Geometry.Net - Basic_C: Cancer & Genetics

Cancer Molecular Genetics Unit
cancer Molecular genetics Unit. Patrice Morin, Ph.D., Head Investigator.Overview. Our laboratory's interest is twofold ovarian cancer
http://www.grc.nia.nih.gov/branches/lbc/cmgu.htm

Extractions: Overview Our laboratory's interest is twofold: ovarian cancer and the Wnt pathway in human cancer. Ovarian cancer is the fourth leading cause of cancer death among women in the United States. Because of a lack of powerful diagnostic tests, early detection has been difficult. Moreover, the molecular mechanisms involved in the initiation and progression of ovarian cancer remain largely unknown. The two main approaches that we will use to tackle these problems are described below. SAGE analysis of normal ovary and ovarian cancer. The best hope for identifying tumor markers resides in a detailed understanding of the differences between normal and cancer cells. It is well documented that, in the process of going from normal to malignant, cells reprogram their gene expression. However, consistent changes that could be useful for diagnosis have remained elusive for most tumor types, including the ovary. SAGE, one of the more powerful techniques currently available for the quantitative study of gene expression, is being used to analyze normal ovary tissue, primary ovarian tumors and ovarian cancer cell lines. This approach has recently been used for colon cancer and has yielded a number of promising tumor marker candidates. Our laboratory is part of a multi-center program sponsored by CGAP (Cancer Genome Anatomy Project, NCI) to perform SAGE on a variety of tissues.
Colon Cancer Alliance - Genetics - Genetics Of Colorectal Cancer
genetics of Colorectal cancer. By Wylie Burke, MD, PhD. Research on the genetics ofcolorectal cancer (CRC) now provides a guide to the inheritance of CRC risk.
http://www.ccalliance.org/news/genetics/burke/

Extractions: Hereditary CRC Specific Genetic Studies ... Genetics News Genetics of Colorectal Cancer By Wylie Burke, MD, PhD Colorectal cancer (CRC) has long been known to cluster in some families. Research on the genetics of colorectal cancer (CRC) now provides a guide to the inheritance of CRC risk. An important benefit of this research is the development of strategies to identify people with a genetic susceptibility to CRC so that targeted prevention can be offered. In the long term, this research will lead to a better understanding of the biology of CRC and may ultimately lead to new treatment and prevention strategies. Family history as a risk factor for colorectal cancer People who have a positive family history of CRC - that is, a history of close relatives with colon or rectal cancer - have an increased risk of developing this cancer themselves. The closer the relative, the greater the risk; therefore, risk is higher if a first-degree relative (a parent, brother or sister, or child) had CRC than if a second-degree relative (grandparent, aunt or uncle) did. Risk is also higher when relatives have been affected with CRC at a young age, particularly if cancer has occurred before age 50.
L'Institut Curie
The main research activities ranging from the physical chemistry of organized molecular complexes to basic biological research and cancer genetics - are conducted in the Research Division of the Curie Institute. This basic research is targeted to the development new diagnostic methods and cancer treatments.
http://www.curie.fr
Colon Cancer Alliance - Genetics - Understanding Cancer Genetics
back to previous page. Understanding cancer genetics. cancer geneticsOverview from NCI genetics overview for professionals.
http://www.ccalliance.org/news/genetics/understand.html

Extractions: EIN # 86-0947831 The information provided by the CCA on this website should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider. proudly hosts this site.
San Antonio Cancer Institute
Combined cancer research programs of the cancer Therapy and Research Center and the University of Texas Health Science Center at San Antonio. Research activities are underway in such areas as genetics, drug development, and cancer prevention and control.
http://www.ccc.saci.org/
University Of Wisconsin Comprehensive Cancer Center-Genetics
cancer genetics. Program Leader William F. Dove, Ph.D. Program Participants.Daniel Albert, MD Thomas S. Anantharaman, Ph.D. Mark
http://www.cancer.wisc.edu/clinician/programs/genetics.html

Extractions: John A. T. Young, Ph.D. Description The mission of the Cancer Genetics Program is to develop the capabilities of experimental genetic analysis to define causative pathways that affect tumor growth. A series of mouse models for human cancer is being developed as a starting point. The Program then aims to develop the capacity for a detailed molecular genetic analysis of tumor in animals and in humans. This knowledge can give a concrete basis for diagnosis and treatment. Specific Aims To explain the origins of cancer in animal models by identifying genetic factors that affect tumor growth.
University Of Virginia Health System
Provides information about prevention, diagnosis, support, community outreach, genetics, nutrition, research, clinical trials and news, as well as an introduction to the center and its programs. Located in Charlottesville, Virginia.
http://www.med.virginia.edu/cancer
Colorectal Cancer And Genetics
Colon cancer and genetics. In the past few years, reports about possiblegenetic elements of colon and colorectal cancers have made headlines.
http://www.csu.edu.au/learning/ncgr/gpi/odyssey/colon/

Extractions: In the past few years, reports about possible genetic elements of colon and colorectal cancers have made headlines. Over 500,000 people throughout the world are diagnosed with colon cancers every year. So, when news spreads about discoveries related to colon cancer, people pay attention. It has long been observed that colon cancer runs in some families. Medical researchers suspected that a portion of colon and rectal cancer cases might have a genetic basis. Geneticists have been studying genetic linkages to colorectal cancer since the mid-1980s. It is important to understand that only about 5 to 10 percent of all colon cancer cases are directly linked to hereditary, or genetic, factors. The other 95 percent are considered sporadic. Just because a disorder such as colon cancer tends to concentrate in some families does not necessarily mean that a predisposition to the disease is passed on genetically. Family members also share similar environments, lifestyles, and diets that are risk factors for cancer. Colon cancer is a multifactorial condition. That means there may be many things that have acted together to cause the cancer in any given case, including DNA. There are several kinds of hereditary colon cancers. Genetic researchers have uncovered evidence that genetics does play a role in two types of familial conditions that can lead to colon cancer. Researchers have undertaken studies of families where these conditions can be traced through family members over several generations.
Division Of Genetics, URMC
Featured is information on laboratory testing, genetic susceptibility to cancer, cystic fibrosis, and sickle cell, thalassemia and other hemoglobinopathies. In addition there are links to counseling services, the graduate program, the Sickle Cell Clinic, newsletters, and list of staff.
http://www.urmc.rochester.edu/Genetics/

Extractions: Our latest Sickle Selections Newsletter *These files are available as Adobe Acrobat Reader 3.0 files - online versions that look just like the originals. The Adobe Acrobat Reader software is freely available for you to download and use from Adobe's software site. Comments/Suggestions to: Mary_True@urmc.rochester.edu . For questions or suggestions concerning the content of these pages, contact the URMC Webmaster
Latest Research On Breast Cancer And Genetics
Breast cancer. Compiled by Lauren McCain and Clay Dillingham INTRODUCTION.WEB LINKS INFORMATION ABOUT BREAST cancer.
http://www.csu.edu.au/learning/ncgr/gpi/odyssey/BCAN2/

Extractions: Compiled by Lauren McCain and Clay Dillingham INTRODUCTION WEB LINKS: INFORMATION ABOUT BREAST CANCER MEDICAL SCIENCE AND GENETICS SOCIAL AND ETHICAL ISSUES LEGAL AND POLICY ISSUES RECENT NEWS STORIES OTHER RESOURCES Introduction Geneticists have been working to locate genes that may play a role in causing breast cancer. The 1994 discovery of the gene mutation for breast cancer made headlines around the world. Studies seeking to discover other relationships between genetic mutations and breast cancer are under way. Following lung cancer, breast cancer is the second leading cause of cancer deaths among women (heart disease is the leading cause of death in women). One out of eight women is expected to develop breast cancer by the age of 80. Men can develop breast cancer, too. About 1% of breast cancers develop in males. In 1996 the Centers for Disease Control and Prevention reported 184,300 new cases of breast cancer. An estimated 44,200 deaths from breast cancer are expected in 1997, and the U.S. government will spend more than $550 million on breast cancer research in 1997 ("In Research, the Sincerest Form of Concern is Money,"
Molecular Oncology Unit Home Page
Dedicated to researching the causes of and treatments for cancer. Includes description of the molecular genetics of pancreatic cancer, and related research into screening, diagnosis, treatment, and genetic vaccination.
http://www.lif.icnet.uk/axp/mphh/
Cleveland Clinic > Gastroenterology > Colon Cancer > Medical Genetics Program
Medical genetics Program. The Center for Colon cancer and Polyps is part of a collaborativegroup offering comprehensive risk assessment, genetic counseling
http://www.clevelandclinic.org/gastro/colon/genetics/

Extractions: Medical Genetics Program The Center for Colon Cancer and Polyps is part of a collaborative group offering comprehensive risk assessment, genetic counseling, screening recommendations and appropriate genetic testing to patients with a family history of polyps and colon cancer. Risk Assessment Services Most diseases occur randomly, or as a result of external exposure (such as cancer-causing agents in the diet or environment) or lifestyle risk factors such as smoking. You may want to consider genetic risk assessment if several members of your family have the same or related diseases. But even what appears to be a family pattern may be due to chance, not genes. The only way to know is to have a complete evaluation performed. Genetic risk assessment starts with your family tree and develops to include important information for disease-related genes within your family. Genetic experts consider the patterns of disease that occur among your blood relatives as one element in determining your risk for having the genes for a specific disease or passing these genes to your children. By combining this with family information and additional risk factors, our specialists can determine your risk of inherited disease. With the addition of genetic testing for an identified gene mutation, experts can determine whether you carry disease-related genes before symptoms occur. Even if a specific gene test is not available, risk assessment is still a worthwhile option for surveillance recommendations and prevention strategies.
Cold Spring Harbor Laboratory
Research in cancer biology, plant genetics, genomics and bioinformatics, and neurobiology.
http://www.cshl.org/
Cleveland Clinic > Gastroenterology > Colon Cancer > Medical Genetics Program
the David G. Jagelman Inherited Colorectal cancer Registries in the Department ofMedical genetics at 216/4446470 or 800/998-4785 to schedule an appointment.
http://www.clevelandclinic.org/gastro/colon/high.htm

Extractions: A special clinic held one afternoon each month at the new Digestive Disease Center, the High Risk Clinic offers the opportunity for high-risk patients to do "one-stop" shopping when they require multiple services. Patients benefit from taking care of all their needs in a single afternoon and in one convenient location. Who is considered high risk? Anyone with an inherited colorectal cancer syndrome, including Hereditary Non-Polyposis Colorectal Cancer (HNPCC), Familial Adenomatous Polyposis (FAP), Peutz-Jeghers syndrome (PJS) or Juvenile Polyposis (JP) is considered to be high risk and can access the services of the High Risk Clinic. What services are available at the High Risk Clinic? At the High Risk Clinic, the registry coordinator will take patients' medical histories and prepare family pedigrees. Patients undergo necessary tests, such as colonoscopies or esophagogastroduodenoscopies, and meet with genetic counselors and geneticists who can provide a comprehensive program of genetic counseling and testing, if appropriate. Patients also can learn about support groups and related organizations that may be of interest. In addition, patients can meet with specialists from the Clinic's departments of Colorectal Surgery and Gastroenterology. Do I need to prepare beforehand?
Welcome To The Center For Inherited Cancer
A cancer genetics facility offering services to individuals with a personal or family history of cancer.
http://www.inheritedcancer.org/

Extractions: Visit genetichealth.com to build your own family tree. You will be asked to provide information about your family and cancer. The information is used to draw a picture, called a pedigree, that represents your family's cancer history and that you can share with your doctor. UT Medical Group, Inc.'s Center for Inherited Cancer is a comprehensive cancer genetics facility offering a variety of services to individuals with a personal or family history of cancer. A team of health professionals work together to determine the best course of action for each patient in terms of cancer risk assessment and management. Learn your true risk for certain types of cancer. Your personal medical history and family medical history is explored and studied in order to determine your risk for developing cancer. Genetic testing Based on the family and personal medical histories, an individualized cancer screening plan is developed for each person who comes to the Center for Inherited Cancer. Our staff also works with you to ensure that cancer screening services are available to you, such as mailing out timely reminders that your colonoscopy or mammogram are due.
Risk Factor Monitoring & Methods - Genetics & Family History
track the diffusion of cancer genetics services in health care delivery.Branch staff carry out this research program by conducting
http://riskfactor.cancer.gov/areas/genetics/

Extractions: Tools Areas of Research Publications About RFMMB Molecular and biological risk factors that confer susceptibility to cancer are an increasingly important area of research because of their potential impact in cancer control. These risk factors include family history of cancer and the presence of cancer susceptibility mutations and other genetic changes. The Risk Factor Monitoring and Methods Branch (RFMMB) supports surveillance studies to monitor these risk factors in the US and to assess their impact on cancer incidence and progression. We also: define measures of risk and develop sound and cost-efficient methods to assess risk; track the diffusion of cancer genetics services in health care delivery. Branch staff carry out this research program by conducting independent surveys and collaborating in state and national surveys, such as the genetics portions of the National Health Interview Survey and the California Health Interview Survey . We also develop and provide public access to survey questionnaires that may be useful for outside investigators who wish to compare state and national estimates with estimates from their own local populations. Current Projects
Roy R Swiger's Biotechnology Homepage, Genetics, Cancer, Links, Research, Academ
Educational links for professionals and researchers in the field of cancer genetics, including the method of fluorescence insitu hybridization and its applications.
http://www.geocities.com/CapeCanaveral/3333/
Riskfactor.cancer.gov - Genetics & Family History
genetics Family History Current Projects. We are conducting the Physician Surveyon cancer Susceptibility Testing, a national survey of 1,251 physicians
http://riskfactor.cancer.gov/areas/genetics/projects.html

Extractions: Tools Areas of Research Publications About RFMMB We are conducting the Physician Survey on Cancer Susceptibility Testing , a national survey of 1,251 physicians, which aims to assess use and knowledge of, and attitudes toward, genetic tests for inherited mutations associated with increased cancer risk. We are working with investigators at the University of New Mexico and the University of Southern California on the Screening for Hereditary Nonpolyposis Colorectal Cancer (HNPCC) study. HNPCC is a syndrome of inherited susceptibility to colorectal cancer. This study is estimating the prevalence of HNPCC in the general population, evaluating current guidelines for identifying individuals with HNPCC, and determining the most effective screening strategy to detect HNPCC mutation carriers among patients with newly diagnosed colorectal cancer. Current Projects
Medical Computing And Media Services, Dalhousie University
Research in the neurosciences, cardiovascular, infectious disease, cancer cell biology, transplantation immunology, molecular genetics and population health.
http://www.mcms.dal.ca/

Extractions: Medical Computing and Media Services (MCMS) provides the best in contemporary media, audiovisuals, and computer imaging technology to the entire Medical School community. The knowledgeable staff at MCMS can provide in-depth, practical experience on every aspect of academic and business presentations. The equipment and expertise provided can fine tune material for teaching, research, or
OBOS: Breast Cancer And Genetics
and age. In addition, family history, and in a small number of casesgenetics, can indicate an increased risk for breast cancer.
http://www.ourbodiesourselves.org/brca1.htm

Extractions: donations BREAST CANCER GENES: MYTHS AND FACTS A fact sheet compiled by the Our Bodies Ourselves and The Council for Responsible Genetics Last revised October 2000 Scientists do not currently know what causes breast cancer or how to prevent it. Research completed over the past twenty years indicates the existence of several risk factors that seem to increase an individuals chance of getting the disease. The two most significant risk factors for breast cancer currently identified are gender and age. In addition, family history, and in a small number of cases genetics, can indicate an increased risk for breast cancer. All women and men are born with two copies of the so-called "breast cancer genes," BRCA-1 and BRCA-2. When functioning properly, these genes are thought to protect against cancer by suppressing abnormal cell growth. If one copy of these tumor suppressor genes becomes damaged, the other copy can act as a "brake" on uncontrolled cell growth. Scientists have identified at least four other genes that may play a role in breast cancer risk. Several hundred variations of the BRCA genes have been identified so far. Some of these appear to be linked to an increased risk of breast and ovarian cancer, particularly in women with a strong family history of one or both of these diseases. A woman born with one damaged version of a BRCA gene has only one working set of "brakes" for uncontrolled cell growth. If her second BRCA gene becomes damaged by exposure to carcinogens or otherwise, the woman can develop cancer. BRCA variants, in and of themselves, do not

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