Page: 1517(6)

Distributed by Thomson Gale ... Read more

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Herpes simplex - Bell palsy, Herpes simplex virus,Herpesviridae, Viral entry, HHV Latency AssociatedTranscript, Valaciclovir, Antiviral drug, Thymidinekinase,Aciclovir, Chickenpox, Cytomegalovirus ... Read more

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This digital document is an article from Gale Encyclopedia of Medicine, 3rd ed., brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 961 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.The third edition of this authoritative, comprehensive, in-depth medical guide features information on medical topics in language accessible to adult laypersons. Disease/disorder articles typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. Test/treatment articles typically cover definition; purposes; precautions; preparation; risks; normal and abnormal results; and much more. ... Read more

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Cytomegaloviruses, members of the beta herpesvirus classification group, are genetically the most complex herpesviruses to replicate in human and animal cells. This publication offers a comprehensive review of what is currently known about cytomegalovirus latency, replication and pathogenesis. The first two chapters describe the sites of latency, dissemination of infected cells in the host, and the target organs for viral replication and pathogenesis. These are followed by a review of cytomegalovirus laboratory strains and recombinant viruses which are used for investigating replication in cell culture and pathogenesis in the mouse model. The molecular aspects of immediate-early, early and late gene transcription regulation and expression receive detailed attention. Subsequent chapters are devoted to viral DNA synthesis, viral capsid assembly, DNA packaging and the assembly of infectious and noninfectious particles. Finally, the viral glycoproteins in the infected cell and in the viral envelope are considered and characterized in relation to the biology of the virus and the host immune response.Written by experienced investigators, this collection of reviews serves as a source of information for virologists, molecular biologists and immunologists. ... Read more