81. JDRF Center For Islet Transplantation At HMS A and Sykes M. Interleukin12 preserves the graft-vs-leukemia effect of allogeneicCD8 T cells while inhibiting CD4-dependent graft-vs-host disease in mice. http://www.jdf-hms-islets.org/investigators/sykes.html

82. Bryon A. Johnson, PhD of allogeneic bone marrow transplantation (BMT) still relate to the immunobiologyof donorrecipient interactions, principally graft-vs-host disease (GVHD) and http://www.mcw.edu/peds/bios/johnson.html

83. Robert L. Truitt, Ph.D. Mechanisms in Successful Therapy of graftvs-host disease with MonoclonalAntibodies (NCI 5 R01 CA39854) IN graft-vs-host disease. http://www.mcw.edu/peds/bios/truitt.html

84. NEJM -- Graft-Versus-Host Disease In Children Who Have Received A Cord-Blood Or stemcell transplantation may lower the risk of graft-versus-host disease (GVHD bloodwere younger than recipients of bone marrow (median age, 5 years vs. http://content.nejm.org/cgi/content/short/342/25/1846

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Volume 342:1846-1854 June 22, 2000 Number 25 Next Graft-Versus-Host Disease in Children Who Have Received a Cord-Blood or Bone Marrow Transplant from an HLA-Identical Sibling Vanderson Rocha, M.D., John E. Wagner, M.D., Kathleen A. Sobocinski, M.S., John P. Klein, Ph.D., Mei-Jie Zhang, Ph.D., Mary M. Horowitz, M.D., Eliane Gluckman, M.D., for The Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources Table of Contents Full Text of this article PDF of this article Editors' Summaries ... Related Articles in Medline Articles in Medline by Author: Rocha, V. Medline Citation Child Health Hematology ... Related Chapters at Harrison's Online ABSTRACT Background Umbilical-cord blood as an alternative to bone marrow for hematopoietic stem-cell transplantation may lower the risk of graft-versus-host disease (GVHD). Methods We studied the records of 113 recipients of cord blood from HLA-identical siblings from the period from 1990 through 1997 and compared them with the records of 2052 recipients of bone marrow from HLA-identical siblings during the same period.

85. News Release From UT Southwestern: Researchers Discover Thymus Gland Plays Role Many of those patients develop graftvs.-host disease, in which the new donor-derivedimmune system recognizes the recipient's body as foreign. http://irweb.swmed.edu/newspub/newsdetl.asp?story_id=290

86. Immunologic Diseases Articles targeted at the general public on allergy and asthma, graftvs-host diseases, immune deficiency diseases and autoimmune diseases. Also contains information on how the immune system works. http://www.niaid.nih.gov/final/immds/immds.htm

50 YEARS NIAID HOMEPAGE INFECTIOUS DISEASES IMMUNOLOGIC DISEASES AIDS ... NIH HOMEPAGE T he immune system is a complex network of specialized cells and organs. When it malfunctions, it can cause a wide array of problems. Scientists are making great strides in detecting, treating, and preventing disorders of the immune system. T Cell The healthy T cell is one type of immune system cell. How does the immune system work? Allergy and Asthma Usually harmless substances can provoke inappropriate immune responses. Graft-vs-Host Disease Transplantation of tissues and organs can cause life-threatening reactions in recipients. Immune Deficiency Diseases These diseases can be inherited or result from infections or drug treatments. Autoimmune Diseases The immune system mistakenly attacks the body. Looking Ahead Gene therapy and improved transplant procedures. IMAGE CREDIT T Cell: NIAID

87. Lymphohematopoietic Graft-vs.-Host Reactions Without GVHD Lymphohematopoietic graftvs.-host reactions can be induced without graft-vs.-hostdisease in murine mixed chimeras established with a cyclophosphamide-based http://bbmt.cjp.com/stories/storyReader$96

Menu Home Purpose and Scope Masthead Author Instructions ... Search CJP Online Journals BloodLine Heart Surgery Forum Journal Center Lymphohematopoietic Graft-vs.-Host Reactions without GVHD Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen Michele R. Pelot, Denise A. Pearson, Kirsten Swenson, Guiling Zhao, Jessica Sachs, Yong-Guang Yang, Megan Sykes 5.3.Pelot Carden Jennings Publishing Co., Ltd. Current Edition Biology of Blood and Marrow Transplantation Laboratory Hematology Blood and Marrow Transplantation Reviews Heart Surgery Forum

88. GVHD graft versus host disease is really two different diseases. An early formof graftversus-host disease is called acute graft-versus-host disease. http://www.hopkinskimmelcancercenter.org/clientpages/gvhdinformation.cfm

GVHD More Information about GVHD Graft versus host disease is really two different diseases. An early form of Graft-versus-Host disease is called acute Graft-versus-Host disease. It occurs immediately after the transplant when the white cells rise. A late form of Graft-versus-Host disease also occurs. This is called chronic Graft-versus-Host disease. The signs and symptoms of these two diseases differ and they will be discussed separately. Graft-versus-Host disease is caused by the T-lymphocyte (or T cell), a type of white cell, recognizing the patient as being foreign. The T-cells are harvested with the bone marrow graft from the donor and transferred in the graft. T-cells normally help protect the body from infections. When a T-cell from the donor realizes it is in a new body it can attack the new body (the patient) as being foreign, based on a set of genetic markers or cells called human leukocyte antigens (HLA). We know that there are many minor markers that differ between donors and patients except when the patient and donor are identical twins. Before a transplant, extensive typing of the donor and recipient take place to try to make sure, as best we can, that donor and recipient are very closely matched. Chronic Graft-versus-Host disease is the late form of Graft-versus-Host disease and usually is seen two to three months after the transplant. The symptoms of chronic Graft-versus-Host disease resemble many spontaneously occurring auto immune disorders, such as lupus or scleroderma. Most patients with chronic Graft-versus-Host disease develop skin and mouth problems. Initially patients develop a dry, itchy rash which is raised. Many patients describe this pebbly rash as like alligator skin. If the Graft-versus-Host disease persists, the skin may become thickened. Areas of increased and decreased skin color may occur. There also may be hair loss, decrease in sweating in the skin, and premature greying of the hair related to chronic Graft-versus-Host disease.

89. Graft Versus Host Disease Links From GrannyBarb And Art's Leukemia Links Preventing Opportunistic Infections After Hematopoietic Stem Cell TransplantationThe Centers for disease Control and Prevention, Infectious diseases Society http://www.acor.org/leukemia/bmt-comp.html

Leukemia Links Navigation Bar Know About Leukemia Treating Leukemia Leukemia and Genetics Causes of Leukemia ... Sitemap GrannyBarb and Art's Complications of BMTs and long term side effects Contents Compilcations Infections Graft vs. Host Disease Long Term Side Effects of BMTs Cataracts Index Detection and Treatment of Infections Journal Articles General Articles on Infections Infections in the Neutropenic Patient- New Views of an Old Problem , by Gerald R. Donowitz, Dennis G. Maki, Christopher J. Crnich, Peter G. Pappas and Kenneth V.I. Rolston, from Hematology , American Society of Hematology Education Program Book , 2001. This articles is an overview of various infections that strike neutropenic patients. It discusses antibiotic resistance, line-related infections, and fungal infections. Preventing Opportunistic Infections After Hematopoietic Stem Cell Transplantation: The Centers for Disease Control and Prevention, Infectious Diseases Society of America, and American Society for Blood and Marrow Transplantation Practice Guidelines and Beyond , by Keith M. Sullivan, Clare A. Dykewicz, David L. Longworth, Michael Boeckh, Lindsey R. Baden, Robert H. Rubin and Kent A. Sepkowitz, from Hematology , American Society of Hematology Education Program Book , 2001. This review presents evidence-based guidelines for the prevention of infection after blood and marrow transplantation. Recommendations apply to all myeloablative transplants regardless of recipient (adult or child), type (allogeneic or autologous) or source (peripheral blood, marrow or cord blood) of transplant. Includes recommendations for hospital infection control (hand hygiene, room ventilation, health care worker and visitor policies), prevention of viral diseases (CMV, Herpes Zoster Shingles, Herpes Simplex Virus and community respiratory virus infections), prevention of fungal infections and prevention of bacterial and protozoal disease.

90. RealTime Cancer Messages Remaining in Remission. » 30 Day Drive. » The Next Step. » graft vs. HostDisease. » The Time Has Come. » Balancing For Me. » What Christmas Means ToMe. http://www.realtimecancer.org/messages/messagelist.asp?series=2&game=11

91. Vhihealthe.com, Irish Health Information On Vhihealthe.com Chron's disease. Crohn's disease is a chronic inflammatory disease of the digestive tract. http://www.vhihealth-e.ie/topic/topic100586884

92. HONselect - Immunologic Diseases Accepted term(s) Immunological diseases -disease, Immunologic -disease, Immunological-diseases, Immunologic. Cross Reference(s) Blood Protein Disorders, http://www.hon.ch/HONselect/Selection/C20.html

HONselect: Introduction Search Browse Favourites List of Rare Disease add HONselect Contents on "Immunologic Diseases": MeSH hierarchy and definition Research Articles Web resources Medical Images Medical News Medical Conferences Clinical Trials Wondering about the holiday blues! MeSH Hierarchy English French German Spanish Portuguese MeSH Broader term(s) Diseases Immunologic Diseases MeSH definition Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated or both. Subheadings : complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy MeSH Narrow term(s) Autoimmune Diseases Blood Group Incompatibility Hypersensitivity Immunologic Deficiency Syndromes Immunoproliferative Disorders Purpura, Thrombocytopenic Glomerulonephritis, Membranoproliferative Graft vs Host Disease Accepted term(s) -Immunological Diseases -Disease, Immunologic -Disease, Immunological -Diseases, Immunologic Cross Reference(s): Blood Protein Disorders Browse New search MEDLINE 's articles for " Immunologic Diseases English French German Spanish Portuguese All categories Selection by study category Refinement by recall or precision All recent articles Therapy Diagnosis Etiology Prognosis Therapy by recall Diagnosis by recall Etiology by recall Prognosis by recall Therapy by precision Diagnosis by precision Etiology by precision Prognosis by precision Browse New search Web resources for " Immunologic Diseases English info: enter the site: (click below) domain of the site: Immunologic Diseases www.ohsu.edu

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