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Since the subject of arenaviruses was visited by Current Topics in Microbiology and Immunology 14 years ago, enormous advances have been made in this area. The receptor for several arenaviruses, alpha-dystroglycan, was identified, the replication strategy of these viruses was decoded, and application of a reverse genetics system for studying viral gene function and viral biology is well underway. In addition to reviewing these advances, Volume I includes discussion of arenaviral molecular phylogeny, reservoirs in rodents and clinical diseases caused by both new world and old world arenaviruses. ... Read more

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The second volume of Arenaviruses deals with the biology and the pathogenesis of arenaviruses primarily through the study of LCMV. Interestingly and appropriately, the fundamental observation of MHC restriction and CD8 cytotoxic T lymphocyte killing derived initially from studies with LCMV in the mouse has been expanded to studies of most human pathogens, viral, bacterial, parasitic, as well as events in cancer. The scope and importance of this observation was recognized by awarding the Nobel Prize in 1996 to Rolf Zinkernagel and Peter Doherty, long-time workers in the field of LCMV and arenavirus biology. Over the last 14 years many of the principles for understanding viral pathogenesis and biology of animal viruses have been defined, in great part from the lessons learned by studying LCMV. Those lessons and their implications are the subject of this second volume on the arenaviruses. ... Read more

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Scientific research on dengue has a long and rich history. The literature has been touched by famous names in medicine- Benjamin Rush, Walter Reed, and Albert Sabin, to name a very few- and has been fertile ground for medical historians . The advances made in those early investigations are all the more remarkable for the limited tools available at the time. The demonstration of a viral etiology for dengue fever, the recognition of mosquitoes as the vector for transmission to humans, and the existence of multiple viral variants (serotypes) with only partial cross-protection were all accomplished prior to the ability to culture and characterize the etiologic agent. Research on dengue in this period was typically driven by circumstances. Epidemics of dengue created public health crises, although these were relatively short-lived in any one location, as the population of susceptible individuals quickly shrank. Military considerations became as a major driving force for research. With the introduction of large numbers of non-immune individuals into endemic areas, dengue could cripple military readiness, taking more soldiers out of action than hostile fire. Dengue and dengue hemorrhagic fever, which assumed pandemic proportions during the latter half of the last century, have shown no indication of slowing their growth during this first decade of the twenty-first century. Challenges remain in understanding the basic mechanisms of viral replication and disease pathogenesis, in clinical management of patients, and in control of dengue viral transmission. Nevertheless, new tools and insights have led to major recent scientific advances. As the first candidate vaccines enter large-scale efficacy trials, there is reason to hope that we may soon "turn the corner" on this disease.

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This book helps primary care physicians understand their roles in preparing for and responding to terrorist events. With a practical approach, the text considers the physical and psychological impact of terrorism on providers and patients who are directly affected, as well as the spillover effects in more distant geographic locals. Proactive measures are outlined, such as educating patients about protective recommendations, addressing concerns about risk, and reporting credible risks to the proper authorities. The text also details how to detect terrorist-caused illness as early as possible, how to provide therapy to defend against or prevent illness, and how to treat patients with terrorist-caused illness. In-depth coverage of biologic agents (anthrax, plague, smallpox, botulism, tularemia, and hemorrhagic viruses), chemical agents (nerve and blister), and radiologic agents that terrorists are likely to use is provided. Readers also learn how to counsel families traumatized by terrorist threats and activities.

In addition, the text takes a hard look at the structure, function, and current planning efforts of the public health system at the local, state, and federal levels. An emphasis is placed on how physicians can work with public health officials to ensure that preventive and therapeutic measures are delivered effectively, legally, and ethically.

Customer Reviews (1)

Excellent resource
As a colleague of Dr. Melnick, I am delighted to be able to provide the most positive review.This book serves well both as a primer for PCPs on the general subject of biological, chemical, and radilogical terrorism and as a quick reference.Beyond its target audience, other medical and public health professionals, including EMS professionals, will find this volume very useful.

The book is well organized with concise sections where appropriate for each disease or agent on microbiology and epidemiology, presentation and treatment, post-exposure prohylaxis, and prevention.The illustrations are useful aids in differential diagnosis, and diagnostic, lab evaluation, and treatment information is given in clear tables.

The ease with which RDDs (dirty bombs) can be constructed and the recent federal full-scale exercise scenario makes the chapter on radiological terrorism timely.

The chapters on mental health issues related to terrorism and the key link between public health response and the PCP are welcome and emphasize matters often ignored.

This volume is a worthy contribution to the preparation of PCPs and others to deal with terrorism threats.Dr. Melnick's style is easy to read and conversational, making this book on a very dark subject a pleasure to read. ... Read more

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This digital document is an article from Emerging Infectious Diseases, published by U.S. National Center for Infectious Diseases on June 1, 2009. The length of the article is 4768 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Hantaviruses in rodents and humans, Inner Mongolia Autonomous Region, China.(RESEARCH)
Author: Yong-Zhen Zhang
Publication: Emerging Infectious Diseases (Magazine/Journal)
Date: June 1, 2009
Publisher: U.S. National Center for Infectious Diseases
Volume: 15Issue: 6Page: 885(7)

Distributed by Gale, a part of Cengage Learning ... Read more

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This is a NAVAL POSTGRADUATE SCHOOL MONTEREY CA report procured by the Pentagon and made available for public release. It has been reproduced in the best form available to the Pentagon. It is not spiral-bound, but rather assembled with Velobinding in a soft, white linen cover. The Storming Media report number is A207083. The abstract provided by the Pentagon follows: This thesis attempts to explore the economic, political and militaryfactors influencing defense expenditures in general and in particular for thecase of Hungary. The description of the empirical models leads to an analysis of the Hungarian defense expenditures and a forecast of the tendency of Hungary'smilitary spending in the near future. The level of defense expenditures is afunction of at least two variables: how threatened a government (or a society)feels and how much security that government (or country) can afford. Therefore,the determinants of defense spending stem from a combination of security policy(dealing with threats to vital national interests) and fiscal policy (theallocation of societal resources). Economic strength is a factor contributing to the determination of military spending. Another significant driving force behind military spending is the power and leverage of the armed forces relative toother national actors. The degree of transparency in military outlays is alsoimportant The size of the military budget is conditioned by geo-strategicconcerns both at the regional and international levels. Finally, increases inmilitary ex expenditures reduce the availability of funds for socio-economicdevelopment projects (guns vs. butter trade off). ... Read more

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This digital document is an article from Gale Encyclopedia of Medicine, 3rd ed., brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 854 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.The third edition of this authoritative, comprehensive, in-depth medical guide features information on medical topics in language accessible to adult laypersons. Disease/disorder articles typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. Test/treatment articles typically cover definition; purposes; precautions; preparation; risks; normal and abnormal results; and much more. ... Read more

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This digital document is an article from UXL Complete Health Resource, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 1018 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.This award-winning resource covers the causes symptoms, diagnoses, tests, treatments and prognoses of 140 health problems; the main systems of the human body, including the circulatory system, the endocrine system, special senses and much more; and a detailed examination of nutrition, and medical and mental health issues. ... Read more

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This digital document is an article from Emerging Infectious Diseases, published by U.S. National Center for Infectious Diseases on February 1, 2009. The length of the article is 4901 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Severe dengue epidemics in Sri Lanka, 2003-2006.(RESEARCH)(Report)
Author: Nalaka Kanakaratne
Publication: Emerging Infectious Diseases (Magazine/Journal)
Date: February 1, 2009
Publisher: U.S. National Center for Infectious Diseases
Volume: 15Issue: 2Page: 192(8)

Article Type: Report

Distributed by Gale, a part of Cengage Learning ... Read more

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This digital document is an article from Pediatric News, published by International Medical News Group on October 1, 2001. The length of the article is 801 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Bioterrorism Symptoms Mimic Flu.
Author: Jennifer Silverman
Publication: Pediatric News (Magazine/Journal)
Date: October 1, 2001
Publisher: International Medical News Group
Volume: 35Issue: 10Page: 48

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This digital document is an article from Morbidity and Mortality Weekly Report, published by U.S. Government Printing Office on December 8, 1989. The length of the article is 785 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Ebola virus infection in imported primates - Virginia, 1989.
Publication: Morbidity and Mortality Weekly Report (Newsletter)
Date: December 8, 1989
Publisher: U.S. Government Printing Office
Volume: v38Issue: n48Page: p831(4)

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This digital document is an article from SuperScience, published by Thomson Gale on April 1, 2007. The length of the article is 1248 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Vanishing apes: gorillas in Africa are facing tough times. Can scientists help the apes survive?(life science)
Author: Claire Miller
Publication: SuperScience (Magazine/Journal)
Date: April 1, 2007
Publisher: Thomson Gale
Volume: 18Issue: 7Page: 6(6)

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This digital document is an article from American Decades: Primary Sources, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 679 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.American Decades Primary Sources provides fresh insight into the decade's most important events, people, and issues. Entries representing a diversity of views that provide insight into the seminal issues, themes, movements and events from the decade. Also included are concise contextual information, notes about the author and further resources. American Decades Primary Sources includes chapters on the arts, medicine and health, media, education, world events, religion, government and politics, lifestyles and social trends, law and justice, religion, business and the economy, and sports. Included to provide unique perspectives and a wealth of understanding are first hand accounts that include oral histories, songs, speeches, advertisements, TV, play and movie scripts, letters, laws, legal decisions, newspaper articles, cartoonsand recipes. ... Read more

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This is a NAVAL POSTGRADUATE SCHOOL MONTEREY CA report procured by the Pentagon and made available for public release. It has been reproduced in the best form available to the Pentagon. It is not spiral-bound, but rather assembled with Velobinding in a soft, white linen cover. The Storming Media report number is A042724. The abstract provided by the Pentagon follows: The Assessment and Investment Model (AIM) introduced in 2003 a fiscally constrained ordnance procurement model to plan procurements of the most capable inventory of munitions while attempting to meet annual Navy Non-Nuclear Ordnance Requirements (NNOR). AIM is the first analytical planning tool to incorporate fiscal constraints, to use true optimization to guide procurement policy, and to establish a quantifiable measure of overall inventory capability. This report reformulates AIM and dramatically improves response times for almost all instances. We report analyses using AIM, involving a variety of budgeting and inventory scenarios. AIM is now a fast, flexible tool that can handle a wide range of budget and requirements scenarios in a manner that was previously impossible. Decision makers can now develop a procurement plan that effectively and efficiently meets the ordnance needs of the world's most powerful Navy. ... Read more