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West Nile virus is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis in humans. Infection of humans is associated with a febrile illness that can progress to meningitis and encephalitis with symptoms including cognitive dysfunction and flaccid paralysis. Following its introduction to the United States in 1999, West Nile virus rapidly disseminated across North America. Outbreaks of West Nile virus fever and neuroinvasive disease now occur annually in the United States, with about 23,000 diagnosed human cases between 1999 and 2006, and likely millions of undiagnosed infections. At present no vaccines or specific therapies for West Nile virus are currently approved for humans.

The emergence of West Nile virus in the Western hemisphere and the corresponding increase in disease burden has been accompanied by intensive study. West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response focuses on recent studies that have identified key steps in the molecular pathogenesis of West Nile virus infection. After introducing the scale of the global problem, the genetic diversity, and the clinical syndromes, the initial chapters describe our most up-to-date understanding of the pathogenesis steps in animals and the viral sequence determinants that mediate virulence. Subsequent chapters focus on the earliest innate host immune response that controls West Nile virus spread and include recent experiments on pathogen recognition receptors, IFN antiviral cascades, and mechanisms of West Nile virus antagonism. The book explores in detail the host-pathogen interface, and analyzes the latest data describing how a balance between host protective responses, host immunopathology, West Nile-induced pathology, and West Nile virus immune evasion determines infection outcome. Finally, the book concludes with novel approaches and prospects for human vaccines and therapeutics.

About the Editor:

Dr. Michael S. Diamond is Associate Professor in the Division of Infectious Diseases at Washington University Medical School, St. Louis, MO, uSA.

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Antibodies are central to vaccines and it is becoming increasingly apparent that understanding how antibodies combat viruses could be crucial in a new era of vaccine development. This book describes the state of the art in explaining the anti-viral activity of antibodies at the molecular level, with chapters from many of the leaders in the field. ... Read more

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This latest edition of the classic text includes new andgreatly revised chapters on laboratory methods in epidemiology, humanherpesvirus types 6 and 7, parvovirus, and retroviruses. The bookcovers the principles and approaches to the study of viral infections,major virus classes of medical and public health importance, andneoplastic and other slowly developing diseases due to viralinfection. ... Read more

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Written from the perspective of the diagnostician, this significantly expanded Third Edition explores all human viral diseases and the use of molecular techniques to detect and manage these diseases. This case-based and example-driven text provides extensive information on molecular detection of viruses and the design and validation of molecular assays.

Key features in the Third Edition: ... Read more

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Fred Hutchinson Cancer Research Center, Seattle, WA. Brings together information specific to the management of infectious complications that occur specifically in immunocompromised patients undergoing transplantation. Reviews epidemiology, diagnosis, and management of opportunistic infections. Extensive references. For clinicians. DNLM: Transplants--adverse effects. ... Read more

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It has been recognized that viruses can induce neuronal damage by a variety of mechanisms. This volume summarizes, for the first time, the various ways that neurons can degenerate under the influence of viral infection, ranging from acute necrosis and virus-induced apoptosis to chronic damage in persistent infections. The mechanisms of neuronal latency are dealt with as well. The volume also includes chapters that review the chronic damage caused by viral proteins that interfere with differentiated functions of the neuron, including signaling by neurotransmitters and signal transduction by trophic factors. Other chapters deal with the controversial role of cellular immune reactions, which may be helpful in controlling infection, but may also be detrimental to the host nervous system. The specific mechanisms of damage involved in retroviral infections and in prion diseases of the nervous system are reviewed, and finally how autoimmune diseases can lead to neuronal damage. ... Read more

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This CTMI volume deals with specific aspects of viral interactions with cellular membranes and includes chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. The chapters provide overviews of viral interactions with cellular membrane trafficking mechanisms and up to date reviews of each field.

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Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration. ... Read more

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Cytotoxic T lymphocytes (CTL) control several viral infections in animals based on deletion and reconstitution experiments with CTL clones and use of CD8 genetically deficient (knock-out) mice. In this volume, data for the role that CTL play in human infectious diseases is presented. As such, this represents the first volume in which such information from several different viral and protozoan infections is brought together. ... Read more

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Temple University, Philadelphia, PA.Clinical atlas of specimens, stains, and other diagnostic cues, for physicians, microbiologists, and pathologists. Quality color images. 10 U.S. contributors. DNLM: Gastroenteritis - diagnosis - atlases. ... Read more

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The hidden dangers surrounding us.

Despite the confident strides of modern science, the threat of deadly unseen organisms such as viruses, bacteria and fungi still grip the imagination with their ferocious intensity.

For instance, resistant strains of bacteria can now survive the strongest antibiotics and deadly new biological weapons are being cooked up in laboratories worldwide.

Microterrors explores these threats as well as humanity's greatest living rivals that have been on the planet far longer than we have.

The introduction covers terms, definitions and a brief natural history, including the role of viruses in human evolution, as well as bioengineering and biological weapons. Microterrors then presents the truly terrifying rogues' gallery of invisible killers.

Dramatic life-like digital illustrations and computer-colored electron images provide mug book profiles of hundreds of naturally occurring and bioengineered microterrors, including:- Ebola, bubonic plague, cholera, malaria- Bacteria: pneumonia, anthrax, botulism- Viruses: HIV, hepatitis, common cold- Fungi and blood and tissue diseases.

Each entry includes concise facts such as date of discovery and place of origin, period of incubation, symptoms and length of suffering, likelihood of death, treatments, vaccines and cures. ... Read more

Customer Reviews (7)

Great Handbook
This book is a great handbook to get easy and quick access to essential information regarding the various viruses, bacteria, fungi and protozoa. I especially like the colored images as well as the way in which the book is written. Information is precise and pretty upto date. The paperback copy is completely affordable and absolutely worth buying.

Great Book!
I got this book for my husband who is studying virology.He loves it!The pictures are great, as are the descriptions! Its now his favorite non-scifi book.

Overall, if you are at all interested in microbiology and infectious things, you will love this book!

Let the terror begin!
I have been looking for an informative book on microbes for a long time, and I've found exactly what I've been looking for with this book. The information in Microterrors is organized and easy to understand, especially for someone that's interested in finding out more about the germs they hear about everyday on the news. This book makes you want to learn more about these deadly terrors, and at the same time lock yourself away in a clean room. Definitely a must read for anyone interested in the genre.

Microterrors
Very fast delivery, great condition. Reassuring since i tried to order this book from another seller and never recieved it. Thanks

Spelling Bee
Nice little reference book. I bought it first and foremost because it was nicely designed. It's brief but informative and has alot of nice images. The downfall of this book, as I noticed after reading it, is that the editor did an appalling job of ...well editing. This book has an insane amount of spelling and grammar errors (for a book in print I mean). I was a bit dissapointed by that, I guess they sacrificed clarity for image. Too bad, it could have been perfect. Anyway not to end on a sour note the graphics and the information make up for that one flaw. ... Read more

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Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides a unique diagnostic reference text for the pathologic diagnosis of infectious diseases of the gastrointestinal tract. Written for the practicing surgical pathologist, this text combines the superior illustrations of an atlas with carefully written prose to create a useful diagnostic companion. The text is divided into four sections covering bacterial, fungal, viral, and parasitic infections of the gastrointestinal tract. The descriptive sections of each chapter are organized into short paragraphs for easy reference and include the use of tables to compare and contrast organisms and summarize differential diagnoses. Each chapter is extensively illustrated, and contains prose discussions of diagnostic features, differential diagnoses, brief clinical descriptions, and ancillary tests that help confirm the diagnosis (i.e. immunohistochemistry, special histochemical stains, and molecular diagnostic techniques).

Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides pertinent clinical, diagnostic, and epidemiologic information that will be valuable to the practicing surgical pathologist. This volume will also help surgical pathologists gain familiarity with other contributory laboratory tests that are available to help confirm diagnosis.

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A comprehensive look at the latest research findings and clinical applications of oncogenic viruses

Written by a panel of academic experts, Viral Oncology is the first self-contained and comprehensive book to present both scientific and clinical information on viruses linked to some of the most important human cancers. Readers can turn to this book for the most in-depth and up-to-date coverage of: HPV-associated cancers; molecular events associated with HPV-induced human cancer; the role of the HPV E6 oncoprotein in malignant progression; virus association with brain tumors; involvement of the polyomavirus JCV in colorectal cancer; possibleassociation of BKV with prostate cancer; oncogenic transformation bypolyomavirus large T antigen; SV40 and human cancer; SV40 and mesothelioma; molecular immunology of hepatitis B–associated viral cancer; hepatitis B vaccine and hepatocellular carcinoma; pathogenesis of acute and chronic hepatitis Cvirus infection; molecular mechanisms of hepatitis C virus-induced cellulartransformation; clinical aspects of HTLV-1 associated cancer; oncogenic potential of the HTLV-1 tax protein; HIV-associated malignancy; HIV-related lymphoma; biology and epidemiology of HHV-8; the role of KSHV in pathogenesis of Kaposi'ssarcoma; molecular pathobiology of EBV infection; and EBV as a pathogen.

Several chapters are devoted to the basic science of oncogenic viruses for thestudy of their pathogenesis, drug development, and employment of viral vectorsfor vaccine and gene therapy. The book also includes complementary clinically based chapters describing natural courses and treatments. Additionally, bonusclinical materials are embedded within chapters and an easy-to-use indexcompletes the book.

Viral Oncology is an essential resource for clinical and research oncologists in medical facilities and biological research laboratories; clinicians and scientists working in related biomedical areas; medical students working toward a first or higher degree in the life sciences and other biomedical fields; and pharmaceutical scientists and developers. ... Read more

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Viruses have been linked to approximately 15 to 20 per-cent of all human tumours world-wide and their empire is expanding over the years. While histopathology and cytopathology have been utilised for decades to arrive at a tissue diagnosis of cancer, the advent of newer and more sophisticated ancillary tools have thrown light on the aetiology of neoplasia including virus as one of the causes. Whereas in occasional cancer, it is possible to observe the cytopathic effect of virus in cancer cells or their precursor lesions, in most malignancies there is so far no morphological clue to their viral aetiology. However, morphological diagnosis continues to be important for the management of malignancies and cytologic tools is a simple and largely non-invasive tool for collection of samples for various ancillary studies. This book deals with the classification of oncogenic viruses and the diagnostic tools utilised for the cytodiagnosis of cancers likely to be caused by these viruses.The role of cytology in diagnosis of malignancies caused by human papillomavirus (HPV) and human polyomaviruses is also discussed, as well as the malignacies caused by Epstein-Barr virus (EBV) and Kaposi sarcoma herpes virus (KSHV). The book concludes with a discussion of possible future developments in this field. ... Read more

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The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care.

Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood.

Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations. ... Read more