Product Description
PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.

· First edition won Best Book in Medical Science Award from the Association of American Publishers

· Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias

· A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references ... Read more

Customer Reviews (1)

Best Book in Medical Science 2002
This publication won, not just the best publication in hemostasis, not just the best publication in hematology, but in all of medical science (Assoc American Publishers, 2002). A well deserved award.

The book contains contributions from nearly all the very best and respected researchers in platelet pathophysiology. It broadly covers every aspect of platelets: from the biology, ultrastructure, biochemistry and physiology of function through to the clinical role of new platelet function analyzers in the diagnosis and management of coronary syndromes. New and emerging antiplatelet agents and clinical trials are discussed in detail.

This book will be of great benefit to both the clinician and the researcher. A landmark publication in the field. ... Read more

Product Description
A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of hematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders. ... Read more

Product Description
This book reviews current science and applications of platelets research in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis and therapeutics of diseases involving platelets. Chapters are devised to provide a critical review of the most clinically relevant aspects of the subject. ... Read more

Product Description
The essential role of human platelets in hemostatis and circulation is well recognized. Basic research of the last two decades has clearly established that platelets play a major role in hemorrhagic / thrombotic and cardiovascular diseases including atherosclerosis and cerebral / myocardial infarction. Recently, important advances in our understanding of platelet structure, function and regulation at the molecular level have been made. In particular, advances in our understanding of the physiology, pathophysiology and pharmacology of adhesion receptors have paved the way for novel, innovative therapeutics. This book highlights these areas of research. ... Read more

Product Description
Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now.
Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing.

Key Features
Includes:
* A basic introduction to platelet anatomy and physiology
* Testing procedures for new anti-platelet therapies
* Descriptions of platelet function abnormalities
* Therapeutic approaches to inhibition of platelet function
* Step-by-step methodologies with clear explanations
* Helpful appendixes of recipes, instructions, sources of reagents, and more ... Read more

Customer Reviews (1)

A book for daily practice
Excellent book. Full of clues for the day-by-day work. It was really important to my practice. After read it wechaged a lot of protocols regarding platelet aggregation. Great deal!!! ... Read more

Product Description
Contributors present a detailed account of basic and clinical aspects of the factor VIII/von Willebrand complex, relating advances in molecular and cellular biology to the clinical disorders associated with congenital and acquired abnormalities of hemostasis and thrombosis. Annotation copyright Book ... Read more

Product Description
This title includes proceedings of the first European Symposium on platelet immunology held in Paris, Palais du Luxembourg (France), 1 to 2 March 1990. ... Read more

Product Description
This issue focuses on platelet disorders that are routinely encountered by practicing hematologists.Since there is a rapidly expanding body of information currently available in this discipline, we have assembled a wide variety of topics by experts in their respective fields. For example, the chapter on assessment of platelet function covers standard assay methods as well as more advanced testing and point of care tests. Similarly, recent advances in the management of heparin induced thrombocytopenia (HIT), thrombotic thrombocytopenic purpura (TTP) and immune thrombocytopenia (ITP) are discussed by authors who have performed original research in these areas. Other interesting topics include anti-platelet drug therapy, drug-induced thrombocytopenia and current evidence-based platelet transfusion therapy. Apart from congenital and acquired platelet dysfunction, a chapter on hyperactive platelets is included because evidence is emerging that supports the hypothesis that increased platelet function can cause thrombotic disorder. It is our sincere hope that this compendium of articles will ease the burden of the practicing hematologist and simplify the task of treating patients with platelet disorders ... Read more

Product Description
The article is excerpted fromGale Encyclopedia of Medicine.

Consultthe second edition of this authoritative, comprehensive, in-depthmedical guide for information on more than 1,700 medical topics inlanguage accessible to adult laypersons. Presented in a singlealphabetical sequence, articles range in length from one or twoparagraphs for minor topics, to several pages or more for major topics.Disease/disorder articles typically cover definition; description;causes and symptoms; diagnosis; treatments; prevention; and more.Test/treatment articles typically cover definition; purposes;precautions; preparation; risks; normal and abnormal results; and muchmore. This second edition includes more than 200 new entries, 300updated entries, approximately 650 color images and illustrations, anda comprehensive subject index. New features include biographical andhistorical sidebars throughout the text.

Disease/disorder articles contain some or all of the following sections:

• Definitions -- brief dictionary-style definition of the disorder
• Descriptions -- overview of the disorder; who gets it and why
• Causes & symptoms -- process, substance or organism thatproduces the condition; any risk factors that increase susceptibilityto the condition; signs and symptoms of the disease
• Diagnosis -- overview of procedures and tests used todiagnose the condition; how the test is done; who should be tested andwhen; time required; cost; whether it's typically covered by insurance
• Treatments -- overview of conventional methods of care ormanagement of the condition, such as drugs, surgeries, physicaltherapy, etc.
• Alternative treatments -- overview of alternative/complementary therapies that may be used to treat the condition
• Prognosis -- probable outcome of the disease
• Preventions -- what actions can be taken to prevent the condition from occurring

Test/treatment articles contain some or all of the following sections:

• Definitions -- brief dictionary-style definition of the test/treatment
• Purposes -- why and when this test/treatment is prescribed
• Precautions -- when this test/treatment should not be prescribed
• Descriptions -- overview of the test/treatment including cost,length of time required, procedures followed, whether typically coveredby insurance
• Preparation -- pre-test treatment procedures, if any
• Aftercare -- post-test treatment procedures, if any
• Risks -- any complications/side effects commonly associated with the test/treatment
• Normal results -- for tests, describes the normal values; for treatments, describes the anticipated outcomes
• Abnormal results -- defines abnormal test values

Published/Released: December 2001

Product Description
This text covers megakaryocytes and platelets. Topics include the evolution of megakaryocytes to platelets and positive and negative regulation of megakaryocytopoiesis. ... Read more