Geometry.Net - Health_Conditions: Familial Hypercholesterolemia

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familial hypercholesterolemia (5) See Also. Sites. Drkoop.com MedicalEncyclopedia An in depth look at familial hypercholesterolemia.
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Laboratory Of Atherosclerosis
familial hypercholesterolemia (FH) is a genetic disorder characterized by elevatedlevels of lowdensity-lipoprotein (LDL)-cholesterol, xanthomas, and
http://www.ncvc.go.jp/english/res/Eti_and_Pat_B.html

Extractions: Studies on abnormalities in plasma lipoprotein metabolism and the pathogenesis of atherosclerosis Atherosclerosis, one of the major causes of ischemic heart disease and cerebrovascular disease, is characterized by the deposition of cholesteryl esters due to the accumulation of lipid-laden foam cells in the arterial walls. One of the causes of the recent increase in the prevalence of coronary heart disease in our country may be the increase in the prevalence of hyperlipidemia, with marked elevation of cholesterol and/or triglyceride in plasma brought about by a Westernized diet. Therefore, in the hopes of eradicating atherosclerotic diseases via both the prevention and treatment of hyperlipidemia we are studying the mechanisms of plasma lipid metabolism and the pathogenesis of atherosclerosis due to plasma lipid metabolism abnormalities. Unable to dissolve in blood by themselves, plasma lipid constituents combine with proteins to form lipoproteins, a soluble form of lipid present in the plasma. The protein moieties are called apolipoproteins and play an important role in lipoprotein metabolism. In this study we investigate the genetic abnormalities of plasma apolipoproteins, the environmental factors leading to hyperlipoproteinemia, and the interactions between the cells in the arterial walls and the abnormal lipoproteins deeply involved in atherosclerosis (atherogenic lipoproteins). Sugano, R., Harada-Shiba, M., Nishimura, N., Miyake, Y., An, J., Dong, X.-J., Yamamura, T. and Yamamoto, A.: CD36 expression in human monocytic leukemia cell lines, THP-1 and THP-1 subtype, showing different expressions of type I and type II scavenger receptors. In: Lipoprotein Metabolism and Atherosclerosis (Kita, T. and Yokode, M., eds.), Springer- Verlag, Tokyo, pp.230-232, 2000.
NDI Terminology - Familial Hypercholesterolemia
familial hypercholesterolemia. DEFINITION Definition has yet to beentered. Check back later. The definitions used in this glossary
http://www.ndif.org/Terms/familial_hypercholesterolemia.html

Extractions: The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine , Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Dorland's Illustrated Medical Dictionary , 28th Edition, W. B. Saunders Company, Philadelphia, 1994; The Random House Dictionary of the English Language , Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary
23-11-1
Identification of familial hypercholesterolemia. in Taiwan Report of ElevenCases. MeiHsin Chung, Kwang-Wen Chen, Jung-Fu Chen, Wen-Tsoung Lu,.
http://www.cgmh.org.tw/paper/22-03-20.htm

Extractions: Identification of Familial Hypercholesterolemia in Taiwan: Report of Eleven Cases Mei-Hsin Chung, Kwang-Wen Chen, Jung-Fu Chen, Wen-Tsoung Lu, Jui-Hung Sun, Jen-Der Lin Background: Familial hypercholesterolemia is associated with a very high risk of premature coronary heart disease. In order to identify cases of familial hypercholesterolemia in Taiwan, we screened the hyperlipidemic patients in our metabolic clinics. Methods: Hyperlipidemic patients were screened in the metabolic outpatient department and the cases which fulfilled the clinical criteria of definitive or possible familial hypercholesterolemia were further analyzed. Their clinical characteristics, including age, gender, physical findings, past history of coronary heart disease or cerebrovascular accident (CVA), family history, and lipid profiles before and after medical treatment, were reviewed. Results: Eight women and 3 men fulfilled the diagnostic criteria. The mean age at diagnosis was 51.1 11.9 years old. Tendon xanthomas were found in 5 patients with definitive familial hypercholesterolemia. Coronary heart disease was confirmed in one patient and old CVA was noted in another 2 patients.
Apolipoprotein B
backhome.gif (1542 bytes) Apolipoprotein B. Detecting familial hypercholesterolemia Familialhypercholesterolemia is an autosomal dominant disorder.
http://www.aruplab.com/testbltn/apolipopro.htm

Extractions: References Boren J, et al. The molecular mechanism for the genetic disorder familial defective apolipoprotein B100. J Bio Chem 2001; 276:9214-8. Brugger D, et al. Familial hypercholesterolemia and familial defective apolipoprotein B-100: comparison of the phenotypic expression in 116 cases. Eur J Med Res 1996; 1:383-386. Gaffney D, et al. Independent mutations at codon 3500 of the apoliporotein B gene are associated with hyperlipidemia. Arteriosclerosis, Thrombosis, and Vascular Biology 1995; 15:1025-1029. http://www.ncbi.nlm .nih.gov/omim/ Saint-Jore B, et al. Autosomal dominant type familial hypercholeterolemia; evaluation of the respective contributions of LDLR and apoB gene defects as well as a third major group of defects. Eur J Hum Genet 2000; 8:621-630. Tai DY, Pan JP, and Lee-Chen GJ. Identification and haplotype analysis of apolipoprotein B-100 Arg3500-Trp mutation in hyperlipidemic Chinese. Clin Chem 1998; 44:1659-1665.
FAMILIAL HYPERCHOLESTEROLEMIA (Search FastHealth.com) FAMILIAL HYPERCHOLESTEROLE
Dictionary FastHealth Email This! familial hypercholesterolemia n an inherited metabolic disorder that is caused by defective
http://www.fasthealth.com/dictionary/f/familial_hypercholesterolemia.php
Medical Research Council Clinical Sciences Centre - Research Groups Lipoprotein
Determinants of variable response to statin treatment in patientswith refractory familial hypercholesterolemia. Arteriosclerosis
http://www.csc.mrc.ac.uk/ResearchGroups/Lipoprotein/LipoproteinRecentPublication
BioMed Central | Full Text | Statins In Homozygous Familial Hypercholesterolemia
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Arch Intern Med -- Page Not Found
Longterm Compliance With Lipid-Lowering Medication After Genetic Screening for FamilialHypercholesterolemia Author Information Marina AW Umans-Eckenhausen, MD
http://archinte.ama-assn.org/issues/v163n1/abs/ioi20277.html

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