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This volume aims to provide the reader with comprehensive, systematic and effective information about pitfalls in the histopathologic diagnosis of malignant melanoma by highlighting a range of pitfalls in histopathologic diagnosis of malignant melanoma and instructing them in a method that enables pitfalls to be avoided. The method utilizes repeatable criteria for the histopathologic diagnosis of melanocytic neoplasms of all kinds, based on features of their architectural pattern, particularly their silhouettes. Proper use of this method is demonstrated in an introduction that establishes firm repeatable criteria for benign and malignant neoplasms of melanocytes. ... Read more

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This digital document is an article from Dermatology Nursing, published by Jannetti Publications, Inc. on February 1, 2009. The length of the article is 646 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

From the author: Dermatology nurses and other health care professionals may sometimes fail to appreciate and recognize the physical and emotional challenges faced by patients with a particular chronic dermatologic disease or condition. "Patients' Perspectives: Living with..." series shares these important patient views and comments to improve patient care. If you know of a patient who would be interested in sharing his/her experiences with the dermatology nursing community, please ask him/her to briefly answer (3-5 sentences) the questions as outlined here. Submissions can be sent via e-mail to the journal office at dnjrnl@ajj.com or mailed to Patients' Perspectives, Dermatology Nursing, East Holly Avenue Box 56, Pitman, NJ 08077-0056.

Citation Details
Title: Living with melanoma.(Patients' Perspectives)(Report)
Author: Gale Reference Team
Publication: Dermatology Nursing (Magazine/Journal)
Date: February 1, 2009
Publisher: Jannetti Publications, Inc.
Volume: 21Issue: 1Page: 43(1)

Article Type: Report

Distributed by Gale, a part of Cengage Learning ... Read more

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This book contains twenty-one chapters written by outstanding scientists in the field of immunobiology and immunotherapy of human melanoma and was made possible by the support of the European Union and the National Institutes of Health, Bethesda, USA. The book reflects the effort of selected speakers to present a comprehensive view of the scientific achievements in their specific field of expertise. The core of the book includes the most recent discoveries in melanoma immunology including cytokines, cell surface antigens and receptors, and antigenic systems that play a critical role in melanoma progression, recognition and interaction with host's immune system. These data are presented and discussed in view of their potential usefulness to implement new strategies of active specific immunotherapy of melanoma in the nearest future. Nevertheless, the dramatic improvement in the knowledge of the immune aspects of human melanoma that took place in the past three years, has already led to new clinical applications. Therefore, the very first results of clinical trials, including gene therapy approaches, for immunotherapy of human melanoma are also reported. This book represents both a unique reading and a comprehensive source of bibliographic material in the field of human melanoma. It is worth to be considered notonly by basic scientists and clinicians who are actively working in the field of melanoma but also by whoever is eager to become acquainted with the newest trends in tumor immunology and immunotherapy.

"Cet ouvrage (...) rassemble les donnes les plus rcentes acquises ou en cours d'tude concernant l'immunologie,la fois sur le plan fondamental et thrapeutique, du mlanome malin. Cette mise au point est d'actualit pour un cancer dont l'incidence augmente dans le monde entier et qui a fait l'objet de nombreux travaux fondamentaux sur la relation hte-tumeur et de nombreuses recherches cliniques en immunothrapie." - J.-L. BreauCahiers d'Oncologie, volume 5, no. 8-9, Aot/Septembre 1996, p. 248 ... Read more

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This digital document is an article from Family Practice News, published by International Medical News Group on May 15, 2004. The length of the article is 525 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Additional primary melanomas were seen in 12% of patients: twice as likely to occur in men.(Clinical Rounds)
Author: Sherry Boschert
Publication: Family Practice News (Magazine/Journal)
Date: May 15, 2004
Publisher: International Medical News Group
Volume: 34Issue: 10Page: 32(1)

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This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Xiphophorus interspecies hybrids provide several well-characterized genetic models of melanoma susceptibility. The Xiphophorus CDKN2A/B gene, homologous to mammalian CDKN2A/B cyclin-dependent kinase inhibitors (p16 and p15), is a candidate tumor susceptibility gene in these models. Using real-time PCR and Western blot analysis, we analyzed expression of CDKN2A/B in spontaneous and UV-induced primary melanomas from individual backcross hybrid fish. We found that CDKN2A/B mRNA is highly expressed in melanomas (18-fold), relative to other fish tissues. Expression is also elevated, to a lesser extent (9.5-fold), in melanized skin from tumor-bearing fish. However, quantitative levels of CDKN2A/B mRNA in tumors varied considerably and positively correlated with expression of the Xmrk oncogene, suggesting possible functional interaction between Xmrk and CDKN2A/B expression. As a homolog corresponding to members of the mammalian CDKN2 family which regulate cell cycle progression at the G1 checkpoint, the CDKN2A/B p13 protein is a putative regulator of the G1 checkpoint apparatus in Xiphophorus. Since CDKN2A is often observed to be inversely regulated compared to RB in some human tumors, and is capable of transcriptionally regulating RB in human ovarian tumors, we cloned the Xiphophorus maculatus RB cDNA and analyzed RB expression by real-time PCR and Western blot analysis in the fish melanomas. These experiments were designed to ascertain whether CDKN2A/B and RB expression were inversely correlated. Our results indicate that RB mRNA was consistently expressed at only a 2-fold higher level in both tumors and melanized skin than in muscle. Qualitatively similar results were obtained for protein expression. These results collectively suggest that (i) Xmrk and CDKN2A/B may be co-regulated at the transcriptional level, and (ii) there is little, if any, alteration of RB expression in Xiphophorus melanomas. ... Read more

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In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading."Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. ... Read more

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This is a ready source of information on melanoma, spanning from basic research to clinical investigations. Special emphasis is placed on immunology and molecular biology, and results derived from the application of biotechnology to melanoma are reviewed. Other topics discussed by leading authorities include: the characteristics of melanoma associated antigens defined by monoclonal antibodies, the role of melanoma associated antigens and HLA antigens in the biology of melanoma cells, the results of immunohistochemical studies and radio-imaging with monoclonal antibodies, and the development and application of therapeutic approaches. ... Read more

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This digital document is an article from Skin & Allergy News, published by International Medical News Group on March 1, 2005. The length of the article is 718 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Melanoma and pregnancy: 'prompt biopsy is key'.(Clinical Rounds)
Author: Doug Brunk
Publication: Skin & Allergy News (Magazine/Journal)
Date: March 1, 2005
Publisher: International Medical News Group
Volume: 36Issue: 3Page: 25(1)

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Universitatskliniken des Saarlandes, Homburg, Germany. Proceedings of the First International Symposium on Minimal Residual Disease in Melanoma, held in Homburg/Saar, Germany in September 1999. Covers all aspects of diagnosis and treatment of micrometastic disease in melanoma. ... Read more

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This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to melanoma (also Malignant melanoma; Melanoblastoma; Melanocarcinoma; Melanoepithelioma; Melanoma; Melanosarcoma), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on melanoma. Given patients' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms. ... Read more

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It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.

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Assembling, reviewing, and synthesizing state-of-the-art information on translational research and therapies of melanoma into one convenient source, Melanoma: Translational Research and Emerging Therapies provides clinicians and researchers the necessary context and perspective to intergrate and effectively deploy cutting-edge therapies into daily practice.

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The field of melanoma biology has experienced a remarkable surge in recent years, owing to progress which has ranged from the most basic laboratory/preclinical discoveries to clinical developments that have begun to transform the management and prognosis for at least certain melanoma patients. Among the key areas that have contributed to this progress are studies relating to signaling and transcriptional pathways that regulate control over differentiation and survival of the melanocyte lineage. The identification of recurring activating mutations in specific signaling factors (B-RAF, N-Ras, c-KIT), amplification of other melanoma oncogenes (MITF, NEDD9), and the crucial recognition that certain of these genomic events occur within melanomas arising with specific clinical features (eg mucosal or acral origin) have led to clear recognition that melanoma is indeed "many different diseases."While the various subclasses of melanoma may share common features, such as profound invasive and metastatic propensity, it is also likely that sharply focused therapeutic strategies may exploit the functionally critical molecular engines, which distinguish these subclasses. Certain strategies focus upon the immunogenicity and striking clinical opportunities afforded by immune modulation, while others focus more directly on tumor-specific targeting.This issue brings together some of the leaders who have contributed significant insights from basic melanoma biology to progress in the clinic. ... Read more