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Viral hepatitis B or C is the most common cause of chronic liver disease worldwide and accounts for about 80% of all hepatocellular carcinoma cases. Thus, combating viral hepatitis remains one of the most pressing public health issues today. Animal models and cell-based systems are essential tools for addressing the many still unresolved basic and clinical problems. Experimental models are needed to better understand the viral life cycles, pathogenetic aspects and natural defense mechanisms, while preclinical models are required for evaluating novel preemptive and therapeutic strategies. This monograph provides a unique synopsis of currently available models of viral hepatitis, highlighting their particular use for basic and translational science. Leading experts discuss new scientific results and evolving methods in various animal and in vitro models, including the woodchuck, duck, mouse, chimpanzee and tupaia, as well as primary hepatocytes and subgenomic HCV replicons.A valuable ... Read more

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The present volume of Frontiers of Virology provides newinformation on the advantages of using the polymerase chainreaction (PCR) in the diagnosis of many viruses that causehuman diseases, and on some difficulties of using it. Thevolume is divided into sections each of which dealing withthediagnosis of a group of human viruses: (1) humanlentiviruses (HIV-1, AIDSvirus) and retroviruses (HTLV Iand II and human spumaviruses), (2) hepatitis viruses A, B,C and Delta, (3) herpesviruses (HSV, VZV, HCMV, EBV,andHHV-6), (4) papilloma JC viruses and BK-J 1 virus, (5)airborne and respiratory viruses, rubella, measles,influenza, rhinoviruses, parovirus B19, adenoviruses andcoronaviruses, and (6) additional disease-causing RNAviruses, e.g. rabies virus, flaviviruses, hantavirusesandintestinal virus (picorna virus and rota virus). In dealingwiththese issues the authors describe both the advantagesoffered by PCRtechnology and the current limitations ofthis technology. In addition, the authors provide basicinformation on the virus and the disease caused by it andexplain how to make an accurate PCR diagnosis.The present book transmits the excitement associated withthis advancing frontier in virologyand is the first attemptto collect the knowledge relating to this newdiagnostictechnology in one volume. ... Read more

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A guide to the facts about virus diseases which students need to know for their professional examination in microbiology. Topics covered include arthropod-borne virus infections, virus replication and neurological disease due to viruses. ... Read more

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Research on viral disease has expanded so rapidly that our knowledge now doubles almost every year, making it difficult to keep abreast of new findings.Bringing together the latest research in viral genetics, cytology, biochemistry, and immunology, Virology in Medicine provides the information most relevant to the practical treatment of viral disease.Concise, practice-oriented, and completely up to date, this volume is both a highly effective introduction for medical students and an invaluable reference for anyone with a need to understand viral diseases and their treatment. ... Read more

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Modern diagnostic virology is a complex and developing subject area. This book brings together the work of experts in the field of clinical virology, and includes discussion on some of the less frequently considered viruses and infective agents, which nonetheless are clinically important. Recent developments in the field of water virology are also considered. This volume provides an up to date overview of topics which will be of interest to anyone working in the field of clinical and diagnostic virology. ... Read more