1. The Body: Cytomegalovirus (CMV) Information on treatment of CMV (cytomegalovirus) at The Body, the complete AIDS/HIV information resource. cytomegalovirus (CMV). Got questions on CMV? Get answers from The Body's experts! http://www.thebody.com/treat/cmv.html

Cytomegalovirus (CMV) Got questions on CMV? Get answers from The Body's experts! The Basics Prevention Treatment Personal Accounts ... Research The Basics CMV (Cytomegalovirus) (February 3, 2003) To read PDF, click here From New Mexico AIDS InfoNet (September 2002) In HIV Treatment ALERTS!, from The Center for AIDS: Hope and Remembrance Project Cytomegalovirus (CMV) (February 21, 2002) A Simple Facts Sheet from AIDS Treatment Data Network Save Your Sight: Eye Disease and HIV (December 2001/January 2002) In Positive Living , from AIDS Project Los Angeles Cytomegalovirus (CMV) Fact Sheet (September 1999) To read PDF, click here From Project Inform Eye Diagram (May 1998) From National Institutes of Health Cytomegalovirus (CMV) and You (December 1997) A guide for people with HIV infection From Centers for Disease Control and Prevention Eye Problems (Summer 1997) From Women Alive CMV Background (April/May 1997) From Gay Men's Health Crisis Ophthalmology (September 1996) From The Johns Hopkins University AIDS Service The Hopkins HIV Report: A bimonthly newsletter for healthcare providers Cytomegalovirus From an article by Joel Gallant, M.D., M.P.H.

2. Cytomegolovirus (CMV) Infection From the Centers for Disease Control. Includes at risk population, transmission, prevention, diagnosis, Category Health Conditions and Diseases Viral cytomegalovirus......National Center for Infectious Diseases cytomegalovirus (CMV) Infection,GENERAL INFORMATION. cytomegalovirus, or CMV, is found universally http://www.cdc.gov/ncidod/diseases/cmv.htm

National Center for Infectious Diseases Cytomegalovirus (CMV) Infection GENERAL INFORMATION Cytomegalovirus, or CMV, is found universally throughout all geographic locations and socioeconomic groups, and infects between 50% and 85% of adults in the United States by 40 years of age. CMV is also the virus most frequently transmitted to a developing child before birth. CMV infection is more widespread in developing countries and in areas of lower socioeconomic conditions. For most healthy persons who acquire CMV after birth there are few symptoms and no long-term health consequences. Some persons with symptoms experience a mononucleosis-like syndrome with prolonged fever, and a mild hepatitis. Once a person becomes infected, the virus remains alive, but usually dormant within that person's body for life. Recurrent disease rarely occurs unless the person's immune system is suppressed due to therapeutic drugs or disease. Therefore, for the vast majority of people, CMV infection is not a serious problem. However, CMV infection is important to certain high-risk groups. Major areas of concern are (1) the risk of infection to the unborn baby during pregnancy, (2) the risk of infection to people who work with children, and (3) the risk of infection to the immunocompromised person, such as organ transplant recipients and persons infected with human immunodeficiency virus (HIV).

3. Cytomegalovirus Research At The Dept. Of Immunotechnology cytomegalovirus research. Department of Immunotechnology, Lund University http://www.immun.lth.se/TEXTER/CMV.html

Cytomegalovirus research Department of Immunotechnology, Lund University Immunofluorescence of CMV-infected human fibroblasts using the pp65-specific human antibody MO61. (Picture kindly provided by Dr. Vivi-Anne Sundqvist, Stockholm, Sweden.) If you are interested in general information on cytomegalovirus , please read this information compiled by the Centers for Disease Control ( CDC , Atlanta, GA, USA) or this brief information text provided by the Epidemiology and Disease Control Program for the State of Maryland This research group has been a part of a new completed international collaboration studying the interaction between CMV glycoprotein B and human antibodies against this antigen. If you would like to obtain more information on this research network, please go to the home page of that project Table of contents: Introduction Antibody V region gene usage in CMV-specific antibodies and auto-reactivity Repertoires of antibodies against the AD-2 epitope on gB - causes of poor immunogenicity. Human antibodies against CMV gB epitopes and virus neutralisation Complement and antibody-mediated neutralisation of CMV Human antibody responses to CMV pp65 Serological analysis of gB-specific antibodies using electrochemiluminescence-based technology Production of human monoclonal antibodies applied to CMV specificities Reagents available for scientific collaborations Cytomegalovirus (CMV) is a (usually non-pathogenic) virus commonly found in the human population. Following infection, the virus persists in the host but the carrier is protected from disease by its immune system. Both cellular and humoral (antibody) activities are believed to be involved in the defense against such CMV-induced active disease. The Department of Immunotechnology has had a longstanding interest in research on antibody responses in humans against cytomegalovirus. The research has mainly focused on such antibody responses against the diagnostically important antigen pp65 (lower matrix protein; ppUL83) and the therapeutically interesting surface glycoprotein B (gB; gp58/116; gpUL55).

4. Viral Infections: Cytomegalovirus Menu Covers symptoms, diagnosis, and treatment. Also describes the pathogen responsible for CMVand strains show to be resistant to treatment. cytomegalovirus. Pathogen. Sites of Infection http://www.hivpositive.com/f-Oi/OppInfections/4-Viral/4-Vir-Cyto/4-CytoSubMenu.h

Cytomegalovirus Pathogen Sites of Infection Symptoms Diagnosis ... Go to the HIVpositive.com Main Menu

5. Cytomegalovirus (CMV). cytomegalovirus (CMV), Deafblind, deafblind, deafblindness, cytomegalovirus (CMV). CMV, a member of the herpes virus family of DNA viruses, is a large, membrane-enveloped virus. http://www.deafblind.com/cmv1.html

Go Back to The Archives Page. Cytomegalovirus (CMV). CMV, a member of the herpes virus family of DNA viruses, is a large, membrane-enveloped virus. Like other members of the herpes virus family, CMV possesses the characteristics of latency and reactivation, which means that viral infection can reactivate repeatedly with viral shedding occurring for many years after initial infection. CMV is widely prevalent throughout the world and most infections are asymptomatic. Major manifestations are: mononucleosis, congenital CMV infection (CMV is the most common cause of virus-induced mental retardation in the Western World); graft rejection in organ transplant recipients; severe pneumonia, hepatitis and CMV retinitis in immunosuppressed individuals. CMV retinitis, an infection that progresses to blindness, afflicts approximately 15 to 40 percent of AIDS patients. CMV retinitis usually begins as a white infiltrate within the retina, and can progress rapidly to cause destruction of retinal tissue. Retinal damage can lead to detachment of the retina, occurring in 15 to 29 percent of patients with AIDS-related CMV retinitis, and permanent loss of vision. Each year, approximately 40,000 infants are born with congenital CMV, which is transmitted congenitally (or in the womb through the placenta) from mother to fetus. Whether due to a severe disease at birth or to long-term sequellae of a latent infection, congenital CMV infection is a leading cause of congenital deafness and mental retardation.

6. Information About Cytomegalovirus. Human cytomegalovirus is a member of the herpesvirus family. cytomegalovirus is a very common infection with 80% of the adult population having evidence of infection. http://oak.cats.ohiou.edu/~biegalke/cytomegalovirus.html

Human cytomegalovirus is a member of the herpesvirus family. Cytomegalovirus is a very common infection with 80% of the adult population having evidence of infection. Once infected with cytomegalovirus, individuals are permanently infected with the virus. Fortunately, most infections do not result in disease although there are exceptions. Infrequently, cytomegalovirus can cause infectious mononucleosis in otherwise normal healthy adults. Much more commonly, cytomegalovirus is associated with disease in newborn infants or people that are immunocompromised including transplant recipients and people with AIDS. Infection of newborn infants usually results from transmission of the virus to the fetus while in utero. Infection of newborn infants is associated with a range of presentations from asymptomatic infection to deafness to mental retardation to death. Infection of people undergoing bone marrow transplantation is associated with pneumonitis while cytomegalovirus infection in people with AIDS is associated with retinitis, gastroenteritis and encephalitis. For additional information about the virus please see links.

7. The Body: New Mexico AIDS InfoNet -- CMV (Cytomegalovirus): Fact Sheet Number 50 CMV (cytomegalovirus), a New Mexico AIDS InfoNet Fact Sheet, at The Body, thecomplete AIDS and HIV information resource. PDF. CMV (cytomegalovirus). http://www.thebody.com/nmai/cmv.html

New Mexico AIDS InfoNet Fact Sheet Number 504 PDF CMV (Cytomegalovirus) February 3, 2003 What Is CMV? How Is CMV Treated? Can CMV Be Prevented? How Do I Choose a Treatment for CMV? ... The Bottom Line What Is CMV? Cytomegalovirus (CMV) is an opportunistic infection. The virus is very common. About 85% of the US population tests positive for CMV by the time they are 40 years old. A healthy immune system keeps this virus in check. When HIV or another disease weakens immune defenses, CMV can attack several parts of the body. The most common illness caused by CMV is retinitis. This is the death of cells in the retinas, the back of the eye. It can quickly cause blindness unless treated. CMV can spread throughout the body and infect several organs at once. The risk of CMV is highest when CD4 cell counts are below 100. The first signs of CMV retinitis are vision problems such as moving black spots. These are called "floaters." They may indicate an inflammation of the retina. Some doctors recommend eye exams to catch CMV retinitis. The exams are done by an ophthalmologist (an eye specialist). If your CD4 count is below 200 and you experience any vision problems, tell your doctor immediately.

8. HUMAN CYTOMEGALOVIRUS HUMAN cytomegalovirus. INTRODUCTION. For more information on cytomegalovirus .General Information on HCMV Research Information on HCMV REFERENCES. 1. Canada. http://www.science.mcmaster.ca/Biology/Virology/19/CYTOG.HTM

HUMAN CYTOMEGALOVIRUS INTRODUCTION 1. VIRION STRUCTURE ICOSAHEDRAL CAPSID MORPHOLOGY: MCP (major capsid protein) - structural mCP (minor capsid protein) - anchors DNA assembly protein (COOH term of pUL80) associated with capsid and plays a role in maturation. It stays associated with an alternative capsid form that matures as non-infectious enveloped particles. PHOSPHOLIPID ENVELOPE: gH - adhesion to host cell receptor(s) gB and gH are both candidates for subunit vaccines gpUL47-52 - bind heparan sulphate to enable cell-virion adhesion gpUS27-28 - G coupled receptor and C-C chemokine receptor respectively. IgG Fc Receptor - evidence of role in allowing HIV entry into CMV-infected cells TEGUMENT PROTEINS: as many as 20, many of which are phosphorylated; complete understanding of these still unclear ppUL83 (pp65) - also called lower matrix protein; most abundant (95% of tegument); primary target of phosphorylation by protein kinases; antigen target in antigenemia assays ppUL82 (pp71) - transactivator ppUL32 (pp150) - alkaline phosphoprotein; strongly immunogenic CORE: Simple!

9. Page Not Found | Aidsinfonet.org | The New Mexico Aids Info Net A nontechnical fact sheet on cytomegalovirus (CMV), an opportunistic infection related to HIV disease. WHAT IS CMV? cytomegalovirus (CMV) is an opportunistic infection. http://www.aidsinfonet.org/501-cmv.html

@import "http://aidsinfonet.org/styles/sophisto.css"; Search Our Site Enter Keywords or Fact Sheet Number: Newest Fact Sheets 461. Enfuvirtide (Fuzeon) 447. Atazanavir 411. AZT (Retrovir) Monthly E-mail Updates If you would like to receive this monthly update by personal e-mail, please provide your e-mail address below, and click on the "Subscribe" button. To remove your e-mail from the mailing list, enter it below and click on the "Unsubscribe" button. e-mail Address: Home Index of Fact Sheets Internet Bookmarks on AIDS Questions? ... Contact Us We subscribe to the HONcode principles. Verify here Page Not Found! Either you have typed in a URL that does not exist at aidsinfonet.org or you have attempted to connect with a part of our site which has been updated and restructured. In any case, you should be able to navigate to your final destination easily from our home page (http:www.aidsinfonet.org). The New Mexico AIDS InfoNet is a project of the New Mexico AIDS Education and Training Center at the University of New Mexico Health Sciences Center. Partially funded by the National Library of Medicine and the New Mexico Department of Health.

10. File Include CENTERS FOR DISEASE CONTROL AND PREVENTION Date Last Rev'd March 9, 1995 cytomegalovirus(CMV) GENERAL INFORMATION cytomegalovirus, or CMV, is found http://www.immun.lth.se/TEXTER/CMV_general.html

Generated by: /usr/local/httpd/cgi-bin/includetext.pl Date: 13:59:1 UT on Fri 1 Dec 95.

11. Page Moved - Cytomegalovirus (CMV) cytomegalovirus, Version en español (CMV). Further Information WadsworthCenter for Laboratories and Research. What is cytomegalovirus, (CMV)? http://www.health.state.ny.us/nysdoh/consumer/cytomega.htm

location.href="/nysdoh/communicable_diseases/en/cytomega.htm"; Page moved click here if your browser does not forward you to the new page. http://www.health.state.ny.us/nysdoh/communicable_diseases/en/cytomega.htm

12. OI: CMV -- ÆGIS Relax, there is a good chance you are already infected with cytomegalovirus.About half of cytomegalovirus. CMV Now that protease http://www.aegis.com/topics/oi/oi-cmv.html

Cytomegalovirus "C.M.V." Now that protease inhibitors are combating HIV to the point that PWAs are living longer, one doctor at a recent conference noted that managing HIV Disease has become managing CMV more than anything else. CMV is very common in those with low t-cell counts less than 100. This is part of a series on Opportunistic Infections ("OIs"). Please note that This Page Is Just A Starting Point: who specializes in treating HIV. Finding The Latest Information: Advances in treating opportunistic infections can happen at any time, so the material on this page may be outdated. Some links in the see also section at the bottom of this page are actually special database links. They may contain information published after this page was written. Classification herpes-type virus (cytomegalovirus) Description Relax, there is a good chance you are already infected with cytomegalovirus. About half of all (not just HIV+) adults in developed countries are infected. Almost all gay/bisexual men with HIV are infected, and 75% of other HIV+ have it. CMV attacks the eyes (retina), colon, and throat. Less commonly, it can infect almost any other internal organ.

13. Simple Facts Sheets: CMV Data Network. cytomegalovirus (CMV). CMV stands for cytomegalovirus.cytomegalovirus is a member of the herpesvirus family. Viruses http://www.aegis.com/factshts/network/simple/cmv.html

a Simple Facts Sheet from the AIDS Treatment Data Network cytomegalovirus (CMV) CMV stands for cytomegalovirus. Cytomegalovirus is a member of the herpesvirus family. Viruses have been around for thousands of years and there are many kinds of viruses. A virus can't live on its own or spread on its own, but needs human cells to live and grow. Most people are infected with some kind of virus, but the immune system usually keeps them from causing active disease. When the immune system is not working well, a virus like CMV can cause illness. T4 cell counts are one way to measure how well the immune system is working in people with HIV. The risk of developing illness due to CMV is greatest when theT4 cell count is less than 100. The most common illness caused by CMV in people with AIDS is retinitis. CMV retinitis is an infection of the eye that can lead to blindness. Other forms of CMV disease are colitis (CMV in the intestine), esophagitis (in the mouth or throat), myelitis (spine), and sometimes encephalopathy (brain), and pneumonitis (in the lungs). Left untreated, CMV can spread throughout the body, infecting one or more organs at once and resulting in a great variety of symptoms. Symptoms The signs of CMV retinitis are vision problems, such as moving black spots known as "floaters," or blind spots. These indicate an inflammation of the retina of the eye. A doctor that specializes in eye problems, called an ophthalmologist, can check for CMV by doing a simple eye examination. If you have a low T4 cell count, it's important to get regular eye exams to check for early signs of CMV retinitis.

14. History Of The Cytomegalovirus History of the cytomegalovirus. HARRIS D. RILEY, JR., MD, Oklahoma City,Okla. References. 1. Alford CA Jr, Britt WJ cytomegalovirus. Virology. http://www.sma.org/smj/97feb4.htm

History of the Cytomegalovirus HARRIS D. RILEY, JR., MD, Oklahoma City, Okla CYTOMEGALOVIRUSES (CMVs) are ubiquitous agents that commonly infect many animals, including humans. Human CMV is an ancient virus closely linked to its natural host, human beings. Evidence of infection has been detected in the Tiriyo Indians in remote sections of Brazil in the absence of evidence of measles and influenza infections. As with other herpesviruses, primary CMV infection is usually followed by persistent and/or recurrent infections.1 When CMV comes in contact with the fetus, the infection may be limited by the various host defense mechanisms of the mother and/or the fetus. The results may range from subtle abnormalities not detectable at birth to severe generalized disease in the newborn period. The latter, more recognizable form of the infection has been better documented than the milder manifestations.2 More recently, evidence has accumulated to document the occurrence of acquired forms of the infection. Since that time CMV has emerged as an important opportunistic pathogen in immunologically compromised hosts.3 In view of the important developments in our knowledge of the biology of cytomegalovirus, it is appropriate to review the history of this important virus. DISCOVERY OF INTRANUCLEAR INCLUSIONS Further experimental evidence confirming the viral etiology of the disease was provided by Cole and Kuttner11 from experimental studies of the disease in guinea pigs. In 1926, these researchers induced the formation of inclusion bodies in guinea pigs. Using filtered material and a Berkefeld N filter impermeable to bacteria, they found the guinea pig virus to be heat sensitive and relatively unstable. Andrewes12 attempted to propagate rodent salivary gland viruses in vitro. Although he was able to show intranuclear inclusion-body formation in primary cultures, attempts at serial propagation of the agent were unsuccessful.2

15. Cytomegalovirus Facts cytomegalovirus. cytomegalovirus (CMV) sito-MEG-uh-lo-vi-rus is avirus that infects most people worldwide. What is cytomegalovirus? http://www.astdhpphe.org/infect/cytomegalo.html

Cytomegalovirus CMV spreads from person to person by direct contact. Although CMV infection is usually harmless, it can cause severe disease in persons with weakened immune systems. There is no treatment for CMV infection. Prevention centers on good personal hygiene, especially frequent handwashing. What is cytomegalovirus? Cytomegalovirus, or CMV, is a common virus that infects most people worldwide. CMV infection is usually harmless and rarely causes illness. A healthy immune system can hold the virus in check. However, if a person's immune system is seriously weakened in any way, the virus can become active and cause CMV disease. What is the infectious agent that causes cytomegalovirus infection? Cytomegalovirus is a member of the herpesvirus family. Other members of the herpesvirus family cause chickenpox, infectious mononucleosis, fever blisters, and genital herpes. These viruses all share the ability to remain alive, but dormant, in the body for life. A first infection with CMV usually causes no symptoms. The virus continues to live in the body silently without causing obvious damage or illness. It rarely becomes active for the first time or reactivates (causes illness again in the same person) unless the immune system weakens and is no longer able to hold the virus in check. Where is cytomegalovirus found?

16. Cytomegalovirus Visual Choice Menu Opportunistic Infections. cytomegalovirus. Standard Text Size. LargeText for the Visually Impaired. Go to the Viral Infections Menu. http://www.hivpositive.com/f-Oi/OppInfections/4-Viral/4-Vir-Cyto/4-CytoChoiceMen

Cytomegalovirus Standard Text Size Large Text for the Visually Impaired Go to the Viral Infections Menu Go to the Opportunistic Infections Menu ... Go to the HIVpositive.com Main Menu

17. InteliHealth: Cytomegalovirus information. cytomegalovirus (CMV) is a virus related to the herpes family. information.cytomegalovirus (CMV) is a virus related to the herpes family. http://www.intelihealth.com/IH/ihtIH/WSIHW000/24505/24505.html

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18. EMedicine - Cytomegalovirus : Article By James M Goodrich, PhD, MD cytomegalovirus cytomegalovirus (CMV) is a member of Betaherpesviridae inthe subfamily Herpesviridae. cytomegalovirus. Last Updated August 2, 2002, http://www.emedicine.com/med/topic504.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Infectious Diseases Cytomegalovirus Last Updated: August 2, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: CMV, Betaherpesviridae, Herpesviridae, mononucleosis, pneumonia, hepatitis, encephalitis, colitis, uveitis, retinitis, neuropathy, HIV, CMV syndrome, fever of unknown origin AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: James M Goodrich, PhD, MD , Associate Professor, Department of Internal Medicine, Division of Infectious Diseases, Southern Illinois University School of Medicine James M Goodrich, PhD, MD, is a member of the following medical societies: Alpha Omega Alpha American Association for Advancement of Science American College of Physicians American Medical Association ... Infectious Diseases Society of America , and Texas Medical Association Editor(s): Douglas A Drevets, MD

19. EMedicine - Cytomegalovirus Infection : Article By Mark R Schleiss, MD cytomegalovirus Infection Of all the human herpesviruses described to date, infectionwith cytomegalovirus (CMV) arguably is the most important cause of http://www.emedicine.com/ped/topic544.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Infectious Diseases Cytomegalovirus Infection Last Updated: January 6, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: cytomegalovirus, CMV, human MCV, HCMV, cytomegalic inclusion disease, CID, cytomegalovirus disease, inclusion body disease, salivary gland virus, herpes, herpesvirus, human herpesvirus 5, HHV-5, Betaherpesvirinae AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Mark R Schleiss, MD , Associate Professor, Department of Pediatrics, Division of Infectious Diseases, University of Cincinnati and Children's Hospital Research Foundation Mark R Schleiss, MD, is a member of the following medical societies: American Pediatric Society Infectious Diseases Society of America , Pediatric Infectious Diseases Society, and Society for Pediatric Research Editor(s): David Jaimovich, MD

20. Advanced Search cytomegalovirus. GREGORY H. TAYLOR, MD, University of Maryland School of Medicine,Baltimore, Maryland cytomegalovirus (CMV) is a prevalent viral pathogen. http://www.aafp.org/afp/20030201/519.html

Advanced Search Cytomegalovirus GREGORY H. TAYLOR, M.D., University of Maryland School of Medicine, Baltimore, Maryland (100 to 150 X 10 A patient information handout on cytomegalovirus, written by the author of this article, is provided on page 526. A PDF version of this document is available. Download PDF now (6 pages / 101 KB). More information on using PDF files. C ytomegalovirus (CMV) is a prevalent pathogen, with 40 to 100 percent of the general population showing prior exposure by serology. Up to 20 percent of children in the United States will have contracted CMV before puberty. Children may in turn be reinfected with different strains of the virus. Infection also is common during adolescence, which directly corresponds to the start of sexual activity. Cytomegalovirus is not highly contagious and is contracted from close personal contact with persons who excrete the virus in their bodily fluids. CMV is a member of the Herpesviridae family, which includes the Epstein-Barr virus (EBV), herpes simplex virus, varicella-zoster virus, and herpesvirus 6, 7, and 8.

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