1. Immunologic Diseases -- Graft Vs Host Disease Conversely, the transplanted immune cells can attack the tissues of the recipient,a potentially lifethreatening reaction called graft-vs-host disease. http://www.niaid.nih.gov/final/immds/grafhost.htm

50 YEARS NIAID HOMEPAGE INFECTIOUS DISEASES IMMUNOLOGIC DISEASES AIDS ... NIH HOMEPAGE The Immune System's Response to Transplants W hen tissue or organs from one person are transplanted into another, the recipient's immune system tries to get rid of this nonself tissue, a process called rejection. Conversely, the transplanted immune cells can attack the tissues of the recipient, a potentially life-threatening reaction called graft-vs-host disease. In 1980 three NIAID-supported scientists won the Nobel Prize in Physiology or Medicine for a discovery that revolutionized organ transplants. Tissue typing The researchers discovered a genetically determined group of cell and tissue "markers" called HLA antigens. Basic scientific research increases our understanding of the immune system's response to transplants. These, they found, were different in each person producing a biochemical profile as unique as a fingerprint. Today this work is the basis for typing tissues to determine compatibility for organ and tissue transplants. The more alike are the donor's and recipient's HLA markers, the better the chance that the recipient's immune system will not reject the foreign tissue. NIAID-sponsored scientists also: developed a tissue-typing technique that made possible the first bone marrow transplant between people other than identical twins.

2. DS 01-04 -Gastrointestinal Graft Vs Host Disease - Compassionate Use Of Oral Bec Roswell Park Cancer Institute Compassionate Use of Oral BeclomethasoneDipropionate for Treatment of Gastrointestinal graft vs host disease. http://www.roswellpark.org/clinicaltrial.asp?lid=1806&reflid=389

3. Graft Vs Host Disease graft vs host disease Companies with products addressing GVHD. Company Rankings,Symbol, Product, Development Stage. Abgenix, ABGX, ABXCBL, Phase III. http://www.bitsplace.com/bitsplace/GVHDcomp.html

Graft vs Host Disease Companies with products addressing GVHD. Company Rankings Symbol Product Development Stage Abgenix ABGX ABX-CBL Phase III Protein Design Labs PDLI Zenapax Phase II Medimmune MEDI MEDI-507 Phase I/II ABX-CBL a monoclonal antibody produced with ABGX's Xenomouse GVHD most acute in bone marrow transplants current therapy includes steroids and horse antibody ATG - anti-thymocyte globulin from horses ABX-CBL intended to avoid steroid resistance CBL antigen on T cells, B cells and natural killer cells ABX-CBL targets only these cells immune suppression less than conventional therapy long term survival should be greater Medi-507 anti-CD2 humanized monoclonal antibody (MAB) binds to CD2 receptor of T cells and NK cells inhibits immune response to transplanted tissue does not inhibit normal immune function intended for use in GvHD (graft vs host disease) GvHD develops in bone marrow and stem cell transplants transplanted cells attack recipient's tissues 70% mortality rates 30,000 bone marrow or stem cell transplants/year MEDI-507 has been granted orphan drug status by FDA benefits for developing drug with small patient pool Zenapax (daclizumab; SMART Anti-Tac Antibody)

4. Graft Vs Host Disease Parker Hughes Cancer Center/ New Drug Effective Against Graft Versus Host DiseaseOffers Hope to Bone Marrow Transplant Recipients 831-01 ROSEVILLE, Minn. http://organtx.org/dc/gvh2001.htm

Graft vs Host Disease Immunoglobulin Mechanism in GVHD Elucidated LONDON (Reuters Health) 10-23-01 Intravenous immunoglobulin (IVIg) decreases the severity of acute graft-versus-host disease (GVHD) by inducing apoptosis of donor T cells, French researchers conclude after completing a series of animal experiments. Dr. Blanche Bellon, and colleagues at INSERM in Paris, induced acute GVHD in rats, which were then given IVIg, F(ab')2 fragments, or no treatment. Seventy-two percent of the rats that did not receive IVIg or F(ab')2 fragments were dead within 20 days, they report in the September issue of the European Journal of Immunology. In contrast, only 39% of the IVIg-treated and 20% of the F(ab')-treated rats had died or had clinical symptoms of GVHD. In further experiments, acute GVHD was induced by transferring cells from male rats to female rats. The investigators found that IVIg induced apoptosis of the allogeneic donor CD4+CD134+ Th1 cytokine-producing T cells and dramatically reduced 0X40 antigen on CD4+ cells, thereby preventing GVHD in the treated rats, according to the report. "Our present observations provide a specific mechanism for immunomodulation of GVHD by IVIg and emphasize the role of normal immunoglobulins in alloantigen immune responsiveness that develops in both deleterious graft-versus-donor and beneficial graft-versus- leukemia reactions," Dr. Bellon and colleagues conclude.

5. Immunologic Diseases Links to information on autoimmune diseases, graft versus host disease, hypersensitivity and immunologic Category Science Biology Immunology...... Membranoproliferative glomerulonephritis, microscopic U. of Utah Webpath.graft vs host disease Ctr. Graftvs.-Host Disease Med. Coll. http://www.ohsu.edu/cliniweb/C20/C20.html

Immunologic Diseases Back to previous level Autoimmune Diseases [25 more specific term/s, 114 more link/s] Search PUBMED for Autoimmune Diseases: All Review Therapy Diagnosis ... Blood Group Incompatibility [2 more specific term/s, 3 more link/s] Search PUBMED for Blood Group Incompatibility: All Review Therapy Diagnosis Glomerulonephritis, Membranoproliferative Search PUBMED for Glomerulonephritis, Membranoproliferative: All Review Therapy Diagnosis ... Membranoproliferative glomerulonephritis, microscopic: U. of Utah Webpath Graft vs Host Disease Search PUBMED for Graft vs Host Disease: All Review Therapy Diagnosis ... Hypersensitivity [7 more specific term/s, 4 more link/s] Search PUBMED for Hypersensitivity: All Review Therapy Diagnosis ... Immunologic Deficiency Syndromes [12 more specific term/s, 225 more link/s] Search PUBMED for Immunologic Deficiency Syndromes: All Review Therapy Diagnosis ... Immunoproliferative Disorders [3 more specific term/s, 4 more link/s] Search PUBMED for Immunoproliferative Disorders: All Review Therapy Diagnosis ... Purpura, Thrombocytopenic [1 more specific term/s, 1 more link/s] Search PUBMED for Purpura, Thrombocytopenic:

6. Immunologic Diseases graft vs host disease Quick clinical facts about Graftvs.-Host Disease- CHORUS; Control of Graft versus Host Disease - BioScience http://www.mic.ki.se/Diseases/c20.html

search help staff Immunologic Diseases Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Alphabetical List of Diseases Search PubMed at NCBI/NLM Immonology Bowers et al. ; educ.] - Univ of South Carolina (US) A 4-pages introduction to The Immune System - Nobel Foundation About the Immune System - NCI/NIH (US) The Anatomy of the Immune System , and an Immunology Glossary - Univ of Leicester (UK) Basic Immunology G Heath ] - Optometry Today, Feb 2002 (UK) The Human Immune System K Bendtzen ] - Rigshospitalet (DK) Understanding the Immune System Schindler et al. ] - Cancer.gov (US) Immunobiology. 5th ed. Janeway et al. , 2001; online book] - via PubMed, NLM (US) The Immune System TJ Copeland An Immunology Study Sheet - Medical Study Guides, Univ of Kansas (US) How Your Immune System Works M Brain Immunobiology animations [Flash 5 Player required] - Garland Science Publ. (UK) Immunological Disorders Edgar and Sewell ; sample chapter] - Textbook of Medicine/Souhami et al.

7. Surgeons Net Web Directory - Home > Transplant Surgery > Graft Vs Host Disease Home/ Transplant Surgery/ graft vs host disease/. Control of GraftVersus Host Disease from Frontiers in Bioscience. Graft Versus http://www.surgeons.org.uk/search/Transplant_Surgery/Graft_vs_Host_Disease/

Free Email Home Transplant Surgery/ Graft vs Host Disease/ Control of Graft Versus Host Disease - from Frontiers in Bioscience. Graft Versus Host Disease Graft Versus Host Disease (GVHD) - info from the Johns Hopkins Oncology Centre's Hematologic Malignancies Division. Rare Diseases Clinical Trials - clinical trials pertaining to Graft Versus Host Disease. We subscribe to the HONcode principles of the Health On the Net Foundation Surgeons Net Ltd Terms and Conditions Advertising Policy ... Discussion Last modified: August 29 2002 01:07:14.

8. McGill Department Of Physiology • Faculty And Staff >> Faculty And Staff Direct The role of endotoxin in the pathogenesis of acute graftvs-host disease. Ingraft vs host disease, 2 nd ed. J. Ferrara, J. Deeg and S. Burakoff, Eds. http://www.medicine.mcgill.ca/physio/staffpages/wlapp.htm

PostDocs Research Labs Affiliated Centres Available Positions Today's date: Wayne Lapp, Faculty Member Department of Physiology McGill University McIntyre Medical Sciences Building, Room 1106 3655 Promenade Sir William Osler wayne.lapp@mcgill.ca Research Area: Physiology of the Immune System Research Description: Our laboratory has been interested in graft-vs-host disease (GVHD), a disease which often appears after bone marrow transplantation. We are investigating the molecular and cellular mechanisms responsible for GVHD induced pathological lesions and immune suppression. Experimentally induced GVHD is used to study immune regulation and it is also being used as a model to study various autoimmune diseases such as lupus and inflammatory bowel disease. Education: Ph.D., McGill Recent Publications: Kichian K, Nestel FP, Kim D, Ponka P, Lapp WS. IL-12 p40 messenger RNA expression in target organs during acute graft-versus-host disease. Possible involvement of IFN-gamma. J Immunol. 1996 Oct 1;157(7):2851-6.

9. ClinicalTrials.gov - Linking Patients To Medical Research: Results 10. Recruiting, Improved Methods of Cell Selection for Bone Marrow TransplantAlternatives Conditions graft vs host disease; Healthy; Lymphopenia. 11. http://www.clinicaltrials.gov/ct/gui/action/SearchAction?term=Heart Transplantat

10. ClinicalTrials.gov - Linking Patients To Medical Research: Results Study comparing ABXCBL (monoclonal antibody) versus Atgam in Patients with SteroidResistant Acute Graft versus Host Disease Condition graft vs host disease. http://www.clinicaltrials.gov/ct/gui/action/SearchAction?term=Heart Attack

11. Johns Hopkins Kimmel Cancer Center Summary The principal goal of Dr. Hess’ laboratory is to elucidate the underlyingimmunobiological mechanisms associated with GVHD (graft vs host disease). http://www.hopkinskimmelcancercenter.org/experts/_doctor.cfm?doctorid=30&action=

12. Graft-vs.-host And Graft-vs.-leukemia Reactions After Delayed CD4Positive T-Lymphocytes/IMMUNOLOGY/TRANSPLANTATION CD8-Positive T-Lymphocytes/IMMUNOLOGY/TRANSPLANTATIONgraft vs host disease/*IMMUNOLOGY/MORTALITY/THERAPY http://www.aegis.com/pubs/aidsline/1999/dec/A99C0998.html

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date. Graft-vs.-host and graft-vs.-leukemia reactions after delayed infusions of donor T-subsets. Biol Blood Marrow Transplant. 1999;5(3):123-32. Unique Identifier : AIDSLINE MED/99320129 Johnson BD; Becker EE; Truitt RL; Department of Pediatrics, Medical College of Wisconsin, Milwaukee; 53226, USA. bjohnson@mcw.edu Abstract: Keywords: JOURNAL ARTICLE Animal Bone Marrow Transplantation CD4-Positive T-Lymphocytes/IMMUNOLOGY/TRANSPLANTATION CD8-Positive T-Lymphocytes/IMMUNOLOGY/TRANSPLANTATION Graft vs Host Disease/*IMMUNOLOGY/MORTALITY/THERAPY Graft vs Tumor Effect/*IMMUNOLOGY Histocompatibility Testing Infusions, Intravenous Leukemia, Experimental/IMMUNOLOGY/THERAPY Mice Mice, Inbred AKR Mice, Inbred C57BL Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocyte Subsets/IMMUNOLOGY/*TRANSPLANTATION Transplantation, Homologous National Library of Medicine . Reproduced under license with the National Library of Medicine, Bethesda, MD. Boehringer Ingelheim iMetrikus, Inc.

13. Graft-vs-host Disease And Immunologic Reconstitution In Bone Antigens, CD3/ANALYSIS Antigens, Differentiation, TLymphocyte/ANALYSIS *Bone MarrowTransplantation CD4-CD8 Ratio graft vs host disease/*IMMUNOLOGY/THERAPY http://www.aegis.com/pubs/aidsline/1993/mar/M9331093.html

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date. Graft-vs-host disease and immunologic reconstitution in bone marrow transplant recipients of related and unrelated grafts using total T-cell depletion (Meeting abstract). Exp Hematol; 20(6):707 1992. Unique Identifier : AIDSLINE ICDB/93688142 Hedderman A; Tricot G; Ballas CB; Leemhuis T; Grigsby S; Graves V; Hoffman R; Lebkowski J; Srour EF; Indiana Univ. Sch. of Medicine, Indianapolis, IN Abstract: Keywords: Antigens, CD/ANALYSIS Antigens, CD3/ANALYSIS Antigens, Differentiation, T-Lymphocyte/ANALYSIS *Bone Marrow Transplantation CD4-CD8 Ratio Graft vs Host Disease/*IMMUNOLOGY/THERAPY Human *Leukocyte Count Lymphocyte Depletion Receptors, IgG/ANALYSIS *T-Lymphocytes T-Lymphocytes, Suppressor-Effector ABSTRACT National Library of Medicine . Reproduced under license with the National Library of Medicine, Bethesda, MD. AEGiS is made possible through unrestricted grants from Boehringer Ingelheim iMetrikus, Inc.

14. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Graft+vs+Host+Disease Similar pages PDFCellular and Cytokine Effectors of Acute Graft Versus Host http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Graft vs Host Disease

15. Inflammatory Myopathy Graftvs-host disease, 7 to 24 months post BMT. graft vs host disease(GVHD) + Myositis Onset 7 to 24 months post bone marrow transplant; http://www.neuro.wustl.edu/neuromuscular/antibody/infmyop.htm

Front Search Index Links ... Patient Info Inflammatory and Immune Myopathies GENERAL FEATURES Antibodies CK: Serum Electrodiagnostic ... Calcinosis : X-rays Chondroitin sulfate C deficient Dermatomyositis Fasciitis Focal myositis ... Signal recognition particle Vasculitis: Small Large vessel SPECIFIC IMMUNE OR INFLAMMATORY MYOPATHIES Polymyositis syndromes General aspects Classification Comparative features Collagen vascular disease Complement ... Quadriceps ; Other TRAPS Granulomatous Hemophagocytic lymphohistiocytosis Hereditary ... Multinodular polymyositis Necrotizing with Encephalopathy Paraneoplastic with Pipestem capillaries SRP antibodies ... MHC class I upregulation Skin lesions Erythema Gottron's papules Nailfold lesions From: Chinju, South Korea GENERAL FEATURES OF INFLAMMATORY MYOPATHIES Antibodies CK: Serum Electrodiagnostic Neoplasm associations ... Weakness Skin lesions Heliotrope rash Distribution Symmetric Disease association: Dermatomyositis External links Facial rash Gottron's sign Red-purple keratotic, atrophic erythema, or macules Disease association: Dermatomyositis External link: Gottron's sign Erythema Red-purple slightly raised On extensor surfaces of elbows or knees Disease association: Dermatomyositis Mechanic's hands Raised scaly dry On extensor surfaces of finger joints Disease association: Nailfold lesions Disease association: Dermatomyositis - Anti-Mi-2 antibody positive Other features Rash more commonly pruritic than rash with lupus erythematosis Skin lesions often photoaggravated Weakness Proximal: Most Dermatomyositis Polymyositis Distal:

16. Non_myeloablative_Cord_Blood_transplant Allogeneic Transplant In an allogeneic transplant, the two main complications thatcould arise are i. Host vs graft or graft failure ii. graft vs host disease. http://www.sgh.com.sg/contents/news_press/press7.htm

18 February 2002 WORLD'S FIRST SUCCESSFUL POOLED UNRELATED CORD BLOOD TRANSPLANT WITH NON-MYELOABLATIVE APPROACH Singapore General Hospital's Department of Haematology's medical team lead by A/Prof Patrick Tan has successfully performed unrelated cord blood transplant for two adult patients using non-myeloablative approach and without high dose chemotherapy. The successful transplant for a 43-year-old man, Mr. Huang, suffering from acute myeloid leukaemia, which pooled two unrelated cord blood samples using non-myeloablative approach, is the first of its kind in the world. The cord blood samples were from local cord blood registry and from an American cord blood registry. He underwent the transplant on 12 December 2001. The other patient, Mr Slamet Sampoerno is a 40-year-old Indonesian man who had multiple myeloma. This is also the first known case of unrelated cord blood transplant using non-myeloablative approach performed for multiple myeloma. The transplant was performed on 28 November 2001. Allogeneic Transplant In an allogeneic transplant, the two main complications that could arise are:

17. Entrez-PubMed Abstract, CNS angiitis in graft vs host disease. Neurology. 2002 Dec24;59(12)19947. PMID 12499502 PubMed - indexed for MEDLINE. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&orig_db=PubMe

18. Indexing Initiative Prototype Female (check tag). Graft Survival (14). graft vs host disease (4). GranulocyteColonyStimulating Factor (7). Histocompatibility (11). Male (check tag). http://ii.nlm.nih.gov/Demo/Citations/98018999.html

link to PubMed: Medline Citation: MEDLINE indexed MeSH expressions are displayed in the left column. MeSH expressions that concur with terms suggested by the Indexing Initiative prototype are displayed in red. The number in parenthesis indicates the prototype's rank order. out of starred MeSH expressions are suggested by Indexing Initiative prototype. out of starred MeSH expressions are suggested by Indexing Initiative prototype. Indexed MeSH Expressions Additional Suggested MeSH Expressions *Bone Marrow Transplantation (5) *Hematopoiesis (6) *Stem Cell Factor (1) Animal (check tag) Dogs (check tag) Female (check tag) Graft Survival (14) Graft vs Host Disease (4) Granulocyte Colony-Stimulating Factor (7) Histocompatibility (11) Male (check tag) Recombinant Proteins Time Factors Bone Marrow (2) Whole-Body Irradiation (3) Monocytes (8) Hematopoietic Stem Cells (9) Radiation Chimera (10) Hematopoietic Stem Cell Transplantation (12) Neutrophils (13) Hematopoietic Cell Growth Factors (15) Lymphocytes (16) Transplantation, Homologous (17)

19. NewScreen(tm) - Frequently Asked Questions About Cord Blood Banking higher survival rate, a higher quality of life after transplant and less frequenthospitalization due to fewer complications such as graft vs host disease (GHVD http://www.newscreentest.com/cord_blood_banking/faqs.htm

About NewScreen Cord Blood Banking Our clients Important to save ... Download instructions Cord Blood Stem Cells What is cord blood? What are stem cells? How are stem cells used in medicine? What types of diseases are treated with stem cell transplantation? ... What is Graft v. Host Disease (GVHD)? What is Cord Blood? Cord blood (sometimes called placental blood or umbilical cord blood) is the blood that remains in the umbilical cord and placenta following birth. Like bone marrow, cord blood has been found to be a rich source of stem cells. The Harvard Health Letter (published in March 1997) named cord blood one of the top 10 medical advances of 1996. Return to Index What are stem cells? Stem cells are the building blocks of your blood and immune system and reside primarily in your bone marrow. There are three known sources of stem cells: Bone Marrow, Peripheral Blood (the blood that circulates throughout your body), and Umbilical Cord Blood. Stem Cells are the "mother cells" that lead to the production of all the various types of cells in the blood. Stem cells reproduce into: Red Blood Cells - which carry oxygen throughout the body White Blood Cells - which fight infection Platelets - which aid in clotting Return to Index How are stem cells used in medicine?

20. CML Discussion Area off residual disease. However, this induces graft vs host diseaseor GVHD and efforts are ongoing to reduce this. The problem is http://www.newcmldrug.com/Discuss/reply.asp?ID=5375&Reply=5375

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