1. Welcome To The American Sickle Cell Anemia Association A nonprofit organisation based in Cleveland Ohio whose objectives are to raise awareness of the conditio Category Health Conditions and Diseases Blood Disorders Sickle Cell...... Welcome to The American Sickle Cell Association web site. Visitors to this site.Copyright © 2000 American Sickle Cell Association All Rights Reserved. http://www.ascaa.org/

A United Way Agency Categories Who We Are Mission Statement Board of Trustees Executive Director ... Contacts NEW!!! Request for Information NEW!!! View Online Video Related Sites/Links Home Search The Site Welcome to The American Sickle Cell Association web site. Please visit often to get the latest news and available information. Click Here for Contribution Information. Visitors to this site. Updated 03/27/02

2. Sickle Cell Information Center Home Page Resource on the disease for both professionals and patients. Features education, news and research. What is sickle cell anemia? Health Care Providers Online Resources and Guidelines http://www.emory.edu/PEDS/SICKLE

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3. MEDLINEplus Medical Encyclopedia: Sickle Cell Anemia Takes a look at this disorder with a definition, causes, incidence and risk factors. http://www.nlm.nih.gov/medlineplus/ency/article/000527.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Sickle cell anemia Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Red blood cells, sickle cell Red blood cells, normal Red blood cells, multiple sickle cells Red blood cells, sickle cells ... Blood cells Alternative names Return to top Anemia - sickle cell; Hemoglobin SS disease (Hb SS); Sickle cell disease Definition Return to top An inherited, chronic disease in which the red blood cells, normally disc-shaped, become crescent shaped. As a result, they function abnormally and cause small blood clots. These clots give rise to recurrent painful episodes called "sickle cell pain crises". Causes, incidence, and risk factors Return to top Sickle cell anemia is caused by an abnormal type of hemoglobin (oxygen carrying molecule) called hemoglobin S. It is inherited as an autosomal recessive trait that is, it occurs in someone who has inherited hemoglobin S from both parents. Someone who inherits hemoglobin S from one parent and normal hemoglobin (A) from the other parent will have sickle cell trait . Approximately 8% of African Americans have sickle cell trait. Someone who inherits hemoglobin S from one parent and another type of abnormal hemoglobin from the other parent will have another form of sickle cell disease, such as sickle cell-b

4. New Hope For People With Sickle Cell Anemia (FDA Consumer Reprint) born with two copies of the genetic mutation have sickle cell anemia, a painful disease that affects the red blood cells http://www.fda.gov/fdac/features/496_sick.html

This article originally appeared in the May 1996 FDA Consumer and contains revisions made in December 1997 and February 1999. The article is no longer being updated. New Hope for People with Sickle Cell Anemia by Eleanor Mayfield In tropical regions of the world where the parasite-borne disease malaria is prevalent, people with a single copy of a particular genetic mutation have a survival advantage. Over time, people from these regions have migrated, had children, and in some cases married each other. Some of their children inherit two copies of the mutation. While inheriting one copy of the mutation confers a benefit, inheriting two copies is a tragedy. Children born with two copies of the genetic mutation have sickle cell anemia, a painful disease that affects the red blood cells and is curable only in rare instances. In February 1998, the Food and Drug Administration approved the drug Droxia (hydroxyurea) for reducing painful episodes in adults with a severe form of sickle cell anemia. The drug doesn't cure the disease. Hydroxyurea also is approved under the name Hydrea for treating certain cancers. Genetic Defect Changes Cell Shape The genetic defect that causes sickle cell anemia affects hemoglobin, a component of red blood cells. Hemoglobin's job is to carry oxygen to all the cells and tissues of the body. Red blood cells that contain normal hemoglobin (such as the one pictured top right) are soft and round. Their soft texture enables them to squeeze through the body's small blood vessels.

5. Sickle Cell Anemia from the National Heart, Lung and Blood Institute, NIH. SCDAA. Sickle Cell Disease Association of America http://www.ncbi.nlm.nih.gov/disease/sickle.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View HBB on chromosome 11 Databases PubMed the literature Key Papers Recent literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information Fact Sheet from the National Heart, Lung and Blood Institute, NIH SCDAA Sickle Cell Disease Association of America SICKLE CELL ANEMIA (SCA) is the most common inherited blood disorder in the United States, affecting about 72,000 Americans or 1 in 500 African Americans. SCA is characterized by episodes of pain, chronic hemolytic anemia and severe infections, usually beginning in early childhood. SCA is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene ( HBB ) found on chromosome 11p15.4. Carrier frequency of HBB varies significantly around the world, with high rates associated with zones of high malaria incidence, since carriers are somewhat protected against malaria. About 8% of the African American population are carriers. A mutation in HBB results in the production of a structurally abnormal hemoglobin (Hb), called HbS. Hb is an oxygen carrying protein that gives red blood cells (RBC) their characteristic color. Under certain conditions, like low oxygen levels or high hemoglobin concentrations, in individuals who are homozygous for HbS, the abnormal HbS clusters together, distorting the RBCs into sickled shapes. These deformed and rigid RBCs become trapped within small blood vessels and block them, producing pain and eventually damaging organs.

6. NHLBI, Sickle Cell Anemia Facts About sickle cell anemia sickle cell anemia is an inherited blood disorder, characterized primarily by chronic anemia and periodic episodes of pain. http://www.nhlbi.nih.gov/health/public/blood/sickle/sca_fact.htm

Facts About Sickle Cell Anemia Sickle cell anemia is an inherited blood disorder, characterized primarily by chronic anemia and periodic episodes of pain. This fact sheet provides concise, accurate information on the causes, populations affected, signs and symptoms, diagnoses, and treatments. 6 pages. NIH Publication Number: 96-4057 You may obtain the document in the following ways: View online (in formats below) [Plain text (ASCII) document, 19 K] [PDF document, 137 K, need Acrobat Reader to review] Information for visitors using screen readers Information about PDF Printed Copies Order online Order by telephone, fax, or mail Price Information Single copy Free Each additional copy 25 copies 100 copies Research studies recruiting patients at NHLBI, NIH, Bethesda, Maryland Home Page Sickle Cell Information for the General Public

7. Do You Know About Sickle Cell Anemia? What's sickle cell anemia? It's a disease of the blood that gets its name because sickle cells look like a farm tool called a sickle. Find out more about this genetic illness in this article for kids. http://kidshealth.org/kid/health_problems/blood/sickle_cell.html

KidsHealth Kids Kids' Health Problems Blood Have you ever seen a sickle? It's a farm tool with a curved, sharp edge for cutting wheat. Sickle cell anemia (say: sih -kul sell uh- nee -mee-uh) is a disease of the blood that gets its name because the blood cells are shaped like a sickle. You or someone you know may have sickle cell anemia. To find out more about it, keep reading. What Is Sickle Cell Anemia? Sickle cell anemia is a disease caused by a problem with the body's red blood cells . Normal red blood cells are soft and round like teeny tiny little doughnuts. These normal cells bend and flow easily through small, tube-like blood vessels to deliver oxygen to all parts of the body. But sickle cells are different. They're much stiffer, with a curved shape. The hard, curved edges of sickle cells can make these cells get clogged up inside of smaller blood vessels. This keeps blood from flowing properly in the body. Important organs like the brain heart , or kidneys need constant blood flow to stay healthy. Although the body attacks the sickle cells and destroys them, it can't make new blood cells fast enough to replace the old ones.

8. Deep Vein Thrombosis Probability Fpnotebook looks at the course, management and complications of this disease. http://www.fpnotebook.com/HEM39.htm

Home About Links Index ... Editor's Choice Paid Advertisement (click above). Please see the privacy statement Hematology and Oncology Examination Anemia ... Cardiovascular Medicine Deep Vein Thrombosis Probability Deep Vein Thrombosis Probability DVT Probability Book Home Page Cardiovascular Medicine Dental Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hematology and Oncology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Surgery Symptom Evaluation Vascular Page Examination Index Anemia CV DVT Probability See Also Deep Vein Thrombosis Indications Assess DVT Pretest Probability Scoring Active malignancy within last six months: 1 point Lower extremity immobility: 1 point Cast Paralysis Restricted mobility within last 4 weeks: 1 point Bedridden for more than 3 days Major surgery Localized pain over deep venous course: 1 point Calf circumference 3 cm over opposite calf: 1 point Measure 10 cm below tibial tuberosity Lower extremity

9. Sickle Cell Anemia A definition of sickle cell anemia, what it is, how one gets it, symptoms, statistics and testing. http://www.mamashealth.com/Sickle_Cell.asp

Mamashealth.com Home Category Links About Us Allergies Bones and Muscles Cancers ... Buy Health Books Links Add Mamashealth to your favorites Email Mama Donate $$$ and help support Mamashealth.com Floral Gift for your Loved Ones What is Sickle Cell Anemia? Sickle Cell is an inherited, chronic blood disease where the red blood cells become crescent shaped and function abnormally. When the blood cells become cresent/sickle shaped, they are unable to deliver adequate amounts of oxygen to other cells. The Sickle Cell Disease results in anemia (low blood counts), episodes of pain and increased susceptibility to infections. Sickle Cell produces a chronic anemia which may become life-threatening when hemolytic crises (the breakdown of red blood cells) or aplastic crises (bone marrow fails to produce blood cells) occur. If repeated crises occurs, damage of the kidneys lungs , bone, liver , and central nervous system may result. Occasionaly, acute painful episodes may occur. These acute episodes may last hours to days affecting the bones of the back, the long bones, and the chest.

10. Patient Information Compares normal red blood cells to those affected by this disorder. Tells who may be born with the condition and how it affects the lives of those who have it. http://www.emory.edu/PEDS/SICKLE/sicklept.htm

Sickle Cell Anemia Sickle Cell anemia is a group of inherited red blood cell disorders. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. What makes the red cell sickle? There is a substance in the red cell called hemoglobin that carries oxygen inside the cell. One little change in this substance causes the hemoglobin to form long rods in the red cell when it gives away oxygen. These rigid rods change the red cell into a sickle shape instead of the round shape. How do you get sickle cell anemia or trait? You inherit the abnormal hemoglobin from your parents, who may be carriers with sickle cell trait or parents with sickle cell disease. You can not catch it. You are born with the sickle cell hemoglobin and it is present for life. If you inherit only one sickle gene, you have sickle cell trait. If you inherit two sickle cell genes you have sickle cell disease. Is Sickle Cell only in African Americans?

11. Have-A-Heart For Sickle Cell Anemia Foundation To educate and inform patients, their families, and the community at large. http://4sicklecellanemia.org

Email Us Site Design By: The Digital Construction Co. Home About Us What Is SCA? ... Links

12. The American Sickle Cell Anemia Association - FAQ'S Search The Site. What is sickle cell anemia. What causes sickle cell anemia.How common is sickle cell anemia. What are signs of sickle cell anemia. http://www.ascaa.org/faq.asp

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13. Patient Information sickle cell anemia. sickle cell anemia is a group of inherited redblood cell disorders. How do you get sickle cell anemia or trait? http://www.scinfo.org/sicklept.htm

Sickle Cell Anemia Sickle Cell anemia is a group of inherited red blood cell disorders. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. What makes the red cell sickle? There is a substance in the red cell called hemoglobin that carries oxygen inside the cell. One little change in this substance causes the hemoglobin to form long rods in the red cell when it gives away oxygen. These rigid rods change the red cell into a sickle shape instead of the round shape. How do you get sickle cell anemia or trait? You inherit the abnormal hemoglobin from your parents, who may be carriers with sickle cell trait or parents with sickle cell disease. You can not catch it. You are born with the sickle cell hemoglobin and it is present for life. If you inherit only one sickle gene, you have sickle cell trait. If you inherit two sickle cell genes you have sickle cell disease. Is Sickle Cell only in African Americans?

14. Carolina WrenPress Nonprofit publisher whose Lollipop Power Books specialize in multicultural, bilingual, nonsexist, and nontraditional childrens books. Publishes Puzzles, the story of a tenyear-old girl with sickle cell anemia. http://www.carolinawrenpress.org/

Poetry Carolina Wren Press Poetry Home About Book List Contact Us ... Manuscripts DON'T MISS... Chapbook Contest: Carolina Wren Press invites submissions to its 2003 Poetry Chapbook Contest. See contest guidelines for more detail. The Current Poetry Corner Feature: Evie Shockley's The Gorgon Goddess Carolina Wren Press is a nonprofit organization whose mission is to publish quality writing, especially by writers historically neglected by mainstream publishing, and to develop diverse and vital audiences through publishing, outreach, and educational programs. Carolina Wren Press is committed to multicultural ideals and to literary quality. We publish books by new authors, authors of color, women authors, and gay/lesbian authors. Lollipop Power Books is the children's book publishing arm affiliated with Carolina Wren Press. It includes bilingual titles and specializes in multicultural, nonsexist, and nontraditional children's books. Poetry

15. Sickle Cell Anemia sickle cell anemia. Introduction. sickle cell anemia (SCA) is caused by a change in the chemical composition of the http://radlinux1.usuf1.usuhs.mil/rad/home/cases/sickle.html

The Department of Radiology and Nuclear Medicine of the Uniformed Services University of the Health Sciences Bethesda, Maryland Sickle Cell Anemia MS-1 ANATOMY MS-2 RADIOLOGY MS-4 ELECTIVE TROPICAL MEDICINE ... Visit The Main Radiology Website! Sickle Cell Anemia Introduction Ironically, the sickle cell trait (the heterozygous HgbSA - not the homozygous HgbSS) seems to have a protective effect against the malaria parasite. By the time many patients reach adulthood, there is often objective evidence of anatomic and/or functional damage to various tissues due to the cumulative effects of recurrent vasoocclusive (clotting) episodes. However, the course of the disease is variable from patient to patient. Learn More About Sickle Cell Anemia - 1 Learn More About Sickle Cell Anemia - 2 Learn More About Sickle Cell Anemia - 3 You may also want to visit the Sickle Cell Anemia Slide Show. Bone Changes Sickle Cell Anemia and its variants produce roentgenographically similar bone changes. These have been divided conveniently into four groups; Deossification due to marrow hyperplasia Thrombosis and infarction Secondary osteomyelitis Growth defects The first is most commonly seen only in sickle cell anemia. Marrow hyperplasia crowds and thins the bone trabeculae which results in bone weakness and osteoporosis. Bone softening at the centra of the vertebral bodies of the spine occurs in 70% of patients; a biconcave shape results as the intervertebral disks push into the softened bone. Infarction on the vertebral bodies may also result in partial or complete collapse of the central portion as well. The biconcave, or "fish mouth" vertebrae (due to compression of the vertebral endplates above and below the disk space) are virtually pathognomonic of sickle cell disease. Such changes are evident on the enclosed chest X-rays.

16. MEDLINEplus: Sickle Cell Anemia Search MEDLINE for recent research articles on • sickle cell anemia. SickleCell Anemia (National Center for Biotechnology Information). http://www.nlm.nih.gov/medlineplus/sicklecellanemia.html

Skip navigation Other health topics: A B C D ... List of All Topics Sickle Cell Anemia Contents of this page: News From the NIH General/Overviews Prevention/Screening ... Teenagers Search MEDLINE for recent research articles on Sickle Cell Anemia You may also be interested in these MEDLINEplus related pages: Blood/Lymphatic System Genetics/Birth Defects Latest News Hydroxyurea Therapy Improves Survival in Most Severely Affected Sickle Cell Patients (04/01/2003, National Heart, Lung, and Blood Institute) From the National Institutes of Health Facts About Sickle Cell Anemia (National Heart, Lung, and Blood Institute) Also available in: Spanish Hydroxyurea Therapy Improves Survival in Most Severely Affected Sickle Cell Patients (National Heart, Lung, and Blood Institute) Sickle Cell Anemia (National Center for Biotechnology Information) General/Overviews Genetic Disease Profile: Sickle Cell Anemia (Dept. of Energy, Human Genome Project) Sickle Cell Anemia (Mayo Foundation for Medical Education and Research) Sickle Cell Anemia (Nemours Foundation) Clinical Trials ClinicalTrials.gov: Anemia, Sickle Cell

17. M. D. Anderson Cancer Center - Pediatric Bone Marrow Transplantation Services, which are for childhood cancers of the blood, neuroblastoma, Ewing's sarcoma, Wilm's tumor, and noncancerous blood disorders, including sickle cell anemia and immunodeficiency syndromes. http://www.mdanderson.org/departments/pedbmt

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18. My Sickle Cell Homepage Provides a first hand look at sickle cell anemia, built by a person suffering from the disease. Frequently asked questions and a personal diary of the owner's own battle with this disease. http://www.geocities.com/HotSprings/Spa/3194/

Glad You Stopped By! My initial intention for building this site was in response to the numerous sites that seemed targeted for the medical profession. After viewing several of these sites, I wondered where the Sicklers were and why hadn't they built any sites? Then it dawned on me... I'm a Sickler and I haven't built a site!  Although I'm not a medical professional, I hope this site can shed some light on Sickle Cell Anemia from a personal view. Page descriptions are below and I invite you  to browse the entire site. Hopefully, we'll both learn something in the end! The Sickle Cell Forum Been looking for people, living with Sickle Cell anemia like you? The Sickle Cell Forum is the place to be! The input has been lively and there's a definite community forming. To join our growing family, simply click on the link below. See you there, Charles Click to Join The Sickle Cell Forum For information about me, be sure to read the "About Me" page. The "Sickle Cell Diaries" is my personal account of life with Sickle Cell.

19. Anemia Iron-Deficiency Natural HealthLink Detailed information on sickle cell anemia symptoms, treatment and diet changes that may be helpful for iron deficiency. http://www.naturalhealthlink.com/ReferenceLibrary/healthnotes.asp?ArticleID=88&a

20. Brian's InterPlaza Personal site of Florida native with information and links to information regarding sickle cell anemia http://home.earthlink.net/~brianhender/

It's new and improved! Welcome to my home on the internet.If this is your first time visiting this site, I extend a hearty welcome. If you have visited here before, I hope that you enjoy the new layout and graphics. I don't know if you can tell by the improved graphics on the site, but I am out of the hospital and back at work.Thanks for all the get well wishes and sympathetic letters I hope that visitors will continue to find my site informative, and I look forward to reading more letters from people with Sickle Cell Anemia and their family and friends. I still hope to showcase some of my 3D graphics in this space, and post information for my co-workers regarding the use of the computers in their classrooms. So once I get a grasp of what the common questions are, I will begin a new section on this site. As far as the3D graphics are concerned, well....they come as soon as I get more free time. My thanks to all who have wished me well during the rough times. Also a special thanks to my family, who always encourage me to keep my head up. And a very special thanks to my friends (Kitten, SexySlim, and RawBass), who daily demonstrate to me the meaning of friendship. Sincerely

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