Editorial Review Product Description Discover the answer to the mysteries of these debilitating illnesses
Explaining “Unexplained Illnesses” provides long-sought explanations for the properties of chronic fatigue syndrome (CFS), multiple chemical sensitivity (MCS), fibromyalgia, and posttraumatic stress disorder. This groundbreaking book examines common symptoms and signs; short-term stressors such as infection, chemical exposure, physical trauma, and severe psychological stress; why people are often diagnosed as having more than one of these illnesses, and approaches for treating the cause of each disease, rather than the symptoms. The book presents a detailed and well-supported mechanism (the NO/ONOO- cycle) that provides consistent explanations for many of the puzzling elements of these diseases.
At least a dozen scientists have proposed that chronic fatigue syndrome, multiple chemical sensitivity, and fibromyalgia must share a common mechanism; others have suggested posttraumatic stress disorder may belong to this group as well. This unique book provides explanations for their previously unexplained properties with more than 1,500 references to scientific literature, creating a whole new approach to therapy and treatment of these illnesses.
Explaining "Unexplained Illnesses" provides answers to these questions:
- how do short-term stressors initiate chronic illness?
- how does the biochemistry of the NO/ONOO- cycle produce chronic illness?
- how can the diverse symptoms and signs of these illnesses be generated as a consequence of their common biochemistry?
- why is there so much variation in symptoms from one sufferer to another?
- what are the principles underlying the NO/ONOO- cycle mechanism?
- how does the NO/ONOO- cycle provide explanations for a dozen previously unexplained properties of these illnesses?
- how might 14 additional illnesses/diseases also be caused by the NO/ONOO- cycle etiology?
- and many more
Explaining “Unexplained Illnesses” is a must-read for physicians and scientists, and for anyone who suffers from-or knows someone who suffers from—these previously puzzling illnesses. ... Read more Customer Reviews (16)
A new paradigm for chronic illness
Explaining Unexplained Illnesses
Disease Paradigm for:Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, Gulf War Syndrome, and Others
By Martin Pall, PhD (Informa Health Care 2009)
By Jackie Steincamp, New Zealand
Dr Pall opens our eyes to the altered biochemistry in chronic disease.A marvellous argument - but awarning, this book is not for the fainthearted, woolly-headed or medically and scientifically ignorant!
Hel presents the NO/ONOO (pronounced, aptly, "No, oh no!) cycle as the causal mechanism for CFS, FM, MCS, PTSD and related illnesses.Nitric oxide (NO) itself has many useful functions in the body, but if its levels are too high, its oxidant by-product, peroxynitrite (ONOO) propagates itself and creates a chronic vicious cycle.He argues that therapies should focus on down-regulating the NO/ONOO cycle and presents many modalities collected from various researchers and clinicians.He quotes extensively from such CFS medical heroes as Drs Paul Cheney, David Bell, Jacob Teitelbaum, Grace Ziem, and Garth Nicolson.
Dr Pall has written and researched M.E./CFS illnesses for many years.He is Professor of Biochemistry and Basic Medical Sciences at Washington State University.His long term interests in the body's regulatory systems and free radicals. Among his many distinguished activities, he is on the editorial board of the Journal of Chronic Fatigue Syndrome (Haworth).
He shows that NO/ONOO damage can be quite local within the body, impacting on one tissue, but not necessarily another.Different people suffering from these illnesses thus can have an infinite variety of symptoms and signs produced by this variation in tissue distribution.Increased inflammatory processes are also engendered by high levels of peroxynitrite and may be quite localized.
He draws from world wide research to argue that whatever type of "unexplained illness" is concerned, that genetic susceptibility leading to hormonal abnormalities arekey factors."No! Oh no!" is not the basic problem.The individual's genetics and hormonal balance are the determining factors.
Lengthy explanations of why agents such as glutathione, selenium, flavonoids, magnesium, carnosine and carnitine (and many others) show why they help down-regulate the ONOO cycle.Summaries oftreatment protocols (all heavily anti-oxidant) from four leading M.E./CFS specialists illustrate how they may be used in treatment. .
Dr Pall provides a remarkable argument on what is surely a central thesis of chronic unexplained and fatiguing illnesses:namely that oxidative stress mechanisms point the way to any therapeutic approach. There is a wealth of information in this book, much of it quite technical, but understandable for any informed and determined reader.
Good in parts but misleading about ME and 'CFS'
It is important to note that Pall should not be considered a M.E. expert and that when he refers to `CFS' this information should not be assumed to apply in whole or in part to M.E.
Some of what he is saying generally may possibly be relevant to M.E. patients to some extent (as regards treatment, rather than symptomatology or aetiology, as it does with multiple sclerosis for example), but this is as yet unclear due to the fact he unfortunately makes no distinction between fatigue and `CFS' and the distinct neurological disease M.E.
M.E. is NOT at all a medically unexplained illness, and has little in common with the conditions Pall claims `share many symptoms and often occur together' such as PTSD and MCS and Fibromyalgia - unlike `CFS.' As Pall claims, `CFS' (or rather, those illnesses which are misdiagnosed as `CFS') can be caused by many different things including bacterial infections, psychological stress and physical trauma but this makes it very clear that when Pall refers to `CFS' he is not referring to genuine M.E.
Anyone who describes an illness that is based on fatigue, is medically unexplained, has symptoms similar to Fibromyalgia or PTSD etc., and that can be caused by many different things such as trauma, physical and emotional stress and bacterial infection and common virus infections such as EBV or herpes etc., IS NOT REFERRING TO M.E. and is not knowledgeable about even the most basic facts of M.E.
The research is very clear that M.E. is not (and cannot) be caused by stress, trauma or bacterial infections and so on. M.E. is caused by a virus, an enterovirus and is primarily a testable and measurable neurological disease with many distinct features and unique symptoms.
Please, if you have a 'CFS' (mis)diagnosis, do everything you can to find your correct diagnosis, do not accept 'CFS' ever as an end point to the process of diagnosis. This theory may have some merit as regards M.E., some of it fits, but this information is inaccurate with many basic facts about M.E. so please go elsewhere for that info!
Jodi Bassett, HFME
An in depth explanation
In this book you will find an in depth etiology of 4 little known diseases (MCS, CFS, PTSD and FM). Their causes, mechanism and how to fight them efficiently.
As well as some thought about collaterals, such as the difficulty to diagnose, the ignorance and skepticism of most people including, sadly, medical profession. And some number on how wide spread (and ignored) they are.
There is a wealth of reference at the end of the book (about 120 pages of them!)
Also you'll find also conjectures on numerous other disease, such as Asthma, Allergy, Lupus.
It was a great read. Although, not being a MD or biologist myself, some passage were a bit difficult and I just browsed over them.
beacon of hope
Dr. Pall's book explains what I want ever doctor and family member or friend to finally understand. MCS is a real, and tragic, illness that results from the casual attitude we have with chemicals in our environment and this is what is happening.The book is an excellent text for the average person, and those with a non-scientific mind, as Dr. Pall teaches a basic science class on the NO/ONOO process responsible for the illnesses which many of us have had to live with for years. As I read the book I felt hope for all who suffer from one of these. More important still is the treatment formula that Dr. Pall, Dr. Grace Ziem and Jim Seymour have introduced. This treatment has changed my life. I highly recommend this book; buy several and gift them to every doctor you know...It's that important.
Excellent book all doctors should read and all with chemical injury
I read this book which I now plan to give to my Dr. so he can read it also.I suffer from this illness and really appreciate this book altho some of it was above my head.I learned lots from what I was able to read and understand.I recommend it for all who are suffering from Chronic Fatigue Syndrome and chemical injury and also for ALL doctors.
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