61. BRCA2 Mutations May Be Associated With Some Hereditary Pancreatic Cancers Mutations in the breast cancer susceptibility gene BRCA2 may be associated witha predisposition to hereditary pancreatic cancer, suggests a new study in the http://www.eurekalert.org/pub_releases/2003-02/jotn-bmm013003.php

Public release date: 4-Feb-2003 Contact: Linda Wang jncimedia@oupjournals.org Journal of the National Cancer Institute BRCA2 mutations may be associated with some hereditary pancreatic cancers Mutations in the breast cancer susceptibility gene BRCA2 may be associated with a predisposition to familial (hereditary) pancreatic cancer, a new study suggests. The findings appear in the February 5 issue of the Journal of the National Cancer Institute Familial pancreatic cancers account for as many as 10% of all pancreatic cancer cases. Although no specific gene has been definitively linked to familial pancreatic cancer, some studies have suggested that germline mutations in the BRCA2 gene may be associated with a modest increase in risk of pancreatic cancer. Mutations in BRCA2 have also been associated with an increased risk of breast and ovarian cancers. To examine the frequency of germline BRCA2 mutations in cases of familial pancreatic cancer, Stephan A. Hahn, M.D., of the Knappschaftskrankenhaus University of Bochum in Germany, Detlef K. Bartsch, M.D., of the Philipps-University Marburg in Germany, and their colleagues identified 26 European families with at least two first-degree relatives with pancreatic cancer. None of the families had an increased incidence of other hereditary cancer syndromes. The authors found that three (12%) of the families carried specific frameshift mutations in their BRCA2 gene. These mutations are predicted to result in a nonfunctional BRCA2 protein. In addition, two other families had BRCA2 genes that contained sequence changes, or unclassified variations whose effect on BRCA2 function is not known. In total, 19% of the families studied had either a frameshift mutation or an unclassified variant of BRCA2.

62. Study Suggests A Possible Link Between High-starch Diet And Pancreatic Cancer In Press Releases September 4, 2002 Study suggests a possible link between highstarchdiet and pancreatic cancer in overweight, sedentary women, Charles Fuchs, MD. http://www.dfci.harvard.edu/abo/news/press/090402.asp

Home About Dana-Farber Press Releases Mission and Values ... Press Releases September 4, 2002 Study suggests a possible link between high-starch diet and pancreatic cancer in overweight, sedentary women Charles Fuchs, MD A diet high in starchy foods such as potatoes, rice and white bread may increase the risk of pancreatic cancer in women who are overweight and sedentary, according to a new study by Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard School of Public Health researchers. Published in the Sept. 4 issue of the Journal of the National Cancer Institute, the study suggests that excess insulin - a substance used by the body to process the sugar in foods - can promote the development of pancreatic cancer. Nearly 30,000 men and women in the United States are diagnosed with pancreatic cancer each year, and an equal number die from it. Pancreatic cancer typically is highly aggressive and is one of the least-curable malignancies. Only four percent of the people with pancreatic cancer are alive five years after diagnosis. "Our findings add to the growing body of evidence that suggests that insulin may have a role in the development of pancreatic cancer," explains senior author Charles Fuchs, MD, of Dana-Farber. "Further research is needed, however, to track the connection in more detail."

63. Cancer Research Treatments - Dana-Farber Cancer Institute Research Advances DanaFarber study links obesity and lack of exerciseto pancreatic cancer, Charles Fuchs, MD. Chalk up another reason http://www.dfci.harvard.edu/res/research/obesity.asp

Home Research Research Advances Research Advances ... Research Advances Dana-Farber study links obesity and lack of exercise to pancreatic cancer Charles Fuchs, MD The study, published in the Aug. 21 issue of the Journal of the American Medical Association, provides the strongest evidence to date that people can take steps, in addition to not smoking, to reduce their chances of developing pancreatic cancer, a notoriously difficult disease to treat. "The message is that there is something people can do to protect themselves from pancreatic cancer," says the study’s senior author, Charles Fuchs, MD, of DFCI’s Department of Adult Oncology. "Moderate exercise on a regular basis can substantially reduce one’s chances of developing the disease, as can losing weight for those who are seriously overweight." Pancreatic cancer is the fifth-leading cause of cancer-related deaths in the United States. Almost 30,000 people nationally are diagnosed with it every year, and an equal number die of it. Only three percent of those who have the disease are alive five years after diagnosis. For those whose cancer has spread beyond the pancreas, the median survival time after diagnosis is just six months. Two strikes "We have shown that losing weight and exercising – in addition to the many other benefits they provide – can significantly reduce one’s chances of developing cancer of the pancreas,” remarks lead author Dominique Michaud, ScD, of the National Cancer Institute, who participated in the research while at HSPH. “Physical activity has a considerable protective effect, especially among those who are overweight."

64. PancreasWeb.com - Links Links. pancreatic cancer. The Johns Hopkins Medical Institutions Pancreas CancerHome Page. National Cancer Institute pancreatic cancer Homepage. http://www.pancreasweb.com/Services/links.asp

Resources - Home - News - Free Communications - Abstracts of the Week ... - Search Services - Consensus Papers - Congress Calendar - Books and Other Media - Journals List ... - Links About PancreasWeb - About PancreasWeb - Contact - Feedback Home Links Pancreatic Cancer The Johns Hopkins Medical Institutions: Pancreas Cancer Home Page National Cancer Institute: Pancreatic Cancer Homepage Pancreatica.org - Confronting Pancreatic Cancer Center Watch, Clinical Trials Listing Service General Information Sites Pancreas.org - Website of the University of Pittsburgh, Pa The Pancreatic Disease Center at the University of Cincinnati, Ohio CliniWeb International: Pancreatic Diseases Medical College of Wisconsin: List of Various Pancreas Diseases and Their Characteristics ... GastroHep.com Societies/Associations European Pancreatic Club (EPC) The Pancreatic Society of Great Britain and Ireland Japan Pancreas Society (JPS) Deutscher Pankreas-Club ... International Hepato-Pancreato-Biliary Association (IHPBA) Study Groups EASD Islet Study Group The Midwest Multicenter Pancreatic Study Group European Study Group for Pancreatic Cancer (ESPAC) MD Anderson Cancer Center Pancreatic Tumor Study Group ... German Familial Pancreatic Cancer Study Group (FaPaCa) Foundations National Pancreas Foundation Lustgarten Foundation for Pancreatic Cancer Research Hirshberg Foundation for Pancreatic Cancer Research Cystic Fibrosis Foundation Miscellaneous International Pancreas Transplant Registry The European Registry Of Hereditary Pancreatitis And Familial Pancreatic Cancer (EUROPAC) Advanced Fellowship in Pancreatology: Mayo Clinic Rochester Database of Genetic Variants in Patients with Chronic Pancreatitis Links

65. PancreasWeb.com News. British Multicenter Team Introduces Phase III Trial Using Combination Therapyto Treat Advanced pancreatic cancer National Cancer Research Institute Trial http://www.pancreasweb.com/

Resources - Home - News - Free Communications - Abstracts of the Week ... - Search Services - Consensus Papers - Congress Calendar - Books and Other Media - Journals List ... - Links About PancreasWeb - About PancreasWeb - Contact - Feedback Home Homepage News Preliminary Study Tags Beta-Cells in the Pancreas PancreasWeb 25/03/03 Is it possible that research into the insulin-producing beta-cell of the pancreas may offer the key to the development of diabetes mellitus, with anatomic and functional loss of these cells? Researchers from the University of Chicago, Ill., feel it is possible. Non-Invasive Test Touted for Analyzing Pancreatic Enzyme Output PancreasWeb 14/03/03 A recently developed breath test may quantify pancreatic enzyme output. A German team of researchers compared results of the secretin-cerulein test (SC-T) and of a newly modified ... GEM-CAP Trial Update PancreasWeb 06/03/03 GEM-CAP is a Phase III, multicentre randomised clinical trial developed by the National Cancer Research Institute to test the hypothesis: Does the addition of capecitabine to gemcitabine improve the survival or quality of life of patients with advanced pancreatic cancer? Neurotransmitters Influence Cancer Cell Growth PancreasWeb 05/03/03 Is it possible that nerves and neurotransmitters have the ability to promote pancreatic cancer progression? In a European study, researchers from Germany, Italy, and Switzerland collectively say "yes."

66. Pancreatic Cancer What is pancreatic cancer? The American Cancer Society estimates that in 2002, 30,300people in the United States will be diagnosed with pancreatic cancer. http://www.seattlecca.org/patientsandfamilies/adultCare/clinicalProgs/pancreatic

var OPENNODE = '1000,1004,1009,1010,1053,'; var CURRNODE = 1053 init( "setID( CURRNODE );" ); What is Pancreatic Cancer? Cancer of the pancreas is a disease in which cancer cells are found in the tissue of the pancreas-an organ located in the abdomen and surrounded by the stomach and the intestines. The American Cancer Society estimates that in 2002, 30,300 people in the United States will be diagnosed with pancreatic cancer. Pancreatic cancer accounts for just two percent of all cancers but is the fourth leading cause of cancer death. Pancreatic cancer has been called a silent disease because few symptoms appear until the latter stages of the disease. The disease is hard to diagnose because the pancreas is hidden behind other organs and therefore hard to find. The fish-shaped pancreas has two basic functions: it produces enzymes that help break down food, and makes hormones, such as insulin, that regulate how the body stores and uses food. About 95 percent of pancreatic cancers begin in the hormone-producing area of the pancreas, called the endocrine pancreas. Not much is known about what causes pancreatic cancer but it is more prevalent in smokers, and is more common in African Americans. Most patients are diagnosed between the ages of 60 and 80.

67. INTRODUCTION The pancreatic cancer gene database (PCGDB), provides information on the genesthat are involved in pancreatic cancer and this data is targeted to help the http://bioinformatics.org/pcgdb/

H ome Introduction Genelist L inks ... Help Welcome to P ancreatic C ancer G ene D atabase The pancreatic cancer gene database (PC-GDB), provides information on the genes that are involved in pancreatic cancer and this data is targeted to help the biological and medical sciences community for easier access of the latest information on genes causing pancreatic cancer. The data in PC-GDB is extracted from the published biomedical research literature and stored as a collection of ‘facts’. These facts of the gene are in turn categorized into 30 different topics. This grouping facilitates quick searches and rapid retrieval of data. The data in PC-GDB is reviewed by the editor and the curator before being made public. The PC-GDB can be viewed based on chromosome number or alphabetical order of gene, the key word search system will be added soon, hyperlinks have been provided for the genes and the facts for easier access. Depending on the availability each gene in PC-GDB is linked to databases like OMIM, GeneCards and CGAP. This database contains information about genes which are targets for cancer-causing mutations in pancreatic cancers. Click

68. Pancreatic Cancer pancreatic cancer. pancreatic cancer is the fifth leading cause of cancer deathsfollowing breast cancer; lung cancer, colon cancer, and prostate cancer. http://bioinformatics.org/pcgdb/Introduction.htm

H ome Introduction Genelist L inks Help Pancreatic Cancer The pancreas is an organ of the digestive system. It is located near the stomach and small intestine. It has two major jobs or functions. First, the exocrine pancreas makes enzymes that help in the digestion of food products. Second, the endocrine pancreas produces several hormones that have diverse functions. Cancers of the pancreas can occur in the exocrine pancreas (classic pancreatic adenocarcinomas) or can occur in the endocrine pancreas. This section will discuss exocrine pancreatic carcinoma. Cancers of the exocrine pancreas are a very serious health issue in the United States where approximately 27,000 patients are diagnosed annually with pancreatic cancer while about the same number die annually from this disease. Due to difficulties in diagnosis, the intrinsic aggressive nature of pancreatic cancers, and the sparse systemic treatment options available, only approximately 4% of patients diagnosed with pancreatic adenocarcinoma will be alive five years after diagnosis. Pancreatic cancer is the fifth leading cause of cancer deaths following breast cancer; lung cancer, colon cancer, and prostate cancer. Because of the extremely poor prognosis for the majority of individuals with pancreatic cancer, it is very important that patients be offered the opportunity to participate in clinical trials. If you or someone you love has been diagnosed with pancreatic cancer, speak with your physician regarding any trials in which you or your loved onemay be eligible to participate.

69. Aspirin And Pancreatic Cancer Bandolier Library. search. Aspirin and pancreatic cancer. Clinical bottom line. Reference.RJ Menezes et al. Regular use of aspirin and pancreatic cancer risk. http://www.jr2.ox.ac.uk/bandolier/booth/aspirin/asppanc.html

Bandolier Bandolier Library search Aspirin and pancreatic cancer Clinical bottom line Pancreatic cancer risk was not changed by use of aspirin. Reference RJ Menezes et al. Regular use of aspirin and pancreatic cancer risk. BMC Public Health 2002 2:18 ( http://www.biomedcentral.com/1471-2458/2/18 Study The study population was individuals at a cancer institute between 1982 and 1998 who agreed to complete a comprehensive epidemiological questionnaire. There were 194 with primary pancreatic cancer. Controls were 582 individuals randomly selected from a pool of over 7,000 individuals receiving treatment for non-cancer conditions. The questionnaire covered use of tobacco, alcohol, family history, occupational and environmental expose, medical history, and diet. Also included were questions assessing aspirin use, about how much was taken, how often, and for how long. Results Case and control patients had an average age of 62 years, and about 45% were women. Neither crude nor adjusted odds ratios showed much deviation from unity, and no statistical relationship was seen with use of aspirin, or number of tablets, or duration of aspirin use. Comment There was no support for any effect of aspirin on pancreatic cancer.

70. Johns Hopkins Pancreatic Cancer Early Detection Laboratory Hopkins Dome.gif (1144 bytes). Back to Hopkins Pancreas Home. pancreascancer ribbon. The pancreatic cancer Early Detection Laboratory. http://pathology.jhu.edu/n.web?EP=N&FL=GOGGINSLAB

71. The National Familial Pancreas Tumor Registry In 406 of these families more than one first degree relative (ie parent/childor siblings) have been diagnosed with pancreatic cancer. http://pathology.jhu.edu/n.web?EP=N&FL=PANCREAS_NFPTR

72. CancerCare - Pancreatic Cancer pancreatic cancer. The links to the left will take you to general informationabout pancreatic cancer, its diagnosis and treatments. http://www.cancercare.org/types/pancreatic/index.asp

73. Your Cancer Risk: Preliminary Questions To estimate your risk of pancreatic cancer, take about 2 to 3 minutes to answersome questions about your health, lifestyle and personal background. http://www.yourcancerrisk.harvard.edu/hccpquiz.pl?func=start&quiz=pancreatic

74. Wired News: Cancer's Enema No. 1? Make That 2 0200 AM Oct. 30, 2002 PT. A study testing a controversial pancreatic cancertreatment that uses coffee enemas should by all rights be nearly complete. http://www.wired.com/news/technology/0,1282,56072,00.html

Welcome to Wired News. Skip directly to: Search Box Section Navigation Content Search: Wired News Animations Wired Magazine HotBot (the Web) Cancer's Enema No. 1? Make That 2 By Kristen Philipkoski Also by this reporter Page 1 of 2 next 02:00 AM Oct. 30, 2002 PT A study testing a controversial pancreatic cancer treatment that uses coffee enemas should by all rights be nearly complete. But three years into it, Dr. Nicholas Gonzalez has only 25 of the 90 patients he needs to complete recruitment for the trial Story Tools See also Taking a Risk for Science FDA Forces Fatal Chemo on Kids Does Ecstasy Cause Parkinson's? Check yourself into Med-Tech Read more Technology news Today's Top 5 Stories Tables Top Typical Bar Diversions Rasta Man Comes in From the Cold The Search for Total Information Saddam's Bunker Stands Tough ... War Hack Attacks Tit For Tat His clinical trial has been stalled by economics, logistics and outright prejudice against the twice-daily enema regimen, despite a promising pilot study. "I'm the first person to say it: In the oncology world I'm a very controversial guy," Gonzalez said. "But we're trying to do very serious research." Because pancreatic cancer is one of the most deadly types, it doesn't take long for researchers to find out if one treatment extends life longer than another. In the pilot study, Gonzalez's treatment more than tripled the 5-1/2 month life expectancy of pancreatic cancer patients on standard treatment.

75. Pancreatic Cancer At IVilllage.com you are here iVillage.com health cancer pancreatic. pancreatic cancer, essentialinfo for pancreatic cancer. Warning signs of pancreatic cancer. http://www.ivillage.com/topics/health/0,10707,232611,00.html

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76. Faulty Gene May Contribute To Pancreatic Cancer | Building Better Health Faulty Gene May Contribute to pancreatic cancer. We don't know that much aboutpancreatic cancer, says Joyce Seldon, a certified genetic counselor. http://www.buildingbetterhealth.com/article/hscoutn/103403186

Medical Library Cool Tools Women's Health Men's Health ... Drug Dictionary In the News Faulty Gene May Contribute to Pancreatic Cancer BRCA2 gene mutations, known to increase the risk of breast and ovarian cancer, may also make some subsceptible to a hereditary form of pancreatic cancer, says a German study that echoes earlier findings. By Kathleen Doheny TUESDAY, Feb. 4 (HealthScoutNews) Mutations in the BRCA2 gene, already known to increase the risk of breast and ovarian cancers, may also make people susceptible to a hereditary form of pancreatic cancer, German researchers conclude. Their findings echo those of previous studies. "We have found mutations which are likely to explain in a subgroup of families with pancreatic cancer cases why the disease occurs," says Dr. Stephan A. Hahn, a professor of oncology at the Knappschaftskrankenhaus University of Bochum in Bochum, Germany. Hahn is also co-author of the new study, which appears in the Feb. 5 issue of the Journal of the National Cancer Institute Hahn and his colleagues identified 26 European families with at least two first-degree relatives a sister or father, for instance with pancreatic cancer. After testing them, the researchers found that 19 percent of the families had at least one member who had either a mutation or a variant of BRCA2. While the new research confirms findings in previous studies, including one done by Johns Hopkins University researchers, Hahn says the study population for his study is broader.

77. Arizona Cancer Center - National Foundation For Cancer Research Hurley, Howard Schaeffer Chair in Pharmaceutical Sciences at the University of ArizonaCollege of Pharmacy, will focus on pancreatic cancer, the fourth leading http://www.researchforacure.com/site/PageServer?pagename=press_AZcenter

78. Cancer Research UK: Pancreatic Cancer pancreatic cancer Summary. pancreatic cancer is the 9th most common cancerin women, and the 10th most common cancer in men in the UK. http://www.cancerresearchuk.org/aboutcancer/specificcancers/15233

About us About cancer Press office Get involved ... Contact our information nurses Pancreatic cancer If you or a friend or relative have been diagnosed with cancer, you will find much more detailed information on our patient information site, CancerHelp UK Summary Pancreatic cancer is the 9th most common cancer in women, and the 10th most common cancer in men in the UK. Each year, there are over 3,400 new cases in women, and over 3,200 cases in men. Pancreatic cancer develops from the cells within the pancreas, a gland located deep in the abdomen. It is about six inches long and similar in shape to a tadpole. The pancreas produces pancreatic juice, which contains chemicals to break down fats and proteins in the diet. More than 9 in 10 pancreatic cancers develop from this part of the gland. The pancreas' other important function is to produce two hormones, known as insulin and glucagon, which control blood sugar levels. If the cancer is not treated, cancer cells can spread into nearby organs or lymph nodes, or, eventually, break away and spread to other parts of the body. Risk factors Smoking Smoking increases the risk of pancreatic cancer by two to three times.

79. InteliHealth: Reviewed by the Faculty of Harvard Medical School pancreatic cancer Prevention.There is no known method of preventing or screening for pancreatic cancer. http://www.intelihealth.com/IH/ihtIH/WSIHW000/24560/24561/187109.html?d=dmtHealt

80. The Relationship Between Diabetes And Pancreatic Cancer 2003; 2 (1) 4 The relationship between diabetes and pancreatic cancer Feng Wang,1 Margery Herrington, 1 ,2 Jörgen Larsson, 1 and Johan Permert 1 1 Surgery http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=149418

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