61. Nature Publishing Group The myelodysplastic syndromes analysis of prognostic factors and comparisonof prognostic systems in 128 Chinese patients from a single institution. http://www.nature.com/cgi-taf/DynaPage.taf?file=/thj/journal/v3/n3/full/6200173a

62. Nature Publishing Group Original Paper. Nontransferrin-bound iron in myelodysplastic syndromesa marker of ineffective erythropoiesis? Agostino Cortelezzi http://www.nature.com/cgi-taf/DynaPage.taf?file=/thj/journal/v1/n3/full/6200028a

63. Resources For Myelodysplasia And Myeloproliferative Disorders From GrannyBarb An Resources for Myelodysplasia or myelodysplastic syndromes and MyeloproliferativeDisorders. Contents. The myelodysplastic syndromes (MDS) Include. MDS Resources. http://www.acor.org/leukemia/mpd.html

Leukemia Links Navigation Bar Know About Leukemia Treating Leukemia Leukemia and Genetics Causes of Leukemia ... HCL Resources MDS and MPD Resources Bone Marrow Transplants Bone Marrow Donor Drives Cord Blood Transplants Online Journals ... Sitemap GrannyBarb and Art's Myelodysplastic Syndromes Myeloproliferative Disorders Resources for Myelodysplasia or Myelodysplastic Syndromes and Myeloproliferative Disorders Contents Resources for Myelodysplasia or Myelodysplastic Syndromes Adult Myelodysplasia Patient Stories Childhood Myelodysplasia Patient Stories In Loving Memory of those who passed away from Myelodysplasia. Information on subscribing to the Aplastic Anemia and Myleodysplastic Syndrome support list (AA-MDS-Talk) mailing list Resources for Myelproliferative Disorders (MPD) Information on subscribing to the Myeloproliferative Disorders (MPD-Net) mailing list Information on subscribing to the BMT-Talk mailing list The Myelodysplastic Syndromes (MDS) Include MDS Resources Refractory Anemia Refractory Anemia with Sideroblasts Refractory Anemia with Excess Blasts Chronic Myelomonocytic Leukemia Refractory Anemia with Excess Blasts in Transformation Preleukemia including Aplastic Anemia caused by environmental exposure PH negative Chronic Myelocytic Leukemia The NCI PDQ patient statement on Myelodysplastic Syndromes (or myelodysplasia).

64. Myelodysplastic Syndrome Clinical Trials In Dundee- UK Clinical trials and clinical research programme formyelodysplastic syndromes in Dundee, Scotland, UK. http://www.dundee.ac.uk/pathology/myelodysplastic/mds.htm

Text only MCP Home Profile Staff ... Contact David T. Bowen MA, MD, MRCPath Reader in Haematology, Phone 01382 660111 ext 33754 or Bleep 4343 (Secretary: Mrs A Robb ext 33893) Fax 01382 645731 Email: d.t.bowen@dundee.ac.uk Research Interests Myelodysplastic syndromes (MDS) / Secondary Acute Myeloid Leukaemia (sAML) These are common haematological malignancies with a median survival from 6 months (high risk) to 50 months (low risk). Therapeutic intervention is at present inadequate. For further information about this disease go to http://www.mds-foundation.org or contact Dr Bowen. Specialist Clinical Service Clinical Trials We have an active clinical trials portfolio coordinated by Dr Bowen and Ann Hyslop (MDS Clinical Research Nurse). Current clinical trials open to all eligible patients are: CTI 1061: Phase I/II study of Trisenox (Arsenic Trioxide) in patients with Myelodysplastic Syndromes. Therapeutic trial of recombinant Human Erythropoietin (rHuEPO, Neorecormon) and Granulocyte Colony-Stimulating Factor (G-CSF, Lenograstim) in the anaemia of Myelodysplasia (MDS): identification of markers of early response.

65. Myelodysplastic Syndromes Foundation toprated.gif myelodysplastic syndromes Foundation. http//www.mdsfoundation.org/.sm_cjpLogo.gifCopyright 2003 - Carden Jennings Publishing Co., Ltd. http://www.bloodline.net/stories/storyReader$3266

Bloodline Home About Call for Papers Free Membership ... Search Educational Features Image Atlas Case Studies Private Lectures Conference Reviews ... Glossary Resources Conference Calendar Hematology Links Full Text Journals Classifieds Specialties BMT/Stem Cell Cord Blood Thrombosis Hemostasis ... Veterinary News Hematology News Blood News Update Discussion Today's Discussion Create New Topic List by Topic Members Join Now Login Myelodysplastic Syndromes Foundation http://www.mds-foundation.org/ Carden Jennings Publishing Co., Ltd. Featured Resources Blood and Marrow Transplantation Reviews Volume 12, Issue 4 New Concepts in the Treatment of GVHD with Photopheresis Private Lecture: Reticulocyte Hemoglobin Content and the Diagnosis of Iron Deficiency Bloodline Reviews Volume 2, Issue 1 Radioimmunotherapy in Non-Hodgkin's Lymphoma BloodLine Image Atlas Autologous Blood and Marrow Transplantation X: Proceedings of the Tenth International Symposium

66. PROFESSIONAL REFERENCE Allergy Immunlogy Cardiology Dermatology Leukemias and myelodysplastic syndromes by Joel Rappeport, MD, Best Practiceof Medicine. January 2002. Last modified February 28, 2002. http://merck.praxis.md/index.asp?page=bpm_brief&chapter=BPM01HE05

67. Myelodysplastic Syndromes (MDS) CedarsSinai Home page myelodysplastic syndromes (MDS) . MyelodysplasticSyndromes (MDS). myelodysplastic syndromes are diseases http://www.csmc.edu/cancer/2087.asp

Cancer Program About Us Our Expert Team Treatments/Programs ... FAQ Search: Cedars-Sinai Home page Myelodysplastic Syndromes (MDS)  Myelodysplastic Syndromes (MDS) Myelodysplastic syndromes are diseases that effect normal blood cell production and behavior. Blood carries oxygen, chemicals and hormones to the cells in the body and helps remove toxins and waste. Bone marrow (the spongy middle part of the large bones) produces the three main categories of blood cells: Red blood cells carry oxygen to the tissues (muscles, bones, nerves and organs). Low or malfunctioning red blood cell production may cause anemia. Symptoms are paleness, tiredness, fast beating or pounding heart, dizziness, shortness of breath or headaches. White blood cells fight infection. Symptoms of infection caused by low white blood counts may include temperature rising to 38.0º C or 100.4º F, coughing, stiff neck, pain or burning with urination, sore throat, mouth or lip sores and sores that do not heal. Platelets help to prevent bleeding. Signs of inadequate platelets include bleeding or bruising too easily. Patients may experience bleeding of the gums when brushing their teeth, blood in the urine or stool, severe headache or visual changes or a stiff neck. MDS may remain stable for several years, or it may get worse quickly and progress to acute myeloid leukemia. The five categories of MDS are:

68. Myelodysplastic Syndromes : Meddie Health Search ITEMS LINKS myelodysplastic syndromes A description of what these diseases are,alternate names, and links for both patient and professional information. http://www.meddie.com/search/Health/Conditions_and_Diseases/Blood_Disorders/Myel

HOME ADD A LINK MODIFY A LINK NEW LINKS ... TOP RATED Search Meddie: the entire directory only this category More search options Home Health Conditions and Diseases ... Blood Disorders : Myelodysplastic Syndromes ITEMS: LINKS: Myelodysplastic Syndromes A description of what these diseases are, alternate names, and links for both patient and professional information. (Rating: 0.00 Votes: 0) Rate It Myelodysplastic Syndromes Foundation Information about the organization as well as the disease itself. Offers research updates, international registry, continuing education and forums. (Rating: 0.00 Votes: 0) Rate It National Cancer Institute General information, cellular classification, stage information, treatment options, de nova, secondary and previously treated myelodysplastic syndromes. (Rating: 0.00 Votes: 0) Rate It HOME ADD A LINK MODIFY A LINK ... Design © ISC Enterprises Inc.

69. Entrez-PubMed Prognostic factors in the myelodysplastic syndromes. Tricot GJ. Departmentof Medicine, Indiana University Medical Center, Indianapolis. http://www.biomedcentral.com/pubmed/1732663

PubMed Nucleotide Protein Genome ... Books Search PubMed Protein Nucleotide Structure Genome PMC OMIM Taxonomy Books PopSet ProbeSet 3D Domains UniSTS Domains SNP Journals UniGene NCBI Web Site for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Browser Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Domain Links 3D Domain Links Genome Links ProbeSet Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links Show: Sort Author Journal Pub Date Text File Clipboard Order Leuk Res 1992;16(1):109-15 Related Articles, Links Prognostic factors in the myelodysplastic syndromes. Tricot GJ. Department of Medicine, Indiana University Medical Center, Indianapolis. Publication Types: Review Review, Tutorial PMID: 1732663 [PubMed - indexed for MEDLINE] Summary Brief Abstract Citation ASN.1

70. Entrez-PubMed Click here to read International scoring system for evaluating prognosisin myelodysplastic syndromes. Greenberg P, Cox C, LeBeau http://www.biomedcentral.com/pubmed/9058730

PubMed Nucleotide Protein Genome ... Books Search PubMed Protein Nucleotide Structure Genome PMC OMIM Taxonomy Books PopSet ProbeSet 3D Domains UniSTS Domains SNP Journals UniGene NCBI Web Site for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Browser Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Domain Links 3D Domain Links Genome Links ProbeSet Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links Show: Sort Author Journal Pub Date Text File Clipboard Order Blood 1997 Mar 15;89(6):2079-88 Related Articles, Links Erratum in: Blood 1998 Feb 1;91(3):1100 Comment in: Blood. 1997 Oct 1;90(7):2843-6. Blood. 2001 Sep 15;98(6):1985. International scoring system for evaluating prognosis in myelodysplastic syndromes. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J. Hematology Division, Stanford University Medical Center, CA 94305, USA.

71. Myelodysplastic Syndromes myelodysplastic syndromes. Def Group of stem cell malignancies characterizedby abnormally formed blood cell precursors, associated. http://umed.med.utah.edu/ms2/hemotolgy/outlines/Myelodysplastic Syndromes.htm

Myelodysplastic Syndromes Def Group of stem cell malignancies characterized by abnormally formed blood cell precursors, associated w/macrocytic anemia due to ineffective erythropoeisis (and maybe leukopenia and thrombocytopenia). They differ from each other in their risks for transforming into acute leukemia K Arise de novo K 5 Subtypes Refractory Anemia RA w/ Sideroblasts RA w/ excess blasts variable Chronic Myelomonocy Leu variable RA w/ excess blasts Trans , Auer Rods Dx Any cytopenias or monocytosis (esp elderly) PMNs—hypogranluated and hyposegmented, Auer Rods Megakaryocytes—monouclear Platelets—Giant and hypogranular RBCs—macrovalocytes w/ basophillic stippling BM— cellularity Chronic Myelomoncytic Leukemia Def l w/ and 20% BM blasts. They derive from the clonal expansion of multi-potent hematopoietic progenitor (RBC, Monocyte, granulocyte, megakaryocyte) usually in elderly, cancer therapy pts, trisomy 21 (8) K Common among many disorders—dysplastic hematopoiesis (HIV) K Differentiate among –CML (bcr/abl), B12 / folate def, aplastic anemia K Risks w/ age K Males predominate Clinical signs asymptomatic anemia w/ bruising *Bacterial infections of skin (granulocyte dysfunction) Pt will be pale, petechiae or purpura

72. NEJM -- Prognostic Importance Of Hypodiploid Hemopoietic Precursors In Myelodysp Original Article from The New England Journal of Medicine Prognostic importanceof hypodiploid hemopoietic precursors in myelodysplastic syndromes. http://content.nejm.org/cgi/content/short/314/23/1472

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 314:1472-1475 June 5, 1986 Number 23 Next Prognostic importance of hypodiploid hemopoietic precursors in myelodysplastic syndromes R Clark, S Peters, T Hoy, S Smith, K Whittaker, and A Jacobs Table of Contents Find Similar Articles in the Journal Notify a friend about this article Add to Personal Archive ... Related Articles in Medline Articles in Medline by Author: Clark, R. Jacobs, A. Medline Citation Abstract This article has been cited by other articles: Takagi, S., Tanaka, O., Origasa, H., Miura, Y. (1999). Prognostic Significance of Magnetic Resonance Imaging of Femoral Marrow in Patients With Myelodysplastic Syndromes. J Clin Oncol [Abstract] [Full Text] HOME SEARCH ... HELP Comments and questions? Please contact us The New England Journal of Medicine is owned, published, and Massachusetts Medical Society

73. ClinicalTrials.gov - Linking Patients To Medical Research: Results Conditions Refractory Anemia; refractory anemia with ringed sideroblasts; refractoryanemia with excess blasts; de novo myelodysplastic syndromes; http://www.clinicaltrials.gov/ct/gui/action/SearchAction?term=Blood/Blood Transf

74. ClinicalTrials.gov - Linking Patients To Medical Research: Results Syndrome Conditions Chronic Myelomonocytic Leukemia; de novo myelodysplastic syndromes;previously treated myelodysplastic syndromes; Refractory Anemia; http://www.clinicaltrials.gov/ct/gui/action/SearchAction?term=Down Syndrome

75. The Medical Algorithms Project, Chapter3 myelodysplastic syndromes, Diagnosis and Classification of the MyelodysplasticSyndromes, Doc. Score of Mufti et al and Prognosis for http://www.medal.org/ch3.html

3. Hematology Section Algorithm Erythrocyte Sedimentation Rate (ESR) Formula for Normal Range Westergren ESR for Gender Doc Correction of ESR to a Hematocrit of 40% Doc Factors That Can Affect the Erythrocyte Sedimentation Rate (ESR) Doc Formulas for Differentiating Iron Deficiency from Thalassemia Minor Mentzler Formula Doc England-Fraser Formula Doc Shine-Lal Formula Doc M / H Ratio Doc RDW * HDW Doc MCV / MCH Ratio Doc MCH / RBC Ratio Doc RDW / RBC Ratio Doc Green and King Formula Doc Discriminant Functions of Eldibany et al for Diagnosing Microcytic Anemias Doc Iron Deficiency and Related Anemias Calculating the Total Iron Replacement Dose in Iron Deficiency Anemia Doc Criteria for the Primary Defective Iron-Reutilization Syndrome Doc Iron Replacement For a Known Blood Loss Doc Clinical Response to Adequate Iron Replacement Doc Indications for Intravenous Iron Replacement with Iron Dextran Doc Equation of Witte et al for Predicting Iron Deficiency from Serum Ferritin and the Erythrocyte Sedimentation Rate (ESR) Doc Algorithm of Mulherin et al for the Diagnosis of Iron Deficiency Anemia vs Anemia of Chronic Disease in a Patient with Rheumatoid Arthritis Doc Use of Soluble Serum Transferrin Receptor to Evaluate an Anemic Patient with a Low Serum Iron Level Doc Reticulocyte Count Correction and Indices Corrected Absolute Reticulocyte Count from RBC Count Doc Corrected Reticulocyte Count for Hct (Reticulocyte Index) Doc Reticulocyte Production Index (RPI) Doc Reticulocyte Production Index by a Single Equation

76. Myelodysplastic Syndromes myelodysplastic syndromes. Definition of myelodysplastic syndromesmyelodysplastic syndromes (MDS) are a heterogeneous group of http://www.angelfire.com/ky/IBMS/mds.html

Myelodysplastic Syndromes Definition of MDS. Classification of MDS. Differentiation of MDS from acute Leukemia. Cytogenetics of MDS. ... Prognosis and management of MDS. Definition of Myelodysplastic Syndromes: Classification of MDS: According to the French-American-British group (FAB), MDS consists of five clinical syndromes (3) .  The classification is based upon blood and bone marrow morphology.  The morphological criteria of subdividing MDS into the five syndromes are 1) the number of myelocytes and ringed sideroblasts in the bone marrow, 2) the number of blasts and monocytes in the peripheral blood, and 3) the presence of Auer rods (4) .  The five subtypes of MDS according to FAB are: 1) Refractory Anaemia (RA) with bone marrow myeloblasts less than 5% of the hematopoietic cells, and peripheral blood blasts less than 1%.  Ringed sideroblasts may or may not be present in the bone marrow (5) . 2) Refractory Anaemia with ringed sideroblasts (RARS) with RA presenting with ringed sideroblasts making up 15% or more of the erythroid precursors (5) . 3) Refractory Anaemia with excess blasts (RAEB) with 5 – 20 % of the bone marrow cells is made up of myeloblasts.  Peripheral blood blasts are less than 5%. (3)   Here, the number of ringed sideroblasts doesn’ t makes a difference.  Moreover, there is a risk of transformation into leukemia (5) .

77. Myelodysplastic Syndromes (PDQ®) myelodysplastic syndromes (PDQ®) Treatment Patients. Table of Contents. NewUpdate. How to use PDQ. General Information. What are myelodysplastic syndromes? http://www.mdmultimedia.com/a/cnpat/cnpat55.htm

Myelodysplastic Syndromes (PDQ®) Treatment - Patients Table of Contents New Update General Information What are myelodysplastic syndromes? Stage Information ... How to use PDQ General Information What are myelodysplastic syndromes? Myelodysplastic syndromes, also called pre-leukemia or "smoldering" leukemia, are diseases in which the bone marrow does not function normally and not enough normal blood cells are made. The bone marrow is the spongy tissue inside the large bones in the body. The bone marrow makes red blood cells (which carry oxygen and other materials to all tissues of the body), white blood cells (which fight infection), and platelets (which make the blood clot). Normally, bone marrow cells called blasts develop (mature) into several different types of blood cells that have specific jobs in the body. Myelodysplastic syndromes occur most often in older people, but they can occur in younger people. The most common sign is anemia, which means there are too few mature red blood cells to carry oxygen. There may also be too few white blood cells in the blood to fight infections. If the number of platelets in the blood is lower than normal, this may cause people to bleed or bruise more easily. A doctor should be seen if a person bleeds without any reason, bruises more easily than normal, has an infection that won't go away, or feels tired all the time. If there are symptoms, a doctor may order blood tests to count the number of each kind of blood cell. If the results of the blood test are not normal, the doctor may do a bone marrow biopsy. During this test, a needle is inserted into a bone and a small amount of bone marrow is taken out and looked at under the microscope. The doctor can then determine the kind of disease and plan the best treatment.

78. Intensive Treatment Of Myelodysplastic Syndromes And Secondary Leukemias - Héma Hématologie Hématologie. Vol. 1, Issue 4, July August 1995 Intensive treatmentof myelodysplastic syndromes and secondary leukemias. Hématologie. Vol. http://www.john-libbey-eurotext.fr/articles/hma/1/4/325-34/en-resum.htm

Intensive treatment of myelodysplastic syndromes and secondary leukemias Summary: The limited efficacy of low dose treatments (including low doses AraC and hormonal treatments) in myelodysplastic syndromes (MDS) and secondary leukemias (acute leukemia secondary to myelodysplastic syndromes, or therapy related) has prompted clinicians to treat those patients intensively whenever age and clinical condition made it possible. Allogeneic bone marrow transplantation (BMT) remains the only rally curative treatment that allows durable remission in about 40% of the cases when performed with a familial HLA identical sibling. It is however associated to a high incidence of toxic mortality, probably due to the relatively important median age of transplanted MDS patients. In myelodysplastic syndromes with an excess of marrow blasts, the relapse rate is important, suggesting a possible interest of intensifying conditioning regimens or treating the patient by intensive chemotherapy prior to allogeneic bone marrow transplantation. Author(s): Pierre Fenaux, Eric Wattel

79. Myelodysplastic Syndrome Myelodysplastic Syndrome. What are myelodysplastic syndromes? myelodysplastic syndromesoccur most often in older people, but they can occur in younger people. http://www.clevelandclinic.org/health/health-info/docs/1400/1421.asp?index=6192

80. Myelodysplastic Syndromes (MDS) 22Oct-02 myelodysplastic syndromes (MDS) http://www.ahp.niu.edu/isabel/ahls302/MDS.htm

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