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Genetic Disorders General: more books (100)

Molecular Genetics of Mental Disorders: The Place of Molecular Genetics in Basic Mechanisms and Clinical Applications in Mental Disorders by Mike Briley, Fridolin Sulser, 2000-01-01

Genetic Biochemical Disorders (Oxford Monographs on Medical Genetics) by Philip F. Benson, Anthony H. Fensom, 1986-11-20

Molecular Genetics of Endocrine Disorders

Genetics for Oncologists: The Molecular Genetic Basis of Oncologic Disorders (Remedica Genetics) by Fiona Lalloo, Eli Hatchwell, 2002-08-01

Genetic Variation and Disorders in Peoples of African Origin (Johns Hopkins Series in Contemporary Medicine and Public Health) by Dr. James E. Bowman MD, Dr. Robert F. Murray Jr. MD MS, 1998-12-07

Mouse Models in the Study of Genetic Neurological Disorders (Advances in Neurochemistry)

Handbook of Neurodevelopmental and Genetic Disorders in Adults

Genetics, Syndromes and Communication Disorders by Robert J. Shprintzen, 1997-10-01

Genetic Studies in Affective Disorders: Overview of Basic Methods, Current Directions, and Critical Research Issues (Publication Series of the Depar) by Demitri F., M.D. Papolos, Herbert M. Lachman, 1994-01

Chronic Myeloproliferative Disorders: Cytogenetic and Molecular Genetic Abnormalities

Mendelian Inheritance in Man: A Catalog of Human Genes and Genetic Disorders by Victor A. McKusick MD, 1998-06-29

Abnormal Skeletal Phenotypes: From Simple Signs to Complex Diagnoses by Alessandro Castriota-Scanderbeg, Bruno Dallapiccola, 2005-12-20

Genetic and Acquired Disorders: Current Topics and Interventions for Educators

Genetic Aberrancies and Neurodegenerative Disorders, Volume 3 (Advances in Cell Aging and Gerontology)

lists with details

Virtual Children's Hospital: Clinical Genetics: A Self Study For Health Care Pro
the most common chronic diseases are multifactorial genetic disorders. explains thefamilial distribution of many disorders. In general, the recurrence risk is
http://www.vh.org/pediatric/provider/pediatrics/ClinicalGenetics/Lesson1/MultiIn

Extractions: Peer Review Status: Internally Peer Reviewed The most common cause of genetic disorders is multifactorial or polygenic inheritance. Traits that are due to the combined effects of multiple genes are polygenic (many genes). When environmental factors also play a role in the development of a trait, the term multifactorial is used to refer to the additive effects of many genetic and environmental factors. Expression of these traits may follow a normal, or "bell-shaped," curve. Examples of multifactorial traits include cleft lip and palate, congenital hip dislocation, schizophrenia, diabetes and neural tube defects such as spine bifida. Multifactorial conditions tend to run in families, but the pattern of inheritance is not as predictable as with single gene disorders. The chance of recurrence is also less than the risk for single gene disorders. The degree of risk of a multifactorial disorder occurring in relatives is related to the number of genes they share in common with the affected individual. The closer the degree of relationship, the more genes in common. The degree of risk also increases with the degree of severity of the disorder. Although multifactorial conditions run in families, the risk is generally less than the 25% or 50% seen in Mendelian conditions. Identical twins who are exactly alike genetically, do not always have the same condition when inheritance is multifactorial. This indicates that there are nongenetic factors that also play a role in the expression of multifactorial traits. For instance, the risk of coronary heart disease increases with smoking or obesity. The risk of emphysema in individuals with alpha-1-antitrypsin deficiency increases greatly with smoking. Maternal ingestion of valproic acid, a medication for seizures, increases the risk of spine bifida. Maternal alcohol abuse or uncontrolled diabetes increases the risk of having a child with a congenital heart defect.
Biozone: GENETICS
it means, and how it affects everyday life, and societies in general. from all aspectsof genetics today, Human chromosomes, genetic disorders, Genome project
http://www.biozone.co.uk/biolinks/GENETICS.html
Mental Health: A Report Of The Surgeon General - Chapter 3
sometimes runs in families, but the precise role of genetic and environmentalfactors has not been established. The etiology of anxiety disorders is more
http://www.surgeongeneral.gov/library/mentalhealth/chapter3/sec6.html

Extractions: Children and Mental Health Normal Development Theories of Development Social and Language Development ... References The combined prevalence of the group of disorders known as anxiety disorders is higher than that of virtually all other mental disorders of childhood and adolescence (Costello et al., 1996). The 1-year prevalence in children ages 9 to 17 is 13 percent (Table 3-1). This section furnishes brief overviews of several anxiety disorders: separation anxiety disorder, generalized anxiety disorder, social phobia, and obsessive-compulsive disorder. Treatments for all but the latter are grouped together below. Separation Anxiety Disorder Separation anxiety is often associated with symptoms of depression, such as sadness, withdrawal, apathy, or difficulty in concentrating, and such children often fear that they or a family member might die. Young children experience nightmares or fears at bedtime. About 4 percent of children and young adolescents suffer from separation anxiety disorder (DSM-IV). Among those who seek treatment, separation anxiety disorder is equally distributed between boys and girls. In survey samples, the disorder is more common in girls (DSM-IV). The disorder may be overdiagnosed in children and teenagers who live in dangerous neighborhoods and have reasonable fears of leaving home. The remission rate with separation anxiety disorder is high. However, there are periods where the illness is more severe and other times when it remits. Sometimes the condition lasts many years or is a precursor to panic disorder with agoraphobia. Older individuals with separation anxiety disorder may have difficulty moving or getting married and may, in turn, worry about separation from their own children and partner.
Mental Health: A Report Of The Surgeon General - Chapter 4
highest category, which called for nonmolecular genetic and/or the treatment of majormental disorders a half ECT are those of brief general anesthesia, which
http://www.surgeongeneral.gov/library/mentalhealth/chapter4/sec3_1.html

Extractions: the biological abnormalities interrelate, how they correlate with behavioral and emotional patterns that seem to distinguish one subcategory of major depression from another, and how they respond to diverse forms of therapy. In the search for biological changes with depression, it must be understood that a biological abnormality reliably associated with depression may not actually be a causal factor. For example, a biologic alteration could be a consequence of sleep deprivation or weight loss. Any biological abnormality found in conjunction with any mental disorder may be a cause, a correlate, or a consequence, as discussed in Chapter 2. What drives research is the determination to find which of the biological abnormalities in depression are true causes, especially ones that might be detectable and treatable before the onset of clinical symptoms. Monoamine Hypothesis For many years the prevailing hypothesis was that depression was caused by an absolute or relative deficiency of monoamine Despite the problems with the hypothesis that monoamine depletion is the primary cause of depression, monoamine impairment is certainly one of the manifestations, or correlates, of depression. Therefore, the monoamine hypothesis remains important for treatment purposes. Many currently available pharmacotherapies that relieve depression or cause mania, or both, enhance monoamine activity. One of the foremost classes of drugs for depression, SSRIs, for example, boost the level of serotonin in the brain.
REVIEWS
on genetics and related subjects for the general public is critical for librarycollections, especially public libraries. genetic disorders Sourcebook, from
http://libres.curtin.edu.au/libres11n1/reviews.htm

Extractions: Bi-annual LIBRES11N2 REVIEWS REVIEWS Reviews in this issue: Cook , Allan R., ed., Alternative Medicine Sourcebook . 1st. ed. Health Reference Series. Detroit, MI: Omnigraphics, 1999. 737 pp. ISBN: 0-7808-0200-4 Reviewed by Necia Parker-Gibson Massimini , Kathy, ed. Genetic Disorders Sourcebook: Basic Consumer Information about Hereditary Diseases and Disorders, Including Hemophilia, Huntington's Disease, Sickle Cell Anemia, and More; Facts about Genes, Gene Research and Therapy, Genetic Screening, Ethics of Gene Testing, Genetic Counseling, and Advice on Coping and Caring; Along with a Glossary of Genetic Terminology and a Resource List for Help, Support, and Further Information . 2nd ed. Detroit: Omnigraphics, 2000. Series: Health Reference Series. 768 p. + xiv. ISBN: 0-7808-0241-1. $78.00. Reviewed by Dean Hendrix Muth , Annemarie S., ed. Asthma Sourcebook . Series: Health Reference Series. Detroit, MI: Omnigraphics, 2000. 627 pp. ISBN: 0-7808-0381-7. Reviewed by Dawn Olmsted Swanson Swanson,
CHDD - MRDDRC - Disorders Of Interest
genetic basis of myotonic dystrophy. NEURODEGENERATIVE disorders, general.
http://depts.washington.edu/chdd/MRDDRC/disorders_of_interest.html

Extractions: Site Map MRDDRC UCEDD Organization ... Admin Disorders Investigated by CHDD Researchers Lisa Frenkel, MD Antiviral resistance in children receiving highly active antiretroviral therapy Gwenn Garden, MD, PhD Molecular pathogenesis of HIV dementia Nancy Haigwood, PhD Perinatal transmission of HIV Rodney Ho, PhD Mother-to-fetus HIV transmission; therapeutic strategies for treating neurological dysfunctions due to HIV transmission William Morton, VMD Pathogenesis of lentiviral infection Jashvant Unadkat, PhD Therapeutic strategies to prevent vertical transmission of HIV Julie Worlein, PhD Neurological dysfunction in infants and children with HIV infection Elizabeth Aylward, PhD fMRI of individuals with dementia to improve early diagnosis of Alzheimer's disease Thomas Bird, MD Linkage analysis in familial Alzheimer's disease James Leverenz, MD Studies of early Alzheimer's disease pathology in Down syndrome Gerard Schellenberg, MD
NHF | Bleeding Disorders Information Center | Gene Therapy: General Information
cure many genetic diseases such as bleeding disorders. in the hemophilic individual,not in their genetic line site is provided for your general information only
http://www.hemophilia.org/bdi/bdi_gene.htm

Extractions: Gene therapy represents a new field of medicine, one which can potentially cure many genetic diseases such as bleeding disorders. Patients with inherited diseases such as hemophilia usually lack a functional protein, which can be replaced with periodic protein replacement therapy. An alternative is to add a normal gene to substitute for the defective one. The normal gene, if delivered to the right cells and in sufficient quantity, can continuously make the normal version of the defective protein, restoring normal clotting mechanisms. However, this is a new and highly experimental field. Many questions remain unanswered and will only be answered through a series of clinical studies, some of which are ongoing using the genes for factors VIII and IX. There have been many failures and disapointments when investigators have found that the technology for delivering the genes was inadequate when used in humans. Sometimes investigators have underestimated the complexity of the diseases they were attempting to cure. Because of some recent successes, hemophilia has emerged as the top candidate for a genetic disease most likely to benefit from gene therapy. Hemophilia is considered an ideal disease for gene therapy because it's caused by a single malfunctioning gene, and only a small increase in clotting factor in the bloodstream could provide great medical benefits. If gene therapy raises levels of missing clotting factors by as little as 2% of normal, it is enough to prevent patients from suffering spontaneous hemorrhages into joints, brain and other organs, as happens with hemophilia. Levels greater than 20% to 30% would be sufficient to prevent bleeding in all but the most traumatic injuries.
Hospital Medicine - Clinical Genetics
Experience of general genetic disorders is gained throughout the programme. Rotationsinclude genetic registers, adult onset disorders and prenatal diagnosis;
http://www.pgmd.man.ac.uk/hospmed/hst/clinicalgenetics.htm

Extractions: Higher Specialist Training List of Specialties Guidelines General STC/STSC Info (20k .pdf file) Application Forms SPECIALTY: Clinical Genetics General Info: Duration: 4 Years Rotation: Clinical Training is organised into modules of 6 months enabling rotation through the various subspecialties of genetics. Experience of general genetic disorders is gained throughout the programme. Rotations include: The training programme is based at St Mary's Hospital with the Paediatric module being largely undertaken at the Royal Manchester Children's Hospital. In addition to clinics in these centres, trainees gain experience in peripheral genetic clinics undertaken at a number of district Hospitals throughout the Region. Attachments to the cytogenetic and molecular genetic laboratories of one month duration are organised during the training programme.
AFRICAN STUDIES DEPARTMENT AT HOWARD UNIVERSITY
Prereqs. general genetics and Immunology or permission of coordinators Analyzes themultiple biological and psychosocial aspects of genetic disorders which the
http://www.gs.howard.edu/gp-Genetics_humangenetics_proginfo.htm

Extractions: HU HOME CALENDARS DIRECTORY Graduate Degree Program For Genetics and Human genetics The Department of Genetics and Human Genetics offers courses leading to the Master of Science and Doctor of Philosophy degrees . The program is associated with the Departments of Pediatrics, and Biology, so that students will not only learn to work creatively in their own field of special interest but will also be able to relate their findings to progress made in related disciplines. Special Admission Requirements Applicants are required to submit three letters of recommendation, a statement of interest, official transcript(s) delivered and/or mailed in a sealed envelope by the Registrar of the college/university attended, and the most recent Graduate Record Examination scores. Master of Science Students wishing to enter the master's program should have a baccalaureate degree and a cumulative average of B or the equivalent. They also should have completed undergraduate courses in modern biology, chemistry through organic chemistry, general physics, mathematics through calculus, and general genetics, or equivalent courses. Students with less than a B average or who have not completed all of the required undergraduate courses may be admitted conditionally if they have very high Graduate Record Examination scores and/or excellent recommendations.
Wiley :: The Family Genetic Sourcebook
general Consumer Health, of the history of genetics, how genetic traits are inherited,genetic counseling, the treatment of genetic disorders, and more.
http://www.wiley.com/cda/product/0,,0471617091,00.html
Genetics And Major Psychiatric Disorders:A Program For Genetic Counselors
of the Surgeon general http//www.surgeongeneral.gov/library/mentalhealth/home.html.This website has information on a wide range of psychiatric disorders.
http://www.nchpeg.org/cdrom/links.html
UASOM Main Digital Library
Diseases Table of contents general Features Access Selected disorders of theLower Motor Neuron Diseases Access document; Molecular genetic Mechanisms of
http://uasom-dl.slis.ua.edu/clinical/metabolism/inborn/lysosomalstorage/sphingol

Extractions: Clinical Resources by Topic: Metabolic Disorders Tay-Sachs Disease Clinical Resources Pediatrics Pathology Genetics Clinical Guidelines ... Miscellaneous Resources See also: Chapter 365: Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases Table of contents Hoffman: Hematology: Basic Principles and Practice 3rd Ed.-2000 (MD Consult): Table of contents Lister Hill Library subscription INFO Goetz: Textbook of Clinical Neurology 1st Ed.-1999 (MD Consult):
Genetic Medicine - Detail
genes for both monogenic and complex genetic disorders. which might otherwise confoundgenetic effects on This general reduction in genetic and environmental
http://www.eurac.edu/Org/GenNova/detail.htm

Extractions: The Neuroepidemiology Project South Tyrol (NEPT) Since 1996 NEPT uses a novel 3-step case ascertainment method to measure the frequency and distribution of common neurological disorders such as Parkinson's disease and related disorders. NEPT is a "competence network" involving local primary care physicians, district nurses and neurologists (Figure 1) and has collaborations with many international research centres on five key areas (Figure 2): Epidemiology, Genetics, Neuropsychology, Functional Neuroimaging, and Neuropathology. Population Isolates Geographically and/or culturally isolated populations such as those living in the South Tyrol area have proven to be a valuable resource for identifying genes for both monogenic and complex genetic disorders. Geographic and cultural isolation also tend to reduce environmental variation, which might otherwise confound genetic effects on disease processes. This general reduction in genetic and environmental variation results in an increase in statistical power to identify genes, particularly in terms of the potential for linkage disequilibrium analysis to finemap genetic disease loci. Previous NEPT-research supports the hypothesis that linkage disequilibrium occurs at high levels in the local German-speaking population and identified the Ladins as genetically isolated group of predominant Paleolithic origin.
Toronto General Hospital To Be Only Canadian Site In First-ever Genetic Study Of
Woodside, Director of the Inpatient Eating disorders Program at Toronto general Hospitaland our understanding of the underlying genetic vulnerabilities in
http://www.eurekalert.org/pub_releases/2003-03/uot-tgh030603.php

Extractions: University of Toronto Toronto, March 6 -Toronto General Hospital researchers have been selected as the only Canadian hospital in the largest genetic study of anorexia nervosa ever conducted. The National Institute of Mental Health-funded study is a five-year, $10 million (US) project, led by University of Pittsburgh School of Medicine. It brings together 11 groups of researchers from North America and Europe (10 clinical centres and one to analyze data) to find regions of the human genome that contain genes influencing the risk for anorexia. To find these regions, the researchers will recruit families with two or more members, mainly siblings, who have or had anorexia nervosa, and analyze DNA from the participants. Dr. Allan S. Kaplan, the Loretta Anne Rogers Chair in Eating Disorders, Head of Eating Disorders Program at Toronto General Hospital and Professor of Psychiatry at University of Toronto, and Dr. Blake Woodside, Director of the Inpatient Eating Disorders Program at Toronto General Hospital and Associate Professor of Psychiatry at the University of Toronto will lead the Canadian-based component of the research. "This research project could be an important turning point in our understanding of the underlying genetic vulnerabilities in anorexia nervosa. The study will identify genes that contribute to anorexia nervosa, ultimately improving our ability to detect, prevent and treat this illness," said Dr. Kaplan.
Cryogenic Laboratories - Genetic Testing
risk for all genetic disorders is higher. genetic screening can reduce this riskto some extent but it cannot entirely eliminate the general population risk.
http://www.cryolab.com/genetest.htm

Extractions: In an attempt to minimize the risk of genetic disorders in donor offspring, CLI obtains a three-generation family history from the donor and performs carrier screening for certain genetic diseases. As part of the donor qualification process, the family medical history obtained from the donor is reviewed by our geneticist. The information is not verified by other sources. The accuracy of the donor's knowledge regarding his family's medical history varies greatly and, in some instances, may be limited. CLI relies totally upon the representations that the donor has the genetic and hereditary characteristics and health profile claimed in the donor profile completed by the donor. CLI does not make any investigations as to donor characteristics or qualifications. Testing Limitations Risks It should be understood that there are many possible sources of diagnostic error. These include sample mix-ups, erroneous paternity identification, and genotyping errors. Even if the donor testing show results within normal limits, the tests have their own limitations and may not produce reliable results, even when properly administered. Even though test results for various diseases may indicate negative results, donor specimens may not be disease free. CLI relies upon its testing laboratories and as such, will not and cannot guarantee that the donor specimens are disease free. For some genetic diseases, such as Tay Sachs and Sickle Cell disease, laboratory testing can accurately identify carriers and non-carriers of the gene responsible for the disease. For other genetic diseases, such as Cystic Fibrosis, laboratory testing is not definitive however the possibility of being a carrier is reduced if a negative test result is obtained. Laboratory testing for genetic disorders is considered to be very accurate but, in rare instances, errors may occur. Genetic testing is usually performed only during the donor qualification process and is generally not repeated.Every pregnancy which occurs within the general population, has a 3-4% risk of producing a child with a birth defect or mental retardation. The life-time risk for all genetic disorders is higher. Genetic screening can reduce this risk to some extent but it cannot entirely eliminate the general population risk.
Genetic Alliance Clinical Descriptions
and for general information throughout the site. GeneClinics is a medical knowledgebase consisting of short descriptions of specific genetic disorders and
http://www.geneticalliance.org/diseaseinfo/clinical.html

Extractions: The Children's Health Information Network provides information and resources to families of children with congenital and acquired heart disease, adults with CHD and their providers. The Combined Health Information Database CHID is a bibliographic database produced by health-related agencies of the Federal Government. This database provides titles, abstracts, and availability information for health information and health education resources. The Family Village community includes informational resources on specific diagnoses, communication connections, adaptive products and technology,adaptive recreational activities, education, worship, health issues, disability-related media and literature, and much, much more! Search by specific condition in the "library" section and for general information throughout the site. GeneClinics is a medical knowledge base consisting of short descriptions of specific genetic disorders and information on the role of genetic testing in the diagnosis, management, and genetic counseling of patients with these conditions.
Policy Statement
general Principles in the Care of Children and Adolescents with genetic Disordersand Other Chronic Health Conditions (RE9717). AMERICAN ACADEMY OF PEDIATRICS.
http://www.aap.org/policy/re9717.html

Extractions: Pediatrics Volume 99, Number 4 April 1997, p 643-644 Committee on Children With Disabilities ABSTRACT. The intent of this statement is to describe the breadth of issues that have special pertinence to pediatricians who care for children and families affected by genetic disorders and other chronic health conditions. The committee on children with disabilities believes that because these children are leading healthier and longer lives, pediatricians are the more highly qualified to serve them, by virtue of their training and experience, and to provide them a "medical home." This statement is designed to assist pediatricians in the treatment of these patients by describing their potential roles in relationship to their patients' changing needs, as they work with various members of the health care team and as they respond to the requirements of government agencies and various third-party payers. During the last decade we have witnessed dramatic changes in the diagnosis and treatment of genetic disorders in children that have fundamentally altered the way pediatricians view such conditions. Children with genetic disorders now live longer, most into adulthood. Using the latest scientific information, pediatricians are in the unique position of assisting children who have genetic conditions to reach their full potential. This goal is best achieved by facilitating the integration of the child and family into the community while minimizing the effects of the genetic condition on the child's overall growth and development.
Exploring Genes & Genetic Disorders
availability of gene tests or clinical trials, support groups, and other generalmaterial. Sample Profiles of Genes and genetic disorders Compilations of
http://www.ornl.gov/hgmis/posters/chromosome/

Extractions: The U.S. Department of Energy Biological and Environmental Research program funds this site. DOWNLOAD: Gene Gateway Handout (PDF) S cientists, enabled by the Human Genome Project , are churning out an unprecedented volume of data on human chromosomes and the tens of thousands of genes residing on them, many associated with genetic disorders. These data, and many Web sites on human genetic disorders, are freely accessible on the Internet. Listed below are guides and tutorials that provide a gateway for the novice or layperson to find and use this growing wealth of information. Information furnished by resources described in this guide should not be used as a substitute for consultation with a physician. Questions or concerns regarding a medical condition should be discussed with a professional, such as a physician, genetic counselor, or medical geneticist. For more information on genetic health professionals, see the HGPI Genetic Counseling page and the Genetic Health Professionals section of the Genetic Disorder Guide Human Genome Landmarks wall poster depicting the 24 human chromosomes and some g enes associated with disorders and traits. To order a free copy
National Center For Medical Home Initiatives
genetic disorders. National Center for Environment Health at the Centersfor Disease Control http//www.cdc.gov/ncbddd/ The National
http://www.medicalhomeinfo.org/web/Specific Diagnoses/gendisord.htm
National Center For Medical Home Initiatives
general Medical Sites. National Organization for Rare disorders (NORD) http//www.rarediseases.org/NORD is a unique federation of more than 140 notfor-profit
http://www.medicalhomeinfo.org/web/Specific Diagnoses/GenSites.html

Extractions: KidsHealth is brought to you by the medical experts at the Nemours Foundation. The Nemours Foundation is a nonprofit organization devoted to children's health and is the largest physician practice delivering subspecialty pediatric care in the United States. All information on KidsHealth is for educational purposes only. The place to get specific medical advice, diagnoses, and treatment is your doctor.

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