61. AIC: ICU - Platelet Dysfunction second only to thrombocytopenia as the major cause of clinical bleeding disorders.'Additionally, several acquired qualitative platelet disorders have been http://gasbone.herston.uq.edu.au/teach/phvc_plat/platelet.html

Platelet Dysfunction P.Cumpston@mailbox.uq.oz.au T.Palmer@mailbox.uq.oz.au Acquired platelet dysfunction has been described as being 'second only to thrombocytopenia as the major cause of clinical bleeding disorders.' Additionally, several acquired qualitative platelet disorders have been associated with thrombotic tendencies. Disorders associated with platelet dysfunction Myeloproliferative disorders. Acquired storage pool or release defects. Renal disease Dysproteinemias Fibrinogen and Fibrin Degradation Products Liver disease Endocrine disease Lipid metabolism Thromboembolic disorders Other diseases Drugs Drugs and their effects on platelets Many drugs have the potential to cause thrombocytopenia. Others have specific actions on platelet function - some rendering them less active, others increasing their capacity to respond to stimuli. Classes of Drugs and agents Platelet cyclo-oxygenase inhibitors Platelet c-AMP Phosphodiesterase inhibitors Prostaglandins Thromboxane synthetase inhibitors Thromboxane inhibitors Membrane-active drugs Miscellaneous agents (various or unknown actions) Aspirin It has long been known that aspirin ingestion is associated with an increased risk of significant bleeding. The mechanism of this effect was clarified when aspirin was shown to inhibit collagen-induced platelet aggregation and the second wave of DP-induced platelet aggregation, as well as blocking the release of ADP from platelets. ADP is known to be a potent platelet-aggregating substance.

62. Coaganswers2 Screening test for platelet disorders and for von Willebrands disease. Howdo you treat most of these platelet disorders? Treat with platelets. http://www.u.arizona.edu/ic/srl/heme/coaganswers2.html

Coagulation Review - Part 2 PLATELETS Platelet Maturation Series Pluripotential stem cell CFU-GEMM, can give rise to megakaryocyte (or other cell lines) Megakaryoblast May be encountered occasionally in the peripheral blood in transit to other tissues; they appear similar to a small lymph. Promegakaryocyte just know it exists Megakaryocyte parent cell of platelets. Stimulated by thrombopoietin to grow and mature into mature platelets. They are the largest normal myeloid cell in the bone marrow. The average 8N-16N produces 1500-2000 platelets Platelet No nucleus Alpha granules are blue to purple on Wright's stain Dense bodies are only visible by electron microscopy 150-450 x 10 / L Life span: 2-10 days Approximately 30% of available platelets are sequestered in the spleen. What is endomitosis? A fascinating process unique to platelet maturation where the nucleus divides while the cytoplasm doesn't separate, usually up to about 8N - 16N. What is the demarcating membrane? Unique to platelets: the cytoplasm sections off and ultimately form the individual platelets Briefly, what are the steps in platelet plug formation?

63. Hemophilia Association Of New Jersey - Hemophilia, Bleeding Disorders Women with von Willebrand disease, platelet disorders, single factor deficienciesand symptomatic hemophilia carrier status oftentimes have more complications http://www.hanj.org/hanjwomn.htm

An Website. DID YOU KNOW... Women can and do have bleeding disorders. It is suspected that 1%-3% of the population has von Willebrand Disease or some other form of factor and/or platelet deficiency. At this time, the major bleeding disorders in woman are: von Willebrand Disease. Single Factor Deficiency. Platelet disorders. Carrier (symptomatic or asymptomatic) for Hemophilia A or B. Approximately 600,000 hysterectomies are performed annually in the United States. Some may have been performed for undiagnosed bleeding causes. Women with von Willebrand disease, platelet disorders, single factor deficiencies and symptomatic hemophilia carrier status oftentimes have more complications (with menstruation cycles and childbirth) and deal more with quality of life issues then male counterparts with the same disorders (remember, we are not talking Hemophila A or B), even in mild levels due to gynecological issues.. DO YOU... Bruise easily. Have heavy or prolonged menstrual periods. Suffer frequent or prolonged nosebleeds. Continue with prolonged bleeding after injury, surgery, childbirth or dental work.

64. Hematologic Disorders In Pregnancy platelet disorders Jaundice and DIC in Pregnancy Medscape; Plateletdisorders March 1997 British Medical Journal; PregnancyAssociated http://www.perinatology.com/exposures/Maternal/hematologic.htm

perinatology.com Hematological Disorders in Pregnancy Return to Table of Contents Return to Homepage Translate Site Map Agencies and Organizations Calculators Critical Care Exposures Chemicals Drugs Infection Physical Agent ... About us Anemia Ambulatory Management of Common Forms of Anemia American Academy of Family Physicians Diagnosing and managing sickle cell disease in pregnancy 2001 Contemporary Ob/Gyn Common' Uncommon Anemias 1999 American Academy of Family Physicians General Haematology Handbook Liverpool Hospital, Australia Hematologic Disease and Pregnancy 2002 eMedicine See Also: MatWeb Directory Guidelines Transfusion Guidelines For Adults American Red Cross Blood Services Guidelines for red blood cell and plasma transfusion for adults and children. 1997 Canadian Medical Association Journal Hemophilia and Thalassemia Beta-Thalassemia GeneClinics Hemophilia and von Willebrand's disease: 2. Management Canadian Medical Association Journal Hemophilia A GeneClinics Hemophilia B GeneClinics Obstetrical management of von Willebrand's disease 2000 OBG Management Platelet Disorders Jaundice and DIC in Pregnancy Medscape Platelet disorders March 1997 British Medical Journal Pregnancy-Associated Thrombocytopenia Revisited: Assessment and Follow-Up of 50 Cases 1998 Blood Thrombocytopenia in Pregnancy 1999 American College of Obstetricians and Gynecologists Thrombocytopenia in Pregnancy 2002 eMedicine Coagulation Disorders and Thromboembolism Antiphospholipid Syndrome Antiphospholipid antibodies (APAs) 2001 Contemporary Ob/Gyn

65. Medslides - The World's Premier Site For Medical Slides , Reference, Size....... 11/01, Porphyria, Victor Ghobrial, MD, Joseph Sobieski, MD, 91k. 11/01, Thrombopoietin,K.Pavithran, MD, DM, 45k. platelet disorders. Date, http://www.medslides.com/member/Hematology/

The World's Premier Site For Medical Slides Hematology Hemostatic Disorders Miscellaneous Platelet Disorders Transfusion Therapy Date Description Reference Size Anemia in the Intensive Care Unit Andrew Shorr, MD. Walter Reed Army Medical Center Aplastic Anemia Dr. Bhavesh Jarwani Hemostatic Disorders Date Description Reference Size Coagulation Disorders K. Pavithran, MD, DM Vitamin K Deficiency and Bleeding Dr Meenakshi Sharma Essentials Of Coagulation Kelly R. Conaty, MD, MBA Miscellaneous Date Description Reference Size Multiple Myeloma G.A. Prasad, MD, U of Wisc Hereditary Hemochromatosis Suhail Allaqaband, MD Thrombopoietin Dr.K.Pavithran Porphyria Victor Ghobrial, MD, Joseph Sobieski, MD Thrombopoietin K.Pavithran, MD, DM Platelet Disorders Date Description Reference Size HIT - Heparin Induced Thrombocytopenia Review www.thrombosite.com Understanding Heparin-Induced Thrombocytopenia Understanding Heparin-Induced Thrombocytopenia Diane Wallis, MD, Theodore Warkentin, MD Essential Thrombocythemia Joel Saltzman, MD Heparin Induced Thrombocytopenia and the use of Argatroban Gregory F. Watkins

66. James G. White Provides expert backup for UMHC Coagulation Laboratory on patients with bleedingproblems and platelet disorders; provides diagnostic and followup service for http://pathology.umn.edu/Faculty/James G_ White.htm

Department of Laboratory Medicine and Pathology University of Minnesota James G. White, M.D. Regents Professor Box 609 Mayo, 420 Delaware Street SE Minneapolis, MN 55455 Office location: 231 A D V C C R C Phone: (612) 626-2846 E-mail: white003@maroon.tc.umn.edu Biomedical Research Interests Platelet physiology and pathology, bleeding disorders, thrombosis and atherosclerosis, vascular injury. Investigations in Dr. White's laboratories are directed toward development of knowledge on blood platelet function in normal hemostasis, the blood platelet's role in the pathogenesis of inherited and acquired bleeding disorders and their contribution to vascular injury, thrombosis and atherosclerosis. Techniques in physiology, biochemistry, pharmacology, immunology, engineering, biophysics, and morphology are combined in a total approach to understanding platelet structure, function, and pathology. Using these and other techniques, White's research team has isolated the circumferential microtubule (MT) supporting the disc-like shape of resting platelets, allowing for the exploration of many aspects of MT function. Platelets exposed simultaneously to detergent extraction and fixation have revealed new information on the nature of their interaction with surfaces and the fate of contractile proteins during platelet aging. White and his colleagues are coupling gold particles to fibrinogen to explore glycoprotein IIb-IIIa receptors on platelets during changes induced by surface and suspension activation. The results have provided a whole new perspective on how cell membranes move in relation to fixed and mobile receptors. Gold particles have also been used to study von Willebrand factor- GPIb/IX complexes and develop new knowledge of this mobile receptor on the platelet surface and characterize their function. This technique also provides a novel means of identifying patients with receptor deficiencies, including patients with thrombasthenia and Bernard-Soulier syndrome.

67. CCHS Clinical Digital Library All MD Consult Reference Books for. The Merck Manual 17th Ed.1999 Tableof contents Chapter 133 platelet disorders Table of contents http://cchs-dl.slis.ua.edu/clinical/hematology/bleedingdisorders/plateletdisorde

Clinical Resources by Topic: Hematology Acquired Platelet Dysfunction Clinical Resources Emergency Pediatrics Geriatrics Pathology ... Miscellaneous Resources See also: General Hematology Clinical Resources Acquired Platelet Dysfunction Patient/Family Resources Harrison's Principles of Internal Medicine 15th Ed.-2001: Table of contents Health Sciences Library subscription INFO Chapter 62: Bleeding and Thrombosis: Table of contents Introduction: Access document Normal Hemostasis: Access document Clinical Evaluation: Access document Physical Examination: Access document Chapter 116: Disorders of the Platelet and Vessel Wall: Table of contents Introduction: Access document Functional Platelet Disorders: Access document Introduction: Access document Acquired vWD: Access document Hoffman: Hematology: Basic Principles and Practice 3rd Ed.-2000 (MD Consult): Table of contents Health Sciences Library subscription INFO Chapter 130 - Hereditary Disorders of Platelet Function: Access document Introduction: Access document Disorders of Platelet Adhesion: Access document Disorders of Platelet Aggregation: Access document Disorders of Platelet Secretion: Access document Disorders of Platelet Procoagulant Activity: Access document Chapter 131 - Acquired Disorders of Platelet Function: Access document Introduction: Access document Drugs That Affect Platelet Function: Access document Systemic Disorders That Affect Platelet Function: Access document Hematologic Disorders That Affect Platelet Function: Access document Rakel: Conn's Current Therapy 55th Ed. - 2003 (MD Consult):

68. Haematologica - September 2002 - 897 6 present results which begin to explore the pathogenic mechanisms underlying aninteresting family of giant platelet disorders in which the genetic defect has http://www.haematologica.it/2002_09/897.htm

Medline PDF prev index ... next Five (un)easy pieces: the MYH9-related giant platelet syndromes John Martignetti Department of Human Genetics, Mount Sinai School of Medicine, Box 1498, Fifth Avenue at 100th Street, New York, USA The pace in defining the molecular basis of megakaryocyte/platelet development and function continues to accelerate. This is readily apparent from the growing list of recognized critical cytokines, their receptors and downstream pathways and transcription factors. It should be foreseen that the resources and data provided by the Human Genome Project applied to the study of inherited platelet defects will not only quicken this pace but should also lead to novel and sometimes unexpected insights. A classic example of the potential power of these hereditary diseases in understanding platelet function is provided by the rare autosomal dominant Bernard-Soulier syndrome (BSS; MIM 231200). It can be said that the pre-Human Genome Project molecular analysis of this giant platelet syndrome, first described over 50 years ago, helped to firmly establish the importance of the GPIb-V-IX complex. In this issue of

69. Diseases From Clotting Problems platelet disorders platelet disorders occur when there are too few platelets, toomany platelets or a normal number of platelets that do not function in the http://www-admin.med.uiuc.edu/hematology/Ptdiseases.htm

University of Illinois - Urbana/Champaign Carle Cancer Center Hematology Resource Page Patient Resources Problems that result from changes in/disorders of the coagulation cascade. Home Factor V Leiden Antiphospholipid Syndrome General Clotting Information ... Protein S deficiency To understand the possible disorders associated with the blood clotting (coagulation) system, consider the goal of the system: to prevent excess bleeding. If the clotting system can not adequately form clots (thrombi), then the result is a bleeding disorder (hemophilia); if the clotting system forms clots too easily, then the result is formation of excess clots (thrombophilia). For more information on how blood forms clots, please see the web page on general clotting information. Platelet Disorders: Platelet disorders occur when there are too few platelets, too many platelets or a normal number of platelets that do not function in the normal manner. Having too few platelet or platelets that do not function well (for example, aspirin use) can lead to a bleeding tendency (hemophilia). Likewise, too many platelets can predispose to a tendency to clot excessively (thrombophilia). Platelet function can be altered in many different situations; many medications to treat diseases such as strokes and heart attacks were specifically designed to alter the ability of platelets to form clots. There are also a number of diseases that can alter how well a platelet can function.

70. MemorialCare - Online Health Screenings By MyElectronicMD.com Irrespective of their etiology, all of these forms of platelet disorderslead to impairment of primary and secondary hemostasis. http://mymd.i2net.com/mc_mymd/refr.php?Id=1233

71. Hematology International Society Of Haematology ISHAPD Education Program 1999 platelet disorders; Diagnosis and Management of Immune ThrombocytopeniaJeanne M. Lusher; Von Willebrand's Disease Gilbert C. White, II http://haem.nus.edu.sg/ishapd/1999/ish1999.htm

Education Program IX th Congress of the International Society of Haematology Asian-Pacific Division Bangkok, Thailand, 1999 CONTENTS Editors These articles in .pdf format may be downloaded or viewed online Articles may be freely reproduced and distributed for the purposes of private study or research, on the condition that the author(s) are fully acknowledged and that no alterations are made to the text, figures or tables. Articles or portions of the text, figures, or tables may not be reproduced in other publication(s) without the prior consent of the author(s). Back CONTENTS Presidential Symposia Plenary Sessions Treatment of Acute Leukemia Haemophilia ... Glossaries Presidential Symposia Pyruvate Kinase Deficiency as a Model of Red Cell Enzymopathies Associated with Hereditary Nonspherocytic Hemolytic Anemia Shiro Miwa Unrelated Donor Transplantation for CML John Goldman Control of Leukemic Cells by Hematopoietic Regulators Donald Metcalf Plenary Sessions Transplantation in Lymphoma James O. Armitage New Concepts of the Blood Coagulation Reactions Harold R. Roberts Recent Advances in Transfusion Medicine Marcela Contreras Thalassaemia in Southeast Asia P. Wasi

72. Platelet Function Disorders | Principal Health News Platelet Function Disorders. Barrett, Julia. Periodicals Liesner, RJ, and SJ Machin. platelet disorders. British Medical Journal 314, no. 7083 (1997) 809. http://www.principalhealthnews.com/topic/topic100587311

About This Site Registration FAQ Contact Us ... Site Awards You are here: Home Health A to Z Platelet Function Disorders Platelet Function Disorders Barrett, Julia Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Platelets are elements within the bloodstream that recognize and cling to damaged areas inside blood vessels. When they do this, the platelets trigger a series of chemical changes that result in the formation of a blood clot. There are certain hereditary disorders that affect platelet function and impair their ability to start the process of blood clot formation. One result is the possibility of excessive bleeding from minor injuries or menstrual flow. Description Platelets are formed in the bone marrowa spongy tissue located inside the long bones of the bodyas fragments of a large precursor cell (a megakaryocyte). These fragments circulate in the bloodstream and form the first line of defense against blood escaping from injured blood vessels. Damaged blood vessels release a chemical signal that increases the stickiness of platelets in the area of the injury. The sticky platelets adhere to the damaged area and gradually form a platelet plug. At the same time, the platelets release a series of chemical signals that prompt other factors in the blood to reinforce the platelet plug. Between the platelet and its reinforcements, a sturdy clot is created that acts as a patch while the damaged area heals. There are several hereditary disorders characterized by some impairment of the platelet's action. Examples include von Willebrand's disease, Glanzmann's thrombasthenia, and Wiskott-Aldrich syndrome. Vulnerable aspects of platelet function include errors in the production of the platelets themselves or errors in the formation, storage, or release of their chemical signals. These defects can prevent platelets from responding to injuries or from prompting the action of other factors involved in clot formation.

73. Zeal.com - United States - New - Personal - Health - Conditions & Illnesses - Bl 1. Mayo Clinic Rochester platelet disorders Group http//www.mayo.edu/mmgrg/rst/mpdpltrb.htmResource was created by the Mayo Clinic Myeloproliferative http://www.zeal.com/category/preview.jhtml?cid=274454

74. Benign Classification: Hematologic (Blood) Disorders: Patient Information: Arizo blood cells) WHITE BLOOD CELL DISORDERS Neutropenia (Low white blood cells) Leukocytosis(Excess white blood cells) platelet disorders Thrombocytopenia (Low http://www.telemedicine.arizona.edu/patient_info/benign_disorders/classification

Patient Information Resource: Classification of Benign and Premalignant Hematologic Disorders A collaborative project of the Arizona Telemedicine Program , the Arizona Health Sciences Library and the Arizona Cancer Center See: Click on a disorder for detailed information BENIGN HEMATOLOGIC DISORDERS RED BLOOD CELL DISORDERS Anemia (Low red blood cells) Folic Acid Deficiency Iron Deficiency Vitamin B Deficiency ... Erythrocytosis/Polycythemia (Excess red blood cells) WHITE BLOOD CELL DISORDERS Neutropenia (Low white blood cells) Leukocytosis (Excess white blood cells) PLATELET DISORDERS Thrombocytopenia (Low platelets) Thrombocytosis (Excess platelets) COAGULATION DISORDERS Blood Vessel Abnormalities Fibrin Clot Formation Abnormalities Inherited Bleeding Disorders: Abnormalities in Fibrin Clot Formation Inherited Hypercoagulation Disorders: The Factor V Leiden Mutation Inherited Platelet Abnormalities Platelet Abnormalities PREMALIGNANT BLOOD DISORDERS Myeloproliferative Disorders See also: Alphabetic List of Benign Hematologic Disorders : This web site and its contents are designed for educational purposes only. This web site does not render medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.

75. Untitled Document The platelet disorders are often subdivided into either quantitative (iethrombocytopenia) or qualitative problems ( ie platelet dysfunction). http://www.sghhealth4u.com.sg/health4u/hematology/Bleeding_tendency.htm

BLEEDING TENDENCY What is Bleeding Tendency? Causes of Bleeding Tendency Diagnostic Tests Treatment What is bleeding tendency? Causes of bleeding tendency There are many causes to vessel defects eg. hereditary (ie Ehlers Danlos syndrome), nutrient deficiency (ie Vit C deficiency), drug induced (ie steroid induced), aging (senile purpura), certain infections (ie streptococcal, meningococcal infections), malignancies (ie lymphoma, leukemia), etc. The platelet disorders are often subdivided into either quantitative (ie thrombocytopenia) or qualitative problems ( ie platelet dysfunction). The former can be a result of decreased platelet production in the bone marrow or an increased destruction/loss of platelets in the peripheral blood stream. The causes can likewise be a primary platelet disorder (eg hereditary, nutrient deficiency, infections, drug induced, etc) or secondary to other disease states affecting the marrow or peripheral blood (eg other malignancies, autoimmune disorder, etc). Clotting defects can either be due to an abnormal production or an accelerated removal of the fiber clots. The common cause of defective production is the hereditary deficiency of clotting factors (eg hemophilia, von Willebrand disease, etc). The problem with an accelerated removal of fiber clots is by far very rare, but nevertheless, could still result from a deficiency of the regulatory proteins in clot removal (eg plasminogen activator inhibitor deficiency).

76. Platelet Function Disorders | Ahealthyme.com You are here Home Health A to Z Platelet Function Disorders. PlateletFunction Disorders. platelet disorders. British Medical Journal 314, no. http://www.ahealthyme.com/topic/topic100587311

Search AHealthyMe! Personalize AHealthyMe! Sign up for our Newsletter! You are here: Home Health A to Z Platelet Function Disorders Barrett, Julia Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Platelets are elements within the bloodstream that recognize and cling to damaged areas inside blood vessels. When they do this, the platelets trigger a series of chemical changes that result in the formation of a blood clot. There are certain hereditary disorders that affect platelet function and impair their ability to start the process of blood clot formation. One result is the possibility of excessive bleeding from minor injuries or menstrual flow. Description Platelets are formed in the bone marrowa spongy tissue located inside the long bones of the bodyas fragments of a large precursor cell (a megakaryocyte). These fragments circulate in the bloodstream and form the first line of defense against blood escaping from injured blood vessels. Damaged blood vessels release a chemical signal that increases the stickiness of platelets in the area of the injury. The sticky platelets adhere to the damaged area and gradually form a platelet plug. At the same time, the platelets release a series of chemical signals that prompt other factors in the blood to reinforce the platelet plug. Between the platelet and its reinforcements, a sturdy clot is created that acts as a patch while the damaged area heals. There are several hereditary disorders characterized by some impairment of the platelet's action. Examples include von Willebrand's disease, Glanzmann's thrombasthenia, and Wiskott-Aldrich syndrome. Vulnerable aspects of platelet function include errors in the production of the platelets themselves or errors in the formation, storage, or release of their chemical signals. These defects can prevent platelets from responding to injuries or from prompting the action of other factors involved in clot formation.

77. Platelet Function Disorders MAIN SEARCH INDEX Platelet function disorders. Periodicals Liesner, RJ, and SJ Machin. platelet disorders. British Medical Journal 314, no. 7083 (1997) 809. http://www.hendrickhealth.org/healthy/001076.htm

MAIN SEARCH INDEX Platelet function disorders Definition Description Causes and symptoms Diagnosis ... Resources Definition Platelets are elements within the bloodstream that recognize and cling to damaged areas inside blood vessels. When they do this, the platelets trigger a series of chemical changes that result in the formation of a blood clot. There are certain hereditary disorders that affect platelet function and impair their ability to start the process of blood clot formation. One result is the possibility of excessive bleeding from minor injuries or menstrual flow. Description Platelets are formed in the bone marrowa spongy tissue located inside the long bones of the bodyas fragments of a large precursor cell (a megakaryocyte). These fragments circulate in the bloodstream and form the first line of defense against blood escaping from injured blood vessels. Damaged blood vessels release a chemical signal that increases the stickiness of platelets in the area of the injury. The sticky platelets adhere to the damaged area and gradually form a platelet plug. At the same time, the platelets release a series of chemical signals that prompt other factors in the blood to reinforce the platelet plug. Between the platelet and its reinforcements, a sturdy clot is created that acts as a patch while the damaged area heals. There are several hereditary disorders characterized by some impairment of the platelet's action. Examples include von Willebrand's disease, Glanzmann's thrombasthenia, and

78. The Royal Society Of Canada - 2002 New Fellows - Academy Of Science / Académie McMaster University John Kelton, Faculty of Health Sciences, McMaster University,is a physician scientist whose investigation of platelet disorders and the http://www.rsc.ca/english/new_fellows_2002_LS.html

Citations of the 2002 New Fellows elected to the Academy of Science Life Sciences / Sciences de la vie Please note that the text of each citation is kept in the language used in the nomination. BLEACKLEY, R. Christopher Department of Biochemistry, University of Alberta BRANTON, Philip E. Department of Biochemistry, McGill University CASS, Carol E. Department of Oncology, University of Alberta Carol E. Cass, Department of Oncology, University of Alberta, is internationally recognized for her research on membrane transport of nucleosides and nucleoside drugs. Her important early studies on nucleoside transport in human erythrocytes laid the foundation for the field and her subsequent studies of nucleoside transport deficiencies established that functional membrane transporters are essential for manifestation of cytotoxicity of many nucleoside drugs. The proteins responsible for nucleoside transport across biological membranes have recently been shown by Dr. Cass and her collaborators to be members of two novel and evolutionarily old membrane protein families that are found in organisms from bacteria and yeast to humans. HALPERIN, Mitchell L.

79. Platelet Disorder Support Association Email pdsa@pdsa.org. Conditions Immune Thrombocytopenic Purpura; Inherited Thrombocytopenia;platelet disorders. Hours Answered 9am - 5pm Voicemail yes. http://www.geneticalliance.org/Resources/displayorganization.html?orgname=Platel

80. VITA-TECH Veterinary Diagnostic Services Only filtered PR') should be used for sustaining the platelet needsof chemotherapy or other patients with severe platelet disorders. http://www.vita-tech.com/VDL/articles/bb6.htm

TREATMENT OF BLEEDING DISORDERS W. Jean Dodds, D.V.M. HEMOPET, 938 Stanford Street, Santa Monica, CA 90403 Contents Von Willebrand's Disease (VWD) Rodenticide Toxicosis (Vitamin K Deficiency) Thrombocytopenia Other Bleeding Disorders Von Willebrand's Disease (VWD) For short-term control of bleeding or prophylaxis for dogs at risk to bleed from VWD: 1. For elective procedures, assess bleeding potential first with a toenail or mucosal bleeding time. Normal values for dogs are 2-5 minutes. 2. Use L-thyroxine therapy at 0.1 mg per 10 pounds body weight twice daily for 7-10 days. Start 48 hours prior to elective surgery where applicable. Continue thyroid replacement if patient is still bleeding or has thyroid disease. Thyroid supplementation promotes hemostasis by improving platelet function, stimulating thrombopoiesis in bone marrow and other sites, and enhancing protein synthesis of von Willebrand factor (VWF) and other coagulation factors. 3. Transfuse Fresh-Frozen Plasma* at 3-5 ml per pound of body weight once or twice daily. For elective procedures [ surgery on Doberman pinschers with VWDI, transfuse first and then perform surgery within 4 hours to maximize the bleeding time correcting effect of transfused VWF.

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