Geometry.Net - Health_Conditions: Platelet Disorders

AIC: ICU - Platelet Dysfunction
second only to thrombocytopenia as the major cause of clinical bleeding disorders.'Additionally, several acquired qualitative platelet disorders have been
http://gasbone.herston.uq.edu.au/teach/phvc_plat/platelet.html

Extractions: P.Cumpston@mailbox.uq.oz.au T.Palmer@mailbox.uq.oz.au Acquired platelet dysfunction has been described as being 'second only to thrombocytopenia as the major cause of clinical bleeding disorders.' Additionally, several acquired qualitative platelet disorders have been associated with thrombotic tendencies. Disorders associated with platelet dysfunction Myeloproliferative disorders. Acquired storage pool or release defects. Renal disease Dysproteinemias Fibrinogen and Fibrin Degradation Products Liver disease Endocrine disease Lipid metabolism Thromboembolic disorders Other diseases Drugs Many drugs have the potential to cause thrombocytopenia. Others have specific actions on platelet function - some rendering them less active, others increasing their capacity to respond to stimuli. Classes of Drugs and agents Platelet cyclo-oxygenase inhibitors Platelet c-AMP Phosphodiesterase inhibitors Prostaglandins Thromboxane synthetase inhibitors Thromboxane inhibitors Membrane-active drugs Miscellaneous agents (various or unknown actions) It has long been known that aspirin ingestion is associated with an increased risk of significant bleeding. The mechanism of this effect was clarified when aspirin was shown to inhibit collagen-induced platelet aggregation and the second wave of DP-induced platelet aggregation, as well as blocking the release of ADP from platelets. ADP is known to be a potent platelet-aggregating substance.
Coaganswers2
Screening test for platelet disorders and for von Willebrands disease. Howdo you treat most of these platelet disorders? Treat with platelets.
http://www.u.arizona.edu/ic/srl/heme/coaganswers2.html

Extractions: Coagulation Review - Part 2 PLATELETS Platelet Maturation Series Pluripotential stem cell CFU-GEMM, can give rise to megakaryocyte (or other cell lines) Megakaryoblast May be encountered occasionally in the peripheral blood in transit to other tissues; they appear similar to a small lymph. Promegakaryocyte just know it exists Megakaryocyte Platelet A fascinating process unique to platelet maturation where the nucleus divides while the cytoplasm doesn't separate, usually up to about 8N - 16N.
Hemophilia Association Of New Jersey - Hemophilia, Bleeding Disorders
Women with von Willebrand disease, platelet disorders, single factor deficienciesand symptomatic hemophilia carrier status oftentimes have more complications
http://www.hanj.org/hanjwomn.htm

Extractions: DID YOU KNOW... Women can and do have bleeding disorders. It is suspected that 1%-3% of the population has von Willebrand Disease or some other form of factor and/or platelet deficiency. At this time, the major bleeding disorders in woman are: Approximately 600,000 hysterectomies are performed annually in the United States. Some may have been performed for undiagnosed bleeding causes. Women with von Willebrand disease, platelet disorders, single factor deficiencies and symptomatic hemophilia carrier status oftentimes have more complications (with menstruation cycles and childbirth) and deal more with quality of life issues then male counterparts with the same disorders (remember, we are not talking Hemophila A or B), even in mild levels due to gynecological issues.. DO YOU... Bruise easily. Have heavy or prolonged menstrual periods. Suffer frequent or prolonged nosebleeds. Continue with prolonged bleeding after injury, surgery, childbirth or dental work.
Hematologic Disorders In Pregnancy
platelet disorders Jaundice and DIC in Pregnancy Medscape; Plateletdisorders March 1997 British Medical Journal; PregnancyAssociated
http://www.perinatology.com/exposures/Maternal/hematologic.htm
Medslides - The World's Premier Site For Medical Slides
, Reference, Size. 11/01, Porphyria, Victor Ghobrial, MD, Joseph Sobieski, MD, 91k. 11/01, Thrombopoietin,K.Pavithran, MD, DM, 45k. platelet disorders. Date,
http://www.medslides.com/member/Hematology/
James G. White
Provides expert backup for UMHC Coagulation Laboratory on patients with bleedingproblems and platelet disorders; provides diagnostic and followup service for
http://pathology.umn.edu/Faculty/James G_ White.htm

Extractions: E-mail: white003@maroon.tc.umn.edu Platelet physiology and pathology, bleeding disorders, thrombosis and atherosclerosis, vascular injury. Investigations in Dr. White's laboratories are directed toward development of knowledge on blood platelet function in normal hemostasis, the blood platelet's role in the pathogenesis of inherited and acquired bleeding disorders and their contribution to vascular injury, thrombosis and atherosclerosis. Techniques in physiology, biochemistry, pharmacology, immunology, engineering, biophysics, and morphology are combined in a total approach to understanding platelet structure, function, and pathology. Using these and other techniques, White's research team has isolated the circumferential microtubule (MT) supporting the disc-like shape of resting platelets, allowing for the exploration of many aspects of MT function. Platelets exposed simultaneously to detergent extraction and fixation have revealed new information on the nature of their interaction with surfaces and the fate of contractile proteins during platelet aging. White and his colleagues are coupling gold particles to fibrinogen to explore glycoprotein IIb-IIIa receptors on platelets during changes induced by surface and suspension activation. The results have provided a whole new perspective on how cell membranes move in relation to fixed and mobile receptors. Gold particles have also been used to study von Willebrand factor- GPIb/IX complexes and develop new knowledge of this mobile receptor on the platelet surface and characterize their function. This technique also provides a novel means of identifying patients with receptor deficiencies, including patients with thrombasthenia and Bernard-Soulier syndrome.
CCHS Clinical Digital Library
All MD Consult Reference Books for. The Merck Manual 17th Ed.1999 Tableof contents Chapter 133 platelet disorders Table of contents
http://cchs-dl.slis.ua.edu/clinical/hematology/bleedingdisorders/plateletdisorde

Extractions: Clinical Resources by Topic: Hematology Acquired Platelet Dysfunction Clinical Resources Emergency Pediatrics Geriatrics Pathology ... Miscellaneous Resources See also: Chapter 116: Disorders of the Platelet and Vessel Wall: Table of contents Hoffman: Hematology: Basic Principles and Practice 3rd Ed.-2000 (MD Consult): Table of contents Health Sciences Library subscription INFO Chapter 131 - Acquired Disorders of Platelet Function: Access document Rakel: Conn's Current Therapy 55th Ed. - 2003 (MD Consult):
Haematologica - September 2002 - 897
6 present results which begin to explore the pathogenic mechanisms underlying aninteresting family of giant platelet disorders in which the genetic defect has
http://www.haematologica.it/2002_09/897.htm

Extractions: John Martignetti Department of Human Genetics, Mount Sinai School of Medicine, Box 1498, Fifth Avenue at 100th Street, New York, USA The pace in defining the molecular basis of megakaryocyte/platelet development and function continues to accelerate. This is readily apparent from the growing list of recognized critical cytokines, their receptors and downstream pathways and transcription factors. It should be foreseen that the resources and data provided by the Human Genome Project applied to the study of inherited platelet defects will not only quicken this pace but should also lead to novel and sometimes unexpected insights. A classic example of the potential power of these hereditary diseases in understanding platelet function is provided by the rare autosomal dominant Bernard-Soulier syndrome (BSS; MIM 231200). It can be said that the pre-Human Genome Project molecular analysis of this giant platelet syndrome, first described over 50 years ago, helped to firmly establish the importance of the GPIb-V-IX complex. In this issue of
Diseases From Clotting Problems
platelet disorders platelet disorders occur when there are too few platelets, toomany platelets or a normal number of platelets that do not function in the
http://www-admin.med.uiuc.edu/hematology/Ptdiseases.htm

Extractions: University of Illinois - Urbana/Champaign Carle Cancer Center Hematology Resource Page Patient Resources Problems that result from changes in/disorders of the coagulation cascade. Home Factor V Leiden Antiphospholipid Syndrome General Clotting Information ... Protein S deficiency To understand the possible disorders associated with the blood clotting (coagulation) system, consider the goal of the system: to prevent excess bleeding. If the clotting system can not adequately form clots (thrombi), then the result is a bleeding disorder (hemophilia); if the clotting system forms clots too easily, then the result is formation of excess clots (thrombophilia). For more information on how blood forms clots, please see the web page on general clotting information. Platelet Disorders: Platelet disorders occur when there are too few platelets, too many platelets or a normal number of platelets that do not function in the normal manner. Having too few platelet or platelets that do not function well (for example, aspirin use) can lead to a bleeding tendency (hemophilia). Likewise, too many platelets can predispose to a tendency to clot excessively (thrombophilia). Platelet function can be altered in many different situations; many medications to treat diseases such as strokes and heart attacks were specifically designed to alter the ability of platelets to form clots. There are also a number of diseases that can alter how well a platelet can function.
MemorialCare - Online Health Screenings By MyElectronicMD.com
Irrespective of their etiology, all of these forms of platelet disorderslead to impairment of primary and secondary hemostasis.
http://mymd.i2net.com/mc_mymd/refr.php?Id=1233
Hematology International Society Of Haematology ISHAPD Education Program 1999
platelet disorders; Diagnosis and Management of Immune ThrombocytopeniaJeanne M. Lusher; Von Willebrand's Disease Gilbert C. White, II
http://haem.nus.edu.sg/ishapd/1999/ish1999.htm

Extractions: Articles may be freely reproduced and distributed for the purposes of private study or research, on the condition that the author(s) are fully acknowledged and that no alterations are made to the text, figures or tables. Articles or portions of the text, figures, or tables may not be reproduced in other publication(s) without the prior consent of the author(s).
Platelet Function Disorders | Principal Health News
Platelet Function Disorders. Barrett, Julia. Periodicals Liesner, RJ, and SJ Machin. platelet disorders. British Medical Journal 314, no. 7083 (1997) 809.
http://www.principalhealthnews.com/topic/topic100587311

Extractions: Platelets are elements within the bloodstream that recognize and cling to damaged areas inside blood vessels. When they do this, the platelets trigger a series of chemical changes that result in the formation of a blood clot. There are certain hereditary disorders that affect platelet function and impair their ability to start the process of blood clot formation. One result is the possibility of excessive bleeding from minor injuries or menstrual flow. Description Platelets are formed in the bone marrowa spongy tissue located inside the long bones of the bodyas fragments of a large precursor cell (a megakaryocyte). These fragments circulate in the bloodstream and form the first line of defense against blood escaping from injured blood vessels. Damaged blood vessels release a chemical signal that increases the stickiness of platelets in the area of the injury. The sticky platelets adhere to the damaged area and gradually form a platelet plug. At the same time, the platelets release a series of chemical signals that prompt other factors in the blood to reinforce the platelet plug. Between the platelet and its reinforcements, a sturdy clot is created that acts as a patch while the damaged area heals. There are several hereditary disorders characterized by some impairment of the platelet's action. Examples include von Willebrand's disease, Glanzmann's thrombasthenia, and Wiskott-Aldrich syndrome. Vulnerable aspects of platelet function include errors in the production of the platelets themselves or errors in the formation, storage, or release of their chemical signals. These defects can prevent platelets from responding to injuries or from prompting the action of other factors involved in clot formation.
Zeal.com - United States - New - Personal - Health - Conditions & Illnesses - Bl
1. Mayo Clinic Rochester platelet disorders Group http//www.mayo.edu/mmgrg/rst/mpdpltrb.htmResource was created by the Mayo Clinic Myeloproliferative
http://www.zeal.com/category/preview.jhtml?cid=274454
Benign Classification: Hematologic (Blood) Disorders: Patient Information: Arizo
blood cells) WHITE BLOOD CELL DISORDERS Neutropenia (Low white blood cells) Leukocytosis(Excess white blood cells) platelet disorders Thrombocytopenia (Low
http://www.telemedicine.arizona.edu/patient_info/benign_disorders/classification

Extractions: Myeloproliferative Disorders See also: Alphabetic List of Benign Hematologic Disorders : This web site and its contents are designed for educational purposes only. This web site does not render medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.
Untitled Document
The platelet disorders are often subdivided into either quantitative (iethrombocytopenia) or qualitative problems ( ie platelet dysfunction).
http://www.sghhealth4u.com.sg/health4u/hematology/Bleeding_tendency.htm

Extractions: Causes of bleeding tendency There are many causes to vessel defects eg. hereditary (ie Ehlers Danlos syndrome), nutrient deficiency (ie Vit C deficiency), drug induced (ie steroid induced), aging (senile purpura), certain infections (ie streptococcal, meningococcal infections), malignancies (ie lymphoma, leukemia), etc. The platelet disorders are often subdivided into either quantitative (ie thrombocytopenia) or qualitative problems ( ie platelet dysfunction). The former can be a result of decreased platelet production in the bone marrow or an increased destruction/loss of platelets in the peripheral blood stream. The causes can likewise be a primary platelet disorder (eg hereditary, nutrient deficiency, infections, drug induced, etc) or secondary to other disease states affecting the marrow or peripheral blood (eg other malignancies, autoimmune disorder, etc). Clotting defects can either be due to an abnormal production or an accelerated removal of the fiber clots. The common cause of defective production is the hereditary deficiency of clotting factors (eg hemophilia, von Willebrand disease, etc). The problem with an accelerated removal of fiber clots is by far very rare, but nevertheless, could still result from a deficiency of the regulatory proteins in clot removal (eg plasminogen activator inhibitor deficiency).
Platelet Function Disorders | Ahealthyme.com
You are here Home Health A to Z Platelet Function Disorders. PlateletFunction Disorders. platelet disorders. British Medical Journal 314, no.
http://www.ahealthyme.com/topic/topic100587311

Extractions: Platelets are elements within the bloodstream that recognize and cling to damaged areas inside blood vessels. When they do this, the platelets trigger a series of chemical changes that result in the formation of a blood clot. There are certain hereditary disorders that affect platelet function and impair their ability to start the process of blood clot formation. One result is the possibility of excessive bleeding from minor injuries or menstrual flow. Description Platelets are formed in the bone marrowa spongy tissue located inside the long bones of the bodyas fragments of a large precursor cell (a megakaryocyte). These fragments circulate in the bloodstream and form the first line of defense against blood escaping from injured blood vessels. Damaged blood vessels release a chemical signal that increases the stickiness of platelets in the area of the injury. The sticky platelets adhere to the damaged area and gradually form a platelet plug. At the same time, the platelets release a series of chemical signals that prompt other factors in the blood to reinforce the platelet plug. Between the platelet and its reinforcements, a sturdy clot is created that acts as a patch while the damaged area heals. There are several hereditary disorders characterized by some impairment of the platelet's action. Examples include von Willebrand's disease, Glanzmann's thrombasthenia, and Wiskott-Aldrich syndrome. Vulnerable aspects of platelet function include errors in the production of the platelets themselves or errors in the formation, storage, or release of their chemical signals. These defects can prevent platelets from responding to injuries or from prompting the action of other factors involved in clot formation.
Platelet Function Disorders
MAIN SEARCH INDEX Platelet function disorders. Periodicals Liesner, RJ, and SJ Machin. platelet disorders. British Medical Journal 314, no. 7083 (1997) 809.
http://www.hendrickhealth.org/healthy/001076.htm

Extractions: Resources Platelets are elements within the bloodstream that recognize and cling to damaged areas inside blood vessels. When they do this, the platelets trigger a series of chemical changes that result in the formation of a blood clot. There are certain hereditary disorders that affect platelet function and impair their ability to start the process of blood clot formation. One result is the possibility of excessive bleeding from minor injuries or menstrual flow. Platelets are formed in the bone marrowa spongy tissue located inside the long bones of the bodyas fragments of a large precursor cell (a megakaryocyte). These fragments circulate in the bloodstream and form the first line of defense against blood escaping from injured blood vessels. Damaged blood vessels release a chemical signal that increases the stickiness of platelets in the area of the injury. The sticky platelets adhere to the damaged area and gradually form a platelet plug. At the same time, the platelets release a series of chemical signals that prompt other factors in the blood to reinforce the platelet plug. Between the platelet and its reinforcements, a sturdy clot is created that acts as a patch while the damaged area heals. There are several hereditary disorders characterized by some impairment of the platelet's action. Examples include von Willebrand's disease, Glanzmann's thrombasthenia, and
The Royal Society Of Canada - 2002 New Fellows - Academy Of Science / Académie
McMaster University John Kelton, Faculty of Health Sciences, McMaster University,is a physician scientist whose investigation of platelet disorders and the
http://www.rsc.ca/english/new_fellows_2002_LS.html

Extractions: Carol E. Cass, Department of Oncology, University of Alberta, is internationally recognized for her research on membrane transport of nucleosides and nucleoside drugs. Her important early studies on nucleoside transport in human erythrocytes laid the foundation for the field and her subsequent studies of nucleoside transport deficiencies established that functional membrane transporters are essential for manifestation of cytotoxicity of many nucleoside drugs. The proteins responsible for nucleoside transport across biological membranes have recently been shown by Dr. Cass and her collaborators to be members of two novel and evolutionarily old membrane protein families that are found in organisms from bacteria and yeast to humans.
Platelet Disorder Support Association
Email pdsa@pdsa.org. Conditions Immune Thrombocytopenic Purpura; Inherited Thrombocytopenia;platelet disorders. Hours Answered 9am - 5pm Voicemail yes.
http://www.geneticalliance.org/Resources/displayorganization.html?orgname=Platel
VITA-TECH Veterinary Diagnostic Services
Only filtered PR') should be used for sustaining the platelet needsof chemotherapy or other patients with severe platelet disorders.
http://www.vita-tech.com/VDL/articles/bb6.htm

Extractions: TREATMENT OF BLEEDING DISORDERS W. Jean Dodds, D.V.M. HEMOPET, 938 Stanford Street, Santa Monica, CA 90403 Contents Von Willebrand's Disease (VWD) Rodenticide Toxicosis (Vitamin K Deficiency) Thrombocytopenia Other Bleeding Disorders Von Willebrand's Disease (VWD) For short-term control of bleeding or prophylaxis for dogs at risk to bleed from VWD: 1. For elective procedures, assess bleeding potential first with a toenail or mucosal bleeding time. Normal values for dogs are 2-5 minutes. 2. Use L-thyroxine therapy at 0.1 mg per 10 pounds body weight twice daily for 7-10 days. Start 48 hours prior to elective surgery where applicable. Continue thyroid replacement if patient is still bleeding or has thyroid disease. Thyroid supplementation promotes hemostasis by improving platelet function, stimulating thrombopoiesis in bone marrow and other sites, and enhancing protein synthesis of von Willebrand factor (VWF) and other coagulation factors. 3. Transfuse Fresh-Frozen Plasma* at 3-5 ml per pound of body weight once or twice daily. For elective procedures [ surgery on Doberman pinschers with VWDI, transfuse first and then perform surgery within 4 hours to maximize the bleeding time correcting effect of transfused VWF.

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