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Inflammatory bowel disease (IBD), which encompasses both Crohn's disease and ulcerative colitis, is a chronically relapsing intestinal disorder that is characterized by diarrhea and abdominal pain.

The incidence of IBD is increasing worldwide. Although some major advances have been made in recent years, the pathogenesis of the disease still remains obscure. As currently understood, a combination of genetic alterations and immunological disturbances causing an interaction of the enteric microflora with the underlying mucosa and a disrupted barrier function may be crucial for the development of disease.

Despite substantial new data that have been obtained over the last several years, it has become increasingly difficult to accommodate these into a unifying disease model. Identification of pro- and anti-inflammatory cytokines has introduced "biologic therapies," but treatment of IBD is still based mainly on broad-spectrum immunosuppressive drugs such as steroids and azathioprine. In this volume, the most relevant pathogenetic aspects are stressed: genetic alterations, disrupted epithelial barrier function, immunological disturbances, and the role of the enteric microflora.

NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member. ... Read more

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Chronic inflammatory bowel disease still represents a majorgastroenterological challenge, in view of the unclear aetiology andunsatisfactory therapy. This book, the proceedings of a Falk Symposiumheld in Lübeck, Germany on 4--5 March 1994, will act as a vehiclefor our current knowledge, and promote the dialogue between cliniciansand those involved with the associated sciences.
The book begins with international experts discussing the more recenttheories concerning the aetiology and pathogenesis. Later on, thediscussion turns to questions of diagnosis, and the conservative andsurgical treatment of Crohn's disease and ulcerative colitis are dealtwith in detail.
This volume in the Falk Symposium both represents a forum of expertsfor discussion of the most recent findings, and provides clinicalgastroenterologists with an opportunity to inform themselves of thestate of the art in the field of inflammatory bowel disease.
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Formation of reactive oxygen species (ROS) is a natural process during oxidative metabolism. ROS play an important role not only in pathological processes of human organism as usually presented but less attention is paid to their proper important role in cell signalling, biosynthesis or non-specific anti-infectious defence. Overproduction of ROS during numerous pathological situations in presence of insufficient antioxidant protection leads to substantial oxidative changes of lipids, proteins, sugars, and also DNA. Protection against ROS is assured by different extracellular or intracellular antioxidant mechanisms as studied during last decades. Antioxidant enzymes rectifying the oxidative damage are studied with regard to their different activities and usefulness in body protection. Their genetic polymorphisms are certainly involved in different response to oxidative stress. Special attention should be devoted to the topic of oxidative nuclear and mitochondrial DNA damage and its restoring via DNA repair process, especially base excision repair (BER). A large scale of antioxidant enzymes is involved in correction of DNA oxidative damage.Natural trend of worsened DNA repair is usually associated with aging. Other pathologies related with deficient DNA repair are susceptibility to carcinogenesis (lack of apoptosis control) or degenerative diseases. Oxidative stress is involved in the pathophysiology of diabetes mellitus (DM - oxidative stress of mainly metabolic origin) and inflammatory bowel diseases (IBD - oxidative stress of mainly inflammatory origin). In spite of confirmed OS in DM or IBD, the substantial information about the intensity of DNA repair and its possible relationship to the disease course and development of chronic complications is missing. The author pilot studies completed both in adult and paediatric patients with DM or IBD confirmed an increased oxidative stress as well as oxidative DNA damage examined with comet assay. The surprising findings were ascertained in intensity of DNA repair (analysed with modified comet assay). ... Read more

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This is a reference text focusing entirely on the current and often controversial diagnosis, management and potential errors of management of inflammatory bowel disease (IBD). The book is logically organized to first review what is known about the cause of and contributing factors to IBD as they relate to management. The subsequent sections focus on current diagnostic and treatment modalities, both medical and surgical, and weigh the pros and cons of each. The final sections offer "pearls" from experienced experts on how to avoid common errors in management of IBD. ... Read more

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Though the aetiology and pathogenesis of inflammatory bowel diseases (ulcerative colitis, Crohn's disease) remain obscure, substantial progress has been made in the understanding of these challenging disorders since the first edition of "Inflammatory Bowel Diseases" in 1983. Scientific advances include characterization of the nature of the intestinal inflammatory reaction, delineation of the varied immunological events, and the application of numerous basic scientific disciplines (including biochemistry, pharmacology, cell biology, gastrointestinal neuroendocrinology, immunology, genetics, and molecular biology) to the investigation of inflammatory bowel diseases. In addition to careful clinical observation, clinical progress includes expanding epidemiological and familial studies, documentation of the clinical complexities of inflammatory bowel disease, assessment of the cancer risk, and such therapeutic advances as improved nutritional support, the use of elemental diets in Crohn's disease, 5-aminosalicylic acid compounds in ulcerative colitis, immunosuppressive and other anti-inflammatory medications.In the surgery of inflammatory bowel diseases, total colectomy and ileoanal anastomosis is increasingly preferred for many patients with ulcerative colitis requiring operation; while in Crohn's disease the advantages and the limitations of surgery have been defined more clearly with particular emphasis on preserving as much small bowel as possible. The second edition of "Inflammatory Bowel Diseases" incorporates all of these developments and more, in a systematic and thorough account of inflammatory bowel diseases. ... Read more

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Written for counsellors working in healthcare settings who want to develop their knowledge and undertake research, this book explores the range of benefits that can be generated by undertaking reflexive research. Focusing on the condition of Inflammatory Bowel Disease (IBD), which she has herself, Gillian Thomas demonstrates how this approach can develop knowledge of a condition, but also offer therapeutic benefits to clients by increasing understanding of their condition and the interaction between the physical and emotional aspects of living with a long term disease. She outlines how to develop ethically appropriate research methods, how to carry out reflexive research and reflects on the knowledge that she has gained from her own research, teasing out its benefits for those working with a range of diseases in healthcare settings. This book will be valued by counsellors and other professionals working in healthcare settings, particularly those working with ongoing medical conditions. ... Read more

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Inflammatory bowel diseases are still a challenging problem intoday's gastroenterology. Although their aetiology is still notunderstood, steady progress has been made recently in theunderstanding of their pathogenesis, due to the application ofinnovative molecular and cellular biological methods. Knowledge of theimmunology of the gut and the basic mechanisms of inflammatoryreactions, especially pro and anti-inflammatory mediators, thecharacterization of inflammatory cell types and their functions andmolecules mediating cell interactions.
This book closes the gap between new findings in pathophysiology andtreatment in order to better understand our current therapeuticconcepts and to develop new strategies for the future. It comprisesthe proceedings of the 67th Falk Symposium, held in Regensburg, June1992, and contains sections on aetiology, pathophysiology,extra-intestinal mainfestations, diagnosis and treatment. It isessential reading for all clinicians treating IBD. ... Read more

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Queen Elizabeth Hospital, Birmingham, U.K. Third edition of a clinical reference for practitioners. Illustrated. 115 contributors, 41 U.S. ... Read more

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The amount of information on the pathogenesis of inflammatory bowel disease is growing rapidly. This is reflected by a continuous increase in the number of papers presented at international GI meetings. To make things more difficult for practicing physicians, there is also a large number of new clinical trials being published which require periodical critical reviews and recommendations. Faced with these issues, the scientific commitee of the Falk Symposium No. 140 decided to take a different approach and to apply a novel format that is reflected in the title of the Symposium: ... Read more

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Several international symposia on chronic inflammatory boweldisease over the last few years have contributed to our understandingof thepathophysiology and treatment of this condition. Molecularbiology andnew analytical techniques have continuously improved ourknowledge ofmucosal immunology and of inflammatory reactions.Progress in this fieldis very rapid and has implications fordiagnosis and treatment, and makes it important to have a scientificexchange between basic research and clinical practice.Thisvolume, the proceedings of Falk Symposium No. 96, held in Freiburg,Germany, October 30-- November 1, 1996, documents the transferof knowledge between clinicians and basic scientists, and clarifiesthedefinitions used in daily practice such as active disease,refractory diseases or remission. The book will open new aspects forfuture research andclinical work in the field of inflammatory boweldiseases. ... Read more

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The 65th Falk Symposium held in Basel was dedicated toinflammatory bowel diseases of children. The emphasis of this book ison the immunological aspect of IBD as well as the current strategiesof treatment. There is an additional focus on two other relatedchildhood diseases: Morbus Hirschsprung and neuronal-intestinaldysplasia, both of which are diseases that concern the paediatricsurgeon as well as the clinician.
This, the II In ternational Falk Symposium on Paediatric and SurgicalGastroenterology, brought together scientists, clinicians and surgeonsfrom around the world to give a comprehensive and cross-disciplinaryoverview of the topics.
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Inflammatory bowel disease (IBD) and familial adenomatous polyposis (FAP) are complex diseases, which are subject to numerous medical researches. Despite increased knowledge on the pathophysiological process, many aspects remain rather unclear, especially concerning IBD. The aim of the researchers will be to prevent these disorders through early detection and intervention, thanks to genetic therapy. This book gathers current methods of treatment of these diseases and also presents the management of their complications. Authors finally intend to give a comprehensive overview of the newer therapies to bring the readers up to date.