21. CNN - Boy Receives First Cord Blood Transplant For Sickle Cell Anemia - December CNN.com http://www.cnn.com/HEALTH/9812/14/cord.blood.sickle.cell/

MAIN PAGE WORLD ASIANOW U.S. ... news quiz CNN WEB SITES: TIME INC. SITES: Go To ... Time.com People Money Fortune EW MORE SERVICES: video on demand video archive audio on demand news email services ... pagenet DISCUSSION: message boards chat feedback SITE GUIDES: help contents search FASTER ACCESS: europe japan WEB SERVICES: Boy receives first cord blood transplant for sickle cell anemia Keone is the first sickle cell patient to receive a cord blood transfusion from an unrelated donor. December 14, 1998 Web posted at: 2:09 p.m. EDT (1809 GMT) From Medical Correspondent Rhonda Rowland ATLANTA (CNN) Researchers say children who might have died from inherited immune disorders or leukemia may be cured with umbilical cord blood transplants. Now scientists at Emory University Hospital have done the world's first "unrelated donor" cord blood transplant in a child with sickle cell anemia. Keone Penn of Snellville, Georgia, looks like a typical 12-year-old. But he has a severe cased of sickle cell anemia, an inherited disorder where red blood cells are abnormally shaped. "He had a stroke when he was 5 and he's been getting chronic blood transfusions ever since he had the stroke lots of fevers, infections, seizures," said his mother, Leslie Penn.

22. The Story On Sickle Cell Anemia Tells what the condition is, how it affects people, how it may be treated and what young people with this condition can do to stay well. http://www.kidshealth.org/teen/diseases_conditions/blood/sickle_cell_anemia.html

KidsHealth Teens Blood Disorders Sickle cell anemia is a hereditary disorder that primarily affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 60,000 Americans have sickle cell anemia, and approximately two million Americans have sickle cell trait (this means they carry one gene for the disease). Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. What Is Sickle Cell Anemia? Sickle cell anemia is a blood disorder that affects hemoglobin (pronounced: hee -muh-glow-bin), a protein found in red blood cells that helps carry oxygen throughout the body. Red blood cells with normal hemoglobin ( HbA ) flow easily through the bloodstream, delivering oxygen to all of the cells of the body. Normal red blood cells are shaped like doughnuts with the centers partially scooped out and are soft and flexible. Sickle cell anemia occurs when an abnormal form of hemoglobin ( HbS ) is produced. HbS molecules tend to clump together, making red blood cells sticky, stiff, and more fragile, and causing them to assume a curved, sickle shape. Red blood cells containing HbS can go back and forth between being shaped normally and being sickle shaped until they eventually become irreversibly sickled. These sickle cells can clog blood vessels and deprive the body's tissues and organs of the oxygen they need to stay healthy.

23. Sickle Cell Anemia: What Is It? logo, DNA Learning Center Link, Concept 15 DNA and proteins are key moleculesof the cell nucleus. Learn the basic chemistry of DNA and proteins. http://www.yourgenesyourhealth.org/ygyh/mason/ygyh.html?syndrome=sickle

24. Sickle Cell Anemia Radiology Home Page, sickle cell anemia. sickle cell anemia (Also see SlideShow). The first is most commonly seen only in sickle cell anemia. http://rad.usuhs.mil/rad/home/cases/sickle.html

The Department of Radiology and Nuclear Medicine of the Uniformed Services University of the Health Sciences Bethesda, Maryland Sickle Cell Anemia MS-1 ANATOMY MS-2 RADIOLOGY MS-4 ELECTIVE TROPICAL MEDICINE ... Visit The Main Radiology Website! Sickle Cell Anemia Introduction Ironically, the sickle cell trait (the heterozygous HgbSA - not the homozygous HgbSS) seems to have a protective effect against the malaria parasite. By the time many patients reach adulthood, there is often objective evidence of anatomic and/or functional damage to various tissues due to the cumulative effects of recurrent vasoocclusive (clotting) episodes. However, the course of the disease is variable from patient to patient. Learn More About Sickle Cell Anemia - 1 Learn More About Sickle Cell Anemia - 2 Learn More About Sickle Cell Anemia - 3 You may also want to visit the Sickle Cell Anemia Slide Show. Bone Changes Sickle Cell Anemia and its variants produce roentgenographically similar bone changes. These have been divided conveniently into four groups; Deossification due to marrow hyperplasia Thrombosis and infarction Secondary osteomyelitis Growth defects The first is most commonly seen only in sickle cell anemia. Marrow hyperplasia crowds and thins the bone trabeculae which results in bone weakness and osteoporosis. Bone softening at the centra of the vertebral bodies of the spine occurs in 70% of patients; a biconcave shape results as the intervertebral disks push into the softened bone. Infarction on the vertebral bodies may also result in partial or complete collapse of the central portion as well. The biconcave, or "fish mouth" vertebrae (due to compression of the vertebral endplates above and below the disk space) are virtually pathognomonic of sickle cell disease. Such changes are evident on the enclosed chest X-rays.

25. Blood Diseases And Resources Information For Patients And The General Public Information, Healthbeat Radio, See Also. Sickle Cell Disease InformationDatos Sobre La Anemia Falciforme (Facts About sickle cell anemia); http://www.nhlbi.nih.gov/health/public/blood/

Health Information Topics on this Page: Sickle Cell Disease Blood Donation Information Other Blood Information Healthbeat Radio ... See Also Sickle Cell Disease Information Datos Sobre La Anemia Falciforme (Facts About Sickle Cell Anemia) Fact Sheet: Hydroxyurea in Pediatric Patients with Sickle Cell Disease Facts About Sickle Cell Anemia Patient Fact Sheet: The Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) Blood Donation Information Everyone can Give the Gift of Life Donando con Regularidad Como Parte de tu Vida-el Proceso es Simple Y Seguro Other Blood Information Hemophilia Update: 1997 Hemophilia Check Your Blood I.Q. Facts About Immune Thrombocytopenic Purpura ... Healthbeat Radio Programs Additional Resources Blood Information for Health Care Professionals List of Publications Information Center Patient Recruitment for Studies Conducted by the NHLBI at the NIH in Bethesda, Maryland ... Contact the NHLBI Please send us your feedback, comments, and questions by using the appropriate link on the page, Contact the NHLBI Note to users of screen readers and other assistive technologies: please report your problems here.

26. Have-A-Heart For Sickle Cell Anemia Foundation HaveA-Heart For sickle cell anemia Foundation - A site dedicated to educate andinform sickle cell anemia patients, their families and the community at large http://www.4sicklecellanemia.org/

Email Us Site Design By: The Digital Construction Co. Home About Us What Is SCA? ... Links

27. The Story On Sickle Cell Anemia Tells what the condition is, how it affects people, how it may be treated and what young people with Category Kids and Teens Health sickle cell anemia......sickle cell anemia occurs when a person inherits two abnormal genes that causetheir red blood cells to change shape. What Is sickle cell anemia? http://kidshealth.org/teen/diseases_conditions/blood/sickle_cell_anemia.html

KidsHealth Teens Blood Disorders Sickle cell anemia is a hereditary disorder that primarily affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 60,000 Americans have sickle cell anemia, and approximately two million Americans have sickle cell trait (this means they carry one gene for the disease). Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. What Is Sickle Cell Anemia? Sickle cell anemia is a blood disorder that affects hemoglobin (pronounced: hee -muh-glow-bin), a protein found in red blood cells that helps carry oxygen throughout the body. Red blood cells with normal hemoglobin ( HbA ) flow easily through the bloodstream, delivering oxygen to all of the cells of the body. Normal red blood cells are shaped like doughnuts with the centers partially scooped out and are soft and flexible. Sickle cell anemia occurs when an abnormal form of hemoglobin ( HbS ) is produced. HbS molecules tend to clump together, making red blood cells sticky, stiff, and more fragile, and causing them to assume a curved, sickle shape. Red blood cells containing HbS can go back and forth between being shaped normally and being sickle shaped until they eventually become irreversibly sickled. These sickle cells can clog blood vessels and deprive the body's tissues and organs of the oxygen they need to stay healthy.

28. Ask NOAH About: Sickle Cell Disease s Facts About sickle cell anemia National Heart Lung and BlookInstitute (PDF File of 6 Pages) (also in Spanish) Facts About Sickle Cell...... Basic http://www.noah-health.org/english/illness/genetic_diseases/sickle.html

Ask NOAH About: Sickle Cell Disease What is Sickle Cell Disease? Care and Treatment Basic Descriptions Sickle Cell Trait Causes/Genetics Screening/Prevention ... Management of Acute Chest Syndrome Special Groups Information Resources Especially For Children Especially For Teens For Families For Women ... Ongoing Research/Clinical Trials Go to the Ask NOAH About Genetic Diseases What Is Sickle Cell Disease? Basic Descriptions Facts About Sickle Cell Anemia - National Heart Lung and Blook Institute ( PDF File of 6 Pages) (also in Spanish Facts About Sickle Cell Anemia - JAMA Patient Page ... PDF File of 1 Page) How Does Sickle Cell Cause Disease? - Harvard University Sickle Cell Anemia - KidsHealth Sickle Cell Anemia - Mayo Clinic Sickle Cell Anemia - Methodist Health Care System, Houston TX (also in Spanish Sickle Cell Disease - March of Dimes (NOAH Provider) (also in Spanish General Information on Sickle Cell Anaemia - Sickle Cell Society What is Sickle Cell Anemia? - Georgia NIH Comprehensive Sickle Cell Center Sickle Cell Trait Sickle Cell Trait - Georgia Comprehensive Sickle Cell Site Sickle Cell Trait - American Sickle Cell Anemia Association Sickle Cell Trait - Virtual Children's Hospital Causes/Genetics How Do People Get Sickle Cell Disease? - Harvard Medical School

29. Sickle Cell Anemia Disease Profile Genetic Disease Profile sickle cell anemia. For gov. Other SickleCell Anemia Resources. MedlinePlus Entry for sickle cell anemia. http://www.ornl.gov/hgmis/posters/chromosome/sca.html

The U.S. Department of Energy Biological and Environmental Research program funds this site. Genetic Disease Profile: Sickle Cell Anemia For more about the gene that causes sickle cell anemia, see the HBB Gene Profile . The following was adapted from NIH Publication No. 96-4057 (PDF requires Adobe Acrobat Reader Sickle Cell Timeline - Herrick provides the first formal description of sickle cell anemia when he reports that the blood smear of a dental student at the Chicago College of Dental Surgery contains "pear-shaped and elongated forms." - Hahn and Gillespie associate the sickling of red blood cells with low oxygen conditions. - Sherman reports that the sickling of red blood cells in the absence of oxygen is caused by a change in the hemoglobin molecule structure. - Watson suggests that the presence of fetal hemoglobin in the red blood cells of sickle cell newborns is the reason they do not show disease symptoms. - Noted physical chemist Linus Pauling and associates publish "Sickle Cell Anemia, a Molecular Disease" in

30. Sickle Cell Anemia Gene The sickle cell anemia Gene, Official Gene Symbol HBB. Mutant beta globin is responsiblefor the sickling of red blood cells seen in sickle cell anemia 2. http://www.ornl.gov/hgmis/posters/chromosome/hbb.html

The U.S. Department of Energy Biological and Environmental Research program funds this site. The Sickle Cell Anemia Gene Official Gene Symbol: HBB Name of Gene Product: hemoglobin, beta Alternate Name of Gene Product: beta globin Locus: 11p15.5 The HBB gene is found in region 15.5 on the short (p) arm of human chromosome 11. Size: The HBB gene's 3 coding regions (exons) are scattered over 1600 base pairs of genomic DNA. Exons translated into the HBB polypeptide chain are interspersed with segments of noncoding DNA (introns). After transcription, introns are spliced out and exons are pieced together to form a 626-bp mRNA transcript that is translated into the 147-amino acid sequence of the HBB polypeptide chain [1]. Approximate gene location is based on Chromosome 11 map from NCBI Entrez Map Viewer. Protein Function Hemoglobin molecules, which reside in red blood cells, are responsible for carrying oxygen from the lungs to various parts of the body for use in respiration. The HBB gene codes for one of the two types of polypeptide chains found in adult hemoglobin. Normal adult hemoglobin is a tetrameric protein consisting of two alpha chains and two beta chains. HBB codes for the beta chain, which is often referred to as beta globin. Mutant beta globin is responsible for the sickling of red blood cells seen in sickle cell anemia [2].

31. Sickle Cell Anemia - DrGreene.com - Caring For The Next Generation Dr. Greene talks about sickle cell anemia, also known as HemoglobinS, including causes,treatments and prevention. sickle cell anemia. http://www.drgreene.com/21_1186.html

QUICK SEARCH A - Z Guide Allergies Allergy Care Guide Asthma Care Guide Bedwetting Breastfeeding Childhood Obesity Diabetes Care Guide Ear Infections Genetics Immunizations Infectious Diseases Parenting Potty Training Rashes Safety Sleep DrGreene.com Topic Centers Mission Reviews Awards Readers Comments Press Room Partners and Supporters Contact Us Pediatric Information A-Z Guide Allergy Care Guide Asthma Care Guide Diabetes Care Guide DrGreene´s Chats FAQ Fast Facts Feature Articles Guidelines Pediatric Updates Special Feature Top Tips Community Activty Guide Advanced Search Community Central Chat Chat Schedule Cute Faces Family Friendly Recipes Parent-to-Parent Resources The DrGreene Team Newsletter Prenatal Newborn Infants Toddlers Pre-Schoolers School Age Teens / Adolescents Multimedia Library Children's Health Fertility Sickle Cell Anemia Also known as: Hemoglobin S Introduction: Normal red blood cells are soft, gel-like discs that can squish as needed to slip through the tiny capillaries of the body. In sickle cell disease, the red blood cells are brittle. What is it?

32. BioMed Central | Abstract | Aged Garlic Extract Therapy For Sickle Cell Anemia P Aged garlic extract therapy for sickle cell anemia patients Junichiro Takasu 1, Rolando Uykimpang 1 , Maria Alenor Sunga 1 , Harunobu Amagase 2 and Yutaka http://www.biomedcentral.com/1471-2326/2/3/abstract

Welcome guest user home journals A-Z journals by subject advanced search ... Volume 2 Viewing options Abstract Full text PDF Pre-publication history Other links: E-mail to a friend Download references Post a comment PubMed record ... Related articles in PubMed Search PubMed For Takasu J Uykimpang R Sunga MA Amagase H ... Niihara Y Key E-mail Corresponding author Research article Aged garlic extract therapy for sickle cell anemia patients Junichiro Takasu Rolando Uykimpang Maria Alenor Sunga Harunobu Amagase and Yutaka Niihara Department of Medicine, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance, CA Wakunaga of America Co., Ltd., Mission Viejo, CA BMC Blood Disorders Abstract Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Results Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia.

33. CBC.ca - Experiencing Technical Difficulties Father calls sickle cell anemia 'neglected' disease Last Updated Mon, 17 Mar2003 193049 Wilson Sanon's 11year-old daughter has sickle cell anemia. http://www.cbc.ca/stories/2003/03/17/sickle_cell030317

We are Experiencing Technical Difficulties You will automatically be returned to the CBC.ca home page as soon as regular service resumes. We apologize for any inconvenience this may cause. To contact CBC Audience Relations please call: or 416-205-3700 for Toronto-area residents E-mail: cbcinput@toronto.cbc.ca

34. Sickle Cell And African-Americans Sickle cell disease is a generic term for a groupof genetic disorders characterized by the predominance of hemoglobin S (Hb S......sickle cell anemia http://www.blackhealthcare.com/BHC/SickleCell/Description.asp

35. African American Health Care And Medical Information Coronary Heart Disease. Stroke. AIDS. Asthma. sickle cell anemia. CommunityBased Health Programs. Healthy Lifestyles. Disease Dictionary. Multimedia Library. http://www.blackhealthcare.com/BHC/Index.asp

36. Hardin MD : Sickle Cell Anemia From the University of Iowa, the *best* lists of Internet sources insickle cell anemia. sickle cell anemia. sickle cell anemia Pictures. http://www.lib.uiowa.edu/hardin/md/sicklecellanemia.html

Sickle Cell Anemia "We list the best sites that list the sites" Site Map Diseases Home Free journals ... Diseases Search Hardin MD See also: Home Blood Diseases Genetic Disorders All links on this page hand-checked Popular Women's Health Dermatology Nursing Pharm Infect Disease Anemia +Pictures Blood Diseases Genetic Disorders +Pictures Lungs Pictures Medical Pictures Skin ... Pictures A Hardin MD Focus Page Sickle Cell Anemia Pictures Sickle cell information center : World-wide resources The Georgia Comprehensive Sickle Cell Center at Grady Health System NOAH: Sickle cell disease Natalie Kupferberg, Ohio State University / NY Online Access to Health MEDLINE plus Sickle cell anemia National Library of Medicine MedWebPlus : Anemia, Sickle cell Steve Foote and Andy Kogelnik, y-DNA,inc, Atlanta, Georgia ClinicalTrials.gov : Anemia, Sickle cell National Library of Medicine, National Institutes of Health Open Directory Project : Health : ... : Blood disorders : Sickle cell (Other versions: Google AOL Michigan Electronic Library : Sickle cell disease Metta Lansdale Yahoo : Sickle cell disease LookSmart : Sickle cell anemia OMNI : Anemia, Sickle cell

37. Sickle Cell Anemia body. In sickle cell anemia, the shape of hemoglobin is altered, andthe red blood cells can become rigid, pointy, and sticky. They http://www.labtestsonline.org/understanding/conditions/sickle.html

TESTS test not listed? ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldosterone Allergies ALP ALT Amylase ANA Antibody Tests Apo A Apo B ApoE Genotyping AST Bilirubin Blood Culture Blood Gases BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcium Cardiac Risk CBC CEA CF Gene Mutation Chlamydia Chloride Cholesterol CK CK-MB CMP Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity Cystatin C DHEAS Differential EGFR Electrolytes ESR Estrogen Estrogen Receptors Fecal Occult Blood Ferritin Flu Tests FSH Genotypic Resistance GFR GGT Glucose Gonorrhea Gram Stain Growth Hormone hCG HDL Hematocrit Hemoglobin Hepatitis A Hepatitis B Hepatitis C Her-2/neu Herpes HIV Antibody Home Tests Homocysteine HPV H-pylori hs-CRP Insulin Iron Tests LD LDH LDL Lead LH Lipase Lipid Profile Liver Panel Lp(a) Lyme Disease Magnesium Microalbumin Mono Monoclonal Protein Myoglobin Pap Smear Phosphorus Platelets Potassium Prealbumin Progesterone Progest. Receptors Prolactin PSA PT PTH Red Count Renin Rheumatoid Factor Rubella Semen Analysis Serum Iron Sickle Cell Sodium Strep Throat Sweat Chloride Syphilis Tau/Aß42 TB Skin Test Testosterone Ther. Drug Monitoring

38. Sickle Cell Anemia sickle cell anemia Understanding the Molecular Biology. Authors JohnM. Sabo, Jamie L. Lynch, and Deanna M. Raineri*. * Department http://peptide.ncsa.uiuc.edu/tutorials_current/Sickle_Cell_Anemia/SC2001/

Sickle Cell Anemia: Understanding the Molecular Biology Authors: John M. Sabo, Jamie L. Lynch, and Deanna M. Raineri* * Department of Microbiology, University of Illinois at Urbana-Champaign. [If you need help or have any questions or comments about this tutorial, please contact Deanna Raineri at raineri@life.uiuc.edu Introduction Part I Part II ... References

39. TUTORIAL: Sickle-cell Anemia shaped. sickle cell anemia glossary. (Not updated to V.3.2!). Usingthe Biology WorkBench. treatment. Treatments of sickle cell anemia http://peptide.ncsa.uiuc.edu/tutorials_current/Sickle_Cell_Anemia/

Sickle-Cell Anemia Primary Author: Meg Loven, Graduate Research Assistant mgrim@uiuc.edu Tutorial Objectives Using the Biology Workbench , we will examine hemoglobin and the sequence of amino acids that make up this protein. This tutorial will demonstrate the simple mutation in the hemoglobin protein that single-handedly causes a terrible disease. From this mutation, we will look at the three-dimensional structure of the hemoglobin protein using a molecular imaging program. The ability to visualize and manipulate hemoglobin adds a dimension of understanding to the mechanism that causes the characteristic sickle-shaped red blood cells of sickle cell anemia. Overview of Sicke-Cell Anemia Sickle cell anemia is a disease in which the patient's red blood cells have an abnormal shape much like that of a sickle. These sickled red blood cells are very fragile and the result is severe anemia, or decreased number of red blood cells. The disease causes many painful symptoms in patients. The abnormal shape of the cells in individuals with sickle cell anemia comes from a defective protein within the blood cells themselves. This defective protein is hemoglobin. The normal hemoglobin protein is made up of four parts, and therefore called a tetramer. Each part of the tetramer has the ability to bind an oxygen molecule and carry it from the lungs to the tissues in which oxygen is needed. When the defective hemoglobin in sickle cell anemia, referred to as Hb S, does not have an oxygen molecule bound, it tends to form a precipitate made up of lots of hemoglobin proteins stuck to each other. This precipitate is what causes the red blood cells to become sickle-shaped.

40. Medical References: Sickle Cell Disease One of the most serious complications of sickle cell anemia is stroke,a bleed or blockage of blood within the blood vessels of the brain. http://www.marchofdimes.com/professionals/681_1221.asp

View All Chapters Find Your Local Chapter April 11, 2003 Select one Folic Acid Pregnancy Prenatal Screening Infections/Diseases Loss Concerns Newborn Information Birth Defects Polio Genetics Research Funding Perinatal Statistics Medical References Continuing Education ... Prematurity Quick Reference and Fact Sheets Sickle Cell Disease What Is Sickle Cell Disease? It is an inherited disease of red blood cells which can cause attacks of pain, damage to vital organs, risk of serious infections and can lead to early death. Sickle cell disease affects the main protein inside the red blood cells called hemoglobin. The disease occurs when a person inherits one sickle cell gene from each parent or a combination of one sickle cell gene plus one of several other abnormal hemoglobin genes. Hemoglobin in the red blood cells carries oxygen from the lungs and takes it to every part of the body. The main hemoglobin in the red blood cells of people with sickle cell disease is not normal. Red blood cells containing mainly normal hemoglobin are round and flexible. In people with sickle cell disease, the abnormal hemoglobin forces the cells to lose their normally round and flexible shape, becoming distorted and rigid. Under a microscope, these abnormal cells may look like the C-shaped farm tool called a sickle. Sickle cells tend to become trapped and to be destroyed in small blood vessels (veins and arteries), the spleen, the liver and other organs. This results in a shortage of red blood cells, or anemia. Anemia can cause an affected child to be pale, short of breath, easily tired and have slowed growth and physical development. Certain conditions, such as infections or enlargement of the spleen, may worsen the anemia by speeding up destruction of red blood cells. Infections also can reduce red blood cell production, leading to worsening of anemia.

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