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A licensed pharmaceutical process is required to beexecuted within the validated ranges throughout thelifetime of product manufacturing. Changes to theprocess usually require the manufacturer todemonstrate that the safety and efficacy of theproduct remains unchanged. Recent changes in theregulations for pharmaceutical processing allowbroader ranges of process settings to be submittedfor regulatory approval, when a manufacturer canscientifically support the rationale for thesesettings. The combined validated ranges of settingsfor process parameters constitute the so calledprocess design space. In this thesis, theapplicability of this concept of the process designspace is investigated for the cultivation processstep for a vaccine against whooping cough disease.This thesis demonstrates that the general principlesof PAT and process design space are general and caneven be applied to an undefined biological productsuch as a whole cell vaccine. ... Read more

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This digital document is an article from Southern Medical Journal, published by Southern Medical Association on December 1, 2003. The length of the article is 4972 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Use of birth certificates and surveillance data to characterize reported pertussis among Texas infants and young children, 1995 to 2000.(Original Article)
Author: Jan W. Pelosi
Publication: Southern Medical Journal (Refereed)
Date: December 1, 2003
Publisher: Southern Medical Association
Volume: 96Issue: 12Page: 1231(7)

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This digital document is an article from Family Practice News, published by International Medical News Group on May 15, 2005. The length of the article is 430 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Rapid testing, antibiotic use stopped pertussis outbreak.(Infectious Diseases)
Author: Alicia Ault
Publication: Family Practice News (Magazine/Journal)
Date: May 15, 2005
Publisher: International Medical News Group
Volume: 35Issue: 10Page: 31(1)

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This digital document is an article from Family Practice News, published by International Medical News Group on January 1, 2004. The length of the article is 595 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Azithromycin rapidly clears pertussis pathogen: adult illness drawing more attention.(Clinical Rounds)
Author: Bruce Jancin
Publication: Family Practice News (Magazine/Journal)
Date: January 1, 2004
Publisher: International Medical News Group
Volume: 34Issue: 1Page: 19(1)

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This digital document is an article from Pediatric News, published by Thomson Gale on November 1, 2005. The length of the article is 617 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Less pertussis immunity exists in adolescent Hispanic mothers, newborns.(News)
Author: Sherry Boschert
Publication: Pediatric News (Magazine/Journal)
Date: November 1, 2005
Publisher: Thomson Gale
Volume: 39Issue: 11Page: 6(1)

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Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Not illustrated. Excerpt: Shiga-like toxin is a toxin generated by Escherichia coli. It is named for its similarity to the AB5-type Shiga toxin produced by the bacteria Shigella dysenteriae. It is also known as verotoxin. There are two types, known as SLT1 and SLT2. In 1977, researchers in Ottawa, Ontario rediscovered the Shiga toxin produced by Shigella dysenteriae in E. coli. The E. coli version was named "verotoxin" because of the ability of the toxic protein to kill Vero cells (African green monkey kidney cells) in culture. Shortly after, the verotoxin was referred to as Shiga-like toxin because of its similarities to Shiga toxin. As with Shiga toxin, the toxin requires highly specific receptors on the cells' surface in order to attach and enter the cell; species such as cattle, swine, and deer which do not carry these receptors may harbor toxigenic bacteria without any ill effect, shedding them in their feces, from where they may be spread to humans. The syndromes associated with shiga toxin include dysentery, hemorrhagic colitis, and hemolytic uremic syndrome. The name is dependent upon the causative organism and the symptoms, which may include severe diarrhea, abdominal pain, vomiting, and bloody urine (in the case of hemolytic uremic syndrome). The onset of symptoms is generally within a few hours, with higher doses leading to more rapid onset. There is no antidote for the toxin. Supportive care requires maintenance of fluid and electrolyte levels, and monitoring and support of kidney function. Immunoassays are available for rapid diagnosis of the toxin. Inactivation of the toxin is achieved by steam treatment, oxidizing agents such as bleach, and chemical sterilizing agents such as glutaraldehyde. The toxicity of Shiga toxin for the mouse (LD... More: http://booksllc.net/?id=174231 ... Read more

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This digital document is an article from Pediatric News, published by International Medical News Group on September 1, 2003. The length of the article is 814 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Macrolides still preferred for pertussis: immunoglobulin, steroids also useful.(Infectious Diseases)
Author: Robert Finn
Publication: Pediatric News (Magazine/Journal)
Date: September 1, 2003
Publisher: International Medical News Group
Volume: 37Issue: 9Page: 19(1)

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The 18th century was a wealth of knowledge, exploration and rapidly growing technology and expanding record-keeping made possible by advances in the printing press. In its determination to preserve the century of revolution, Gale initiated a revolution of its own: digitization of epic proportions to preserve these invaluable works in the largest archive of its kind. Now for the first time these high-quality digital copies of original 18th century manuscripts are available in print, making them highly accessible to libraries, undergraduate students, and independent scholars.
Medical theory and practice of the 1700s developed rapidly, as is evidenced by the extensive collection, which includes descriptions of diseases, their conditions, and treatments. Books on science and technology, agriculture, military technology, natural philosophy, even cookbooks, are all contained here.
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The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification:
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British Library

T145319

With a half-title.

Edinburgi : apud Balfour et Smellie, 1790. [6],34p. ; 8° ... Read more

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This digital document is an article from Pediatric News, published by International Medical News Group on September 1, 2003. The length of the article is 451 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Pertussis persists in Oregon outbreak despite vaccination: more cases in older children.(Infectious Diseases)
Author: Heidi Splete
Publication: Pediatric News (Magazine/Journal)
Date: September 1, 2003
Publisher: International Medical News Group
Volume: 37Issue: 9Page: 19(1)

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This digital document is an article from Pediatric News, published by International Medical News Group on January 1, 2005. The length of the article is 953 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Pertussis boosters for adolescents look promising: replacement of Td booster may be in sight.(News)
Author: Miriam E. Tucker
Publication: Pediatric News (Magazine/Journal)
Date: January 1, 2005
Publisher: International Medical News Group
Volume: 39Issue: 1Page: 1(2)

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This digital document is an article from Family Practice News, published by Thomson Gale on January 1, 2006. The length of the article is 620 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Low pertussis immunity in teen Hispanic mothers.(Infectious Diseases)
Author: Sherry Boschert
Publication: Family Practice News (Magazine/Journal)
Date: January 1, 2006
Publisher: Thomson Gale
Volume: 36Issue: 1Page: 30(1)

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This digital document is an article from Family Practice News, published by International Medical News Group on March 1, 2000. The length of the article is 421 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Pertussis Rings Up to $145,903 for 87 Cases Treated.(Brief Article)(Statistical Data Included)
Author: Miriam E. Tucker
Publication: Family Practice News (Magazine/Journal)
Date: March 1, 2000
Publisher: International Medical News Group
Volume: 30Issue: 5Page: 42

Article Type: Brief Article, Statistical Data Included

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This digital document is an article from Internal Medicine News, published by International Medical News Group on January 1, 2005. The length of the article is 797 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Rise in pertussis spurs efforts to curb transmission: FDA now reviewing two new vaccines.(News)
Author: Alicia Ault
Publication: Internal Medicine News (Magazine/Journal)
Date: January 1, 2005
Publisher: International Medical News Group
Volume: 38Issue: 1Page: 1(2)

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This digital document is an article from Internal Medicine News, published by International Medical News Group on July 1, 2004. The length of the article is 495 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Pertussis booster for adolescents could decrease susceptibility.(Infectious Diseases)
Author: Michele G. Sullivan
Publication: Internal Medicine News (Magazine/Journal)
Date: July 1, 2004
Publisher: International Medical News Group
Volume: 37Issue: 13Page: 51(1)

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This digital document is an article from The Register-Guard (Eugene, OR), published by The Register Guard on July 24, 2003. The length of the article is 919 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Whooping cough vaccines urged.(Health)(Officials seek stepped-up protection from pertussis, especially for infants, in hard-hit Lane County)
Publication: The Register-Guard (Eugene, OR) (Newspaper)
Date: July 24, 2003
Publisher: The Register Guard
Page: D1

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This digital document is an article from Family Practice News, published by International Medical News Group on March 15, 2000. The length of the article is 662 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: 'Mixing and Matching' Okay for Fifth DTaP Dose.(diptheria-tetanus-acellular pertussis vaccine)(Brief Article)
Author: Miriam E. Tucker
Publication: Family Practice News (Magazine/Journal)
Date: March 15, 2000
Publisher: International Medical News Group
Volume: 30Issue: 6Page: 73

Article Type: Brief Article

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This digital document is an article from Validation Times, published by Washington Information Source on February 1, 2000. The length of the article is 809 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Pertussis toxin validation is N. American Vaccine issue. (Blood/Biologics).
Publication: Validation Times (Newsletter)
Date: February 1, 2000
Publisher: Washington Information Source
Volume: 2Issue: 11Page: 11

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This digital document is an article from Family Practice News, published by International Medical News Group on April 15, 2005. The length of the article is 1564 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: FDA panel supports preteen pertussis boosters; in June, the CDC is likely to address the use of Tdap, instead of Td, in adults who need boosters.(News)
Author: Miriam E. Tucker
Publication: Family Practice News (Magazine/Journal)
Date: April 15, 2005
Publisher: International Medical News Group
Volume: 35Issue: 8Page: 6(1)

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